Matthew R Hayes

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner
    S Zhao
    Department of Physiology and Pathophysiology, School of Medicine, Xi an Jiaotong University, Xi an, People s Republic of China
    Int J Obes (Lond) 36:1522-8. 2012
  2. pmc Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Cell Metab 13:320-30. 2011
  3. pmc Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation
    Matthew R Hayes
    University of Pennsylvania, Philadelphia, 19104, USA
    Cell Metab 11:77-83. 2010
  4. pmc Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling
    Matthew R Hayes
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:2654-9. 2009
  5. pmc Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance
    Matthew R Hayes
    Graduate Group of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:2175-82. 2009
  6. pmc Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation
    Matthew R Hayes
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 149:4059-68. 2008
  7. doi request reprint Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:1342-9. 2011
  8. pmc Role of the glucagon-like-peptide-1 receptor in the control of energy balance
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Physiol Behav 100:503-10. 2010
  9. pmc The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1
    Matthew R Hayes
    Translational Neuroscience Program, Dept of Psychiatry, Perelman School of Medicine at the Univ of Pennsylvania, TRL Bldg, Office 2219, 125 South 31st St, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1479-85. 2011
  10. pmc Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency
    Bart C De Jonghe
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia PA, USA
    Am J Physiol Endocrinol Metab 303:E644-51. 2012

Collaborators

Detail Information

Publications37

  1. pmc Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner
    S Zhao
    Department of Physiology and Pathophysiology, School of Medicine, Xi an Jiaotong University, Xi an, People s Republic of China
    Int J Obes (Lond) 36:1522-8. 2012
    ....
  2. pmc Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Cell Metab 13:320-30. 2011
    ..Pharmacotherapies targeting these signaling pathways, which mediate intake-suppressive effects of CNS GLP-1R activation, may prove efficacious in treating obesity...
  3. pmc Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation
    Matthew R Hayes
    University of Pennsylvania, Philadelphia, 19104, USA
    Cell Metab 11:77-83. 2010
    ..Overall these findings demonstrate that LepRs in mNTS and AP neurons are required for normal energy balance control...
  4. pmc Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling
    Matthew R Hayes
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:2654-9. 2009
    ..We conclude that endogenous NTS GLP-1R activation driven by gastric satiation signals contributes to the control of normal feeding...
  5. pmc Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance
    Matthew R Hayes
    Graduate Group of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:2175-82. 2009
    ....
  6. pmc Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation
    Matthew R Hayes
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 149:4059-68. 2008
    ..Contrary to the literature, hypothalamic/forebrain processing and forebrain-caudal brainstem communication is not required for the observed responses...
  7. doi request reprint Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:1342-9. 2011
    ..i.d.) and liraglutide (q.d.), lead to comparable and pronounced suppression of food intake and body weight in DIO rats, suggesting a potential role for these drugs as a clinical tool for obesity treatment...
  8. pmc Role of the glucagon-like-peptide-1 receptor in the control of energy balance
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Physiol Behav 100:503-10. 2010
    ..The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009...
  9. pmc The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1
    Matthew R Hayes
    Translational Neuroscience Program, Dept of Psychiatry, Perelman School of Medicine at the Univ of Pennsylvania, TRL Bldg, Office 2219, 125 South 31st St, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1479-85. 2011
    ....
  10. pmc Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency
    Bart C De Jonghe
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia PA, USA
    Am J Physiol Endocrinol Metab 303:E644-51. 2012
    ..These studies are the first to show that hindbrain administration of leptin or a melanocortin receptor agonist alters energy balance in mice likely via participation of hindbrain POMC neurons...
  11. pmc Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals
    Scott E Kanoski
    Dept of Psychology, School of Arts and Sciences, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 303:E496-503. 2012
    ..Overall, these findings deepen the understanding of the distributed neuronal systems and behavioral mechanisms that mediate the effects of leptin receptor signaling on the control of food intake...
  12. pmc Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake
    Elizabeth G Mietlicki-Baase
    Translational Neuroscience Program, Department of Psychiatry, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 38:1685-97. 2013
    ....
  13. doi request reprint The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide
    Scott E Kanoski
    Department of Psychology, School of Art and Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropharmacology 62:1916-27. 2012
    ....
  14. pmc Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4
    Scott E Kanoski
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 152:3103-12. 2011
    ....
  15. pmc TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin
    Andrea M Spaeth
    Dept of Psychology, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 302:E1252-60. 2012
    ..Collectively, these results indicate that TrkB-mediated signaling in the mNTS negatively regulates food intake and, in part, the intake inhibitory effects of leptin administered into the NTS...
  16. pmc Hindbrain GLP-1 receptor-mediated suppression of food intake requires a PI3K-dependent decrease in phosphorylation of membrane-bound Akt
    Laura E Rupprecht
    Translational Neuroscience Program, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Am J Physiol Endocrinol Metab 305:E751-9. 2013
    ....
  17. ncbi request reprint Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance
    Harvey J Grill
    Graduate Group of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 16:296-309. 2012
    ..These hindbrain-mediated controls are neuroanatomically distributed; they involve endemic hindbrain neurons and circuits, hindbrain projections to peripheral circuits, and projections to and from midbrain and forebrain nuclei...
  18. pmc GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake
    Amber L Alhadeff
    Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 153:647-58. 2012
    ..Current data highlight these nuclei within the MRS as novel sites for GLP-1R-mediated control of food intake and body weight...
  19. pmc Regulation of energy balance and body weight by the brain: a distributed system prone to disruption
    Lucy F Faulconbridge
    Center for Weight and Eating Disorders, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
    Psychiatr Clin North Am 34:733-45. 2011
    ..With greater understanding of these mechanisms, the field moves closer to understanding and eventually treating the causalities of obesity...
  20. pmc Intraduodenal milk protein concentrate augments the glycemic and food intake suppressive effects of DPP-IV inhibition
    Diana R Olivos
    Translational Neuroscience Program, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Am J Physiol Regul Integr Comp Physiol 306:R157-63. 2014
    ..These data support the hypothesis that dietary intake of dairy protein may be beneficial as an adjunct behavioral therapy to enhance the glycemic and food intake suppressive effects of GLP-1-based pharmacotherapies. ..
  21. pmc Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure
    Bart C De Jonghe
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 300:E1002-11. 2011
    ..These data show that PTP1B in POMC neurons plays a role in short-term cold-induced reduction of SPA and may influence cold-induced thermogenesis via enhanced activation of the thyroid axis...
  22. ncbi request reprint Imaging obesity: fMRI, food reward, and feeding
    Harvey J Grill
    Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 6:423-5. 2007
    ..Recent papers by Batterham et al. (2007) and Farooqi et al. (2007) link peptide YY(3-36) and leptin to the activation of nonhomeostatic brain regions...
  23. pmc Hippocampal leptin signaling reduces food intake and modulates food-related memory processing
    Scott E Kanoski
    Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 36:1859-70. 2011
    ..To conclude, the results support a role for hippocampal leptin signaling in the control of food intake and food-related memory processing...
  24. pmc Neuronal and intracellular signaling pathways mediating GLP-1 energy balance and glycemic effects
    Matthew R Hayes
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States
    Physiol Behav 106:413-6. 2012
    ..In addition, focus is devoted to recent studies that examine the GLP-1R-mediated intracellular signaling pathways that are required for GLP-1's glycemic and feeding responses...
  25. pmc Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake
    Naomi J McKay
    Behavioral Neuroscience Program, Department of Psychology, The State University of New York at Buffalo, Buffalo, New York 14260, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1755-64. 2011
    ..Overall, these results show that GLP-1R agonists have a hypodipsic effect that is independent of GLP-1R-mediated effects on food intake, and this occurs, in part, through central nervous system GLP-1R activation...
  26. pmc Melanocortin control of energy balance: evidence from rodent models
    Bart C De Jonghe
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Mol Life Sci 68:2569-88. 2011
    ..In addition, distinctions and controversy between rodent species will be discussed...
  27. ncbi request reprint Incretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose
    Matthew R Hayes
    Translational Neuroscience Program, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 email
    Annu Rev Nutr 34:237-60. 2014
    ....
  28. ncbi request reprint Glucagon-like Peptide-1 receptor signaling in the lateral parabrachial nucleus contributes to the control of food intake and motivation to feed
    Amber L Alhadeff
    Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 39:2233-43. 2014
    ..Taken together, these data establish the lPBN as a novel site of action for GLP-1R-mediated control of food intake and reward. ..
  29. ncbi request reprint Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats
    Blake A Kimmey
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Addict Biol 19:539-51. 2014
    ..Collectively, these results indicate that increased extracellular acetylcholine levels are sufficient to attenuate nicotine taking and seeking in rats and that these effects are not due to adverse malaise symptoms such as nausea. ..
  30. pmc Galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats
    Thomas J Hopkins
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 37:2310-21. 2012
    ....
  31. ncbi request reprint A carbohydrate-restricted diet alters gut peptides and adiposity signals in men and women with metabolic syndrome
    Matthew R Hayes
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 137:1944-50. 2007
    ....
  32. ncbi request reprint Serotonin-type 3 receptors mediate intestinal lipid-induced satiation and Fos-like immunoreactivity in the dorsal hindbrain
    David M Savastano
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, 126 South Henderson, University Park, PA 16802, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1063-70. 2007
    ..These data support the hypothesis that 5-HT(3) receptors mediate both satiation, as well as hindbrain neuronal responses evoked by intestinal lipids...
  33. ncbi request reprint Dorsal hindbrain 5-HT3 receptors participate in control of meal size and mediate CCK-induced satiation
    Matthew R Hayes
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, 126 South Henderson, University Park, PA 16802, USA
    Brain Res 1103:99-107. 2006
    ..0 and 12.3 +/- 1.4 ml, for 0.5 microg and 1.0 microg/100 nl, respectively). These data demonstrate that 5-HT3 receptors located in the medial NTS participate in control of meal size and mediate CCK-induced suppression of food intake...
  34. ncbi request reprint Gastric distension enhances CCK-induced Fos-like immunoreactivity in the dorsal hindbrain by activating 5-HT3 receptors
    Matthew R Hayes
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, 126 South Henderson, University Park, PA 16802 6504, USA
    Brain Res 1088:120-30. 2006
    ..In conjunction with previous behavioral data, these results show that gastric distension enhances CCK-induced neuronal activation in the DVC by activating 5-HT3 receptors...
  35. ncbi request reprint CCK and 5-HT act synergistically to suppress food intake through simultaneous activation of CCK-1 and 5-HT3 receptors
    Matthew R Hayes
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, 126 South Henderson, University Park, PA 16802 6504, USA
    Peptides 26:2322-30. 2005
    ..Furthermore, CCK and 5-HT interact to produce an enhanced suppression of food intake, an effect mediated through concomitant activation of CCK-1 and 5-HT3 receptors...
  36. ncbi request reprint Cholecystokinin-induced satiety is mediated through interdependent cooperation of CCK-A and 5-HT3 receptors
    Matthew R Hayes
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, 126 South Henderson, University Park, PA 16802 6504, USA
    Physiol Behav 82:663-9. 2004
    ..Most likely, this interconnection exists through a feed-forward parallel model arising from CCK-A and 5-HT3 receptors, where activation of one system engages the other to intensify the overall satiety signal...
  37. ncbi request reprint 5-HT3 receptors participate in CCK-induced suppression of food intake by delaying gastric emptying
    Matthew R Hayes
    Dept of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State Univ, 126 South Henderson, University Park, PA 16802, USA
    Am J Physiol Regul Integr Comp Physiol 287:R817-23. 2004
    ..We conclude that 5-HT(3) receptors mediate CCK-induced satiation through indirect mechanisms as part of a feedback cascade involving inhibition of gastric emptying...