Colleen E Hayes

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi The immunological functions of the vitamin D endocrine system
    C E Hayes
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Cell Mol Biol (Noisy-le-grand) 49:277-300. 2003
  2. ncbi Vitamin D: a natural inhibitor of multiple sclerosis
    C E Hayes
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Proc Nutr Soc 59:531-5. 2000
  3. ncbi Estrogen controls vitamin D3-mediated resistance to experimental autoimmune encephalomyelitis by controlling vitamin D3 metabolism and receptor expression
    Faye E Nashold
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    J Immunol 183:3672-81. 2009
  4. ncbi A unifying multiple sclerosis etiology linking virus infection, sunlight, and vitamin D, through viral interleukin-10
    Colleen E Hayes
    Department of Biochemistry, University of Wisconsin, Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Med Hypotheses 71:85-90. 2008
  5. ncbi The Ifng gene is essential for Vdr gene expression and vitamin D₃-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model
    Justin A Spanier
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    J Immunol 189:3188-97. 2012
  6. ncbi Murine BAFF-receptor residues 168-175 are essential for optimal CD21/35 expression but dispensable for B cell survival
    Christopher G Mayne
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, United States
    Mol Immunol 47:590-9. 2009
  7. ncbi Vitamin D3 confers protection from autoimmune encephalomyelitis only in female mice
    Karen M Spach
    Department of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin, Madison, WI 53706, USA
    J Immunol 175:4119-26. 2005
  8. ncbi Altered BAFF-receptor signaling and additional modifier loci contribute to systemic autoimmunity in A/WySnJ mice
    Christopher G Mayne
    Department of Genetics, University of Wisconsin Madison, WI 53706, USA
    Eur J Immunol 39:589-99. 2009
  9. ncbi 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by inhibiting chemokine synthesis and monocyte trafficking
    Laura B Pedersen
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Neurosci Res 85:2480-90. 2007
  10. ncbi IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis
    Karen M Spach
    Department of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    J Immunol 177:6030-7. 2006

Collaborators

Detail Information

Publications15

  1. ncbi The immunological functions of the vitamin D endocrine system
    C E Hayes
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Cell Mol Biol (Noisy-le-grand) 49:277-300. 2003
    ..The recent progress in infectious disease, autoimmunity and transplantation has stimulated a gratifying renaissance of interest in the vitamin D endocrine system and its role in immunological health...
  2. ncbi Vitamin D: a natural inhibitor of multiple sclerosis
    C E Hayes
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Proc Nutr Soc 59:531-5. 2000
    ..If vitamin D is a natural inhibitor of MS, providing supplemental vitamin D to individuals who are at risk for MS would be advisable...
  3. ncbi Estrogen controls vitamin D3-mediated resistance to experimental autoimmune encephalomyelitis by controlling vitamin D3 metabolism and receptor expression
    Faye E Nashold
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    J Immunol 183:3672-81. 2009
    ..Moreover, declining E(2) synthesis and vitamin D(3)-mediated protection with increasing age might be contributing to MS disease progression in older women...
  4. ncbi A unifying multiple sclerosis etiology linking virus infection, sunlight, and vitamin D, through viral interleukin-10
    Colleen E Hayes
    Department of Biochemistry, University of Wisconsin, Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Med Hypotheses 71:85-90. 2008
    ....
  5. ncbi The Ifng gene is essential for Vdr gene expression and vitamin D₃-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model
    Justin A Spanier
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    J Immunol 189:3188-97. 2012
    ..Individuals with inadequate Ifng expression may have increased MS risk despite high ambient UV irradiation because of low Vdr gene expression and a high encephalitogenic T cell burden in the CNS...
  6. ncbi Murine BAFF-receptor residues 168-175 are essential for optimal CD21/35 expression but dispensable for B cell survival
    Christopher G Mayne
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, United States
    Mol Immunol 47:590-9. 2009
    ..We suggest that discrete BAFF-R cytoplasmic domains may interact with distinct downstream pathways to provide fine control over B cell survival, maturation, and tolerance induction...
  7. ncbi Vitamin D3 confers protection from autoimmune encephalomyelitis only in female mice
    Karen M Spach
    Department of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin, Madison, WI 53706, USA
    J Immunol 175:4119-26. 2005
    ....
  8. ncbi Altered BAFF-receptor signaling and additional modifier loci contribute to systemic autoimmunity in A/WySnJ mice
    Christopher G Mayne
    Department of Genetics, University of Wisconsin Madison, WI 53706, USA
    Eur J Immunol 39:589-99. 2009
    ..We propose that in A/WySnJ mice an excess of BAFF per B cell rescues self-reactive B cells through a partially functional BAFF-R in a B-lymphopenic environment...
  9. ncbi 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by inhibiting chemokine synthesis and monocyte trafficking
    Laura B Pedersen
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Neurosci Res 85:2480-90. 2007
    ..In this way, the sunlight-derived hormone could reduce the risk of chronic CNS inflammation and autoimmune-mediated neurodegenerative disease...
  10. ncbi IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis
    Karen M Spach
    Department of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    J Immunol 177:6030-7. 2006
    ..In this way, a genetic IL-10-IL-10R pathway defect could interact with an environmental risk factor, vitamin D(3) insufficiency, to increase MS risk and severity...
  11. ncbi Gene expression analysis suggests that 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by stimulating inflammatory cell apoptosis
    Karen M Spach
    Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA
    Physiol Genomics 18:141-51. 2004
    ..Together, these results suggest that sensitization of inflammatory cells to apoptotic signals may be one mechanism by which the 1,25-(OH)2D3 resolved EAE...
  12. ncbi Systemic autoimmunity in BAFF-R-mutant A/WySnJ strain mice
    Christopher G Mayne
    Department of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Eur J Immunol 38:587-98. 2008
    ..Baffr(+/+) mice carrying a wild-type allele developed none of these phenotypes. Our data provide the first evidence linking altered BAFF-R signaling to the development of B cell-mediated autoimmunity...
  13. ncbi 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis
    Christopher G Mayne
    Division of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53706, USA
    Eur J Immunol 41:822-32. 2011
    ..These data support a model wherein 1,25-(OH)(2) D(3) acts directly on pathogenic CD4(+) T cells to inhibit EAE...
  14. ncbi Rag-1-dependent cells are necessary for 1,25-dihydroxyvitamin D(3) prevention of experimental autoimmune encephalomyelitis
    F E Nashold
    Department of Biochemistry, University of Wisconsin-Madison 53706, USA
    J Neuroimmunol 119:16-29. 2001
    ..Instead, the evidence supports a model wherein the 1,25-(OH)(2)D(3) acts through a Rag-1-dependent cell to limit the occurrence of activated, autoreactive T cells in the CNS...
  15. ncbi 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis
    M T Cantorna
    Department of Biochemistry, University of Wisconsin, Madison 53706, USA
    Proc Natl Acad Sci U S A 93:7861-4. 1996
    ..Thus, the block by 1,25-(OH)2D3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)2D3 or its analogs are potentially important for treatment of MS...