Melvin R Hayden

Summary

Affiliation: University of Missouri School of Medicine
Country: USA

Publications

  1. ncbi request reprint "A" is for amylin and amyloid in type 2 diabetes mellitus
    M R Hayden
    Department of Cardiovascular Atherosclerosis, Metabolism and Aging, Camdenton Community Health Center Camdenton, MO 65020, USA
    JOP 2:124-39. 2001
  2. pmc Attenuation of endocrine-exocrine pancreatic communication in type 2 diabetes: pancreatic extracellular matrix ultrastructural abnormalities
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, MO 65121 0001, USA
    J Cardiometab Syndr 3:234-43. 2008
  3. pmc Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in the HIP rat model of diabetes
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Exp Biol Med (Maywood) 233:1109-23. 2008
  4. doi request reprint Calciphylaxis: calcific uremic arteriolopathy and the emerging role of sodium thiosulfate
    Melvin R Hayden
    Department of Internal Medicine, Endocrinology Diabetes and Metabolism, Diabetes and Cardiovascular Disease Research Group, University of Missouri School of Medicine, Health Sciences Center, MA410, DC043 00, Columbia, MO 65212, USA
    Int Urol Nephrol 40:443-51. 2008
  5. ncbi request reprint Calciphylaxis and the cardiometabolic syndrome: the emerging role of sodium thiosulfate as a novel treatment option
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65020, USA
    J Cardiometab Syndr 3:55-9. 2008
  6. ncbi request reprint Isletopathy in Type 2 diabetes mellitus: implications of islet RAS, islet fibrosis, islet amyloid, remodeling, and oxidative stress
    Melvin R Hayden
    University of Missouri School of Medicine Department of Internal Medicine, Endocrinology Diabetes and Metabolism, Diabetes and Cardiovascular Disease Research Group, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Antioxid Redox Signal 9:891-910. 2007
  7. ncbi request reprint Longitudinal ultrastructure study of islet amyloid in the HIP rat model of type 2 diabetes mellitus
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Exp Biol Med (Maywood) 232:772-9. 2007
  8. ncbi request reprint Calciphylaxis and the cardiometabolic syndrome
    Melvin R Hayden
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism University of Missouri Columbia, Columbia, MO, USA
    J Cardiometab Syndr 1:76-9. 2006
  9. ncbi request reprint Ultrastructural islet study of early fibrosis in the Ren2 rat model of hypertension. Emerging role of the islet pancreatic pericyte-stellate cell
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri School of Medicine, D109 HSC Diabetes Center, Columbia, MO 65212, USA
    JOP 8:725-38. 2007
  10. ncbi request reprint Islet amyloid and fibrosis in the cardiometabolic syndrome and type 2 diabetes mellitus
    Melvin R Hayden
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Cardiometab Syndr 2:70-5. 2007

Collaborators

Detail Information

Publications75

  1. ncbi request reprint "A" is for amylin and amyloid in type 2 diabetes mellitus
    M R Hayden
    Department of Cardiovascular Atherosclerosis, Metabolism and Aging, Camdenton Community Health Center Camdenton, MO 65020, USA
    JOP 2:124-39. 2001
    ..In the 21st century our goal should be to prevent remodeling, save the pancreatic islet, conquer islet amyloid, and amyloid diabetes...
  2. pmc Attenuation of endocrine-exocrine pancreatic communication in type 2 diabetes: pancreatic extracellular matrix ultrastructural abnormalities
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, MO 65121 0001, USA
    J Cardiometab Syndr 3:234-43. 2008
    ....
  3. pmc Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in the HIP rat model of diabetes
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Exp Biol Med (Maywood) 233:1109-23. 2008
    ..The transgenic human islet amyloid polypeptide (HIP) rat model of type 2 diabetes mellitus (T2DM) parallels the functional and structural changes in human islets with T2DM...
  4. doi request reprint Calciphylaxis: calcific uremic arteriolopathy and the emerging role of sodium thiosulfate
    Melvin R Hayden
    Department of Internal Medicine, Endocrinology Diabetes and Metabolism, Diabetes and Cardiovascular Disease Research Group, University of Missouri School of Medicine, Health Sciences Center, MA410, DC043 00, Columbia, MO 65212, USA
    Int Urol Nephrol 40:443-51. 2008
    ..Indeed, as with any new treatment this emerging therapy should be studied in greater detail, but this old drug seems to have a new life in the hands of treating physicians...
  5. ncbi request reprint Calciphylaxis and the cardiometabolic syndrome: the emerging role of sodium thiosulfate as a novel treatment option
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65020, USA
    J Cardiometab Syndr 3:55-9. 2008
  6. ncbi request reprint Isletopathy in Type 2 diabetes mellitus: implications of islet RAS, islet fibrosis, islet amyloid, remodeling, and oxidative stress
    Melvin R Hayden
    University of Missouri School of Medicine Department of Internal Medicine, Endocrinology Diabetes and Metabolism, Diabetes and Cardiovascular Disease Research Group, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Antioxid Redox Signal 9:891-910. 2007
    ....
  7. ncbi request reprint Longitudinal ultrastructure study of islet amyloid in the HIP rat model of type 2 diabetes mellitus
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Exp Biol Med (Maywood) 232:772-9. 2007
    ....
  8. ncbi request reprint Calciphylaxis and the cardiometabolic syndrome
    Melvin R Hayden
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism University of Missouri Columbia, Columbia, MO, USA
    J Cardiometab Syndr 1:76-9. 2006
  9. ncbi request reprint Ultrastructural islet study of early fibrosis in the Ren2 rat model of hypertension. Emerging role of the islet pancreatic pericyte-stellate cell
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri School of Medicine, D109 HSC Diabetes Center, Columbia, MO 65212, USA
    JOP 8:725-38. 2007
    ..We have integrated the role of the islet renin-angiotensin system (RAS) in the pathogenesis of early islet fibrosis utilizing the transgenic (mRen2)27 rodent model of hypertension and tissue RAS overexpression...
  10. ncbi request reprint Islet amyloid and fibrosis in the cardiometabolic syndrome and type 2 diabetes mellitus
    Melvin R Hayden
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Cardiometab Syndr 2:70-5. 2007
  11. ncbi request reprint Introduction: organ involvement in the cardiometabolic syndrome
    Melvin R Hayden
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Diabetes and Cardiovascular Disease Research Center, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Cardiometab Syndr 1:16-24. 2006
    ..The MINER acronym will serve as an outline, representing: Myocardial and metabolic-hepatopathy, Intimal and islet, Neurovascular, Endothelial, and Renal oxidation-reduction (redox) stress and remodeling...
  12. ncbi request reprint Myocardial myocyte remodeling and fibrosis in the cardiometabolic syndrome
    Melvin R Hayden
    Department of Internal Medicine University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Cardiometab Syndr 1:326-33. 2006
    ..This review and the preliminary observational findings may provide the clinician and researcher a better understanding of remodeling changes in the myocardium and ultimately foster earlier recognition and therapeutic interventions...
  13. ncbi request reprint Diastolic dysfunction in the cardiometabolic syndrome
    Poorna R Karuparthi
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Cardiometab Syndr 1:369-72. 2006
  14. ncbi request reprint Autoimmune vasculitis and plaque erosion in the cardiometabolic syndrome and type 2 diabetes mellitus
    Melvin R Hayden
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Missouri School of Medicine, Harry S Truman VA Medical Center, Columbia, MO, USA
    J Cardiometab Syndr 1:228-32. 2006
  15. ncbi request reprint Renal redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and diabetic nephropathy: paying homage to the podocyte
    Melvin R Hayden
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Diabetes and Cardiovascular Disease Center, University of Missouri School of Medicine, Columbia, 65212, USA
    Am J Nephrol 25:553-69. 2005
    ....
  16. doi request reprint Sodium thiosulfate: new hope for the treatment of calciphylaxis
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, Missouri, USA
    Semin Dial 23:258-62. 2010
    ..STS used alone or in combination with other novel emerging therapies may result in the improved clinical outcomes in this challenging clinical condition...
  17. ncbi request reprint Microalbuminuria and proximal tubule remodeling in the cardiometabolic syndrome
    Melvin R Hayden
    Department of Internal Medicine, Division of Endocrinology Diabetes and Metabolism, University of Missouri School of Medicine, Columbia, MO, USA
    J Cardiometab Syndr 1:107-14. 2006
    ..These observations suggest that albuminuria is associated with proximal tubule injury, as well as loss of integrity of the glomerular filtration barrier in association with obesity and insulin resistance...
  18. ncbi request reprint Myocardial redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and congestive heart failure
    Melvin R Hayden
    Department of Family and Community Medicine University of Missouri Columbia, Missouri 65020, USA
    Med Sci Monit 9:SR35-52. 2003
    ..Appropriately, we need to examine the mechanisms that result in the development and transition from diastolic and systolic dysfunction to the clinical syndrome of overt CHF with its inherent increase in morbidity and mortality...
  19. pmc Pericytopathy: oxidative stress and impaired cellular longevity in the pancreas and skeletal muscle in metabolic syndrome and type 2 diabetes
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO, USA
    Oxid Med Cell Longev 3:290-303. 2010
    ..In conclusion, we have provided a review of current knowledge regarding the pericyte and novel ultrastructural findings regarding its role in metabolic syndrome and T2DM...
  20. ncbi request reprint Pancreatic islet amyloid in type 2 diabetes mellitus: a clinical and historical review
    M R Hayden
    Camdenton Community Health Center, Department of Cardiovascular Atherosclerosis, Metabolism and Aging, Department of Family and Community Medicine, University of Missouri Columbia, USA
    Mo Med 99:495-8. 2002
    ..Although amyloid is present in at least 70 percent of type 2 diabetic patients, the subject has not been clinically emphasized. This paper reviews the history of Opie's discovery and current clinical implications of islet amyloid...
  21. ncbi request reprint Neural redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and diabetic neuropathy
    Melvin R Hayden
    Department of Family and Community Medicine, University of Missouri, Columbia, MO 65020, USA
    Med Sci Monit 10:RA291-307. 2004
    ..The pain, foot ulceration, limb loss, organ dysfunction, and the associated morbidity and financial burden all contribute to the need for a better understanding of DPN and the role of redox stress and global risk reduction...
  22. ncbi request reprint Islet amyloid, metabolic syndrome, and the natural progressive history of type 2 diabetes mellitus
    Melvin R Hayden
    Department of Family and Community Medicine, University of Missouri School of Medicine Columbia, Missouri, USA
    JOP 3:126-38. 2002
    ..The natural history and a shift in the treatment paradigm of type 2 diabetes mellitus is explored as a result of these century old findings...
  23. pmc Isolated low high density lipoprotein-cholesterol (HDL-C): implications of global risk reduction. Case report and systematic scientific review
    Melvin R Hayden
    Department of Family and Community Medicine, University of Missouri Columbia, PO BOX 1140 Lk Rd 5 87, Camdenton, Missouri 65020, USA
    Cardiovasc Diabetol 4:1. 2005
    ..The antiatherosclerotic roles of reverse cholesterol transport and the pleiotropic antioxidant--anti-inflammatory mechanistic effects of HDL-C are undergoing rapid exponential growth...
  24. pmc Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate
    Melvin R Hayden
    Department of Family and Community Medicine, University of Missouri Columbia, PO BOX 1140 Lk Rd 5 87, Camdenton, Missouri 65020, USA
    Cardiovasc Diabetol 4:4. 2005
    ..The endothelium seems to be at the very center of these disease processes, acting as the first line of defense against these multiple metabolic toxicities and the first to encounter their damaging effects to the arterial vessel wall...
  25. pmc The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded
    Melvin R Hayden
    Department of Family and Community Medicine, University of Missouri School of Medicine Columbia, PO BOX 1140 Lk, Rd, 5 87 Camdenton, Missouri 65020, USA
    Cardiovasc Diabetol 4:9. 2005
    ....
  26. ncbi request reprint Islet redox stress: the manifold toxicities of insulin resistance, metabolic syndrome and amylin derived islet amyloid in type 2 diabetes mellitus
    Melvin R Hayden
    Department of Cardiovascular Atherosclerosis, Metabolism and Aging, Camdenton Community Health Center Camdenton, Missouri, USA
    JOP 3:86-108. 2002
    ..The presence of islet amyloid has also been described in association with type 2 diabetes mellitus for a century...
  27. pmc Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat
    Adam Whaley-Connell
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    Am J Physiol Renal Physiol 298:F655-61. 2010
    ..Our results highlight both the importance of pressor-related reductions on podocyte integrity and albuminuria as well as RAS-mediated oxidant stress largely comparable between ARB and renin inhibition treatment...
  28. pmc Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment
    Adam Whaley-Connell
    University of Missouri Columbia School of Medicine, Department of Internal Medicine, Division of Nephrology, MA436, DC043 0, One Hospital Dr, Columbia, MO 65212, USA
    Hypertension 51:474-80. 2008
    ....
  29. ncbi request reprint Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling
    Sameer Stas
    Division of Endocrinology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Endocrinology 148:3773-80. 2007
    ....
  30. ncbi request reprint Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, decreases cardiac oxidative stress and remodeling in Ren2 transgenic rats
    Javad Habibi
    University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Endocrinology 148:2181-8. 2007
    ..05). These results suggest that in vivo statin treatment through its direct actions on the heart reduces oxidative stress and remodeling including ventricular mass regression in the Ang-II-dependent Ren2 model...
  31. pmc Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression
    Guido Lastra
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    Endocrinology 150:2561-8. 2009
    ..This is associated with reductions in skeletal muscle tissue Ang II, AT(1)R, and MR expression; oxidative stress; fibrosis; and mitochondrial abnormalities...
  32. pmc Renin inhibition and AT(1)R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling
    Adam Whaley-Connell
    Research Service, Harry S Truman Memorial Veterans Hospital, 800 Hospital Drive, Columbia, MO 65201, USA
    Metabolism 62:861-72. 2013
    ....
  33. pmc Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat
    Xinli Zhou
    Department of Internal Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO 65212, USA
    Hypertension 55:880-8. 2010
    ....
  34. pmc Nebivolol improves insulin sensitivity in the TGR(Ren2)27 rat
    Camila Manrique
    Diabetes Cardiovascular Center of Excellence, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    Metabolism 60:1757-66. 2011
    ....
  35. doi request reprint Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat
    Vincent G Demarco
    Department of Child Health, University of Missouri School of Medicine, Columbia, Missouri 65210, USA
    Am J Physiol Heart Circ Physiol 294:H2659-68. 2008
    ..05). Collectively, the results of this investigation support a seminal role for enhanced tissue RAS/oxidative stress as factors in development of PH and pulmonary vascular remodeling...
  36. pmc Nebivolol attenuates redox-sensitive glomerular and tubular mediated proteinuria in obese rats
    Javad Habibi
    Diabetes and Cardiovascular Center, the University of Missouri ColumbiaSchool of Medicine, Columbia, Missouri 65211, USA
    Endocrinology 152:659-68. 2011
    ....
  37. ncbi request reprint Insulin resistance, oxidative stress, and podocyte injury: role of rosuvastatin modulation of filtration barrier injury
    Adam Whaley-Connell
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    Am J Nephrol 28:67-75. 2008
    ..The glomerular filtration barrier is emerging as a critical determinant of albumin filtration. We investigated the effects of insulin resistance and rosuvastatin or placebo on the glomerular filtration barrier...
  38. ncbi request reprint Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat
    Adam Whaley-Connell
    University of Missouri Columbia School of Medicine, Division of Nephrology, MA436, DC043 0, One Hospital Dr, Columbia, MO 65212, USA
    Am J Physiol Endocrinol Metab 293:E355-63. 2007
    ..05). Collectively, these data suggest cardiac oxidative stress-induced structural and functional changes are driven, in part, by AT(1)R-mediated increases in NADPH oxidase activity...
  39. pmc Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat
    Guido Lastra
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Am J Physiol Endocrinol Metab 295:E110-6. 2008
    ..05). Our findings suggest that aldosterone contributes to insulin resistance in the transgenic Ren2, in part, by increasing NADPH oxidase activity in skeletal muscle tissue...
  40. pmc Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 rat
    Javad Habibi
    Departments of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    Endocrinology 149:5643-53. 2008
    ....
  41. pmc Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat
    Adam Whaley-Connell
    The University of Missouri School of Medicine, Department of Medicine, Columbia, Missouri, USA
    Am J Physiol Endocrinol Metab 295:E103-9. 2008
    ..Collectively, these data suggest that both reduce changes driven, in part, by Ang II-mediated increases in NADPH oxidase and, in part, increases in blood pressure...
  42. ncbi request reprint Proximal tubule microvilli remodeling and albuminuria in the Ren2 transgenic rat
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri, Columbia, USA
    Am J Physiol Renal Physiol 292:F861-7. 2007
    ..These data indicate that PTC structural damage in the Ren2 rat is related to the oxidative stress response to ANG II and/or albuminuria...
  43. pmc Nebivolol attenuates maladaptive proximal tubule remodeling in transgenic rats
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, USA
    Am J Nephrol 31:262-72. 2010
    ..Accordingly, we hypothesized that nebivolol therapy would attenuate PTC damage and tubulointerstitial fibrosis...
  44. pmc Comparative analysis of telmisartan and olmesartan on cardiac function in the transgenic (mRen2)27 rat
    Vincent G Demarco
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Am J Physiol Heart Circ Physiol 300:H181-90. 2011
    ....
  45. pmc Salt loading exacerbates diastolic dysfunction and cardiac remodeling in young female Ren2 rats
    Adam T Whaley-Connell
    Research Service Harry S Truman Memorial Veterans Hospital, Research Service, 800 Hospital Dr, Columbia, MO 65212, USA University of Missouri School of Medicine, Departments of Internal Medicine, Divisions of Nephrology and Hypertension, Columbia, MO, USA University of Missouri School of Medicine, Departments of Internal Medicine, Division of Endocrinology and Metabolism, Columbia, MO, USA University of Missouri School of Medicine, Diabetes and Cardiovascular Center, Columbia, MO, USA Electronic address
    Metabolism 62:1761-71. 2013
    ....
  46. doi request reprint Obesity and insulin resistance induce early development of diastolic dysfunction in young female mice fed a Western diet
    Camila Manrique
    MD, Professor of Medicine and Medical Pharmacology and Physiology, University of Missouri, D109 Diabetes Center Health Sciences Center, One Hospital Drive, Columbia, Missouri 65212
    Endocrinology 154:3632-42. 2013
    ..These data are consistent with the notion that higher aldosterone levels, in concert with insulin resistance, may promote myocardial stiffness and diastolic dysfunction in response to overnutrition in females. ..
  47. pmc Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat
    Adam Whaley-Connell
    Harry S Truman VA Medical Center, University of Missouri Columbia School of Medicine, Columbia, MO 65211, USA
    Regul Pept 176:36-44. 2012
    ..Further, combination therapy did not improve markers of oxidative stress and podocyte and proximal tubule integrity in this transgenic model of RAAS-mediated kidney damage despite greater reductions in serum aldosterone and BP levels...
  48. ncbi request reprint Metabolic derangements in the insulin-resistant heart
    Gurushankar Govindarajan
    University of Missouri School of Medicine, Divisions of Endocrinology, Columbia, MO 65212, USA
    J Cardiometab Syndr 1:102-6. 2006
    ....
  49. pmc Dipeptidylpeptidase inhibition is associated with improvement in blood pressure and diastolic function in insulin-resistant male Zucker obese rats
    Annayya R Aroor
    Department of Internal Medicine, University of Missouri School of Medicine, and Diabetes and Cardiovascular Center, Columbia, MO 65212, USA
    Endocrinology 154:2501-13. 2013
    ....
  50. pmc Overweight female rats selectively breed for low aerobic capacity exhibit increased myocardial fibrosis and diastolic dysfunction
    Vincent G Demarco
    Diabetes and Cardiovascular Center, University of Missouri, Columbia, USA
    Am J Physiol Heart Circ Physiol 302:H1667-82. 2012
    ....
  51. pmc Mineralocorticoid receptor-dependent proximal tubule injury is mediated by a redox-sensitive mTOR/S6K1 pathway
    Adam T Whaley-Connell
    Harry S Truman VA Medical Center, Columbia, MO, USA
    Am J Nephrol 35:90-100. 2012
    ..Recent data indicate aldosterone signaling through the mineralocorticoid receptor (MR) can activate the mTOR pathway. Further, antagonism of the MR has beneficial effects on proteinuria that occur independent of hemodynamics...
  52. ncbi request reprint Insulin resistance and blood pressure
    Sonya Addison
    Diabetes and Cardiovascular Center, University of Missouri School of Medicine, D109 HSC Diabetes Center, One Hospital Drive, Harry S Truman VA Medical Center, Columbia, MO 65212, USA
    Curr Hypertens Rep 10:319-25. 2008
    ..In this article we review the current knowledge about the effects of lifestyle modification and pharmacologic antihypertensive agents on insulin resistance and hypertension...
  53. ncbi request reprint Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat
    Adam T Whaley-Connell
    Department of Internal Medicine, University of Missouri School of Medicine, 1 Hospital Dr, MA410 Medical Science Bldg, Columbia, MO 65212, USA
    Am J Physiol Renal Physiol 291:F1308-14. 2006
    ..Thus reductions in blood pressure, albuminuria, and tissue oxidative stress with AT1R blockade were associated with improved indexes of glomerular filtration barrier integrity and renal RAS in Ren2 rats...
  54. ncbi request reprint Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells
    Adam T Whaley-Connell
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Am J Nephrol 27:15-23. 2007
    ..Thus in states of albumin overload, Rac1 activation could lead to NOX activation and ROS formation in the PTC. Furthermore, accumulating evidence supports that HMG-CoA reductase inhibition may reduce oxidative stress and albuminuria...
  55. pmc Obesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db mice
    Vincent G Demarco
    Departments of Internal Medicine, University of Missouri Columbia School of Medicine, One Hospital Drive, Columbia, MO 65212, USA
    Endocrinology 154:159-71. 2013
    ..In conclusion, a distinct pattern of myocardial lipid remodeling, accompanied by oxidative stress, is associated with the onset of diastolic dysfunction in obese, insulin-resistant db/db mice...
  56. ncbi request reprint Diabetic nephropathy and tubulointerstitial fibrosis in cardiometabolic syndrome and type 2 diabetes mellitus
    Kurt M Sowers
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Cardiometab Syndr 2:143-8. 2007
  57. ncbi request reprint Nephrogenic systemic fibrosis: a mysterious disease in patients with renal failure--role of gadolinium-based contrast media in causation and the beneficial effect of intravenous sodium thiosulfate
    Preethi Yerram
    Department of Internal Medicine, MA406, School of Medicine, University of Missouri Columbia, Columbia, MO 65212, USA
    Clin J Am Soc Nephrol 2:258-63. 2007
    ..Discussed are the possible association of Gd3+-based contrast media with the development of NSF and potential for the use of sodium thiosulfate in the treatment of NSF...
  58. ncbi request reprint High-cortisol states can masquerade as the cardiometabolic syndrome
    Poorna R Karuparthi
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Cardiometab Syndr 2:223-6. 2007
  59. ncbi request reprint Type 2 diabetes mellitus as a conformational disease
    Melvin R Hayden
    Department of Family and Community Medicine, University of Missouri, Columbia, USA
    JOP 6:287-302. 2005
    ....
  60. ncbi request reprint The role of beta-cell dysfunction in the cardiometabolic syndrome
    Guido Lastra
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Diabetes, and Cardiovascular Disease Research Center, University of Missouri School of Medicine, Columbia, MO, USA
    J Cardiometab Syndr 1:41-6. 2006
    ....
  61. ncbi request reprint Nonalcoholic steatohepatitis and the cardiometabolic syndrome
    Mohammad Bosem Abdeen
    Department of Internal Medicine, 2 University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    J Cardiometab Syndr 1:36-40. 2006
    ..Expert opinion emphasizes the importance of exercise, weight loss in obese and overweight individuals, treatment of hyperlipidemia, and glucose control...
  62. ncbi request reprint Understanding essential hypertension from the perspective of the cardiometabolic syndrome
    Poorna R Karuparthi
    Department of Internal Medicine, University of Missouri, Columbia, Missouri, USA
    J Am Soc Hypertens 1:120-34. 2007
    ..A better understanding of the pathophysiology of HTN may provide clinician and researcher, tools to effectively investigate and manage this complicated disease process...
  63. ncbi request reprint Expression of matrix metalloproteinase activity in idiopathic dilated cardiomyopathy: a marker of cardiac dilatation
    Hanumanth K Reddy
    Division of Cardiology, Department of Internal Medicine, University of Missouri Columbia, MO, USA
    Mol Cell Biochem 264:183-91. 2004
    ..Accordingly, we have sought to correlate (a) collagen degradation with MMP elevations and, (b) assay the neutralizing potential of a known inhibitor of MMP, tetracycline on MMPs in DCM...
  64. ncbi request reprint Intraventricular mechanical asynchrony in asymptomatic morbidly obese individuals
    Kimberly S Delcour
    Division of Cardiology, The Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Cardiometab Syndr 2:305-8. 2007
  65. pmc Treating hypertension while protecting the vulnerable islet in the cardiometabolic syndrome
    Melvin R Hayden
    Departments of Internal Medicine, Endocrinology Diabetes and Metabolism, and Diabetes and Cardiovascular Disease Research Center, School of Medicine, University of Missouri Columbia, Health Sciences Center, Columbia, Missouri, USA
    J Am Soc Hypertens 2:239-66. 2008
    ..Various classes of antihypertensive drugs are reviewed, especially their roles in delaying or preventing damage to the vulnerable pancreatic islet, and thus delaying the development of type 2 diabetes mellitus...
  66. ncbi request reprint Matrix metalloproteinase in left ventricular remodeling and heart failure
    Suresh Shastry
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Curr Cardiol Rep 5:200-4. 2003
    ..Identification of major players involved in the control of oxidative and proteolytic stresses that ameliorate matrix deposition by integrin shading will help to develop strategies to prevent congestive heart failure...
  67. pmc GABA receptors ameliorate Hcy-mediated integrin shedding and constrictive collagen remodeling in microvascular endothelial cells
    Suresh Shastry
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY, USA
    Cell Biochem Biophys 45:157-65. 2006
    ....
  68. ncbi request reprint Role of nitric oxide in matrix remodeling in diabetes and heart failure
    Suresh C Tyagi
    Department of Physiology and Biophysics, The University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Heart Fail Rev 8:23-8. 2003
    ..In addition Hcy competes with PPAR ligands. The understanding of molecular, cellular, and extracellular mechanisms by which Hcy amplifies DM will have therapeutic ramifications for diabetic cardiomyopathy...
  69. ncbi request reprint Redox imbalance in diabetes
    Melvin R Hayden
    Antioxid Redox Signal 9:865-7. 2007
  70. ncbi request reprint Role of matrix metalloproteinase-9 in endothelial apoptosis in chronic heart failure in mice
    Alexander V Ovechkin
    Dept of Physiology and Biophysics, School of Medicine, University of Louisville, KY 40202, USA
    J Appl Physiol (1985) 99:2398-405. 2005
    ..The results suggest that impaired cardiac function in volume overload is associated with EE apoptosis, cardiac remodeling, and endothelium-myocytes uncoupling in response to MMP-9 activation...
  71. ncbi request reprint Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure
    Matthew J Hunt
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Am J Physiol Lung Cell Mol Physiol 283:L239-45. 2002
    ..In vitro, treatment of CIMP abrogated the DMP activity. The treatment with CIMP may prevent degradation of integrin and connexin and ameliorate heart failure...
  72. ncbi request reprint Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats
    Teresa M Camp
    Departmen tof Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
    J Hypertens 21:1719-27. 2003
    ..However, the mechanism of matrix accumulation is unclear. Spontaneously hypertensive rats (SHR) develop hypertension at between 2 and 6 weeks of age...
  73. ncbi request reprint Doxycycline ameliorates ischemic and border-zone remodeling and endothelial dysfunction after myocardial infarction in rats
    Teresa M Camp
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40202, USA
    J Heart Lung Transplant 23:729-36. 2004
    ..The antibiotic doxycycline inhibits MMP activity in vitro. The role of doxycycline-mediated MMP inhibition in endothelial function is unclear...
  74. ncbi request reprint Homocysteine competes for the peroxisome proliferator-activated receptor nuclear receptors
    Melvin R Hayden
    J Cardiometab Syndr 3:70-1. 2008
  75. ncbi request reprint Atherogenic dyslipidemia
    Melvin R Hayden
    J Cardiometab Syndr 1:166-7. 2006