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Genomes and Genes | Melvin R HaydenSummaryAffiliation: University of Missouri School of Medicine Country: USA Publications
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Publications
"A" is for amylin and amyloid in type 2 diabetes mellitusM R Hayden
Department of Cardiovascular Atherosclerosis, Metabolism and Aging, Camdenton Community Health Center Camdenton, MO 65020, USA
JOP 2:124-39. 2001..In the 21st century our goal should be to prevent remodeling, save the pancreatic islet, conquer islet amyloid, and amyloid diabetes...- Renal redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and diabetic nephropathy: paying homage to the podocyteMelvin R Hayden
Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Diabetes and Cardiovascular Disease Center, University of Missouri School of Medicine, Columbia, 65212, USA
Am J Nephrol 25:553-69. 2005.... 
Sodium thiosulfate: new hope for the treatment of calciphylaxisMelvin R Hayden
Department of Internal Medicine, University of Missouri School of Medicine, Columbia, Missouri, USA
Semin Dial 23:258-62. 2010..STS used alone or in combination with other novel emerging therapies may result in the improved clinical outcomes in this challenging clinical condition...
Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in the HIP rat model of diabetesMelvin R Hayden
Department of Internal Medicine, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
Exp Biol Med (Maywood) 233:1109-23. 2008..The transgenic human islet amyloid polypeptide (HIP) rat model of type 2 diabetes mellitus (T2DM) parallels the functional and structural changes in human islets with T2DM...- Isletopathy in Type 2 diabetes mellitus: implications of islet RAS, islet fibrosis, islet amyloid, remodeling, and oxidative stressMelvin R Hayden
University of Missouri School of Medicine Department of Internal Medicine, Endocrinology Diabetes and Metabolism, Diabetes and Cardiovascular Disease Research Group, University of Missouri School of Medicine, Columbia, MO 65212, USA
Antioxid Redox Signal 9:891-910. 2007.... - Longitudinal ultrastructure study of islet amyloid in the HIP rat model of type 2 diabetes mellitusMelvin R Hayden
Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
Exp Biol Med (Maywood) 232:772-9. 2007.... - Calciphylaxis and the cardiometabolic syndromeMelvin R Hayden
Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism University of Missouri-Columbia, Columbia, MO, USA
J Cardiometab Syndr 1:76-9. 2006 - Calciphylaxis: calcific uremic arteriolopathy and the emerging role of sodium thiosulfateMelvin R Hayden
Department of Internal Medicine, Endocrinology Diabetes and Metabolism, Diabetes and Cardiovascular Disease Research Group, University of Missouri School of Medicine, Health Sciences Center, MA410, DC043 00, Columbia, MO 65212, USA
Int Urol Nephrol 40:443-51. 2008..Indeed, as with any new treatment this emerging therapy should be studied in greater detail, but this old drug seems to have a new life in the hands of treating physicians... - Calciphylaxis and the cardiometabolic syndrome: the emerging role of sodium thiosulfate as a novel treatment optionMelvin R Hayden
Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65020, USA
J Cardiometab Syndr 3:55-9. 2008 - Introduction: organ involvement in the cardiometabolic syndromeMelvin R Hayden
Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Diabetes and Cardiovascular Disease Research Center, University of Missouri School of Medicine, Columbia, MO 65212, USA
J Cardiometab Syndr 1:16-24. 2006..The MINER acronym will serve as an outline, representing: Myocardial and metabolic-hepatopathy, Intimal and islet, Neurovascular, Endothelial, and Renal oxidation-reduction (redox) stress and remodeling... - Myocardial myocyte remodeling and fibrosis in the cardiometabolic syndromeMelvin R Hayden
Department of Internal Medicine University of Missouri School of Medicine, Columbia, MO 65212, USA
J Cardiometab Syndr 1:326-33. 2006..This review and the preliminary observational findings may provide the clinician and researcher a better understanding of remodeling changes in the myocardium and ultimately foster earlier recognition and therapeutic interventions... - Diastolic dysfunction in the cardiometabolic syndromePoorna R Karuparthi
Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
J Cardiometab Syndr 1:369-72. 2006 - Autoimmune vasculitis and plaque erosion in the cardiometabolic syndrome and type 2 diabetes mellitusMelvin R Hayden
Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Missouri School of Medicine, Harry S.Truman VA Medical Center, Columbia, MO, USA
J Cardiometab Syndr 1:228-32. 2006 - Microalbuminuria and proximal tubule remodeling in the cardiometabolic syndromeMelvin R Hayden
Department of Internal Medicine, Division of Endocrinology Diabetes and Metabolism, University of Missouri School of Medicine, Columbia, MO, USA
J Cardiometab Syndr 1:107-14. 2006..These observations suggest that albuminuria is associated with proximal tubule injury, as well as loss of integrity of the glomerular filtration barrier in association with obesity and insulin resistance... - Attenuation of endocrine-exocrine pancreatic communication in type 2 diabetes: pancreatic extracellular matrix ultrastructural abnormalitiesMelvin R Hayden
Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, MO 65121 0001, USA
J Cardiometab Syndr 3:234-43. 2008.... - Islet amyloid and fibrosis in the cardiometabolic syndrome and type 2 diabetes mellitusMelvin R Hayden
Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Missouri School of Medicine, Columbia, MO 65212, USA
J Cardiometab Syndr 2:70-5. 2007 - Myocardial redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and congestive heart failureMelvin R Hayden
Department of Family and Community Medicine University of Missouri Columbia, Missouri 65020, USA
Med Sci Monit 9:SR35-52. 2003..Appropriately, we need to examine the mechanisms that result in the development and transition from diastolic and systolic dysfunction to the clinical syndrome of overt CHF with its inherent increase in morbidity and mortality... - Pericytopathy: oxidative stress and impaired cellular longevity in the pancreas and skeletal muscle in metabolic syndrome and type 2 diabetesMelvin R Hayden
Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO, USA
Oxid Med Cell Longev 3:290-303. 2010..In conclusion, we have provided a review of current knowledge regarding the pericyte and novel ultrastructural findings regarding its role in metabolic syndrome and T2DM... - Pancreatic islet amyloid in type 2 diabetes mellitus: a clinical and historical reviewM R Hayden
Camdenton Community Health Center, Department of Cardiovascular Atherosclerosis, Metabolism and Aging, Department of Family and Community Medicine, University of Missouri Columbia, USA
Mo Med 99:495-8. 2002..Although amyloid is present in at least 70 percent of type 2 diabetic patients, the subject has not been clinically emphasized. This paper reviews the history of Opie's discovery and current clinical implications of islet amyloid... - Islet amyloid, metabolic syndrome, and the natural progressive history of type 2 diabetes mellitusMelvin R Hayden
Department of Family and Community Medicine, University of Missouri School of Medicine Columbia, Missouri, USA
JOP 3:126-38. 2002..The natural history and a shift in the treatment paradigm of type 2 diabetes mellitus is explored as a result of these century old findings... - Islet redox stress: the manifold toxicities of insulin resistance, metabolic syndrome and amylin derived islet amyloid in type 2 diabetes mellitusMelvin R Hayden
Department of Cardiovascular Atherosclerosis, Metabolism and Aging, Camdenton Community Health Center Camdenton, Missouri, USA
JOP 3:86-108. 2002..The presence of islet amyloid has also been described in association with type 2 diabetes mellitus for a century... - Neural redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and diabetic neuropathyMelvin R Hayden
Department of Family and Community Medicine, University of Missouri, Columbia, MO 65020, USA
Med Sci Monit 10:RA291-307. 2004..The pain, foot ulceration, limb loss, organ dysfunction, and the associated morbidity and financial burden all contribute to the need for a better understanding of DPN and the role of redox stress and global risk reduction... - Isolated low high density lipoprotein-cholesterol (HDL-C): implications of global risk reduction. Case report and systematic scientific reviewMelvin R Hayden
Department of Family and Community Medicine, University of Missouri Columbia, PO BOX 1140 Lk Rd 5 87, Camdenton, Missouri 65020, USA
Cardiovasc Diabetol 4:1. 2005..The antiatherosclerotic roles of reverse cholesterol transport and the pleiotropic antioxidant--anti-inflammatory mechanistic effects of HDL-C are undergoing rapid exponential growth... - Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfateMelvin R Hayden
Department of Family and Community Medicine, University of Missouri Columbia, PO BOX 1140 Lk Rd 5 87, Camdenton, Missouri 65020, USA
Cardiovasc Diabetol 4:4. 2005..The endothelium seems to be at the very center of these disease processes, acting as the first line of defense against these multiple metabolic toxicities and the first to encounter their damaging effects to the arterial vessel wall... - The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloadedMelvin R Hayden
Department of Family and Community Medicine, University of Missouri School of Medicine Columbia, PO BOX 1140 Lk, Rd, 5 87 Camdenton, Missouri 65020, USA
Cardiovasc Diabetol 4:9. 2005.... - Ultrastructural islet study of early fibrosis in the Ren2 rat model of hypertension. Emerging role of the islet pancreatic pericyte-stellate cellMelvin R Hayden
Department of Internal Medicine, University of Missouri School of Medicine, D109 HSC Diabetes Center, Columbia, MO 65212, USA
JOP 8:725-38. 2007..We have integrated the role of the islet renin-angiotensin system (RAS) in the pathogenesis of early islet fibrosis utilizing the transgenic (mRen2)27 rodent model of hypertension and tissue RAS overexpression... - Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 ratAdam Whaley-Connell
Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
Am J Physiol Renal Physiol 298:F655-61. 2010..Our results highlight both the importance of pressor-related reductions on podocyte integrity and albuminuria as well as RAS-mediated oxidant stress largely comparable between ARB and renin inhibition treatment... - Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatmentAdam Whaley-Connell
University of Missouri Columbia School of Medicine, Department of Internal Medicine, Division of Nephrology, MA436, DC043 0, One Hospital Dr, Columbia, MO 65212, USA
Hypertension 51:474-80. 2008.... - Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodelingSameer Stas
Division of Endocrinology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
Endocrinology 148:3773-80. 2007.... - Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpressionGuido Lastra
Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
Endocrinology 150:2561-8. 2009..This is associated with reductions in skeletal muscle tissue Ang II, AT(1)R, and MR expression; oxidative stress; fibrosis; and mitochondrial abnormalities... - Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, decreases cardiac oxidative stress and remodeling in Ren2 transgenic ratsJavad Habibi
University of Missouri School of Medicine, Columbia, Missouri 65212, USA
Endocrinology 148:2181-8. 2007..05). These results suggest that in vivo statin treatment through its direct actions on the heart reduces oxidative stress and remodeling including ventricular mass regression in the Ang-II-dependent Ren2 model... - Nebivolol improves insulin sensitivity in the TGR(Ren2)27 ratCamila Manrique
Diabetes Cardiovascular Center of Excellence, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
Metabolism 60:1757-66. 2011.... - Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese ratXinli Zhou
Department of Internal Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO 65212, USA
Hypertension 55:880-8. 2010.... - Nebivolol attenuates redox-sensitive glomerular and tubular mediated proteinuria in obese ratsJavad Habibi
Diabetes and Cardiovascular Center, the University of Missouri ColumbiaSchool of Medicine, Columbia, Missouri 65211, USA
Endocrinology 152:659-68. 2011.... - Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 ratVincent G Demarco
Department of Child Health, University of Missouri School of Medicine, Columbia, Missouri 65210, USA
Am J Physiol Heart Circ Physiol 294:H2659-68. 2008..05). Collectively, the results of this investigation support a seminal role for enhanced tissue RAS/oxidative stress as factors in development of PH and pulmonary vascular remodeling... - Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 ratAdam Whaley-Connell
University of Missouri Columbia School of Medicine, Division of Nephrology, MA436, DC043 0, One Hospital Dr, Columbia, MO 65212, USA
Am J Physiol Endocrinol Metab 293:E355-63. 2007..05). Collectively, these data suggest cardiac oxidative stress-induced structural and functional changes are driven, in part, by AT(1)R-mediated increases in NADPH oxidase activity... - Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 ratGuido Lastra
Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
Am J Physiol Endocrinol Metab 295:E110-6. 2008..05). Our findings suggest that aldosterone contributes to insulin resistance in the transgenic Ren2, in part, by increasing NADPH oxidase activity in skeletal muscle tissue... - Insulin resistance, oxidative stress, and podocyte injury: role of rosuvastatin modulation of filtration barrier injuryAdam Whaley-Connell
Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
Am J Nephrol 28:67-75. 2008..The glomerular filtration barrier is emerging as a critical determinant of albumin filtration. We investigated the effects of insulin resistance and rosuvastatin or placebo on the glomerular filtration barrier... - Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 ratAdam Whaley-Connell
The University of Missouri School of Medicine, Department of Medicine, Columbia, Missouri, USA
Am J Physiol Endocrinol Metab 295:E103-9. 2008..Collectively, these data suggest that both reduce changes driven, in part, by Ang II-mediated increases in NADPH oxidase and, in part, increases in blood pressure... - Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 ratJavad Habibi
Departments of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
Endocrinology 149:5643-53. 2008.... - Nebivolol attenuates maladaptive proximal tubule remodeling in transgenic ratsMelvin R Hayden
Department of Internal Medicine, University of Missouri Columbia School of Medicine, USA
Am J Nephrol 31:262-72. 2010..Accordingly, we hypothesized that nebivolol therapy would attenuate PTC damage and tubulointerstitial fibrosis... - Proximal tubule microvilli remodeling and albuminuria in the Ren2 transgenic ratMelvin R Hayden
Department of Internal Medicine, University of Missouri, Columbia, USA
Am J Physiol Renal Physiol 292:F861-7. 2007..These data indicate that PTC structural damage in the Ren2 rat is related to the oxidative stress response to ANG II and/or albuminuria... - Comparative analysis of telmisartan and olmesartan on cardiac function in the transgenic (mRen2)27 ratVincent G Demarco
Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
Am J Physiol Heart Circ Physiol 300:H181-90. 2011.... - Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 ratAdam Whaley-Connell
Harry S Truman VA Medical Center, University of Missouri Columbia School of Medicine, Columbia, MO 65211, USA
Regul Pept 176:36-44. 2012..Further, combination therapy did not improve markers of oxidative stress and podocyte and proximal tubule integrity in this transgenic model of RAAS-mediated kidney damage despite greater reductions in serum aldosterone and BP levels... - Metabolic derangements in the insulin-resistant heartGurushankar Govindarajan
University of Missouri School of Medicine, Divisions of Endocrinology, Columbia, MO 65212, USA
J Cardiometab Syndr 1:102-6. 2006.... - Overweight female rats selectively breed for low aerobic capacity exhibit increased myocardial fibrosis and diastolic dysfunctionVincent G Demarco
Diabetes and Cardiovascular Center, University of Missouri, Columbia, USA
Am J Physiol Heart Circ Physiol 302:H1667-82. 2012.... - Mineralocorticoid receptor-dependent proximal tubule injury is mediated by a redox-sensitive mTOR/S6K1 pathwayAdam T Whaley-Connell
Harry S Truman VA Medical Center, Columbia, MO, USA
Am J Nephrol 35:90-100. 2012..Recent data indicate aldosterone signaling through the mineralocorticoid receptor (MR) can activate the mTOR pathway. Further, antagonism of the MR has beneficial effects on proteinuria that occur independent of hemodynamics... - Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic ratAdam T Whaley-Connell
Department of Internal Medicine, University of Missouri School of Medicine, 1 Hospital Dr, MA410 Medical Science Bldg, Columbia, MO 65212, USA
Am J Physiol Renal Physiol 291:F1308-14. 2006..Thus reductions in blood pressure, albuminuria, and tissue oxidative stress with AT1R blockade were associated with improved indexes of glomerular filtration barrier integrity and renal RAS in Ren2 rats... - Insulin resistance and blood pressureSonya Addison
Diabetes and Cardiovascular Center, University of Missouri School of Medicine, D109 HSC Diabetes Center, One Hospital Drive, Harry S Truman VA Medical Center, Columbia, MO 65212, USA
Curr Hypertens Rep 10:319-25. 2008..In this article we review the current knowledge about the effects of lifestyle modification and pharmacologic antihypertensive agents on insulin resistance and hypertension... - Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cellsAdam T Whaley-Connell
Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
Am J Nephrol 27:15-23. 2007..Thus in states of albumin overload, Rac1 activation could lead to NOX activation and ROS formation in the PTC. Furthermore, accumulating evidence supports that HMG-CoA reductase inhibition may reduce oxidative stress and albuminuria... - Obesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db miceVincent G Demarco
Departments of Internal Medicine, University of Missouri Columbia School of Medicine, One Hospital Drive, Columbia, MO 65212, USA
Endocrinology 154:159-71. 2013..In conclusion, a distinct pattern of myocardial lipid remodeling, accompanied by oxidative stress, is associated with the onset of diastolic dysfunction in obese, insulin-resistant db/db mice... - Diabetic nephropathy and tubulointerstitial fibrosis in cardiometabolic syndrome and type 2 diabetes mellitusKurt M Sowers
Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
J Cardiometab Syndr 2:143-8. 2007 - Nephrogenic systemic fibrosis: a mysterious disease in patients with renal failure--role of gadolinium-based contrast media in causation and the beneficial effect of intravenous sodium thiosulfatePreethi Yerram
Department of Internal Medicine, MA406, School of Medicine, University of Missouri Columbia, Columbia, MO 65212, USA
Clin J Am Soc Nephrol 2:258-63. 2007..Discussed are the possible association of Gd3+-based contrast media with the development of NSF and potential for the use of sodium thiosulfate in the treatment of NSF... - The role of beta-cell dysfunction in the cardiometabolic syndromeGuido Lastra
Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Diabetes, and Cardiovascular Disease Research Center, University of Missouri School of Medicine, Columbia, MO, USA
J Cardiometab Syndr 1:41-6. 2006.... - High-cortisol states can masquerade as the cardiometabolic syndromePoorna R Karuparthi
Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
J Cardiometab Syndr 2:223-6. 2007 - Type 2 diabetes mellitus as a conformational diseaseMelvin R Hayden
Department of Family and Community Medicine, University of Missouri, Columbia, USA
JOP 6:287-302. 2005.... - Nonalcoholic steatohepatitis and the cardiometabolic syndromeMohammad Bosem Abdeen
Department of Internal Medicine, 2 University of Missouri-Columbia School of Medicine, Columbia, MO 65212, USA
J Cardiometab Syndr 1:36-40. 2006..Expert opinion emphasizes the importance of exercise, weight loss in obese and overweight individuals, treatment of hyperlipidemia, and glucose control... - Understanding essential hypertension from the perspective of the cardiometabolic syndromePoorna R Karuparthi
Department of Internal Medicine, University of Missouri, Columbia, Missouri, USA
J Am Soc Hypertens 1:120-34. 2007..A better understanding of the pathophysiology of HTN may provide clinician and researcher, tools to effectively investigate and manage this complicated disease process... - Expression of matrix metalloproteinase activity in idiopathic dilated cardiomyopathy: a marker of cardiac dilatationHanumanth K Reddy
Division of Cardiology, Department of Internal Medicine, University of Missouri-Columbia, MO, USA
Mol Cell Biochem 264:183-91. 2004..The non-antibiotic property of tetracycline may be of potential value in the prevention of ventricular dilatation in idiopathic dilated cardiomyopathy... - Intraventricular mechanical asynchrony in asymptomatic morbidly obese individualsKimberly S Delcour
Division of Cardiology, The Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
J Cardiometab Syndr 2:305-8. 2007 - Treating hypertension while protecting the vulnerable islet in the cardiometabolic syndromeMelvin R Hayden
Departments of Internal Medicine, Endocrinology Diabetes and Metabolism, and Diabetes and Cardiovascular Disease Research Center, School of Medicine, University of Missouri Columbia, Health Sciences Center, Columbia, Missouri, USA
J Am Soc Hypertens 2:239-66. 2008..Various classes of antihypertensive drugs are reviewed, especially their roles in delaying or preventing damage to the vulnerable pancreatic islet, and thus delaying the development of type 2 diabetes mellitus... - Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failureMatthew J Hunt
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
Am J Physiol Lung Cell Mol Physiol 283:L239-45. 2002..In vitro, treatment of CIMP abrogated the DMP activity. The treatment with CIMP may prevent degradation of integrin and connexin and ameliorate heart failure... - Role of nitric oxide in matrix remodeling in diabetes and heart failureSuresh C Tyagi
Department of Physiology and Biophysics, The University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
Heart Fail Rev 8:23-8. 2003..In addition Hcy competes with PPAR ligands. The understanding of molecular, cellular, and extracellular mechanisms by which Hcy amplifies DM will have therapeutic ramifications for diabetic cardiomyopathy... - Matrix metalloproteinase in left ventricular remodeling and heart failureSuresh Shastry
Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
Curr Cardiol Rep 5:200-4. 2003..Identification of major players involved in the control of oxidative and proteolytic stresses that ameliorate matrix deposition by integrin shading will help to develop strategies to prevent congestive heart failure... - Role of matrix metalloproteinase-9 in endothelial apoptosis in chronic heart failure in miceAlexander V Ovechkin
Dept of Physiology and Biophysics, School of Medicine, University of Louisville, KY 40202, USA
J Appl Physiol 99:2398-405. 2005..The results suggest that impaired cardiac function in volume overload is associated with EE apoptosis, cardiac remodeling, and endothelium-myocytes uncoupling in response to MMP-9 activation... - Redox imbalance in diabetesMelvin R Hayden
Antioxid Redox Signal 9:865-7. 2007 - GABA receptors ameliorate Hcy-mediated integrin shedding and constrictive collagen remodeling in microvascular endothelial cellsSuresh Shastry
Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY, USA
Cell Biochem Biophys 45:157-65. 2006.... - Doxycycline ameliorates ischemic and border-zone remodeling and endothelial dysfunction after myocardial infarction in ratsTeresa M Camp
Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40202, USA
J Heart Lung Transplant 23:729-36. 2004..CONCLUSION: Results suggest a protective action of doxycycline in the ischemic heart, possibly because of additional pharmacologic actions such as metalloproteinase inhibition... - Atherogenic dyslipidemiaMelvin R Hayden
J Cardiometab Syndr 1:166-7. 2006 - Homocysteine competes for the peroxisome proliferator-activated receptor nuclear receptorsMelvin R Hayden
J Cardiometab Syndr 3:70-1. 2008 - Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive ratsTeresa M Camp
Departmen tof Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
J Hypertens 21:1719-27. 2003..However, the mechanism of matrix accumulation is unclear. Spontaneously hypertensive rats (SHR) develop hypertension at between 2 and 6 weeks of age...