Research Topics
| F G HaydenSummaryAffiliation: University of Virginia Country: USA Publications
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Publications
Newer influenza antivirals, biotherapeutics and combinationsFrederick G Hayden
Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Influenza Other Respi Viruses 7:63-75. 2013..The development of combination interventions, immunomodulators and host-directed therapies presents unique clinical trial design and regulatory hurdles that remain to be addressed...- Experimental human influenza: observations from studies of influenza antiviralsFrederick G Hayden
Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA, USA
Antivir Ther 17:133-41. 2012..The lack of availability of contemporary, safety-tested virus inoculation pools in recent years needs to be resolved in order to avoid hindering the development of new drugs and vaccines... 
Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trialsFrederick G Hayden
Department of Internal Medicine, University of Virginia, Charlottesville, USA
Clin Infect Dis 36:1523-32. 2003..Early pleconaril treatment was well tolerated and significantly reduced the duration and severity of colds due to picornaviruses in adults...- Management of influenza in households: a prospective, randomized comparison of oseltamivir treatment with or without postexposure prophylaxisFrederick G Hayden
University of Virginia School of Medicine, Charlottesville, Virginia, USA
J Infect Dis 189:440-9. 2004..No oseltamivir-resistant variants were detected in treated index cases or contacts. PEP of household contacts of those with influenza reduces the secondary spread of influenza in families when the initial household case is treated... 
Perspectives on antiviral use during pandemic influenzaF G Hayden
Department of Internal Medicine, PO Box 800473, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
Philos Trans R Soc Lond B Biol Sci 356:1877-84. 2001....- Respiratory viral threatsFrederick G Hayden
Department of Internal Medicine, University of Virginia School of Medicine, Box 800473, Charlottesville, VA 22908, USA
Curr Opin Infect Dis 19:169-78. 2006..To assess new information from peer-reviewed publications in 2005 regarding emerging respiratory viral threats... - Oral pleconaril treatment of picornavirus-associated viral respiratory illness in adults: efficacy and tolerability in phase II clinical trialsFrederick G Hayden
University of Virginia Medical School, Charlottesville, USA
Antivir Ther 7:53-65. 2002..003). Pleconaril 400 mg administered three-times daily reduced the duration and severity of picornaviral VRI in adolescents and adults... - Antiviral management of seasonal and pandemic influenzaFrederick G Hayden
Departments of Internal Medicine and Pathology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA
J Infect Dis 194:S119-26. 2006..Alternative agents and approaches, including parenteral and combination therapy, for the treatment of influenza are needed in the near and long term... - Developing new antiviral agents for influenza treatment: what does the future hold?Frederick Hayden
Global Influenza Programme, World Health Organization, Geneva, Switzerland
Clin Infect Dis 48:S3-13. 2009..Among these agents are T-705, a polymerase inhibitor, and DAS181, an attachment inhibitor. Combination therapy with currently available agents is supported by data from animal models but has received limited clinical study to date... - Antivirals for influenza: historical perspectives and lessons learnedFrederick G Hayden
University of Virginia, School of Medicine, Department of Internal Medicine, Box 800473, Charlottesville, VA 22908, USA
Antiviral Res 71:372-8. 2006.... - Influenza virus and rhinovirus-related otitis media: potential for antiviral interventionF G Hayden
Department of Internal Medicine, University of Virginia School of Medicine, Box 800473, Charlottesville, VA 22908, USA
Vaccine 19:S66-70. 2000..Depending on the virus, early antiviral therapy has the potential to impact the risk of otitis media following respiratory tract infections... - Rhinovirus and the lower respiratory tractFrederick G Hayden
University of Virginia School of Medicine, Hospital Drive, Private Clinics Building, Room 6557, PO Box 800473, Charlottesville, Virginia 22908, USA
Rev Med Virol 14:17-31. 2004..Given the large unmet medical need associated with HRV infections, safe and effective antiviral agents are needed for both prevention and treatment of these infections... - Oral oseltamivir in human experimental influenza B infectionF G Hayden
University of Virginia School of Medicine, Department of Internal Medicine, Charlottesville, USA
Antivir Ther 5:205-13. 2000..These results indicate that oseltamivir has significant antiviral activity in experimental human influenza B virus infection when used for prophylaxis or early treatment... - Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteersFrederick G Hayden
Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
Antimicrob Agents Chemother 47:3907-16. 2003..Results from these studies in experimental rhinoviral infection support continued investigation of intranasal ruprintrivir in the setting of natural HRV infection... - Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatmentF G Hayden
University of Virginia School of Medicine, Charlottesville, USA
JAMA 282:1240-6. 1999..Influenza virus neuraminidase is thought to be essential for virus replication in humans; however, to date, available neuraminidase inhibitors are limited to zanamivir, which is topically administered... - Neuraminidase inhibitor susceptibility network position statement: antiviral resistance in influenza A/H5N1 virusesFrederick Hayden
Division of Infectious Disease and International Health, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
Antivir Ther 10:873-7. 2005..The editors of Antiviral Therapy are pleased to be able to provide this document in an expeditious manner... - Pandemic influenza: is an antiviral response realistic?Frederick G Hayden
University of Virginia School of Medicine, Charlottesville, VA, USA
Pediatr Infect Dis J 23:S262-9. 2004..Antiviral agents could be important in managing and treating pandemic influenza and reduce lower respiratory complications and hospitalizations... - Influenza virus neuraminidase inhibitorsL V Gubareva
Department of Internal Medicine, University of Virginia, School of Medicine, Charlottesville 22908, USA
Lancet 355:827-35. 2000..Because of a broader antiviral spectrum, better tolerance, and less potential for emergence of resistance than is seen with the M2 inhibitors, the neuraminidase inhibitors represent an important advance in the treatment of influenza... - Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variantsL V Gubareva
Division of Epidemiology and Virology, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Antimicrob Agents Chemother 45:3403-8. 2001..We conclude that RWJ-270201 is a potent inhibitor of NAs of wild-type and some zanamivir-resistant or oseltamivir-resistant influenza A and B virus variants... - Impact of zanamivir on antibiotic use for respiratory events following acute influenza in adolescents and adultsL Kaiser
University of Virginia School of Medicine, Department of Internal Medicine, Division of Epidemiology and Virology, Box 800473, Charlottesville, VA 22908, USA
Arch Intern Med 160:3234-40. 2000..Influenza infections commonly lead to respiratory tract complications that result in antibiotic treatment... - Detection of rhinovirus, respiratory syncytial virus, and coronavirus infections in acute otitis media by reverse transcriptase polymerase chain reactionA Pitkaranta
Department of Medicine, University of Virginia, Health Sciences Center, Charlottesville, Virginia 22908, USA
Pediatrics 102:291-5. 1998..To determine the frequencies of human rhinovirus (HRV), respiratory syncytial virus (RSV), and coronavirus (HCV) infection in children with acute otitis media (AOM)... - In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinovirusesL Kaiser
Department of Medicine, Division of Epidemiology and Virology, University of Virginia School of Medicine, Box 473, Charlottesville, VA 22908, USA
Antiviral Res 47:215-20. 2000..In vitro AG7088 appeared to be more potent and to have a broader antirhinoviral spectrum than pleconaril among clinical HRV isolates. The clinical relevance of these in vitro results needs to be determined in controlled clinical trials... - Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivirL V Gubareva
Department of Internal Medicine, Division of Epidemiology and Virology, University of Virginia, PO Box 473, Charlottesville, VA 22908, USA
J Infect Dis 183:523-31. 2001..Thus, HA affinity for receptors is an essential feature of influenza virus susceptibility to NA inhibitors, both in cell culture and in humans... - Influenza in the acute hospital settingCassandra D Salgado
University of Virginia Health System, Charlottesville, VA 22908, USA
Lancet Infect Dis 2:145-55. 2002.... - Effect of hemagglutinin glycosylation on influenza virus susceptibility to neuraminidase inhibitorsVasiliy P Mishin
Department of Internal Medicine, School of Medicine, University of Virginia, Charlottesville, VA, USA
J Virol 79:12416-24. 2005.... - Antiviral resistance in influenza viruses--implications for management and pandemic responseFrederick G Hayden
Division of Infectious Diseases and International Health, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, USA
N Engl J Med 354:785-8. 2006 - Accumulation of defective neuraminidase (NA) genes by influenza A viruses in the presence of NA inhibitors as a marker of reduced dependence on NAMarina S Nedyalkova
Department of Internal Medicine, Division of Epidemiology and Virology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Infect Dis 185:591-8. 2002..Because of a lack of cell culture-based assays for susceptibility testing of human influenza viruses, detection of DeltaRNA segments should be considered an additional assay for monitoring of NA inhibitor resistance... - Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: randomized, controlled trials for prophylaxis and treatmentLuis Barroso
Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
Antivir Ther 10:901-10. 2005..Prophylaxis did not significantly reduce viral shedding. The relatively low blood peramivir concentrations observed may explain the lack of more robust antiviral effects, and parenteral dosing should be studied... - Safety and efficacy of nebulized zanamivir in hospitalized patients with serious influenzaMichael G Ison
University of Virginia, Charlottesville, VA, USA
Antivir Ther 8:183-90. 2003..Two rimantadine-resistant viruses emerged during rimantadine monotherapy; no ZNV resistance was observed. Nebulized ZNV appears to be well tolerated in this hospitalized population but further studies are needed to assess its efficacy... - Therapeutic options for the management of influenzaM G Ison
University of Virginia Health Sciences Center, Division of Infectious Diseases, Charlottesville 22908, USA
Curr Opin Pharmacol 1:482-90. 2001..Studies are also needed to address other groups at increased risk for influenza complications, such as pregnant women and children below one year of age... - Nasopharyngeal reservoir of bacterial otitis media and sinusitis pathogens in adults during wellness and viral respiratory illnessDavid H Chi
Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia 22906-0713, USA
Am J Rhinol 17:209-14. 2003..influenzae were 45, 33, and 30%, respectively. Both a nasal and an oral sample were required for optimal detection. CONCLUSION: Bacterial pathogens were present in the NP of three-quarters of adults during wellness and during colds... - Recovery of drug-resistant influenza virus from immunocompromised patients: a case seriesMichael G Ison
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
J Infect Dis 193:760-4. 2006..We describe a novel Asp198Asn NA mutation in an influenza B virus and its decreased susceptibility to both oseltamivir and zanamivir... - Performance of virus isolation and Directigen Flu A to detect influenza A virus in experimental human infectionL Kaiser
Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908, USA
J Clin Virol 14:191-7. 1999..Few data exist to assess the sensitivity of different specimen types for viral detection during the course of influenza virus infection... - Clinical features of patients with acute respiratory illness and rhinovirus in their bronchoalveolar lavagesE Malcolm
Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, USA
J Clin Virol 21:9-16. 2001..Whether HRV directly causes viral pneumonia or predispose to pulmonary injury and/or superinfection remains uncertain... - Epidemiologic evidence for Lancefield group C beta-hemolytic streptococci as a cause of exudative pharyngitis in college studentsJ C Turner
Department of Student Health, University of Virginia, Charlottesville 22908, USA
J Clin Microbiol 35:1-4. 1997..equisimilis and group A beta-hemolytic streptococci were isolated. Lancefield group C beta-hemolytic streptococci appear to be associated with exudative pharyngitis in college students... - Comparative activities of oseltamivir and A-322278 in immunocompetent and immunocompromised murine models of influenza virus infectionMichael G Ison
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
J Infect Dis 193:765-72. 2006..This model would be useful for elucidation of the molecular mechanisms of resistance to NA inhibitors and for testing of anti-influenza therapy options that might prevent the emergence of resistant variants... - Middle ear pressure in preschool age children: influence of respiratory illness, season, and picornavirus or bacteria in the nasopharynxBirgit Winther
Department of Otolaryngology, Head and Neck Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
Acta Otolaryngol 127:796-800. 2007..Middle ear pressure was affected by respiratory illness and season; picornavirus (without illness) or pathogenic bacteria in the nasopharynx had no or minor effect... - John F. Enders lecture 2006: antivirals for influenzaAdrian K Ong
Communicable Diseases Cluster, World Health Organization, Geneva, Switzerland, Geneva, CH 1211, Switzerland
J Infect Dis 196:181-90. 2007..Continued vigilance in drug resistance surveillance is imperative, as is research into the development of new agents that will provide the potential for alternative and combination antiviral therapy... - Detection of influenza virus resistance to neuraminidase inhibitors by an enzyme inhibition assayLarisa V Gubareva
Department of Internal Medicine, Division of Epidemiology and Virology, University of Virginia School of Medicine, P O Box 800473, Charlottesville, VA 22908 0473, USA
Antiviral Res 53:47-61. 2002..Because variants selected in the presence of one NA inhibitor could be variably resistant to other inhibitors, all three inhibitors should be used in drug susceptibility testing... - Picornavirus infections in children diagnosed by RT-PCR during longitudinal surveillance with weekly sampling: Association with symptomatic illness and effect of seasonBirgit Winther
Department of Otolaryngology, Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
J Med Virol 78:644-50. 2006..51/child-month), episodic, and usually associated with brief illness; one fifth of infections were asymptomatic. The infection rate was highest in fall; infections in winter occurred at the same rate as in spring and summer... - Symptom profile of common colds in school-aged childrenDiane E Pappas
Division of General Pediatrics, Department of Pediatrics, University of Virginia, Charlottesville, VA 22908, USA
Pediatr Infect Dis J 27:8-11. 2008..Subjective symptoms include nasal congestion, feverishness, headache, and sore throat. School-aged children may provide a more accurate picture of the symptom profile during colds because they can self-report... - Weekly point prevalence of Streptococcus pneumoniae, Hemophilus influenzae and Moraxella catarrhalis in the upper airways of normal young children: effect of respiratory illness and seasonJ Owen Hendley
Department of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908, USA
APMIS 113:213-20. 2005..82, p=0.01). Detection of bacteria varied with the amount of secretion in the sample. This variation accounts for the apparent differences in bacterial carriage during illness vs. wellness and during different seasons... - Experimental rhinovirus challenges in adults with mild asthma: response to infection in relation to IgEJuan C Zambrano
Department of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908-0386, USA
J Allergy Clin Immunol 111:1008-16. 2003.... - Assessment of hemagglutinin sequence heterogeneity during influenza virus transmission in familiesLarisa V Gubareva
Department of Internal Medicine, University of Virginia School of Medicine Health Sciences System, Charlottesville 22908, USA
J Infect Dis 186:1575-81. 2002..Substantial genetic conservation during virus transmission within households is indicated... - A release-competent influenza A virus mutant lacking the coding capacity for the neuraminidase active siteLarisa V Gubareva
Department of Internal Medicine, University of Virginia, 1300 Jefferson Park Avenue, Jordan Hall Room 2231, PO Box 800473, Charlottesville 22908, USA
J Gen Virol 83:2683-92. 2002..Hyperglycosylation of HA is common in influenza A viruses circulating in humans and has the potential to reduce virus sensitivity to NA inhibitors... - Effects of dietary supplementation with conjugated linoleic acid on experimental human rhinovirus infection and illnessKRISTINE M PETERSON
Department of Internal Medicine, University of Virginia, Charlottesville, VA, USA
Antivir Ther 14:33-43. 2009..Because studies suggest that the dietary supplement conjugated linoleic acid (CLA) has immunomodulatory activities that might benefit common colds, we performed two studies of CLA effects in experimental human rhinovirus (HRV) infection... - Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezingPeter W Heymann
Department of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908 0386, USA
J Allergy Clin Immunol 114:239-47. 2004..However, information about the relationship between viral infections and atopy among children whose attacks of wheezing lead to hospitalization is unclear... - Viral respiratory infection in schoolchildren: effects on middle ear pressureBirgit Winther
University of Virginia Health System, Charlottesville, Virginia 22906, USA
Pediatrics 109:826-32. 2002..To evaluate the effect of uncomplicated viral respiratory infections (colds) on middle ear pressure in healthy school-aged children... - Symptom pathogenesis during acute influenza: interleukin-6 and other cytokine responsesL Kaiser
University of Virginia School of Medicine, Department of Internal Medicine, Division of Epidemiology and Virology, Charlottesville, Virginia, USA
J Med Virol 64:262-8. 2001..As in experimental influenza, symptoms and fever in natural acute influenza correlate with the release of IL-6... - "Gesundheit!" sneezing, common colds, allergies, and Staphylococcus aureus dispersionWerner E Bischoff
Department of Internal Medicine, Section on Infectious Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157 1042, USA
J Infect Dis 194:1119-26. 2006..Staphylococcus aureus is among the most important pathogens in today's hospital setting... - Evaluation of methyl inosine monophosphate (MIMP) and peramivir activities in a murine model of lethal influenza A virus infectionVasiliy P Mishin
Department of Internal Medicine, University of Virginia Health Sciences System, Charlottesville, USA
Antiviral Res 71:64-8. 2006..Our results emphasize the need for careful consideration of murine strains and routes of virus challenge in the design of experiments utilizing lethal influenza virus infection... - Susceptibilities of antiviral-resistant influenza viruses to novel neuraminidase inhibitorsVasiliy P Mishin
Division of Infectious Diseases and International Health, Department of Internal Medicine, University of Virginia Health Sciences Center, P.O. Box 800473, 1300 Jefferson Ave, Rm. 2231, Charlottesville, Virginia 22908, USA
Antimicrob Agents Chemother 49:4515-20. 2005..These studies indicate that different patterns of susceptibility and cross-resistance between NA inhibitors may prove important if antiviral resistance to zanamivir and oseltamivir were to emerge... - Expression of ICAM-1 in nasal epithelium and levels of soluble ICAM-1 in nasal lavage fluid during human experimental rhinovirus infectionBirgit Winther
University of Virginia Health System, Department of Internal Medicine, Box 800473, Charlottesville, VA 22908, USA
Arch Otolaryngol Head Neck Surg 128:131-6. 2002..Up-regulation of ICAM-1 receptor expression on nasal epithelial cells occurred within 24 hours after inoculation in experimental rhinovirus infections (prior to onset of symptoms) and declined promptly by day 5... - Viral infections in immunocompromised patients: what's new with respiratory viruses?Michael G Ison
Division of Infectious Diseases, University of Virginia, Charlottesville, Virginia 22908, USA
Curr Opin Infect Dis 15:355-67. 2002..The respiratory viruses, particularly respiratory syncytial virus, influenza, parainfluenza, adenovirus, and picornaviruses, are increasingly recognized as significant pathogens in these populations... - Rhinovirus infections in hematopoietic stem cell transplant recipients with pneumoniaMichael G Ison
Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA
Clin Infect Dis 36:1139-43. 2003..Whether the poor prognosis is due to HRV or the copathogen is not clear... - Protection afforded by intranasal immunization with the neuraminidase-lacking mutant of influenza A virus in a ferret modelVasiliy P Mishin
Division of Infectious Diseases and International Health, Department of Internal Medicine, Health Sciences Center, University of Virginia, 1300 Jefferson Park Avenue, P.O. Box 800473, Charlottesville, Virginia 22908, USA
Vaccine 23:2922-7. 2005..We conclude that the NA as antigen is dispensable in the live attenuated influenza virus vaccine and that the NA-lacking mutant can be used as a virus vector... - Seasonal and pandemic influenza: recommendations for preparedness in the United StatesRichard J Whitley
Department of Pediatric, University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
J Infect Dis 194:S155-61. 2006.... - Shedding and immunogenicity of live attenuated influenza vaccine virus in subjects 5-49 years of ageStan L Block
Kentucky Pediatric and Adult Research, Bardstown, KY 40004, United States
Vaccine 26:4940-6. 2008..Live attenuated influenza vaccine (LAIV) is indicated for influenza prevention in persons 2-49 years of age. This study describes the incidence and duration of vaccine virus shedding and serum immune responses after receipt of LAIV... - Update on avian influenza A (H5N1) virus infection in humansAbdel-Nasser Abdel-Ghafar
Ministry of Health and Population, Cairo
N Engl J Med 358:261-73. 2008 - Safety and immunogenicity of a baculovirus-expressed hemagglutinin influenza vaccine: a randomized controlled trialJohn J Treanor
University of Rochester, Rochester, NY, USA
JAMA 297:1577-82. 2007..A high priority in vaccine research is the development of influenza vaccines that do not use embryonated eggs as the substrate for vaccine production... - Kinetics of influenza A virus infection in humansPrasith Baccam
Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
J Virol 80:7590-9. 2006.... - Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their useArnold S Monto
University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Antimicrob Agents Chemother 50:2395-402. 2006..The frequency of variants with decreased sensitivity to the NAIs did not increase significantly during this period, but continued surveillance is required, especially in regions with higher NAI use... - Influenza treatment with neuraminidase inhibitors: cost-effectiveness and cost-utility in healthy adults in the United KingdomBeate Sander
Institute for Medical Outcome Research GmbH, Lörrach, Germany
Eur J Health Econ 6:244-52. 2005..Oseltamivir dominates usual care from the societal perspective. Treatment with oseltamivir is a cost-effective strategy for otherwise healthy adults in the UK from both the healthcare payer and societal perspective... - Multiple sclerosis attacks are associated with picornavirus infectionsJohn D Kriesel
Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Mult Scler 10:145-8. 2004..By contrast, only two of 12 (17%) picornavirus-negative URIs were associated with an MS attack (P = 0.01). The possible role of picornaviruses in the pathogenesis of MS deserves further study... - Rhinovirus and coronavirus infection-associated hospitalizations among older adultsAnn R Falsey
Division of Infectious Diseases and Department of Medicine, University of Rochester School of Medicine and Dentistry, and Rochester General Hospital, Rochester, New York 14621, USA
J Infect Dis 185:1338-41. 2002..These data suggest that rhinoviruses and coronaviruses may be associated with serious respiratory illnesses in frail older adults... - Pharmacophore modeling, docking, and principal component analysis based clustering: combined computer-assisted approaches to identify new inhibitors of the human rhinovirus coat proteinTheodora M Steindl
Department of Pharmaceutical Chemistry, Institute of Pharmacy, and Center for Molecular Biosciences Innsbruck (CMBI, University of Innsbruck, Innrain 52c, A-6020 Innsbruck, Austria
J Med Chem 48:6250-60. 2005..These combined efforts led to the selection of six candidate structures, for which in vitro anti-rhinoviral activity could be shown in a biological assay... - Avian influenza A (H5N1) infection in humansJohn H Beigel
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
N Engl J Med 353:1374-85. 2005 - Relationship of pleconaril susceptibility and clinical outcomes in treatment of common colds caused by rhinovirusesDaniel C Pevear
ViroPharma Incorporated, Exton, Pennsylvania 19341, USA
Antimicrob Agents Chemother 49:4492-9. 2005..7% of drug-treated subjects, respectively. These patients shed low levels of virus and had no unusual clinical outcomes. Nevertheless, studies on the biologic properties and transmissibility of these variant viruses are warranted... - Influenza, Winter Olympiad, 2002Adi V Gundlapalli
University of Utah School of Medicine, Salt Lake City, Utah, USA
Emerg Infect Dis 12:144-6. 2006..Influenza A/B was diagnosed in 36 of 188 patients, including 13 athletes. Prompt management limited the spread of this outbreak... - Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infectionMichael P Malakhov
NexBio, Inc, 6330 Nancy Ridge Dr, Suite 105, San Diego, CA 92121, USA
Antimicrob Agents Chemother 50:1470-9. 2006..04 to 0.9 nM. Mouse and ferret studies confirmed significant in vivo efficacy of the sialidase fusion in both prophylactic and treatment modes... - Drug resistance and influenza pandemicsNikolaos I Stilianakis
Lancet 359:1862-3. 2002 - Post-exposure influenza prophylaxis with oseltamivir: cost effectiveness and cost utility in families in the UKBeate Sander
Division of Clinical Decision-Making and Health Care Research, University Health Network, Toronto, Ontario, Canada
Pharmacoeconomics 24:373-86. 2006.... - Resistant influenza A viruses in children treated with oseltamivir: descriptive studyMaki Kiso
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Lancet 364:759-65. 2004..Furthermore, children can be a source of viral transmission, even after 5 days of treatment with oseltamivir... - The Southeast Asian Influenza Clinical Research Network: development and challenges for a new multilateral research endeavorElizabeth S Higgs
Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Antiviral Res 78:64-8. 2008..The establishment of a clinical research network is a vital part of preparedness and an important element during an initial response phase to a pandemic... - Clinical issues and research in respiratory failure from severe acute respiratory syndromeMitchell M Levy
Department of Medicine, Brown University/Rhode Island Hospital, Providence, USA
Am J Respir Crit Care Med 171:518-26. 2005..The group recommended preparation for studies, including protocols, ethical considerations, Web-based registries, and data entry systems... - Preventing the airborne spread of Staphylococcus aureus by persons with the common cold: effect of surgical scrubs, gowns, and masksWerner E Bischoff
Section on Infectious Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Infect Control Hosp Epidemiol 28:1148-54. 2007..This study investigates the impact of barrier precautions on the spread of airborne S. aureus by volunteers with experimentally induced rhinovirus infection (ie, the common cold)... - Influenza A (H5N1): will it be the next pandemic influenza? Are we ready?John G Bartlett
Ann Intern Med 143:460-2. 2005 - Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trialsM Elizabeth Halloran
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Epidemiol 165:212-21. 2007..Studies of influenza antivirals in transmission units would be improved if randomization schemes were used that allow estimation of the antiviral effect on infectiousness from individual studies... - WHO Rapid Advice Guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virusHolger J Schunemann
Italian National Cancer Institute Regina Elena, INFORMA Unit, Department of Epidemiology, Istituto Regina Elena, Rome, Italy
Lancet Infect Dis 7:21-31. 2007..Emergence of other novel influenza A viral subtypes with pandemic potential, or changes in the pathogenicity of H5N1 virus strains, will require an update of these guidelines and WHO will be monitoring this closely...