Research Topics
Species | William W HaySummaryAffiliation: University of Colorado Denver Country: USA Publications
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Protein for preterm infants: how much is needed? How much is enough? How much is too much?William W Hay
Department of Pediatrics, University of Colorado School of Medicine, Aurora, USA
Pediatr neonatol 51:198-207. 2010..Further research is necessary to determine optimal amounts and mixtures of protein and amino acids for both intravenous and enteral feeding to improve growth, development, and functional capacity of preterm infants...- Child health research funding and policy: imperatives and investments for a healthier worldWilliam W Hay
Department of Pediatrics, Colorado Clinical and Translational Sciences Institute, University of Colorado School of Medicine, Aurora, Colorado, USA
Pediatrics 125:1259-65. 2010.... - Care of the infant of the diabetic motherWilliam W Hay
Anschutz Medical Campus, F441, Perinatal Research Center, University of Colorado School of Medicine, 13243 East 23rd Avenue, Aurora, CO 80045, USA
Curr Diab Rep 12:4-15. 2012.... 
Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restrictionPaul J Rozance
Department of Pediatrics, University of Colorado Denver and Health Sciences Center, Aurora, Colorado 80045, USA
Pediatr Res 65:72-8. 2009..275 +/- 0.071 Glu vs. 7.354 +/- 0.003 Sal, p < 0.01) in the Glu group. We conclude that correction of fetal hypoglycemia is not well tolerated and fails to increase insulin concentrations or beta-cell mass in IUGR fetuses...
Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheepPaul J Rozance
Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 294:E365-70. 2008..These results demonstrate that chronic fetal hypoglycemia triggers signals that can activate gluconeogenesis in the fetal liver...- A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemiaStephanie R Thorn
Perinatal Research Center, Department of Pediatrics, Univ of Colorado School of Medicine, Aurora 80045, USA
Am J Physiol Regul Integr Comp Physiol 303:R861-9. 2012..These results demonstrate that fetuses exposed to sustained hypoglycemia have maintained hepatic insulin action in contrast to fetuses exposed to placental insufficiency... - Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscleStephanie R Thorn
Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
Endocrinology 150:3021-30. 2009.... - Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheepLaura D Brown
Perinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 303:E352-64. 2012.... - Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restrictionSean W Limesand
Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, Colorado, USA
Am J Physiol Endocrinol Metab 293:E1716-25. 2007.... - Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidationPaul J Rozance
Perinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 297:E638-46. 2009..Decreased concentrations of certain essential amino acids, increased amino acid oxidation, fetal acidosis, and fetal hypoxia are possible mechanisms to explain fetal toxicity during maternal amino acid supplementation... - Insulin is required for amino acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetusLaura D Brown
UCD Perinatal Research Center, F441, 13243 East 23rd Ave, PO Box 6508, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 296:E56-63. 2009..Furthermore, the effect of amino acids is dependent on a concomitant increase in fetal insulin concentrations, because amino acid infusion upregulates p70(S6k) and Erk only when amino acid-stimulated increase in insulin occurs... - Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulinStephanie R Thorn
Perinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Diabetes 62:65-73. 2013..These data are consistent with a novel mechanism involving persistent transcriptional activation in the liver that seems to be unique in the fetus with IUGR... - Increased fetal insulin concentrations for one week fail to improve insulin secretion or β-cell mass in fetal sheep with chronically reduced glucose supplyJinny R Lavezzi
Perinatal Research Center, Section of Neonatology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, USA
Am J Physiol Regul Integr Comp Physiol 304:R50-8. 2013..These results indicate that chronically reduced fetal glucose supply is sufficient to reduce pancreatic insulin secretion in response to glucose, primarily due to reduced pancreatic and β-cell mass, and is not correctable with insulin... - Decreased nutrient-stimulated insulin secretion in chronically hypoglycemic late-gestation fetal sheep is due to an intrinsic islet defectPaul J Rozance
Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 291:E404-11. 2006.... - Developmental changes in ovine myocardial glucose transporters and insulin signaling following hyperthermia-induced intrauterine fetal growth restrictionJames S Barry
Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, The Children s Hospital, 1056 East 19th Avenue, Box B070, Denver, CO 80218, USA
Exp Biol Med (Maywood) 231:566-75. 2006.... - Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic beta-cellsPaul J Rozance
Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
Am J Physiol Endocrinol Metab 292:E1256-64. 2007..In conclusion, these studies show that chronic hypoglycemia in late gestation decreases insulin secretion by inhibiting the later steps of stimulus-secretion coupling after glucose metabolism, membrane depolarization, and calcium entry... - Nutritional requirements of the very preterm infantWilliam W Hay
Neonatal Clinical Research Center and the UCHSC Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, Colorado 80010, USA
Acta Paediatr Suppl 94:37-46. 2005 - Effect of hyperinsulinemia on amino acid utilization and oxidation independent of glucose metabolism in the ovine fetusLaura D Brown
Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 291:E1333-40. 2006..In acute hyperinsulinemic conditions, AA oxidation does not change when insulin-induced glucose utilization is prevented... - Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase β-cell mass in fetal sheepMonika M Gadhia
Perinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 304:E352-62. 2013..This may be enhanced by the paracrine action of glucagon on the β-cell... - Nutrient supplies for optimal health in preterm infantsWilliam W Hay
Neonatal Clinical Research Center, Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, USA
J Pediatr Gastroenterol Nutr 45:S163-9. 2007..It is clear, therefore, that just the right amount of the essential nutrients is required to produce optimal outcome; this is as true for the preterm infant as it is for the fetus... - The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetesStephanie R Thorn
University of Colorado School of Medicine, Aurora, Colorado, USA
Semin Reprod Med 29:225-36. 2011..Such adaptations, if persistent, also have the potential in later life to promote nutrient uptake and storage, which directly lead to complications of obesity, insulin resistance, reduced insulin production, and type 2 diabetes... - Intravenous nutrition of the very preterm neonateWilliam W Hay
Neonatal Clinical Research Center and the UCHSC Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, Colorado 80010, USA
Acta Paediatr Suppl 94:47-56. 2005 - Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restrictionSean W Limesand
Perinatal Research Center, Dept of Pediatrics, Univ of Colorado Health Sciences Center, P O Box 6508, F441, Aurora CO 80045, USA
Am J Physiol Regul Integr Comp Physiol 288:R1297-305. 2005..Diminished beta-cell mass in IUGR infants at birth, if not adequately compensated for after birth, may contribute to insufficient insulin production in later life and, thus, a predisposition to noninsulin-dependent diabetes... - Recent observations on the regulation of fetal metabolism by glucoseWilliam W Hay
University of Colorado Health Sciences Center, Perinatal Research Center, F441, 13243 E 23rd Avenue, PO Box 6508, Aurora, CO 80045, USA
J Physiol 572:17-24. 2006.... - Strategies for feeding the preterm infantWilliam W Hay
Department of Pediatrics, Perinatal Research Center, Colorado Clinical Translational Science Institute, University of Colorado School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
Neonatology 94:245-54. 2008..Infants with IUGR and postnatal growth failure may be uniquely 'set up' for this outcome, while infants with in utero obesity, such as infants of diabetic mothers, already are well along this adverse outcome pathway... - Describing hypoglycemia--definition or operational threshold?Paul J Rozance
Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
Early Hum Dev 86:275-80. 2010.... - Adiponectin enhances mouse fetal fat depositionLiping Qiao
Department of Pediatrics, University of California San Diego, La Jolla, California, USA
Diabetes 61:3199-207. 2012..Together, our study indicates that adiponectin enhances fetal fat deposition and plays an important role in maternal obesity-induced high birth weight... - Differential effects of chronic pulsatile versus chronic constant maternal hyperglycemia on fetal pancreatic β-cellsMackenzie S Frost
Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA, USA
J Pregnancy 2012:812094. 2012..These findings demonstrate differential effects that the pattern of maternal hyperglycemia has on fetal pancreatic β-cell development, which might contribute to later life limitation in insulin secretion... - Hypoglycemia in newborn infants: Features associated with adverse outcomesPaul J Rozance
Section of Neonatology, Division of Perinatal Medicine, Department of Pediatrics and The Children's Hospital, University of Colorado School of Medicine, Denver, CO, USA
Biol Neonate 90:74-86. 2006..Our intent in this review article is to highlight the studies relevant to this issue and help clinicians formulate a safe and, hopefully, effective strategy for the diagnosis and treatment of hypoglycemia... - In vivo techniques for studying fetoplacental nutrient uptake, metabolism, and transportTimothy R H Regnault
Perinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, USA
Methods Mol Med 122:207-24. 2006..Details are provided to illustrate key concepts for net rates of uteroplacental glucose and amino acid uptake, transfer to the fetus, and net uteroplacental uptake... - Pharmacokinetics of protein C and antithrombin in the fetal lamb: a model to predict human neonatal replacement dosingMarilyn J Manco-Johnson
Mountain States Regional Hemophilia and Thrombosis Center, Aurora, CO 80045 0507, USA
Neonatology 95:279-85. 2009..The preterm infant is at risk for consumptive coagulopathy and thrombosis due to late maturation of coagulation regulatory proteins. Replacement proteins are available, but neonatal pharmacokinetic data are lacking... - Effects of acute hyperinsulinemia on insulin signal transduction and glucose transporters in ovine fetal skeletal muscleMarianne S Anderson
Pediatrics Neonatology, University of Colorado Health Sciences Center, Denver, Colorado, USA
Am J Physiol Regul Integr Comp Physiol 288:R473-81. 2005.... - Adaptation of ovine fetal pancreatic insulin secretion to chronic hypoglycaemia and euglycaemic correctionSean W Limesand
Perinatal Research Center, Division of Perinatal Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Physiol 547:95-105. 2003..We conclude that programming of pancreatic insulin secretion responsiveness can occur in response to fetal glucose deprivation, indicating a possible mechanism for establishing, in fetal life, a predisposition to type 2 diabetes...