William W Hay

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi Protein for preterm infants: how much is needed? How much is enough? How much is too much?
    William W Hay
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, USA
    Pediatr neonatol 51:198-207. 2010
  2. doi Care of the infant of the diabetic mother
    William W Hay
    Anschutz Medical Campus, F441, Perinatal Research Center, University of Colorado School of Medicine, 13243 East 23rd Avenue, Aurora, CO 80045, USA
    Curr Diab Rep 12:4-15. 2012
  3. doi Child health research funding and policy: imperatives and investments for a healthier world
    William W Hay
    Department of Pediatrics, Colorado Clinical and Translational Sciences Institute, University of Colorado School of Medicine, Aurora, Colorado, USA
    Pediatrics 125:1259-65. 2010
  4. pmc Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction
    Paul J Rozance
    Department of Pediatrics, University of Colorado Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Pediatr Res 65:72-8. 2009
  5. ncbi Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep
    Paul J Rozance
    Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 294:E365-70. 2008
  6. pmc Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase β-cell mass in fetal sheep
    Monika M Gadhia
    Perinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 304:E352-62. 2013
  7. pmc A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia
    Stephanie R Thorn
    Perinatal Research Center, Department of Pediatrics, Univ of Colorado School of Medicine, Aurora 80045, USA
    Am J Physiol Regul Integr Comp Physiol 303:R861-9. 2012
  8. pmc Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle
    Stephanie R Thorn
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    Endocrinology 150:3021-30. 2009
  9. pmc Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep
    Laura D Brown
    Perinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 303:E352-64. 2012
  10. ncbi Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction
    Sean W Limesand
    Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    Am J Physiol Endocrinol Metab 293:E1716-25. 2007

Collaborators

Detail Information

Publications33

  1. doi Protein for preterm infants: how much is needed? How much is enough? How much is too much?
    William W Hay
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, USA
    Pediatr neonatol 51:198-207. 2010
    ..Further research is necessary to determine optimal amounts and mixtures of protein and amino acids for both intravenous and enteral feeding to improve growth, development, and functional capacity of preterm infants...
  2. doi Care of the infant of the diabetic mother
    William W Hay
    Anschutz Medical Campus, F441, Perinatal Research Center, University of Colorado School of Medicine, 13243 East 23rd Avenue, Aurora, CO 80045, USA
    Curr Diab Rep 12:4-15. 2012
    ....
  3. doi Child health research funding and policy: imperatives and investments for a healthier world
    William W Hay
    Department of Pediatrics, Colorado Clinical and Translational Sciences Institute, University of Colorado School of Medicine, Aurora, Colorado, USA
    Pediatrics 125:1259-65. 2010
    ....
  4. pmc Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction
    Paul J Rozance
    Department of Pediatrics, University of Colorado Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Pediatr Res 65:72-8. 2009
    ..275 +/- 0.071 Glu vs. 7.354 +/- 0.003 Sal, p < 0.01) in the Glu group. We conclude that correction of fetal hypoglycemia is not well tolerated and fails to increase insulin concentrations or beta-cell mass in IUGR fetuses...
  5. ncbi Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep
    Paul J Rozance
    Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 294:E365-70. 2008
    ..These results demonstrate that chronic fetal hypoglycemia triggers signals that can activate gluconeogenesis in the fetal liver...
  6. pmc Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase β-cell mass in fetal sheep
    Monika M Gadhia
    Perinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 304:E352-62. 2013
    ..This may be enhanced by the paracrine action of glucagon on the β-cell...
  7. pmc A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia
    Stephanie R Thorn
    Perinatal Research Center, Department of Pediatrics, Univ of Colorado School of Medicine, Aurora 80045, USA
    Am J Physiol Regul Integr Comp Physiol 303:R861-9. 2012
    ..These results demonstrate that fetuses exposed to sustained hypoglycemia have maintained hepatic insulin action in contrast to fetuses exposed to placental insufficiency...
  8. pmc Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle
    Stephanie R Thorn
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    Endocrinology 150:3021-30. 2009
    ....
  9. pmc Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep
    Laura D Brown
    Perinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 303:E352-64. 2012
    ....
  10. ncbi Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction
    Sean W Limesand
    Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    Am J Physiol Endocrinol Metab 293:E1716-25. 2007
    ....
  11. pmc Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation
    Paul J Rozance
    Perinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 297:E638-46. 2009
    ..Decreased concentrations of certain essential amino acids, increased amino acid oxidation, fetal acidosis, and fetal hypoxia are possible mechanisms to explain fetal toxicity during maternal amino acid supplementation...
  12. pmc Differential effects of chronic pulsatile versus chronic constant maternal hyperglycemia on fetal pancreatic β-cells
    Mackenzie S Frost
    Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA, USA
    J Pregnancy 2012:812094. 2012
    ..These findings demonstrate differential effects that the pattern of maternal hyperglycemia has on fetal pancreatic β-cell development, which might contribute to later life limitation in insulin secretion...
  13. pmc Insulin is required for amino acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetus
    Laura D Brown
    UCD Perinatal Research Center, F441, 13243 East 23rd Ave, PO Box 6508, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 296:E56-63. 2009
    ..Furthermore, the effect of amino acids is dependent on a concomitant increase in fetal insulin concentrations, because amino acid infusion upregulates p70(S6k) and Erk only when amino acid-stimulated increase in insulin occurs...
  14. pmc Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin
    Stephanie R Thorn
    Perinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
    Diabetes 62:65-73. 2013
    ..These data are consistent with a novel mechanism involving persistent transcriptional activation in the liver that seems to be unique in the fetus with IUGR...
  15. pmc Increased fetal insulin concentrations for one week fail to improve insulin secretion or β-cell mass in fetal sheep with chronically reduced glucose supply
    Jinny R Lavezzi
    Perinatal Research Center, Section of Neonatology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, USA
    Am J Physiol Regul Integr Comp Physiol 304:R50-8. 2013
    ..These results indicate that chronically reduced fetal glucose supply is sufficient to reduce pancreatic insulin secretion in response to glucose, primarily due to reduced pancreatic and β-cell mass, and is not correctable with insulin...
  16. ncbi Decreased nutrient-stimulated insulin secretion in chronically hypoglycemic late-gestation fetal sheep is due to an intrinsic islet defect
    Paul J Rozance
    Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 291:E404-11. 2006
    ....
  17. ncbi Developmental changes in ovine myocardial glucose transporters and insulin signaling following hyperthermia-induced intrauterine fetal growth restriction
    James S Barry
    Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, The Children s Hospital, 1056 East 19th Avenue, Box B070, Denver, CO 80218, USA
    Exp Biol Med (Maywood) 231:566-75. 2006
    ....
  18. ncbi Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic beta-cells
    Paul J Rozance
    Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Am J Physiol Endocrinol Metab 292:E1256-64. 2007
    ..In conclusion, these studies show that chronic hypoglycemia in late gestation decreases insulin secretion by inhibiting the later steps of stimulus-secretion coupling after glucose metabolism, membrane depolarization, and calcium entry...
  19. ncbi Nutritional requirements of the very preterm infant
    William W Hay
    Neonatal Clinical Research Center and the UCHSC Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, Colorado 80010, USA
    Acta Paediatr Suppl 94:37-46. 2005
  20. ncbi Effect of hyperinsulinemia on amino acid utilization and oxidation independent of glucose metabolism in the ovine fetus
    Laura D Brown
    Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 291:E1333-40. 2006
    ..In acute hyperinsulinemic conditions, AA oxidation does not change when insulin-induced glucose utilization is prevented...
  21. ncbi Intravenous nutrition of the very preterm neonate
    William W Hay
    Neonatal Clinical Research Center and the UCHSC Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, Colorado 80010, USA
    Acta Paediatr Suppl 94:47-56. 2005
  22. ncbi Nutrient supplies for optimal health in preterm infants
    William W Hay
    Neonatal Clinical Research Center, Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, USA
    J Pediatr Gastroenterol Nutr 45:S163-9. 2007
    ..It is clear, therefore, that just the right amount of the essential nutrients is required to produce optimal outcome; this is as true for the preterm infant as it is for the fetus...
  23. pmc The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes
    Stephanie R Thorn
    University of Colorado School of Medicine, Aurora, Colorado, USA
    Semin Reprod Med 29:225-36. 2011
    ..Such adaptations, if persistent, also have the potential in later life to promote nutrient uptake and storage, which directly lead to complications of obesity, insulin resistance, reduced insulin production, and type 2 diabetes...
  24. pmc Recent observations on the regulation of fetal metabolism by glucose
    William W Hay
    University of Colorado Health Sciences Center, Perinatal Research Center, F441, 13243 E 23rd Avenue, PO Box 6508, Aurora, CO 80045, USA
    J Physiol 572:17-24. 2006
    ....
  25. ncbi Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction
    Sean W Limesand
    Perinatal Research Center, Dept of Pediatrics, Univ of Colorado Health Sciences Center, P O Box 6508, F441, Aurora CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1297-305. 2005
    ..Diminished beta-cell mass in IUGR infants at birth, if not adequately compensated for after birth, may contribute to insufficient insulin production in later life and, thus, a predisposition to noninsulin-dependent diabetes...
  26. pmc Strategies for feeding the preterm infant
    William W Hay
    Department of Pediatrics, Perinatal Research Center, Colorado Clinical Translational Science Institute, University of Colorado School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    Neonatology 94:245-54. 2008
    ..Infants with IUGR and postnatal growth failure may be uniquely 'set up' for this outcome, while infants with in utero obesity, such as infants of diabetic mothers, already are well along this adverse outcome pathway...
  27. pmc Describing hypoglycemia--definition or operational threshold?
    Paul J Rozance
    Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    Early Hum Dev 86:275-80. 2010
    ....
  28. pmc Adiponectin enhances mouse fetal fat deposition
    Liping Qiao
    Department of Pediatrics, University of California San Diego, La Jolla, California, USA
    Diabetes 61:3199-207. 2012
    ..Together, our study indicates that adiponectin enhances fetal fat deposition and plays an important role in maternal obesity-induced high birth weight...
  29. ncbi Hypoglycemia in newborn infants: Features associated with adverse outcomes
    Paul J Rozance
    Section of Neonatology, Division of Perinatal Medicine, Department of Pediatrics and The Children s Hospital, University of Colorado School of Medicine, Denver, CO, USA
    Biol Neonate 90:74-86. 2006
    ..Our intent in this review article is to highlight the studies relevant to this issue and help clinicians formulate a safe and, hopefully, effective strategy for the diagnosis and treatment of hypoglycemia...
  30. ncbi In vivo techniques for studying fetoplacental nutrient uptake, metabolism, and transport
    Timothy R H Regnault
    Perinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, USA
    Methods Mol Med 122:207-24. 2006
    ..Details are provided to illustrate key concepts for net rates of uteroplacental glucose and amino acid uptake, transfer to the fetus, and net uteroplacental uptake...
  31. pmc Pharmacokinetics of protein C and antithrombin in the fetal lamb: a model to predict human neonatal replacement dosing
    Marilyn J Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, Aurora, CO 80045 0507, USA
    Neonatology 95:279-85. 2009
    ..The preterm infant is at risk for consumptive coagulopathy and thrombosis due to late maturation of coagulation regulatory proteins. Replacement proteins are available, but neonatal pharmacokinetic data are lacking...
  32. ncbi Effects of acute hyperinsulinemia on insulin signal transduction and glucose transporters in ovine fetal skeletal muscle
    Marianne S Anderson
    Pediatrics Neonatology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Physiol Regul Integr Comp Physiol 288:R473-81. 2005
    ....
  33. pmc Adaptation of ovine fetal pancreatic insulin secretion to chronic hypoglycaemia and euglycaemic correction
    Sean W Limesand
    Perinatal Research Center, Division of Perinatal Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Physiol 547:95-105. 2003
    ..We conclude that programming of pancreatic insulin secretion responsiveness can occur in response to fetal glucose deprivation, indicating a possible mechanism for establishing, in fetal life, a predisposition to type 2 diabetes...