Nissim Hay

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc The effect Akt2 deletion on tumor development in Pten(+/-) mice
    P Z Xu
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA
    Oncogene 31:518-26. 2012
  2. ncbi p53 strikes mTORC1 by employing sestrins
    Nissim Hay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Cell Metab 8:184-5. 2008
  3. ncbi Upstream and downstream of mTOR
    Nissim Hay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 60607, USA
    Genes Dev 18:1926-45. 2004
  4. pmc Interplay between FOXO, TOR, and Akt
    Nissim Hay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, IL 60607, USA
    Biochim Biophys Acta 1813:1965-70. 2011
  5. pmc Akt isoforms and glucose homeostasis - the leptin connection
    Nissim Hay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Trends Endocrinol Metab 22:66-73. 2011
  6. pmc FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor
    Chia Chen Chen
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Dev Cell 18:592-604. 2010
  7. ncbi Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
    Annett Hahn-Windgassen
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 60607, USA
    J Biol Chem 280:32081-9. 2005
  8. ncbi Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
    Nathan Majewski
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Mol Cell 16:819-30. 2004
  9. ncbi Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner
    Jennifer E Skeen
    Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, USA
    Cancer Cell 10:269-80. 2006
  10. pmc mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition
    Prashanth T Bhaskar
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Mol Cell Biol 29:5136-47. 2009

Research Grants

Collaborators

Detail Information

Publications57

  1. pmc The effect Akt2 deletion on tumor development in Pten(+/-) mice
    P Z Xu
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA
    Oncogene 31:518-26. 2012
    ....
  2. ncbi p53 strikes mTORC1 by employing sestrins
    Nissim Hay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Cell Metab 8:184-5. 2008
    ..p53 also induces a metabolic checkpoint by inhibiting the mammalian target of rapamycin complex 1 (mTORC1). Recent results by Budanov and Karin, (2008) reveal that p53 exerts its effect on mTORC1 through sestrin1 and sestrin2...
  3. ncbi Upstream and downstream of mTOR
    Nissim Hay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 60607, USA
    Genes Dev 18:1926-45. 2004
    ..We also summarize the roles of mTOR in the control of cell growth and proliferation, as well as its relevance to cancer and synaptic plasticity...
  4. pmc Interplay between FOXO, TOR, and Akt
    Nissim Hay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, IL 60607, USA
    Biochim Biophys Acta 1813:1965-70. 2011
    ..The biological significance of these regulatory circuits is discussed in this article. This article is part of a Special Issue entitled: P13K-AKT-FoxO axis in cancer and aging...
  5. pmc Akt isoforms and glucose homeostasis - the leptin connection
    Nissim Hay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Trends Endocrinol Metab 22:66-73. 2011
    ..The significance of these findings, together with recent observations suggesting that leptin emulates insulin action, is also discussed...
  6. pmc FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor
    Chia Chen Chen
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Dev Cell 18:592-604. 2010
    ..Thus, under stress conditions, FoxO inhibits the anabolic activity of mTORC1, a major consumer of cellular energy, while activating Akt, which increases cellular energy metabolism, thereby maintaining cellular energy homeostasis...
  7. ncbi Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
    Annett Hahn-Windgassen
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 60607, USA
    J Biol Chem 280:32081-9. 2005
    ..We propose that the activation of mTOR by Akt-mediated cellular energy and inhibition of AMPK is the predominant pathway by which Akt activates mTOR in vivo...
  8. ncbi Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
    Nathan Majewski
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Mol Cell 16:819-30. 2004
    ....
  9. ncbi Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner
    Jennifer E Skeen
    Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, USA
    Cancer Cell 10:269-80. 2006
    ..Surprisingly, upon mTORC1 hyperactivation, the reduction in Akt activity does not impair cell proliferation and susceptibility to oncogenic transformation; thus, Akt may mediate these processes exclusively via mTORC1...
  10. pmc mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition
    Prashanth T Bhaskar
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Mol Cell Biol 29:5136-47. 2009
    ..Consistently, the reduction of eIF4E levels abrogates the resistance of Tsc2(-/)(-) cells to serum deprivation-induced apoptosis...
  11. pmc Role of the Akt pathway in mRNA translation of interferon-stimulated genes
    Surinder Kaur
    Division of Hematology Oncology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School and Lakeside Veterans Affairs Medical Center, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 105:4808-13. 2008
    ..Thus, activation of the Akt pathway by the IFN receptors complements the function of IFN-activated JAK-STAT pathways, by allowing mRNA translation of IFN-stimulated genes and, ultimately, the induction of the biological effects of IFNs...
  12. ncbi Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling
    Surinder Kaur
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 282:1757-68. 2007
    ..Taken altogether, our data suggest an important role for mTOR-dependent pathways in IFN signaling and identify 4E-BP1 and TSC1-TSC2 as key components in the generation of IFN-dependent biological responses...
  13. pmc Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice
    William S Chen
    University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics, Chicago, IL 60607, USA
    Mol Cell Biol 29:3151-62. 2009
    ..These results uncover a new mechanism linking Akt to diabetes, provide a therapeutic strategy, and show that diabetes induced as a consequence of cancer therapy, via Akt inhibition, could be reversed by leptin therapy...
  14. pmc PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer
    Yu Zheng
    Department of Biochemistry, Biopharmaceutical Sciences, and Pathology, University of Illinois at Chicago, Chicago, IL 60607, USA
    Cancer Res 73:5426-37. 2013
    ..Our findings reveal novel functions for PTK6 in the pathophysiology of prostate cancer, and they define this kinase as a candidate therapeutic target. Cancer Res; 73(17); 5426-37. ©2013 AACR. ..
  15. pmc AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
    Sang Min Jeon
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Nature 485:661-5. 2012
    ....
  16. pmc Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases
    Nathan Majewski
    Department of Biochemistry and Molecular Genetics M C 669, College of Medicine, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
    Mol Cell Biol 24:730-40. 2004
    ..These results suggest that Akt inhibits BID-mediated apoptosis downstream of BID cleavage via promotion of mitochondrial hexokinase association and antagonism of tBID-mediated BAX and BAK activation at the mitochondria...
  17. pmc Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis
    Veronique Nogueira
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA
    EMBO J 31:1134-46. 2012
    ..Skp2 re-expression in Akt-deficient preadipocytes, which are impaired in adipogenesis, is sufficient to restore adipogenesis. These results uncover the mechanism by which Akt mediates adipogenesis...
  18. pmc Role of the translational repressor 4E-BP1 in the regulation of p21(Waf1/Cip1) expression by retinoids
    Padma Kannan-Thulasiraman
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Jesse Brown VA Medical Center, 303 East Superior, Chicago, IL, USA
    Biochem Biophys Res Commun 368:983-9. 2008
    ..Altogether, these findings strongly suggest a key regulatory role for the translational repressor 4E-BP1 in the generation of retinoid-dependent functional responses...
  19. ncbi Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein
    Fatima Lekmine
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, IL 60611, USA
    Exp Cell Res 295:173-82. 2004
    ....
  20. ncbi Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells
    Lakhvir Lal
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Blood 105:1669-77. 2005
    ....
  21. pmc FoxM1, a critical regulator of oxidative stress during oncogenesis
    Hyun Jung Park
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    EMBO J 28:2908-18. 2009
    ..Together, our results identify FoxM1 as a key regulator of ROS in dividing cells, and provide insights into the mechanism how tumour cells use FoxM1 to control oxidative stress to escape premature senescence and apoptosis...
  22. ncbi Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc
    Abhishek Datta
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
    J Biol Chem 279:36698-707. 2004
    ..Our results strongly suggest that cMyc is a bona fide target of ARF and that ARF attenuates c-Myc independently of the ARF-p53 axis...
  23. pmc The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice
    Mei Ling Chen
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 20:1569-74. 2006
    ..Even haplodeficiency of Akt1 was sufficient to markedly attenuate the development of high-grade prostate intraepithelial neoplasia (PIN) and endometrial carcinoma. These results have significant implications for cancer therapy...
  24. pmc ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β
    Kelly A O'Brien
    Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Arterioscler Thromb Vasc Biol 32:2232-40. 2012
    ..We sought to determine the role of the Akt family of serine/threonine kinases and activation mechanisms of the PI3K/Akt pathway in outside-in signaling...
  25. pmc Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci
    Ivana Tonic
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    J Biol Chem 285:23790-8. 2010
    ..We show that Akt inhibits BRCA1 function that induces G2 cell cycle arrest. Akt prevents the translocation of BRCA1 to DNA damage foci and, thereby, inhibiting the activation of Chk1 following DNA damage...
  26. ncbi Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses
    Jessica K Altman
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Lakeside Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 283:1992-2001. 2008
    ....
  27. pmc Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
    Veronique Nogueira
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Cancer Cell 14:458-70. 2008
    ..Given that rapamycin alone is mainly cytostatic, this constitutes a strategy for cancer therapy that selectively eradicates cancer cells via Akt activation...
  28. pmc MADD is a downstream target of PTEN in triggering apoptosis
    Shankar Jayarama
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, 60612
    J Cell Biochem 115:261-70. 2014
    ..Taken together, our data reveal that PTEN can convey the death signal by preventing MADD phosphorylation by Akt...
  29. pmc Combination of oxidative stress and FOXM1 inhibitors induces apoptosis in cancer cells and inhibits xenograft tumor growth
    Marianna Halasi
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Pathol 183:257-65. 2013
    ..We conclude that the combination of ROS inducers and FOXM1 inhibitors could be used as a therapeutic strategy to selectively eliminate cancer cells...
  30. ncbi The two TORCs and Akt
    Prashanth T Bhaskar
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine, 900 South Ashland Avenue, Chicago, IL 60607, USA
    Dev Cell 12:487-502. 2007
    ..This review highlights recent developments aimed at deciphering the interplay between Akt and mTORCs as well as their role in embryonic development and in cancer...
  31. ncbi Immunohistochemical expression of components of the Akt-mTORC1 pathway is associated with hepatocellular carcinoma in patients with chronic liver disease
    Scott J Cotler
    Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA
    Dig Dis Sci 53:844-9. 2008
    ..Activation of the Akt-mTORC1 signaling pathway was evaluated in premalignant and hepatocellular carcinoma (HCC) lesions by assessing the expression of pS6, an Akt effector, and PTEN, an Akt suppressor...
  32. pmc An important role for Akt3 in platelet activation and thrombosis
    Kelly A O'Brien
    Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA
    Blood 118:4215-23. 2011
    ..Importantly, Akt3(-/-) mice showed retardation in FeCl₃-induced carotid artery thrombosis in vivo. Thus, Akt3 plays an important and distinct role in platelet activation and in thrombosis...
  33. ncbi Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons
    Fatima Lekmine
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 278:27772-80. 2003
    ..Altogether, our data establish that the Type I IFN receptor-activated PI 3'-kinase pathway mediates activation of the p70 S6 kinase and inactivation of 4E-BP1, to regulate mRNA translation and induction of Type I IFN responses...
  34. doi ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors
    Marianna Halasi
    Department of Medicine, University of Illinois at Chicago, 60612, USA
    Biochem J 454:201-8. 2013
    ....
  35. doi Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma
    Jennifer Woodard
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, Illinois, USA
    Clin Cancer Res 14:4640-9. 2008
    ....
  36. ncbi Mitochondrial hexokinases: guardians of the mitochondria
    R Brooks Robey
    Department of Medicine, University of Illinois at Chicago, 60607 7170, USA
    Cell Cycle 4:654-8. 2005
    ..We also propose that this "guardian" function of mtHK may be specifically exploited for therapeutic purposes...
  37. pmc Deregulation of FoxM1b leads to tumour metastasis
    Hyun Jung Park
    Department of Biochemistry and Molecular Genetics, UIC Cancer Center, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    EMBO Mol Med 3:21-34. 2011
    ..The observations indicate that FoxM1b is a potent activator of tumour metastasis and that the Arf-mediated inhibition of FoxM1b is a critical mechanism for suppression of tumour metastasis...
  38. ncbi c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1
    Joslyn K Brunelle
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611 3010, USA
    J Biol Chem 279:4305-12. 2004
    ..Thus, oxygen deprivation-induced cell death in fibroblasts with deregulated expression of c-Myc is independent of p53 or HIF-1 status, but is dependent on the Bcl-2 family member Bax or Bak to initiate mitochondrial dependent cell death...
  39. pmc Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy
    Veronique Nogueira
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607
    Clin Cancer Res 19:4309-14. 2013
    ....
  40. pmc Akt isoforms differentially regulate neutrophil functions
    Jia Chen
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Blood 115:4237-46. 2010
    ..These results demonstrate a predominant role of Akt2 in regulating neutrophil functions and provide evidence for differential activation of the 2 Akt isoforms in neutrophils...
  41. ncbi The Akt-mTOR tango and its relevance to cancer
    Nissim Hay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine, 60607, USA
    Cancer Cell 8:179-83. 2005
    ..Two recent studies used mouse genetics to assess the roles of PTEN and TSC2 in cancer, underscoring the importance of Akt-mTOR interplay for cancer progression and therapy...
  42. pmc AMPK as a therapeutic target in renal cell carcinoma
    Jennifer Woodard
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Jesse Brown VA Medical Center, Chicago, IL, USA
    Cancer Biol Ther 10:1168-77. 2010
    ..Altogether, our studies demonstrate that AMPK plays critical regulatory roles in the regulation of growth of RCC cells and raise the prospect of future use of AMPK activators in the treatment of renal cell carcinoma in humans...
  43. pmc The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts
    Viktor Todorovic
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine, Chicago, IL 60607, USA
    J Cell Biol 171:559-68. 2005
    ....
  44. pmc Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer
    Krushna C Patra
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA
    Cancer Cell 24:213-28. 2013
    ..Hk2 deletion in lung cancer cells suppressed glucose-derived ribonucleotides and impaired glutamine-derived carbon utilization in anaplerosis...
  45. pmc The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin
    Benjamin N Gantner
    Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Immunol 189:3104-11. 2012
    ..Taken together, these results demonstrate that the Akt1 isoform is required for β-catenin-mediated promotion of IFN-β transcription downstream of TLR3 activation...
  46. ncbi A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation
    Aleksandra Stojanovic
    Department of Pharmacology, University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA
    J Biol Chem 281:16333-9. 2006
    ..Thus, this study delineates a novel platelet activation pathway involving sequential activation of PI3K, Akt, nitric-oxide synthase 3, sGC, and cGMP-dependent protein kinase...
  47. pmc Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4
    Peifeng Li
    Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 285:22713-22. 2010
    ..Because Akt is active in most cancer cells and phosphorylated MADD confers resistance to TRAIL-induced apoptosis, co-targeting Akt-MADD axis is likely to increase efficacy of TRAIL-based therapies...
  48. pmc Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
    Xiao ding Peng
    Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 17:1352-65. 2003
    ....
  49. pmc Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage
    Eugene S Kandel
    Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Mol Cell Biol 22:7831-41. 2002
    ..We suggest that this new activity of Akt in conjunction with its antiapoptotic activity may contribute to genetic instability and could explain its frequent activation in human cancers...
  50. ncbi Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death
    Jane M Bryson
    Department of Medicine, College of Medicine, University of Illinois, Chicago 60612, USA
    J Biol Chem 277:11392-400. 2002
    ..These findings also support the contention that HKs contribute to the protective effects of growth factors...
  51. pmc Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death
    David S McClintock
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60601 3010, USA
    Mol Cell Biol 22:94-104. 2002
    ..Proapoptotic Bcl-2 family members and a functional electron transport chain are required to initiate cell death in response to oxygen deprivation...
  52. ncbi Inhibition of Chk1 by activated PKB/Akt
    Frank W King
    Cancer Research Institute, University of California San Francisco, 94115, USA
    Cell Cycle 3:634-7. 2004
    ..Inhibition of these steps provides a plausible explanation for the observed attenuation of Chk1 activation by activated PKB after DNA damage...
  53. ncbi A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells
    Yan M Li
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 65:3257-63. 2005
    ....
  54. pmc The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation
    Hong Yin
    Department of Pharmacology, University of Illinois at Chicago 60612, USA
    Blood 111:658-65. 2008
    ..Thus, Akt1 and Akt2 mediate GPIb-IX signaling via the cGMP-dependent signaling pathway...
  55. pmc Akt1 governs breast cancer progression in vivo
    Xiaoming Ju
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 104:7438-43. 2007
    ..Akt1 governs MEC polarity, migratory directionality and breast cancer onset induced by ErbB2 in vivo...
  56. ncbi Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis
    Francesca Zazzeroni
    Gwen Knapp Center for Lupus and Immunoolgy Research, Ben May Institute, and Committee on Immunology, University of Chicago, IL 60637, USA
    Blood 102:3270-9. 2003
    ..These findings identify Gadd45 beta as a critical mediator of the prosurvival response to CD40 stimulation and provide important new insights into the apoptotic mechanism that is triggered by Fas in B cells...
  57. pmc Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice
    Juhua Chen
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Foundation, NB50, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Blood 104:1703-10. 2004
    ..As a consequence of impaired alpha(IIb)beta(3) activation and platelet aggregation, Akt-1 null mice showed significantly longer bleeding times than wild-type mice...

Research Grants29

  1. The role of Akt in cell survival and cell growth
    Nissim Hay; Fiscal Year: 2006
    ..We will use the Akt KO mice and cells derived from these mice to provide genetic evidence for the role of Akt in these processes. ..
  2. P13K/PTEN/Akt signaling and the genesis of cancer
    Nissim Hay; Fiscal Year: 2006
    ..The second part of this grant application will address these issues at the organism level and assess the susceptibility of various Akt knockout (KO) mice to the development of various neoplasia. ..
  3. Akt, cellular senescence, and lifespan
    Nissim Hay; Fiscal Year: 2007
    ....
  4. P13K/PTEN/Akt signaling and the genesis of cancer
    Nissim Hay; Fiscal Year: 2007
    ..The second part of this grant application will address these issues at the organism level and assess the susceptibility of various Akt knockout (KO) mice to the development of various neoplasia. ..
  5. The role of Akt in cell survival and cell growth
    Nissim Hay; Fiscal Year: 2007
    ..We will use the Akt KO mice and cells derived from these mice to provide genetic evidence for the role of Akt in these processes. ..
  6. Akt, cellular senescence, and lifespan
    Nissim Hay; Fiscal Year: 2009
    ..abstract_text> ..
  7. The role of Akt in cell survival and cell growth
    Nissim Hay; Fiscal Year: 2009
    ..Studies are also intended to delineate the role of this pathway in the development of hepatocellular carcinoma. ..
  8. P13K/PTEN/Akt signaling and the genesis of cancer
    Nissim Hay; Fiscal Year: 2009
    ..The second part of this grant application will address these issues at the organism level and assess the susceptibility of various Akt knockout (KO) mice to the development of various neoplasia. ..
  9. The role of Akt in cell survival and cell growth
    Nissim Hay; Fiscal Year: 2010
    ..Studies are also intended to delineate the role of this pathway in the development of hepatocellular carcinoma. ..
  10. Akt, cellular senescence, and lifespan
    Nissim Hay; Fiscal Year: 2010
    ..abstract_text> ..
  11. Akt, cellular senescence, and lifespan
    Nissim Hay; Fiscal Year: 2006
    ....
  12. The role of Akt in cell survival and cell growth
    Nissim Hay; Fiscal Year: 2005
    ..We will use the Akt KO mice and cells derived from these mice to provide genetic evidence for the role of Akt in these processes. ..
  13. P13K/PTEN/Akt (PKB), Signaling and genesis of cancer
    Nissim Hay; Fiscal Year: 2005
    ....
  14. MECHANISM OF SERINE/THREONINE KINASE SURVIVAL PROMOTION
    Nissim Hay; Fiscal Year: 1999
    ..cascade at the level of Bcl-2 family members, integrity of mitochondria, caspase activity or Ced-4/Apaf-1? (3) Does Akt promote survival by increasing cell-cell adhesion and/or intracellular levels of b-catenin via inhibition of GSK3? ..
  15. MECHANISM OF SERINE/THREONINE KINASE SURVIVAL PROMOTION
    Nissim Hay; Fiscal Year: 1999
    ..cascade at the level of Bcl-2 family members, integrity of mitochondria, caspase activity or Ced-4/Apaf-1? (3) Does Akt promote survival by increasing cell-cell adhesion and/or intracellular levels of b-catenin via inhibition of GSK3? ..
  16. MECHANISM OF SERINE/THREONINE KINASE SURVIVAL PROMOTION
    Nissim Hay; Fiscal Year: 2000
    ..cascade at the level of Bcl-2 family members, integrity of mitochondria, caspase activity or Ced-4/Apaf-1? (3) Does Akt promote survival by increasing cell-cell adhesion and/or intracellular levels of b-catenin via inhibition of GSK3? ..
  17. P13K/PTEN/Akt (PKB), Signaling and genesis of cancer
    Nissim Hay; Fiscal Year: 2001
    ....
  18. MECHANISM OF SERINE/THREONINE KINASE SURVIVAL PROMOTION
    Nissim Hay; Fiscal Year: 2000
    ..cascade at the level of Bcl-2 family members, integrity of mitochondria, caspase activity or Ced-4/Apaf-1? (3) Does Akt promote survival by increasing cell-cell adhesion and/or intracellular levels of b-catenin via inhibition of GSK3? ..
  19. MECHANISM OF SERINE/THREONINE KINASE SURVIVAL PROMOTION
    Nissim Hay; Fiscal Year: 2001
    ..cascade at the level of Bcl-2 family members, integrity of mitochondria, caspase activity or Ced-4/Apaf-1? (3) Does Akt promote survival by increasing cell-cell adhesion and/or intracellular levels of b-catenin via inhibition of GSK3? ..
  20. P13K/PTEN/Akt (PKB), Signaling and genesis of cancer
    Nissim Hay; Fiscal Year: 2002
    ....
  21. MECHANISM OF SERINE/THREONINE KINASE SURVIVAL PROMOTION
    Nissim Hay; Fiscal Year: 2002
    ..cascade at the level of Bcl-2 family members, integrity of mitochondria, caspase activity or Ced-4/Apaf-1? (3) Does Akt promote survival by increasing cell-cell adhesion and/or intracellular levels of b-catenin via inhibition of GSK3? ..
  22. Akt in cell survival and cell growth
    Nissim Hay; Fiscal Year: 2003
    ..We will use the Akt KO mice and cells derived from these mice to provide genetic evidence for the role of Akt in these processes. ..
  23. P13K/PTEN/Akt (PKB), Signaling and genesis of cancer
    Nissim Hay; Fiscal Year: 2003
    ....
  24. P13K/PTEN/Akt (PKB), Signaling and genesis of cancer
    Nissim Hay; Fiscal Year: 2004
    ....
  25. The role of Akt in cell survival and cell growth
    Nissim Hay; Fiscal Year: 2004
    ..We will use the Akt KO mice and cells derived from these mice to provide genetic evidence for the role of Akt in these processes. ..
  26. P13K/PTEN/Akt signaling and the genesis of cancer
    Nissim Hay; Fiscal Year: 2010
    ..The second part of this grant application will address these issues at the organism level and assess the susceptibility of various Akt knockout (KO) mice to the development of various neoplasia. ..