Affiliation: University of Washington
Hawn T, Berrington W, Smith I, Uematsu S, Akira S, Aderem A, et al
. Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila. J Immunol. 2007;179:6981-7 pubmed
..Thus, TLR5 mediates recognition of Lp in AMs and performs a distinct role during the in vivo pulmonary immune response through regulation of early PMN recruitment and subsequent later development of pneumonia. ..
Hawn T, Verbon A, Janer M, Zhao L, Beutler B, Aderem A. Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. Proc Natl Acad Sci U S A. 2005;102:2487-9 pubmed
..This protective association illustrates that an innate immune receptor can mediate either beneficial or deleterious inflammatory responses and that these outcomes vary with different pathogens. ..
Hawn T, Day T, Scriba T, Hatherill M, Hanekom W, Evans T, et al
. Tuberculosis vaccines and prevention of infection. Microbiol Mol Biol Rev. 2014;78:650-71 pubmed publisher
..Together, these points support expanding the focus of TB vaccine development efforts to include prevention of infection as a primary goal along with vaccines or other interventions that reduce the rate of transmission and reactivation. ..
Hawn T, Verbon A, Lettinga K, Zhao L, Li S, Laws R, et al
. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med. 2003;198:1563-72 pubmed
..Together, these observations suggest that TLR5392STOP increases human susceptibility to infection through an unusual dominant mechanism that compromises TLR5's essential role as a regulator of the lung epithelial innate immune response. ..
Hawn T, Wu H, Grossman J, Hahn B, Tsao B, Aderem A. A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2005;102:10593-7 pubmed
..These data support a role for flagellated bacteria and the innate immune response in the development of SLE with implications for novel immunomodulatory treatment strategies. ..
Hawn T, Misch E, Dunstan S, Thwaites G, Lan N, Quy H, et al
. A common human TLR1 polymorphism regulates the innate immune response to lipopeptides. Eur J Immunol. 2007;37:2280-9 pubmed
Hawn T, Scholes D, Li S, Wang H, Yang Y, Roberts P, et al
. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. PLoS ONE. 2009;4:e5990 pubmed publisher
..Although these data suggest that TLR polymorphisms are associated with adult susceptibility to UTIs, the statistical significance was modest and will require further study including validation with independent cohorts. ..
Hawn T, Scholes D, Wang H, Li S, Stapleton A, Janer M, et al
. Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women. PLoS ONE. 2009;4:e8300 pubmed publisher
..We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria...