LEIF HAVTON

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Re-established micturition reflexes show differential activation patterns after lumbosacral ventral root avulsion injury and repair in rats
    Hui Yi Chang
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Exp Neurol 212:291-7. 2008
  2. ncbi request reprint Partial peripheral motor nerve lesions induce changes in the conduction properties of remaining intact motoneurons
    L A Havton
    Department of Neurology, University of California, Los Angeles, and Reed Neurological Research Center, 710 Westwood Plaza, Los Angeles, California 90095 1769, USA
    Muscle Nerve 24:662-6. 2001
  3. ncbi request reprint Transformation of synaptic vesicle phenotype in the intramedullary axonal arbors of cat spinal motoneurons following peripheral nerve injury
    L A Havton
    Department of Neurology and Brain Research Institute, University of California, Los Angeles, Reed Neurological Research Center, 90095 1769, USA
    Exp Brain Res 139:297-302. 2001
  4. ncbi request reprint Neurofilamentous hypertrophy of intramedullary axonal arbors in intact spinal motoneurons undergoing peripheral sprouting
    L A Havton
    Department of Neurology and Brain Research Institute, Neurologic Rehabilitation and Neural Repair Programs, University of California, Los Angeles, CA 90095 1769, USA
    J Neurocytol 30:917-26. 2001
  5. doi request reprint Repair and rehabilitation of plexus and root avulsions in animal models and patients
    Leif A Havton
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Curr Opin Neurol 22:570-4. 2009
  6. ncbi request reprint Plasticity of lumbosacral monosynaptic reflexes after a ventral root transection injury in the adult cat
    Leif A Havton
    Department of Neurology and Brain Research Institute, University of California, Los Angeles, Reed Neurological Research Center, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Exp Brain Res 155:111-4. 2004
  7. ncbi request reprint Correlation of median forearm conduction velocity with carpal tunnel syndrome severity
    Leif A Havton
    Department of Neurology and Brain Research Institute, David Geffen School of Medicine at UCLA, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Clin Neurophysiol 118:781-5. 2007
  8. ncbi request reprint Systemic administration of cholera toxin B subunit conjugated to horseradish peroxidase in the adult rat labels preganglionic autonomic neurons, motoneurons, and select primary afferents for light and electron microscopic studies
    Leif A Havton
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
    J Neurosci Methods 149:101-9. 2005
  9. ncbi request reprint Basic advances and new avenues in therapy of spinal cord injury
    Bruce H Dobkin
    Neurologic Rehabilitation and Neural Repair Research Programs, Department of Neurology, Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, California 90095 1769, USA
    Annu Rev Med 55:255-82. 2004
  10. pmc Motor axonal regeneration after partial and complete spinal cord transection
    Paul Lu
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 32:8208-18. 2012

Collaborators

Detail Information

Publications28

  1. doi request reprint Re-established micturition reflexes show differential activation patterns after lumbosacral ventral root avulsion injury and repair in rats
    Hui Yi Chang
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Exp Neurol 212:291-7. 2008
    ..Our future studies will aim to increase successful axonal regeneration in attempts to augment the recovery of the LUT after cauda equina injury and repair...
  2. ncbi request reprint Partial peripheral motor nerve lesions induce changes in the conduction properties of remaining intact motoneurons
    L A Havton
    Department of Neurology, University of California, Los Angeles, and Reed Neurological Research Center, 710 Westwood Plaza, Los Angeles, California 90095 1769, USA
    Muscle Nerve 24:662-6. 2001
    ..Partial injury to motor nerves thus induces reactive electrophysiologic changes in the remaining intact motoneurons and their axons, perhaps associated with compensatory sprouting within partially denervated muscle...
  3. ncbi request reprint Transformation of synaptic vesicle phenotype in the intramedullary axonal arbors of cat spinal motoneurons following peripheral nerve injury
    L A Havton
    Department of Neurology and Brain Research Institute, University of California, Los Angeles, Reed Neurological Research Center, 90095 1769, USA
    Exp Brain Res 139:297-302. 2001
    ..This may, in turn, be responsible for the strengthening and recovery of the recurrent inhibitory reflex action exerted by the axotomized spinal motoneurons following a prolonged permanent motor nerve injury...
  4. ncbi request reprint Neurofilamentous hypertrophy of intramedullary axonal arbors in intact spinal motoneurons undergoing peripheral sprouting
    L A Havton
    Department of Neurology and Brain Research Institute, Neurologic Rehabilitation and Neural Repair Programs, University of California, Los Angeles, CA 90095 1769, USA
    J Neurocytol 30:917-26. 2001
    ..We conclude that, neurofilamentous hypertrophy of the intramedullary arbors of motor axons may also be part of a reactive and non-degenerative response in intact motoneurons undergoing compensatory peripheral sprouting...
  5. doi request reprint Repair and rehabilitation of plexus and root avulsions in animal models and patients
    Leif A Havton
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Curr Opin Neurol 22:570-4. 2009
    ....
  6. ncbi request reprint Plasticity of lumbosacral monosynaptic reflexes after a ventral root transection injury in the adult cat
    Leif A Havton
    Department of Neurology and Brain Research Institute, University of California, Los Angeles, Reed Neurological Research Center, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Exp Brain Res 155:111-4. 2004
    ..The reflexes had almost doubled in size at 6 and 12 weeks postoperatively. Possible mechanisms and factors contributing to the reflex enhancement are discussed...
  7. ncbi request reprint Correlation of median forearm conduction velocity with carpal tunnel syndrome severity
    Leif A Havton
    Department of Neurology and Brain Research Institute, David Geffen School of Medicine at UCLA, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Clin Neurophysiol 118:781-5. 2007
    ..Here, it was asked if there is a correlation between markers of CTS severity and median forearm MNCV, and if there is an explanation for the preceding conflicting results...
  8. ncbi request reprint Systemic administration of cholera toxin B subunit conjugated to horseradish peroxidase in the adult rat labels preganglionic autonomic neurons, motoneurons, and select primary afferents for light and electron microscopic studies
    Leif A Havton
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
    J Neurosci Methods 149:101-9. 2005
    ..We demonstrate also that this method can be combined with post-embedding immunogold labeling to detect amino acid transmitters in synaptic boutons...
  9. ncbi request reprint Basic advances and new avenues in therapy of spinal cord injury
    Bruce H Dobkin
    Neurologic Rehabilitation and Neural Repair Research Programs, Department of Neurology, Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, California 90095 1769, USA
    Annu Rev Med 55:255-82. 2004
    ..These bench-to-bedside studies are defining the neurobiology of spinal cord injury rehabilitation...
  10. pmc Motor axonal regeneration after partial and complete spinal cord transection
    Paul Lu
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 32:8208-18. 2012
    ..These findings highlight the complexity of spinal cord repair and the need for additional control and shaping of axonal regeneration...
  11. ncbi request reprint A single re-implanted ventral root exerts neurotropic effects over multiple spinal cord segments in the adult rat
    Thao X Hoang
    Department of Neurology and Brain Research Institute, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Exp Brain Res 169:208-17. 2006
    ....
  12. ncbi request reprint Novel repair strategies to restore bladder function following cauda equina/conus medullaris injuries
    Thao X Hoang
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Prog Brain Res 152:195-204. 2006
    ..A brief discussion on a variety of outcome measures that may be suitable to evaluate the function of the lower urinary tract in rodent neural repair models is also provided...
  13. pmc Local and remote growth factor effects after primate spinal cord injury
    John H Brock
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 30:9728-37. 2010
    ..Remote cortical effects of spinally administered growth factors could "prime" the neuron to respond to experimental therapies that promote axonal plasticity or regeneration...
  14. ncbi request reprint Autonomic and motor neuron death is progressive and parallel in a lumbosacral ventral root avulsion model of cauda equina injury
    Thao X Hoang
    Department of Neurology and Brain Research Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 467:477-86. 2003
    ..The findings suggest that early neuroprotection will be an important consideration in future attempts of treating acute cauda equina injuries...
  15. ncbi request reprint Ultrastructural synaptic features differ between alpha- and gamma-motoneurons innervating the tibialis anterior muscle in the rat
    Ronaldo M Ichiyama
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    J Comp Neurol 499:306-15. 2006
    ....
  16. ncbi request reprint Complement activation after lumbosacral ventral root avulsion injury
    Marcus Ohlsson
    Department of Neurology and Brain Research Institute, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Neurosci Lett 394:179-83. 2006
    ..We speculate that inhibition of MAC may constitute a potential neuroprotective strategy following cauda equina injuries...
  17. pmc Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse
    Martha S Windrem
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 2:553-65. 2008
    ..These data demonstrate that the neonatal transplantation of human glial progenitor cells can effectively treat disorders of congenital and perinatal hypomyelination...
  18. ncbi request reprint Improved detection of fluorogold-labeled neurons in long-term studies
    Mahnaz Akhavan
    Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    J Neurosci Methods 152:156-62. 2006
    ..We conclude that FG-labeling is a useful tool to determine neuronal counts in long-term studies, but should be used cautiously for neuronal size measurements...
  19. doi request reprint Regeneration of long-tract axons through sites of spinal cord injury using templated agarose scaffolds
    Thomas Gros
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Biomaterials 31:6719-29. 2010
    ..Further development must reduce reactive cellular interfaces to support effective axonal penetration of host parenchyma...
  20. pmc Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury
    Laura Taylor Alto
    Department of Neurosciences, University of California, San Diego, La Jolla, California, USA
    Nat Neurosci 12:1106-13. 2009
    ..Thus, we report for the first time, to the best of our knowledge, the reinnervation of brainstem targets after SCI and an essential role for chemotropic axon guidance in target selection...
  21. pmc Retrogradely transported fluorogold accumulates in lysosomes of neurons and is detectable ultrastructurally using post-embedding immuno-gold methods
    Stefan Persson
    Department of Neurology, David Geffen School of Medicine at UCLA, Neuroscience Research Building, 635 Charles E Young Drive South, Los Angeles, CA 90095, United States
    J Neurosci Methods 184:42-7. 2009
    ..g., neuro-transmitter studies in the electron microscope. We suggest that the described method for sensitive detection of FG in the spinal cord may also have broad applicability to other areas of the central nervous system...
  22. doi request reprint A white matter stroke model in the mouse: axonal damage, progenitor responses and MRI correlates
    Elif G Sozmen
    Department of Neurology, David Geffen School of Medicine at UCLA, Neuroscience Research Building, 635 Charles Young Drive South, Los Angeles, CA 90095, United States
    J Neurosci Methods 180:261-72. 2009
    ....
  23. pmc Extensive spinal decussation and bilateral termination of cervical corticospinal projections in rhesus monkeys
    Ephron S Rosenzweig
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Comp Neurol 513:151-63. 2009
    ..Thus, augmentation of sprouting of these extensive bilateral CST projections may provide a novel target for enhancing recovery after spinal cord injury...
  24. pmc Differential effects of urethane and isoflurane on external urethral sphincter electromyography and cystometry in rats
    Hui Yi Chang
    Department of Neurology, David Geffen School of Medicine at UCLA, 635 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Am J Physiol Renal Physiol 295:F1248-53. 2008
    ..We suggest that these anesthetic properties be taken into consideration during the experimental design and interpretation of urodynamic recordings in rodent models...
  25. ncbi request reprint Glial reactions in a rodent cauda equina injury and repair model
    Marcus Ohlsson
    Department of Neurology and Brain Research Institute, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Exp Brain Res 170:52-60. 2006
    ....
  26. ncbi request reprint Titanium mesh implantation--a method to stabilize the spine and protect the spinal cord following a multilevel laminectomy in the adult rat
    Jaime H Nieto
    Department of Neurology and Brain Research Institute, David Geffen School of Medicine at UCLA Los Angeles, 90095 1769, USA
    J Neurosci Methods 147:1-7. 2005
    ..We propose that the use of a titanium mesh implant may assist in the development of clinically relevant larger spinal cord injury and repair models...
  27. pmc Minocycline protects motor but not autonomic neurons after cauda equina injury
    Thao X Hoang
    Department of Neurology, David Geffen School of Medicine at UCLA, Neuroscience Research Building, 635 Charles E Young Drive South, Los Angeles, CA 90095 7334, USA
    Exp Brain Res 189:71-7. 2008
    ..Our findings suggest that minocycline may protect degenerating motoneurons and expand the therapeutic window of opportunity for surgical repair of proximal root lesions affecting spinal motoneurons...
  28. ncbi request reprint Bilateral corticospinal projections arise from each motor cortex in the macaque monkey: a quantitative study
    Steve Lacroix
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    J Comp Neurol 473:147-61. 2004
    ..Furthermore, bilateral CST projections from a single motor cortex could represent a potential source of plasticity after injury, as well as a target of therapeutic effort in neural regeneration strategies...

Research Grants9

  1. Repair of Bladder Function after Cauda Equina Injury
    LEIF HAVTON; Fiscal Year: 2009
    ..We believe that our proposal has translational research potential for the development of new treatments for patients with conus medullaris/cauda equina injuries. ..
  2. Innervation of Bladder Neurons After Spinal Cord Injury
    LEIF HAVTON; Fiscal Year: 2005
    ..Furthermore, this work may have important clinical implications, possibly leading to a surgical intervention for patients with cauda equina / conus medullaris injuries. ..
  3. Repair of Bladder Function after Cauda Equina Injury
    Leif A Havton; Fiscal Year: 2010
    ..We believe that our proposal has translational research potential for the development of new treatments for patients with conus medullaris/cauda equina injuries. ..
  4. Repair of Bladder Function after Cauda Equina Injury
    LEIF HAVTON; Fiscal Year: 2009
    ..We believe that our proposal has translational research potential for the development of new treatments for patients with conus medullaris/cauda equina injuries. ..
  5. Repair of Bladder Function after Cauda Equina Injury
    Leif A Havton; Fiscal Year: 2010
    ..We believe that our proposal has translational research potential for the development of new treatments for patients with conus medullaris/cauda equina injuries. ..