Peter Havel

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM rats
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA
    Diabetes 59:2653-61. 2010
  2. pmc Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans
    Chad L Cox
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
    Nutr Metab (Lond) 9:68. 2012
  3. ncbi request reprint Evidence that vasoactive intestinal polypeptide is a parasympathetic neurotransmitter in the endocrine pancreas in dogs
    P J Havel
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Regul Pept 71:163-70. 1997
  4. ncbi request reprint Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism
    Peter J Havel
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
    Nutr Rev 63:133-57. 2005
  5. ncbi request reprint Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism
    Peter J Havel
    Department of Nutrition, University of California, Davis, Davis, California 95616, USA
    Diabetes 53:S143-51. 2004
  6. pmc Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in overweight/obese men and women consuming fructose- or glucose-sweetened beverages for 10 weeks
    Chad L Cox
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    J Clin Endocrinol Metab 96:E2034-8. 2011
  7. ncbi request reprint Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin
    Peter J Havel
    Department of Nutrition, University of California, Davis, California 95616, USA
    Curr Opin Lipidol 13:51-9. 2002
  8. ncbi request reprint Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis
    P J Havel
    Department of Nutrition, University of California, Davis, California 95616, USA
    Exp Biol Med (Maywood) 226:963-77. 2001
  9. ncbi request reprint Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance
    P J Havel
    Department of Nutrition, University of California, Davis 95616, USA
    Proc Nutr Soc 59:359-71. 2000
  10. ncbi request reprint High-fat meals reduce 24-h circulating leptin concentrations in women
    P J Havel
    Department of Nutrition, University of California, Davis 95616, USA
    Diabetes 48:334-41. 1999

Detail Information

Publications55

  1. pmc Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM rats
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA
    Diabetes 59:2653-61. 2010
    ..The efficacy of liraglutide, a human glucagon-like peptide-1 (GLP-1) analog, to prevent or delay diabetes in UCD-T2DM rats, a model of polygenic obese type 2 diabetes, was investigated...
  2. pmc Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans
    Chad L Cox
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
    Nutr Metab (Lond) 9:68. 2012
    ..abstract:..
  3. ncbi request reprint Evidence that vasoactive intestinal polypeptide is a parasympathetic neurotransmitter in the endocrine pancreas in dogs
    P J Havel
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Regul Pept 71:163-70. 1997
    ..We hypothesize that VIP could mediate the glucagon response to parasympathetic activation which has been shown to resistant to cholinergic blockade with atropine in several species...
  4. ncbi request reprint Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism
    Peter J Havel
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
    Nutr Rev 63:133-57. 2005
    ..Recent publications, studies in human subjects, and areas in which additional research is needed are emphasized...
  5. ncbi request reprint Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism
    Peter J Havel
    Department of Nutrition, University of California, Davis, Davis, California 95616, USA
    Diabetes 53:S143-51. 2004
    ..The production of all three hormones is influenced by nutritional status. These hormones, the pathways controlling their production, and their receptors are promising targets for managing obesity, hyperlipidemia, and insulin resistance...
  6. pmc Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in overweight/obese men and women consuming fructose- or glucose-sweetened beverages for 10 weeks
    Chad L Cox
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    J Clin Endocrinol Metab 96:E2034-8. 2011
    ..Data describing the effects of fructose consumption on circulating levels of proinflammatory and prothrombotic markers in humans are unavailable...
  7. ncbi request reprint Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin
    Peter J Havel
    Department of Nutrition, University of California, Davis, California 95616, USA
    Curr Opin Lipidol 13:51-9. 2002
    ..These adipocyte hormones, the pathways controlling their production, and their receptors represent promising targets for managing obesity, hyperlipidemia, and insulin resistance...
  8. ncbi request reprint Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis
    P J Havel
    Department of Nutrition, University of California, Davis, California 95616, USA
    Exp Biol Med (Maywood) 226:963-77. 2001
    ....
  9. ncbi request reprint Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance
    P J Havel
    Department of Nutrition, University of California, Davis 95616, USA
    Proc Nutr Soc 59:359-71. 2000
    ..A better understanding of the precise mechanisms regulating leptin production and leptin action may lead to new approaches for managing obesity...
  10. ncbi request reprint High-fat meals reduce 24-h circulating leptin concentrations in women
    P J Havel
    Department of Nutrition, University of California, Davis 95616, USA
    Diabetes 48:334-41. 1999
    ..This result may be a consequence of decreased adipocyte glucose metabolism. Decreases of 24-h circulating leptin could contribute to the weight gain during consumption of high-fat diets...
  11. ncbi request reprint Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats
    P J Havel
    Department of Nutrition, University of California, Davis 95616, USA
    Diabetes 49:244-52. 2000
    ..These responses, in concert with increased muscle UCP-3 expression, may also contribute to the catabolic effects of uncontrolled diabetes on fuel metabolism in peripheral tissues...
  12. pmc Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616 8669, USA
    Am J Clin Nutr 87:1194-203. 2008
    ..However, pure fructose and glucose are not commonly used as sweeteners. High-fructose corn syrup (HFCS) has replaced sucrose as the predominant sweetener in beverages in the United States...
  13. pmc Effects of hypothalamic neurodegeneration on energy balance
    Allison Wanting Xu
    Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 3:e415. 2005
    ..These findings provide new insight into the roles of hypothalamic neurons in energy balance regulation, and provide a model for understanding defects in human energy balance associated with neurodegeneration and aging...
  14. pmc Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women
    Michael M Swarbrick
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Br J Nutr 100:947-52. 2008
    ....
  15. pmc Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 88:1733S-1737S. 2008
    ....
  16. pmc Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    Kimber L Stanhope
    Department of Molecular Biosciences, UCD, Davis, California 95616, USA
    J Clin Invest 119:1322-34. 2009
    ..These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults...
  17. pmc Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acid
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1343-50. 2010
    ..In conclusion, dietary fructose accelerates the onset of T2DM in UCD-T2DM rats, and LA ameliorates the effects of fructose by improving glucose homeostasis, possibly by preserving beta-cell function...
  18. pmc Satiety-related hormonal dysregulation in behavioral variant frontotemporal dementia
    Josh D Woolley
    From the Departments of Psychiatry J D W, Physiology M D, and Neuroscience M D, and Department of Neurology, Memory and Aging Center B K K, A N, A K, B L M, K P R, University of California, San Francisco Department of Psychiatry J D W, San Francisco Veterans Affairs Medical Center and Departments of Molecular Biosciences and Nutrition P H, School of Veterinary Medicine, University of California, Davis
    Neurology 82:512-20. 2014
    ..To investigate whether patients with behavioral variant frontotemporal dementia (bvFTD) have dysregulation in satiety-related hormonal signaling using a laboratory-based case-control study...
  19. pmc Fructose consumption: considerations for future research on its effects on adipose distribution, lipid metabolism, and insulin sensitivity in humans
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Nutr 139:1236S-1241S. 2009
    ....
  20. pmc Relationship between adiposity and cardiovascular risk factors in prevalent hemodialysis patients
    George A Kaysen
    Renal Research Institute, New York, New York, USA
    J Ren Nutr 19:357-64. 2009
    ..Renal failure is associated with dyslipidemia and inflammation in normal-weight patients. We hypothesized that the effects of obesity may be obscured by renal failure in HD...
  21. pmc Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1782-93. 2008
    ..Thus diabetes in the UC Davis-T2DM rat is more similar to clinical T2DM in humans than in other existing rat models and provides a useful model for future studies of the pathophysiology, treatment, and prevention of T2DM...
  22. doi request reprint Increased soluble leptin receptor levels in morbidly obese patients with insulin resistance and nonalcoholic fatty liver disease
    Valentina Medici
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of California Davis Medical Center, Sacramento, California, USA
    Obesity (Silver Spring) 18:2268-73. 2010
    ..In conclusion, increased SLR levels in morbidly obese patients with diabetes are correlated with the stage of liver fibrosis, and may reflect progressive liver disease...
  23. ncbi request reprint Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin, compared with regular/NPH insulin in female patients with type 1 diabetes
    Steven C Griffen
    Medical Center, Patient Support and Services Building Suite G 400, University of California Davis, 4150 V Street, Sacramento, CA 95817, USA
    J Clin Endocrinol Metab 91:485-91. 2006
    ..Exogenous insulin administration often poorly reproduces normal insulin patterns and may less effectively regulate leptin and ghrelin, two hormones involved in the control of appetite and adiposity...
  24. pmc Improvement in peripheral glucose uptake after gastric bypass surgery is observed only after substantial weight loss has occurred and correlates with the magnitude of weight lost
    Guilherme M Campos
    Department of Surgery, University of California San Francisco, San Francisco, CA, USA
    J Gastrointest Surg 14:15-23. 2010
    ..Altered gut and pancreatic hormone secretion may bolster resolution of insulin resistance after Roux-en-Y gastric bypass (RYGB), but the independent effects of weight loss and hormonal secretion on peripheral glucose disposal are unknown...
  25. pmc Metabolic and endocrine profiles in response to systemic infusion of fructose and glucose in rhesus macaques
    Sean H Adams
    US Department of Agriculture Agricultural Research Service Western Human Nutrition Research Center, University of California, Davis, Davis, California 95616, USA
    Endocrinology 149:3002-8. 2008
    ..e. limited post-fructose insulin excursions and/or hexose-specific differences in adipocyte metabolism) are likely to underlie disparate effects of fructose and glucose to increase circulating leptin concentrations...
  26. doi request reprint Calcium supplementation does not alter lipid oxidation or lipolysis in overweight/obese women
    Vanitha Sampath
    Western Human Nutrition Research Center, United States Department of Agriculture, Agricultural Research Service, University of California, Davis, California, USA
    Obesity (Silver Spring) 16:2400-4. 2008
    ..Calcium supplementation for 3 months increased urinary calcium excretion, decreased circulating levels of 1,25(OH)(2)-D, but had no effect on rates of lipid oxidation or lipolysis, in these overweight women...
  27. pmc Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys
    Michael M Swarbrick
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Endocrinology 150:1670-9. 2009
    ....
  28. pmc Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptors
    Jennifer M Wade
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158, USA
    Endocrinology 149:955-61. 2008
    ..These pharmacological and genetic findings provide evidence that the serotonin 2C receptor has direct effects on glucose homeostasis...
  29. ncbi request reprint Fructose consumption and moderate zinc deficiency influence growth and adipocyte metabolism in young rats prone to adult-onset obesity
    Erin L Streiff
    Department of Nutrition, University of California at Davis, One Shields Avenue, Davis, CA, USA
    Biol Trace Elem Res 118:53-64. 2007
    ..The mesenteric adipocytes from the animals in the LZF group utilized more glucose. Thus, the addition of fructose to a LZ diet reduced energy intake and growth and altered adipocyte fuel metabolism in young growing rats...
  30. pmc Ileal interposition surgery improves glucose and lipid metabolism and delays diabetes onset in the UCD-T2DM rat
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California 95616, USA
    Gastroenterology 138:2437-46, 2446.e1. 2010
    ..In this study we investigated effects of IT surgery on glucose tolerance and diabetes onset in UCD-T2DM (University of California at Davis type 2 diabetes mellitus) rats, a polygenic obese animal model of type 2 diabetes...
  31. ncbi request reprint The yellow agouti mutation alters some but not all responses to diet and exercise
    Sally Chiu
    Rowe Program in Genetics, University of California, Davis, Davis, CA 95616, USA
    Obes Res 12:1243-55. 2004
    ..Effects of ectopic expression of the agouti signaling protein were studied on responses to diet restriction and exercise in C57BL/6J (B6) mice and obese B6 mice congenic for the yellow agouti mutation [B6.Cg-Ay (Ay)]...
  32. ncbi request reprint Effects of inhibiting transcription and protein synthesis on basal and insulin-stimulated leptin gene expression and leptin secretion in cultured rat adipocytes
    Maria J Moreno-Aliaga
    Department of Nutrition, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
    Biochem Biophys Res Commun 307:907-14. 2003
    ..01) during the first 4 h of treatment and at all later time points, which indicate that de novo protein synthesis is required for insulin-mediated glucose metabolism to increase leptin secretion...
  33. pmc Metabolic syndrome in adolescents with spinal cord dysfunction
    Mindy Dopler Nelson
    University of California Department of Nutrition, Davis, California, USA
    J Spinal Cord Med 30:S127-39. 2007
    ....
  34. ncbi request reprint Longitudinal measures of circulating leptin and ghrelin concentrations are associated with the growth of young Peruvian children but are not affected by zinc supplementation
    Joanne E Arsenault
    Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, Davis, CA 95616, USA
    Am J Clin Nutr 86:1111-9. 2007
    ..Leptin, ghrelin, and insulin are hormonal regulators of energy balance and, therefore, may be related to growth during infancy. Zinc is essential for growth, and its growth effects may be mediated through these hormones...
  35. ncbi request reprint Evidence that tumor necrosis factor-alpha-induced hyperinsulinemia prevents decreases of circulating leptin during fasting in rats
    Edward A Medina
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis 95616, USA
    Metabolism 51:1104-10. 2002
    ..Elevated leptin levels may in turn contribute to the effect of TNF-alpha to decrease food intake...
  36. pmc Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Curr Opin Lipidol 19:16-24. 2008
    ..From these results and a review of the current literature, we present two potential sequences of events by which fructose consumption may contribute to metabolic syndrome...
  37. pmc Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans
    Michael M Swarbrick
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA
    Metab Syndr Relat Disord 6:87-102. 2008
    ....
  38. pmc Fructose consumption: recent results and their potential implications
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Ann N Y Acad Sci 1190:15-24. 2010
    ....
  39. pmc Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases
    Christine Beeton
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 103:17414-9. 2006
    ..Repeated dosing with Kv1.3 inhibitors in rats has not revealed systemic toxicity. Further development of Kv1.3 blockers for autoimmune disease therapy is warranted...
  40. ncbi request reprint Fructose, weight gain, and the insulin resistance syndrome
    Sharon S Elliott
    Department of Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 76:911-22. 2002
    ....
  41. ncbi request reprint Consuming fructose-sweetened beverages increases body adiposity in mice
    Hella Jürgens
    Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Obes Res 13:1146-56. 2005
    ....
  42. ncbi request reprint Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects
    May Faraj
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 88:1594-602. 2003
    ....
  43. ncbi request reprint Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1884-8. 2002
    ..Prospectively, low plasma adiponectin concentration at baseline precedes a decrease in insulin sensitivity. Our data indicate that adiponectin plays an important role in regulation of insulin sensitivity in humans...
  44. ncbi request reprint The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments
    Miriam Cnop
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System, and Harborview Medical Center, Seattle, Washington 98108, USA
    Diabetes 51:1005-15. 2002
    ....
  45. ncbi request reprint Adiponectin is present in cord blood but is unrelated to birth weight
    Robert S Lindsay
    MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Diabetes Care 26:2244-9. 2003
    ..We assessed whether adiponectin was 1) present in the fetal circulation, 2) altered in the fetal circulation in the presence of maternal diabetes, and 3) had relations to fetal cord blood insulin or adiposity...
  46. ncbi request reprint Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women
    Karen L Teff
    Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA
    J Clin Endocrinol Metab 89:2963-72. 2004
    ....
  47. pmc 48-h glucose infusion in humans: effect on hormonal responses, hunger and food intake
    Karen L Teff
    Monell Chemical Senses Center, Philadelphia, PA 19104, United States
    Physiol Behav 90:733-43. 2007
    ..These data are the first to demonstrate a relationship between leptin and hunger in normal weight, non-calorically restricted human subjects...
  48. ncbi request reprint Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolism
    Patricia Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Am J Physiol Regul Integr Comp Physiol 288:R1682-8. 2005
    ..84, P < 0.01). Together, the results suggest that EPA, like insulin, stimulates leptin production by increasing the nonanaerobic/oxidative metabolism of glucose...
  49. ncbi request reprint Circulating leptin and cortisol after burn injury: loss of diurnal pattern
    Kristina G Hobson
    Department of Surgery, Shriners Hospitals for Children of Northern California, 2426 Stockton Boulevard, Sacramento, CA 95817, USA
    J Burn Care Rehabil 25:491-9. 2004
    ..Because low leptin levels should induce appetite, burn-related anorexia is probably controlled by other regulatory systems...
  50. ncbi request reprint Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: evidence for a skeletal muscle-to-fat signaling pathway
    LeBris S Quinn
    Geriatric Research, Education, and Clinical Center, 151 American Lake Division, VA Puget Sound Health Care System, Tacoma, WA 98493, USA
    Cell Biol Int 29:449-57. 2005
    ..These findings provide support for the hypothesis that IL-15 functions in a muscle-to-fat endocrine axis which modulates fat:lean body composition and insulin sensitivity...
  51. ncbi request reprint The decrease in C-reactive protein concentration after diet and physical activity induced weight reduction is associated with changes in plasma lipids, but not interleukin-6 or adiponectin
    Alena Dvoráková-Lorenzová
    Laboratory for Atherosclerosis Research, Centre for Experimental Cardiovascular Research, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic
    Metabolism 55:359-65. 2006
    ....
  52. pmc Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women
    Mario Kratz
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 87:347-53. 2008
    ..Recent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents...
  53. ncbi request reprint Adiponectin levels are associated with coronary artery disease across Caucasian and African-American ethnicity
    Guijing Lu
    Department of Medicine, University of California Davis, USA, and Department of Medicine, Xiangya Hospital of Xiangya Medical School, Central South University, Changsha, P R China
    Transl Res 149:317-23. 2007
    ..05). The results indicate that, across gender and ethnicity, low adiponectin levels may be an independent risk factor for CAD...
  54. ncbi request reprint Metabolic syndrome in Yup'ik Eskimos: the Center for Alaska Native Health Research (CANHR) Study
    Bert B Boyer
    University of Alaska Fairbanks, Institute of Arctic Biology, Center for Alaska Native Health Research, 311 Irving I Building, Fairbanks, AK 99775 7000, USA
    Obesity (Silver Spring) 15:2535-40. 2007
    ..This study investigated the prevalence of metabolic syndrome and its defining components among Yup'ik Eskimos...
  55. ncbi request reprint Differential impairment of glucagon responses to hypoglycemia, neuroglycopenia, arginine, and carbachol in alloxan-diabetic mice
    Bo Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Metabolism 51:12-9. 2002
    ....

Research Grants19

  1. DIETARY FRUCTOSE: HORMONES & TG/LIPOPROTEIN METABOLISM
    Peter Havel; Fiscal Year: 2007
    ..The results are pertinent to the dietary control of cardiovascular disease, obesity, and other components of the metabolic syndrome. ..
  2. Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resis
    Peter J Havel; Fiscal Year: 2010
    ....
  3. Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resis
    Peter Havel; Fiscal Year: 2008
    ....
  4. Prevention of Diabetes with Nutritional Supplements
    Peter Havel; Fiscal Year: 2007
    ..Further studies to investigate the mechanism(s) of action of the supplements or the supplement combinations that are effective in preventing/delaying diabetes onset of diabetes in this model are proposed. [unreadable] [unreadable]..
  5. DIETARY FRUCTOSE: HORMONES & TG/LIPOPROTEIN METABOLISM
    Peter Havel; Fiscal Year: 2006
    ..The results are pertinent to the dietary control of cardiovascular disease, obesity, and other components of the metabolic syndrome. ..
  6. DIETARY FRUCTOSE: HORMONES & TG/LIPOPROTEIN METABOLISM
    Peter Havel; Fiscal Year: 2004
    ..The results are pertinent to the dietary control of cardiovascular disease, obesity, and other components of the metabolic syndrome. ..
  7. Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resis
    Peter Havel; Fiscal Year: 2009
    ....
  8. ANS HYPOGLYCEMIA INDUCED GLUCAGON SECRETION IN DIABETES
    Peter Havel; Fiscal Year: 1999
    ..Collectively, these experiments will lead to greater understanding of the pathophysiology and treatment of impaired hypoglycemic counterregulation in diabetes and the greater use of animal models for this area of investigation. ..
  9. Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resis
    Peter Havel; Fiscal Year: 2009
    ....
  10. DIETARY FRUCTOSE: HORMONES & TG/LIPOPROTEIN METABOLISM
    Peter Havel; Fiscal Year: 2008
    ..The results are pertinent to the dietary control of cardiovascular disease, obesity, and other components of the metabolic syndrome. ..
  11. Effects of fish oil and alpha lipoic on the progression of insulin resistance
    Peter Havel; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. Effects of Chromium on Progression of Insulin Resistance
    Peter Havel; Fiscal Year: 2006
    ..The results of these studies will provide valuable information for the design and implementation of new clinical studies examining the effects of chromium supplements in the management of metabolic syndrome in humans. ..
  13. ANS HYPOGLYCEMIA INDUCED GLUCAGON SECRETION IN DIABETES
    Peter Havel; Fiscal Year: 2000
    ..Collectively, these experiments will lead to greater understanding of the pathophysiology and treatment of impaired hypoglycemic counterregulation in diabetes and the greater use of animal models for this area of investigation. ..
  14. DIETARY FRUCTOSE: HORMONES & TG/LIPOPROTEIN METABOLISM
    Peter Havel; Fiscal Year: 2005
    ..The results are pertinent to the dietary control of cardiovascular disease, obesity, and other components of the metabolic syndrome. ..
  15. ANS HYPOGLYCEMIA INDUCED GLUCAGON SECRETION IN DIABETES
    Peter Havel; Fiscal Year: 2001
    ..Collectively, these experiments will lead to greater understanding of the pathophysiology and treatment of impaired hypoglycemic counterregulation in diabetes and the greater use of animal models for this area of investigation. ..
  16. Fructose vs Glucose: Leptin, Appetite and Food Intake
    Peter Havel; Fiscal Year: 2002
    ....