Research Topics
Species | Peter HavelSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humansChad L Cox
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
Nutr Metab (Lond) 9:68. 2012..abstract:..
Evidence that vasoactive intestinal polypeptide is a parasympathetic neurotransmitter in the endocrine pancreas in dogsP J Havel
Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis 95616, USA
Regul Pept 71:163-70. 1997..We hypothesize that VIP could mediate the glucagon response to parasympathetic activation which has been shown to resistant to cholinergic blockade with atropine in several species...- Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolismPeter J Havel
Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
Nutr Rev 63:133-57. 2005..Recent publications, studies in human subjects, and areas in which additional research is needed are emphasized... - Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in overweight/obese men and women consuming fructose- or glucose-sweetened beverages for 10 weeksChad L Cox
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
J Clin Endocrinol Metab 96:E2034-8. 2011..Data describing the effects of fructose consumption on circulating levels of proinflammatory and prothrombotic markers in humans are unavailable... - Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectinPeter J Havel
Department of Nutrition, University of California, Davis, California 95616, USA
Curr Opin Lipidol 13:51-9. 2002..These adipocyte hormones, the pathways controlling their production, and their receptors represent promising targets for managing obesity, hyperlipidemia, and insulin resistance... - Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolismPeter J Havel
Department of Nutrition, University of California, Davis, Davis, California 95616, USA
Diabetes 53:S143-51. 2004..The production of all three hormones is influenced by nutritional status. These hormones, the pathways controlling their production, and their receptors are promising targets for managing obesity, hyperlipidemia, and insulin resistance... - Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasisP J Havel
Department of Nutrition, University of California, Davis, California 95616, USA
Exp Biol Med (Maywood) 226:963-77. 2001.... - Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balanceP J Havel
Department of Nutrition, University of California, Davis 95616, USA
Proc Nutr Soc 59:359-71. 2000..A better understanding of the precise mechanisms regulating leptin production and leptin action may lead to new approaches for managing obesity... - High-fat meals reduce 24-h circulating leptin concentrations in womenP J Havel
Department of Nutrition, University of California, Davis 95616, USA
Diabetes 48:334-41. 1999..This result may be a consequence of decreased adipocyte glucose metabolism. Decreases of 24-h circulating leptin could contribute to the weight gain during consumption of high-fat diets... - Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in ratsP J Havel
Department of Nutrition, University of California, Davis 95616, USA
Diabetes 49:244-52. 2000..These responses, in concert with increased muscle UCP-3 expression, may also contribute to the catabolic effects of uncontrolled diabetes on fuel metabolism in peripheral tissues... - Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with mealsKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616 8669, USA
Am J Clin Nutr 87:1194-203. 2008..However, pure fructose and glucose are not commonly used as sweeteners. High-fructose corn syrup (HFCS) has replaced sucrose as the predominant sweetener in beverages in the United States... - Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese womenMichael M Swarbrick
Department of Nutrition, University of California, Davis, CA 95616, USA
Br J Nutr 100:947-52. 2008.... - Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acidBethany P Cummings
Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, One Shields Ave, Davis, CA 95616, USA
Am J Physiol Regul Integr Comp Physiol 298:R1343-50. 2010..In conclusion, dietary fructose accelerates the onset of T2DM in UCD-T2DM rats, and LA ameliorates the effects of fructose by improving glucose homeostasis, possibly by preserving beta-cell function... - Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humansKimber L Stanhope
Department of Molecular Biosciences, UCD, Davis, California 95616, USA
J Clin Invest 119:1322-34. 2009..These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults... - Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrupKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Clin Nutr 88:1733S-1737S. 2008.... - Fructose consumption: considerations for future research on its effects on adipose distribution, lipid metabolism, and insulin sensitivity in humansKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Nutr 139:1236S-1241S. 2009.... - Relationship between adiposity and cardiovascular risk factors in prevalent hemodialysis patientsGeorge A Kaysen
Renal Research Institute, New York, New York, USA
J Ren Nutr 19:357-64. 2009..Renal failure is associated with dyslipidemia and inflammation in normal-weight patients. We hypothesized that the effects of obesity may be obscured by renal failure in HD... - Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin, compared with regular/NPH insulin in female patients with type 1 diabetesSteven C Griffen
Medical Center, Patient Support and Services Building Suite G 400, University of California Davis, 4150 V Street, Sacramento, CA 95817, USA
J Clin Endocrinol Metab 91:485-91. 2006..Exogenous insulin administration often poorly reproduces normal insulin patterns and may less effectively regulate leptin and ghrelin, two hormones involved in the control of appetite and adiposity... - Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM ratBethany P Cummings
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
Am J Physiol Regul Integr Comp Physiol 295:R1782-93. 2008..Thus diabetes in the UC Davis-T2DM rat is more similar to clinical T2DM in humans than in other existing rat models and provides a useful model for future studies of the pathophysiology, treatment, and prevention of T2DM... 
Increased soluble leptin receptor levels in morbidly obese patients with insulin resistance and nonalcoholic fatty liver diseaseValentina Medici
Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of California Davis Medical Center, Sacramento, California, USA
Obesity (Silver Spring) 18:2268-73. 2010..In conclusion, increased SLR levels in morbidly obese patients with diabetes are correlated with the stage of liver fibrosis, and may reflect progressive liver disease...- Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeysMichael M Swarbrick
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Endocrinology 150:1670-9. 2009.... - Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptorsJennifer M Wade
Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158, USA
Endocrinology 149:955-61. 2008..These pharmacological and genetic findings provide evidence that the serotonin 2C receptor has direct effects on glucose homeostasis... - Calcium supplementation does not alter lipid oxidation or lipolysis in overweight/obese womenVanitha Sampath
Western Human Nutrition Research Center, United States Department of Agriculture, Agricultural Research Service, University of California, Davis, California, USA
Obesity (Silver Spring) 16:2400-4. 2008..Calcium supplementation for 3 months increased urinary calcium excretion, decreased circulating levels of 1,25(OH)(2)-D, but had no effect on rates of lipid oxidation or lipolysis, in these overweight women... - Fructose consumption and moderate zinc deficiency influence growth and adipocyte metabolism in young rats prone to adult-onset obesityErin L Streiff
Department of Nutrition, University of California at Davis, One Shields Avenue, Davis, CA, USA
Biol Trace Elem Res 118:53-64. 2007..The mesenteric adipocytes from the animals in the LZF group utilized more glucose. Thus, the addition of fructose to a LZ diet reduced energy intake and growth and altered adipocyte fuel metabolism in young growing rats... - Effects of inhibiting transcription and protein synthesis on basal and insulin-stimulated leptin gene expression and leptin secretion in cultured rat adipocytesMaria J Moreno-Aliaga
Department of Nutrition, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
Biochem Biophys Res Commun 307:907-14. 2003..01) during the first 4 h of treatment and at all later time points, which indicate that de novo protein synthesis is required for insulin-mediated glucose metabolism to increase leptin secretion... - Metabolic and endocrine profiles in response to systemic infusion of fructose and glucose in rhesus macaquesSean H Adams
US Department of Agriculture Agricultural Research Service Western Human Nutrition Research Center, University of California, Davis, Davis, California 95616, USA
Endocrinology 149:3002-8. 2008..e. limited post-fructose insulin excursions and/or hexose-specific differences in adipocyte metabolism) are likely to underlie disparate effects of fructose and glucose to increase circulating leptin concentrations... - The yellow agouti mutation alters some but not all responses to diet and exerciseSally Chiu
Rowe Program in Genetics, University of California, Davis, Davis, CA 95616, USA
Obes Res 12:1243-55. 2004..Our results are consistent with the hypothesis that the melanocortin portion of the leptin-signaling pathway mediates effects primarily on certain fat depots and on some, but not all, components of cholesterol homeostasis... - Ileal interposition surgery improves glucose and lipid metabolism and delays diabetes onset in the UCD-T2DM ratBethany P Cummings
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California 95616, USA
Gastroenterology 138:2437-46, 2446.e1. 2010..In this study we investigated effects of IT surgery on glucose tolerance and diabetes onset in UCD-T2DM (University of California at Davis type 2 diabetes mellitus) rats, a polygenic obese animal model of type 2 diabetes... - Improvement in peripheral glucose uptake after gastric bypass surgery is observed only after substantial weight loss has occurred and correlates with the magnitude of weight lostGuilherme M Campos
Department of Surgery, University of California San Francisco, San Francisco, CA, USA
J Gastrointest Surg 14:15-23. 2010..Altered gut and pancreatic hormone secretion may bolster resolution of insulin resistance after Roux-en-Y gastric bypass (RYGB), but the independent effects of weight loss and hormonal secretion on peripheral glucose disposal are unknown... - Longitudinal measures of circulating leptin and ghrelin concentrations are associated with the growth of young Peruvian children but are not affected by zinc supplementationJoanne E Arsenault
Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, Davis, CA 95616, USA
Am J Clin Nutr 86:1111-9. 2007..Leptin, ghrelin, and insulin are hormonal regulators of energy balance and, therefore, may be related to growth during infancy. Zinc is essential for growth, and its growth effects may be mediated through these hormones... - Evidence that tumor necrosis factor-alpha-induced hyperinsulinemia prevents decreases of circulating leptin during fasting in ratsEdward A Medina
Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis 95616, USA
Metabolism 51:1104-10. 2002..Elevated leptin levels may in turn contribute to the effect of TNF-alpha to decrease food intake... - Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM ratsBethany P Cummings
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA
Diabetes 59:2653-61. 2010..The efficacy of liraglutide, a human glucagon-like peptide-1 (GLP-1) analog, to prevent or delay diabetes in UCD-T2DM rats, a model of polygenic obese type 2 diabetes, was investigated... - Metabolic syndrome in adolescents with spinal cord dysfunctionMindy Dopler Nelson
University of California Department of Nutrition, Davis, California, USA
J Spinal Cord Med 30:S127-39. 2007.... - Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistanceKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Curr Opin Lipidol 19:16-24. 2008..From these results and a review of the current literature, we present two potential sequences of events by which fructose consumption may contribute to metabolic syndrome... - Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humansMichael M Swarbrick
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA
Metab Syndr Relat Disord 6:87-102. 2008.... - Fructose consumption: recent results and their potential implicationsKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Ann N Y Acad Sci 1190:15-24. 2010.... - Fructose, weight gain, and the insulin resistance syndromeSharon S Elliott
Department of Nutrition, University of California, Davis 95616, USA
Am J Clin Nutr 76:911-22. 2002.... - Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseasesChristine Beeton
Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 103:17414-9. 2006..Repeated dosing with Kv1.3 inhibitors in rats has not revealed systemic toxicity. Further development of Kv1.3 blockers for autoimmune disease therapy is warranted... - Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humansNorbert Stefan
Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 51:1884-8. 2002..Prospectively, low plasma adiponectin concentration at baseline precedes a decrease in insulin sensitivity. Our data indicate that adiponectin plays an important role in regulation of insulin sensitivity in humans... - The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartmentsMiriam Cnop
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System, and Harborview Medical Center, Seattle, Washington 98108, USA
Diabetes 51:1005-15. 2002.... - Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjectsMay Faraj
Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University, Montreal, Quebec, Canada
J Clin Endocrinol Metab 88:1594-602. 2003.... - Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in womenKaren L Teff
Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA
J Clin Endocrinol Metab 89:2963-72. 2004.... - Circulating leptin and cortisol after burn injury: loss of diurnal patternKristina G Hobson
Department of Surgery, Shriners Hospitals for Children of Northern California, 2426 Stockton Boulevard, Sacramento, CA 95817, USA
J Burn Care Rehabil 25:491-9. 2004..Because low leptin levels should induce appetite, burn-related anorexia is probably controlled by other regulatory systems... - Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolismPatricia Pérez-Matute
Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
Am J Physiol Regul Integr Comp Physiol 288:R1682-8. 2005..84, P < 0.01). Together, the results suggest that EPA, like insulin, stimulates leptin production by increasing the nonanaerobic/oxidative metabolism of glucose... - 48-h glucose infusion in humans: effect on hormonal responses, hunger and food intakeKaren L Teff
Monell Chemical Senses Center, Philadelphia, PA 19104, United States
Physiol Behav 90:733-43. 2007..These data are the first to demonstrate a relationship between leptin and hunger in normal weight, non-calorically restricted human subjects... - Adiponectin is present in cord blood but is unrelated to birth weightRobert S Lindsay
MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA
Diabetes Care 26:2244-9. 2003..We assessed whether adiponectin was 1) present in the fetal circulation, 2) altered in the fetal circulation in the presence of maternal diabetes, and 3) had relations to fetal cord blood insulin or adiposity... - Consuming fructose-sweetened beverages increases body adiposity in miceHella Jürgens
Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
Obes Res 13:1146-56. 2005.... - Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: evidence for a skeletal muscle-to-fat signaling pathwayLeBris S Quinn
Geriatric Research, Education, and Clinical Center, 151 American Lake Division, VA Puget Sound Health Care System, Tacoma, WA 98493, USA
Cell Biol Int 29:449-57. 2005..These findings provide support for the hypothesis that IL-15 functions in a muscle-to-fat endocrine axis which modulates fat:lean body composition and insulin sensitivity... - The decrease in C-reactive protein concentration after diet and physical activity induced weight reduction is associated with changes in plasma lipids, but not interleukin-6 or adiponectinAlena Dvoráková-Lorenzová
Laboratory for Atherosclerosis Research, Centre for Experimental Cardiovascular Research, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic
Metabolism 55:359-65. 2006.... - Metabolic syndrome in Yup'ik Eskimos: the Center for Alaska Native Health Research (CANHR) StudyBert B Boyer
University of Alaska Fairbanks, Institute of Arctic Biology, Center for Alaska Native Health Research, 311 Irving I Building, Fairbanks, AK 99775 7000, USA
Obesity (Silver Spring) 15:2535-40. 2007..This study investigated the prevalence of metabolic syndrome and its defining components among Yup'ik Eskimos... - Adiponectin levels are associated with coronary artery disease across Caucasian and African-American ethnicityGuijing Lu
Department of Medicine, University of California Davis, USA, and Department of Medicine, Xiangya Hospital of Xiangya Medical School, Central South University, Changsha, P R China
Transl Res 149:317-23. 2007..05). The results indicate that, across gender and ethnicity, low adiponectin levels may be an independent risk factor for CAD... - Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and womenMario Kratz
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA
Am J Clin Nutr 87:347-53. 2008..Recent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents... - Differential impairment of glucagon responses to hypoglycemia, neuroglycopenia, arginine, and carbachol in alloxan-diabetic miceBo Ahren
Department of Medicine, Lund University, Lund, Sweden
Metabolism 51:12-9. 2002....
Research Grants
- DIETARY FRUCTOSE: HORMONES & TG/LIPOPROTEIN METABOLISMPeter Havel; Fiscal Year: 2007..The results are pertinent to the dietary control of cardiovascular disease, obesity, and other components of the metabolic syndrome. ..
- Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resisPeter J Havel; Fiscal Year: 2010....
- Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resisPeter Havel; Fiscal Year: 2009....
- Effects of fish oil and alpha lipoic on the progression of insulin resistancePeter Havel; Fiscal Year: 2007....
- Prevention of Diabetes with Nutritional SupplementsPeter Havel; Fiscal Year: 2007..Further studies to investigate the mechanism(s) of action of the supplements or the supplement combinations that are effective in preventing/delaying diabetes onset of diabetes in this model are proposed. ..
- Effects of Chromium on Progression of Insulin ResistancePeter Havel; Fiscal Year: 2006..The results of these studies will provide valuable information for the design and implementation of new clinical studies examining the effects of chromium supplements in the management of metabolic syndrome in humans. ..
- Fructose vs Glucose: Leptin, Appetite and Food IntakePeter Havel; Fiscal Year: 2002....
- ANS HYPOGLYCEMIA INDUCED GLUCAGON SECRETION IN DIABETESPeter Havel; Fiscal Year: 2001..Collectively, these experiments will lead to greater understanding of the pathophysiology and treatment of impaired hypoglycemic counterregulation in diabetes and the greater use of animal models for this area of investigation. ..
- Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resisPeter Havel; Fiscal Year: 2009....