Dominik R Haudenschild

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein
    Dominik R Haudenschild
    Lawrence J Ellison Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Biol Chem 286:43250-8. 2011
  2. pmc Rho kinase-dependent activation of SOX9 in chondrocytes
    Dominik R Haudenschild
    The Scripps Research Institute, La Jolla, California, USA
    Arthritis Rheum 62:191-200. 2010
  3. pmc Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis
    Dominik R Haudenschild
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, La Jolla, California 92037, USA
    J Orthop Res 29:20-5. 2011
  4. doi Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2
    Kazunari Ishida
    Lawrence J Ellison Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of California Davis Medical Center, 4635 Second Avenue Suite 2000, Sacramento CA 95817, USA
    Bone 55:23-35. 2013
  5. pmc Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes
    Dominik R Haudenschild
    Scripps Research Institute, and Scripps Clinic, La Jolla, California 92037, USA
    Arthritis Rheum 58:2735-42. 2008
  6. pmc Identification of a 3Kbp mechanoresponsive promoter region in the human cartilage oligomeric matrix protein gene
    Derek F Amanatullah
    Department of Orthopaedic Surgery, University of California, Davis School of Medicine, Sacramento, CA 95817, USA
    Tissue Eng Part A 18:1882-9. 2012
  7. ncbi Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA
    Dominik R Haudenschild
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California, Sacramento, California 95817, USA
    Prostate 66:1268-74. 2006
  8. pmc Immunolocalization of IL-17A, IL-17B, and their receptors in chondrocytes during fracture healing
    Takeshi Kokubu
    Center for Tissue Regeneration and Repair, Department of Orthopedics, University of California, School of Medicine, 4635 Second Avenue, Sacramento, CA 95817, USA
    J Histochem Cytochem 56:89-95. 2008
  9. doi Interactions between FGF21 and BMP-2 in osteogenesis
    Kazunari Ishida
    Lawrence J Ellison Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of California Davis, 4635 Second Avenue, Sacramento, CA 95817, USA
    Biochem Biophys Res Commun 432:677-82. 2013
  10. ncbi Bone morphogenetic protein (BMP)-6 signaling and BMP antagonist noggin in prostate cancer
    Dominik R Haudenschild
    Center for Tissue Regeneration and Repair, Department of Orthopedic Surgery, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    Cancer Res 64:8276-84. 2004

Collaborators

Detail Information

Publications12

  1. pmc Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein
    Dominik R Haudenschild
    Lawrence J Ellison Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Biol Chem 286:43250-8. 2011
    ..Finally, we show that COMP-bound TGF-β1 causes increased TGF-β1-dependent transcription. We conclude that TGF-β1 binds to COMP and that TGF-β1 bound to COMP has enhanced bioactivity...
  2. pmc Rho kinase-dependent activation of SOX9 in chondrocytes
    Dominik R Haudenschild
    The Scripps Research Institute, La Jolla, California, USA
    Arthritis Rheum 62:191-200. 2010
    ..However, the mechanisms linking ROCK to altered chondrocyte gene expression remain unknown. The purpose of the present study was to test for a direct interaction between ROCK and SOX9...
  3. pmc Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis
    Dominik R Haudenschild
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, La Jolla, California 92037, USA
    J Orthop Res 29:20-5. 2011
    ..This 3D experimental system revealed contributions of vimentin to chondrocyte stiffness previously not apparent, and correlated changes in vimentin-based chondrocyte stiffness with osteoarthritis...
  4. doi Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2
    Kazunari Ishida
    Lawrence J Ellison Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of California Davis Medical Center, 4635 Second Avenue Suite 2000, Sacramento CA 95817, USA
    Bone 55:23-35. 2013
    ..In summary, this study demonstrates that COMP enhances the osteogenic activity of BMP-2, both in-vitro and in-vivo...
  5. pmc Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes
    Dominik R Haudenschild
    Scripps Research Institute, and Scripps Clinic, La Jolla, California 92037, USA
    Arthritis Rheum 58:2735-42. 2008
    ..Reorganization of the actin cytoskeleton results from Rho GTPase activation. The purpose of this study was to examine the roles of both actin and Rho in mechanotransduction in chondrocytes...
  6. pmc Identification of a 3Kbp mechanoresponsive promoter region in the human cartilage oligomeric matrix protein gene
    Derek F Amanatullah
    Department of Orthopaedic Surgery, University of California, Davis School of Medicine, Sacramento, CA 95817, USA
    Tissue Eng Part A 18:1882-9. 2012
    ..This information is critical to understanding how mechanical force regulates the transcriptional activation of cartilage genes in three-dimensional culture...
  7. ncbi Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA
    Dominik R Haudenschild
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California, Sacramento, California 95817, USA
    Prostate 66:1268-74. 2006
    ..Predominant IL-17RL splice isoform variants have not been identified, hindering functional studies...
  8. pmc Immunolocalization of IL-17A, IL-17B, and their receptors in chondrocytes during fracture healing
    Takeshi Kokubu
    Center for Tissue Regeneration and Repair, Department of Orthopedics, University of California, School of Medicine, 4635 Second Avenue, Sacramento, CA 95817, USA
    J Histochem Cytochem 56:89-95. 2008
    ..Moreover, we found significant parallels to the localization of these cytokines and their receptors in chondrocytes during an endochondral differentiation program in the epiphyseal growth plate...
  9. doi Interactions between FGF21 and BMP-2 in osteogenesis
    Kazunari Ishida
    Lawrence J Ellison Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of California Davis, 4635 Second Avenue, Sacramento, CA 95817, USA
    Biochem Biophys Res Commun 432:677-82. 2013
    ..In summary, this study demonstrates interactions between BMP-2 and FGF21 pathways exist in vitro, and that FGF21 enhances the osteogenic activity of BMP-2 by up-regulating the BMP-2-dependent Smad signaling pathway...
  10. ncbi Bone morphogenetic protein (BMP)-6 signaling and BMP antagonist noggin in prostate cancer
    Dominik R Haudenschild
    Center for Tissue Regeneration and Repair, Department of Orthopedic Surgery, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    Cancer Res 64:8276-84. 2004
    ....
  11. doi Comparison of loading rate-dependent injury modes in a murine model of post-traumatic osteoarthritis
    Kevin A Lockwood
    Department of Orthopaedic Surgery, University of California Davis Medical Center, 4635 2nd Ave, Suite 2000, Sacramento, California, 95817
    J Orthop Res 32:79-88. 2014
    ..This model presents an opportunity to explore fundamental questions regarding the role of bone turnover in PTOA, and the findings of this study support a biomechanical mechanism of osteophyte formation following injury...
  12. doi The oncogene LRF is a survival factor in chondrosarcoma and contributes to tumor malignancy and drug resistance
    Ratna Kumari
    Department of Orthopaedic Surgery, Lawrence J Ellison Musculoskeletal Research Center, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Carcinogenesis 33:2076-83. 2012
    ..Our data implicate the potential role of LRF as both a diagnostic marker and therapeutic target for chondrosarcomas...