Eiji Hattori

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series
    Eiji Hattori
    Department of Psychiatry, The University of Chicago, IL 60637, USA
    Am J Hum Genet 72:1131-40. 2003
  2. pmc Neurotransmission and bipolar disorder: a systematic family-based association study
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1270-7. 2008
  3. pmc No evidence for association between 19 cholinergic genes and bipolar disorder
    Jiajun Shi
    Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 144:715-23. 2007
  4. pmc Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1047-55. 2008
  5. ncbi Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism
    Katsuhiko Nishimura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Biochem Biophys Res Commun 356:200-6. 2007
  6. ncbi SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autism
    Takao Toyoda
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Biochem Biophys Res Commun 360:715-20. 2007
  7. ncbi Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia
    Mizuho Takeshita
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Schizophr Res 99:359-64. 2008
  8. doi Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder
    Kenji Amano
    Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako Shi, Japan
    Psychiatr Genet 18:1-10. 2008
  9. doi Genetic analyses of roundabout (ROBO) axon guidance receptors in autism
    A Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1019-27. 2008
  10. ncbi A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Neuropsychopharmacology 32:1727-37. 2007

Collaborators

Detail Information

Publications21

  1. pmc Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series
    Eiji Hattori
    Department of Psychiatry, The University of Chicago, IL 60637, USA
    Am J Hum Genet 72:1131-40. 2003
    ..Taken together with the earlier report, this is the first demonstration of a novel gene(s), discovered through a positional approach, independently associated with both bipolar illness and schizophrenia...
  2. pmc Neurotransmission and bipolar disorder: a systematic family-based association study
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1270-7. 2008
    ....
  3. pmc No evidence for association between 19 cholinergic genes and bipolar disorder
    Jiajun Shi
    Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 144:715-23. 2007
    ..Thus, it is unlikely that these 19 cholinergic genes play a major role in the pre-disposition to BD in these pedigrees...
  4. pmc Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1047-55. 2008
    ..00000172). It remains significant after correcting for multiple testing using the False Discovery Rate method. Our results indicate an interaction between three circadian genes in susceptibility to bipolar disorder...
  5. ncbi Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism
    Katsuhiko Nishimura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Biochem Biophys Res Commun 356:200-6. 2007
    ..We suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system...
  6. ncbi SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autism
    Takao Toyoda
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Biochem Biophys Res Commun 360:715-20. 2007
    ..No significant SNP or haplotypic associations were observed for TGFbeta1 or HGF. Given the role of EGF in brain and neuronal development, we suggest a possible role of EGF in the pathogenesis of autism...
  7. ncbi Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia
    Mizuho Takeshita
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Schizophr Res 99:359-64. 2008
    ..These findings suggest that PLXNA2 confers a varying genetic risk for schizophrenia among different populations...
  8. doi Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder
    Kenji Amano
    Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako Shi, Japan
    Psychiatr Genet 18:1-10. 2008
    ....
  9. doi Genetic analyses of roundabout (ROBO) axon guidance receptors in autism
    A Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1019-27. 2008
    ..Abnormalities of ROBO may lead to autism either by interfering with serotonergic system, or by disrupting neurodevelopment. To the best of our knowledge, this is the first report relating ROBO with autism...
  10. ncbi A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Neuropsychopharmacology 32:1727-37. 2007
    ..In conclusion, the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations...
  11. ncbi Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders
    Tomoko Toyota
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet 114:84-92. 2002
    ..The DNA polymorphisms detected in this study can be tested in other ethnic samples and/or other psychiatric diseases...
  12. ncbi Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia
    Hiromitsu Shimizu
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Schizophr Res 84:244-52. 2006
    ..These data suggest that the contribution of MAP6 to the processes that lead to schizophrenia should be further investigated...
  13. ncbi Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Kawaguchi, Saitama, Japan
    Biol Psychiatry 60:192-201. 2006
    ..But the polymorphisms highlighted in these reports map to different locations in the two genes, therefore it is unclear which gene exerts a stronger effect on susceptibility...
  14. ncbi Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts
    Kazuo Yamada
    RIKEN Brain Science Institute, Laboratory for Molecular Psychiatry, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biol Psychiatry 56:683-90. 2004
    ..We recently identified FEZ1 as an interacting partner for DISC1. To investigate the role of FEZ1 in schizophrenia and bipolar disorder, case-control association analyses were conducted in Japanese cohorts...
  15. ncbi Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia
    Yoshimi Iwayama-Shigeno
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Am J Med Genet B Neuropsychiatr Genet 118:20-4. 2003
    ..Haplotypes derived from all three polymorphisms generated similar results. These data do not support the notion that the NR4A2 gene plays a major role in risk for schizophrenia among Japanese individuals...
  16. ncbi Transcriptional activities of cholecystokinin promoter haplotypes and their relevance to panic disorder susceptibility
    Mitsuru Ebihara
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Am J Med Genet B Neuropsychiatr Genet 118:32-5. 2003
    ..0032; odds ratio, 95% confidence interval = 0.06, 0.01-0.69). These results suggest that the L-(-188G) haplotype may act as a protective factor against panic by reducing the expression of anxiogenic CCK...
  17. pmc Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenics
    Mizuho Nakajima
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama, 351 0198, Japan
    J Hum Genet 52:86-91. 2007
    ..These results suggest that the upstream variants have a primary functional effect in the etiology of schizophrenia in the Japanese population...
  18. ncbi Association study of the short tandem repeat in the 5' upstream region of the cholecystokinin gene with mood disorders in the Japanese population
    Eiji Hattori
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute BSI, Wako, Saitama, Japan
    Am J Med Genet 114:523-6. 2002
    ..885), the unipolar group (P = 0.296), or the bipolar group (P = 0.605). These data suggest that the CCK promoter STR is unlikely to have a major genetic effect on the development of mood disorders in the Japanese population...
  19. ncbi A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia
    Masanari Itokawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Pharmacogenetics 13:271-8. 2003
    ..These results illustrate a genotype-phenotype correlation in schizophrenia and suggest that the longer (GT)(n) stretch may act as a risk-conferring factor that worsens chronic outcome by reducing GRIN2A levels in the brain...
  20. ncbi Association between schizophrenia with ocular misalignment and polyalanine length variation in PMX2B
    Tomoko Toyota
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Hum Mol Genet 13:551-61. 2004
    ....
  21. ncbi Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation
    Noriaki Nakatani
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Hum Mol Genet 15:1949-62. 2006
    ..Finally, gene network analysis using the currently obtained expression data highlighted cellular growth and nervous system development pathways as potential targets in the molecular pathophysiology of bipolar disorder...