Research Topics
Genomes and Genes
Species | Eiji HattoriSummaryAffiliation: University of Chicago Country: USA Publications
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Detail Information
Publications
Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree seriesEiji Hattori
Department of Psychiatry, The University of Chicago, IL 60637, USA
Am J Hum Genet 72:1131-40. 2003..Taken together with the earlier report, this is the first demonstration of a novel gene(s), discovered through a positional approach, independently associated with both bipolar illness and schizophrenia...- Neurotransmission and bipolar disorder: a systematic family-based association studyJiajun Shi
Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
Am J Med Genet B Neuropsychiatr Genet 147:1270-7. 2008.... - No evidence for association between 19 cholinergic genes and bipolar disorderJiajun Shi
Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
Am J Med Genet B Neuropsychiatr Genet 144:715-23. 2007..Thus, it is unlikely that these 19 cholinergic genes play a major role in the pre-disposition to BD in these pedigrees... - Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythmJiajun Shi
Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
Am J Med Genet B Neuropsychiatr Genet 147:1047-55. 2008..00000172). It remains significant after correcting for multiple testing using the False Discovery Rate method. Our results indicate an interaction between three circadian genes in susceptibility to bipolar disorder... 
Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autismKatsuhiko Nishimura
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
Biochem Biophys Res Commun 356:200-6. 2007..We suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system...- SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autismTakao Toyoda
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
Biochem Biophys Res Commun 360:715-20. 2007..No significant SNP or haplotypic associations were observed for TGFbeta1 or HGF. Given the role of EGF in brain and neuronal development, we suggest a possible role of EGF in the pathogenesis of autism... - Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophreniaMizuho Takeshita
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
Schizophr Res 99:359-64. 2008..These findings suggest that PLXNA2 confers a varying genetic risk for schizophrenia among different populations... 
Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorderKenji Amano
Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako Shi, Japan
Psychiatr Genet 18:1-10. 2008....- Genetic analyses of roundabout (ROBO) axon guidance receptors in autismA Anitha
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
Am J Med Genet B Neuropsychiatr Genet 147:1019-27. 2008..Abnormalities of ROBO may lead to autism either by interfering with serotonergic system, or by disrupting neurodevelopment. To the best of our knowledge, this is the first report relating ROBO with autism... - A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcriptionTetsuo Ohnishi
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
Neuropsychopharmacology 32:1727-37. 2007..In conclusion, the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations... - Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disordersTomoko Toyota
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
Am J Med Genet 114:84-92. 2002..The DNA polymorphisms detected in this study can be tested in other ethnic samples and/or other psychiatric diseases... - Genetic and expression analyses of the STOP (MAP6) gene in schizophreniaHiromitsu Shimizu
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
Schizophr Res 84:244-52. 2006..These data suggest that the contribution of MAP6 to the processes that lead to schizophrenia should be further investigated... - Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depressionKazuo Yamada
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Kawaguchi, Saitama, Japan
Biol Psychiatry 60:192-201. 2006..But the polymorphisms highlighted in these reports map to different locations in the two genes, therefore it is unclear which gene exerts a stronger effect on susceptibility... - Association analysis of FEZ1 variants with schizophrenia in Japanese cohortsKazuo Yamada
RIKEN Brain Science Institute, Laboratory for Molecular Psychiatry, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Biol Psychiatry 56:683-90. 2004..We recently identified FEZ1 as an interacting partner for DISC1. To investigate the role of FEZ1 in schizophrenia and bipolar disorder, case-control association analyses were conducted in Japanese cohorts... - Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophreniaYoshimi Iwayama-Shigeno
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
Am J Med Genet B Neuropsychiatr Genet 118:20-4. 2003..Haplotypes derived from all three polymorphisms generated similar results. These data do not support the notion that the NR4A2 gene plays a major role in risk for schizophrenia among Japanese individuals... - Transcriptional activities of cholecystokinin promoter haplotypes and their relevance to panic disorder susceptibilityMitsuru Ebihara
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
Am J Med Genet B Neuropsychiatr Genet 118:32-5. 2003..0032; odds ratio, 95% confidence interval = 0.06, 0.01-0.69). These results suggest that the L-(-188G) haplotype may act as a protective factor against panic by reducing the expression of anxiogenic CCK... - Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenicsMizuho Nakajima
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama, 351 0198, Japan
J Hum Genet 52:86-91. 2007..These results suggest that the upstream variants have a primary functional effect in the etiology of schizophrenia in the Japanese population... - Association study of the short tandem repeat in the 5' upstream region of the cholecystokinin gene with mood disorders in the Japanese populationEiji Hattori
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute BSI, Wako, Saitama, Japan
Am J Med Genet 114:523-6. 2002..885), the unipolar group (P = 0.296), or the bipolar group (P = 0.605). These data suggest that the CCK promoter STR is unlikely to have a major genetic effect on the development of mood disorders in the Japanese population... - A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophreniaMasanari Itokawa
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
Pharmacogenetics 13:271-8. 2003..These results illustrate a genotype-phenotype correlation in schizophrenia and suggest that the longer (GT)(n) stretch may act as a risk-conferring factor that worsens chronic outcome by reducing GRIN2A levels in the brain... - Association between schizophrenia with ocular misalignment and polyalanine length variation in PMX2BTomoko Toyota
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
Hum Mol Genet 13:551-61. 2004.... - Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbationNoriaki Nakatani
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
Hum Mol Genet 15:1949-62. 2006..Finally, gene network analysis using the currently obtained expression data highlighted cellular growth and nervous system development pathways as potential targets in the molecular pathophysiology of bipolar disorder...