Nicholas Hatsopoulos

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Instant neural control of a movement signal
    Mijail D Serruya
    Department of Neuroscience, Box 1953, Brown University, Providence, Rhode Island 02912, USA
    Nature 416:141-2. 2002
  2. ncbi request reprint Microelectrode array fabrication by electrical discharge machining and chemical etching
    Timothy A Fofonoff
    BioInstrumentation Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Biomed Eng 51:890-5. 2004
  3. ncbi request reprint Decoding continuous and discrete motor behaviors using motor and premotor cortical ensembles
    Nicholas Hatsopoulos
    Dept of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    J Neurophysiol 92:1165-74. 2004
  4. ncbi request reprint Propagating waves mediate information transfer in the motor cortex
    Doug Rubino
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA
    Nat Neurosci 9:1549-57. 2006
  5. ncbi request reprint Encoding of movement fragments in the motor cortex
    Nicholas G Hatsopoulos
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 27:5105-14. 2007
  6. pmc Heterogeneous neural coding of corrective movements in motor cortex
    Adam S Dickey
    Committee on Computational Neuroscience, University of Chicago Chicago, IL, USA
    Front Neural Circuits 7:51. 2013
  7. pmc Propagating waves in human motor cortex
    Kazutaka Takahashi
    Department of Organismal Biology and Anatomy, University of Chicago Chicago, IL, USA
    Front Hum Neurosci 5:40. 2011
  8. pmc Synthesizing complex movement fragment representations from motor cortical ensembles
    Nicholas G Hatsopoulos
    Dept of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, United States
    J Physiol Paris 106:112-9. 2012
  9. ncbi request reprint Sequential movement representations based on correlated neuronal activity
    Nicholas G Hatsopoulos
    Department of Organismal Biology and Anatomy, University of Chicago, 1027 East 57th Street, Chicago, IL 60637, USA
    Exp Brain Res 149:478-86. 2003
  10. pmc Sensing with the motor cortex
    Nicholas G Hatsopoulos
    Committee on Computational Neuroscience, University of Chicago, IL 60637, USA
    Neuron 72:477-87. 2011

Research Grants

  1. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2004
  2. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2005
  3. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2006
  4. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2005
  5. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2007
  6. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2009
  7. Coding of action by motor & premotor cortical ensembles
    Nicholas G Hatsopoulos; Fiscal Year: 2010

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Instant neural control of a movement signal
    Mijail D Serruya
    Department of Neuroscience, Box 1953, Brown University, Providence, Rhode Island 02912, USA
    Nature 416:141-2. 2002
    ..Our results, which are based on recordings made by an electrode array that is suitable for human use, indicate that neurally based control of movement may eventually be feasible in paralysed humans...
  2. ncbi request reprint Microelectrode array fabrication by electrical discharge machining and chemical etching
    Timothy A Fofonoff
    BioInstrumentation Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Biomed Eng 51:890-5. 2004
    ..Several structures relevant to the fabrication of microelectrode arrays are also offered in order to demonstrate the capabilities of EDM...
  3. ncbi request reprint Decoding continuous and discrete motor behaviors using motor and premotor cortical ensembles
    Nicholas Hatsopoulos
    Dept of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    J Neurophysiol 92:1165-74. 2004
    ..These results also support the hierarchical view that MI ensembles are involved in lower-level movement execution, whereas PMd populations represent the early intention to move to visually presented targets...
  4. ncbi request reprint Propagating waves mediate information transfer in the motor cortex
    Doug Rubino
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA
    Nat Neurosci 9:1549-57. 2006
    ..These findings suggest that high-frequency oscillations may subserve intra- and inter-cortical information transfer during movement preparation and execution...
  5. ncbi request reprint Encoding of movement fragments in the motor cortex
    Nicholas G Hatsopoulos
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 27:5105-14. 2007
    ..These findings suggest that single motor cortical neurons encode whole movement fragments, which are temporally extensive and can be quite complex...
  6. pmc Heterogeneous neural coding of corrective movements in motor cortex
    Adam S Dickey
    Committee on Computational Neuroscience, University of Chicago Chicago, IL, USA
    Front Neural Circuits 7:51. 2013
    ..Neural activity in the subpopulation showing replacement is more likely to lag the observed movement, and may therefore be involved in the monitoring of the sensory consequences of a motor command...
  7. pmc Propagating waves in human motor cortex
    Kazutaka Takahashi
    Department of Organismal Biology and Anatomy, University of Chicago Chicago, IL, USA
    Front Hum Neurosci 5:40. 2011
    ..This consistent finding of wave propagation may imply the existence of a hardwired organization of motor cortex that mediates this spatiotemporal pattern...
  8. pmc Synthesizing complex movement fragment representations from motor cortical ensembles
    Nicholas G Hatsopoulos
    Dept of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, United States
    J Physiol Paris 106:112-9. 2012
    ..These results suggest that complex movement representations can be synthesized in simultaneously firing neuronal ensembles by adding the trajectory representations of the constituents in the ensemble...
  9. ncbi request reprint Sequential movement representations based on correlated neuronal activity
    Nicholas G Hatsopoulos
    Department of Organismal Biology and Anatomy, University of Chicago, 1027 East 57th Street, Chicago, IL 60637, USA
    Exp Brain Res 149:478-86. 2003
    ..Our results suggest that spatially distributed groups of MI neurons form dynamic correlation structures that distinguish different forms of sequential action...
  10. pmc Sensing with the motor cortex
    Nicholas G Hatsopoulos
    Committee on Computational Neuroscience, University of Chicago, IL 60637, USA
    Neuron 72:477-87. 2011
    ..We review current work that emphasizes the heterogeneity in sensorimotor responses in the motor cortex and focus on its implications for cortical control of movement as well as for brain-machine interface development...
  11. pmc The science of neural interface systems
    Nicholas G Hatsopoulos
    Department of Organismal Biology and Anatomy, and Committees on Computational Neuroscience and Neurobiology, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Neurosci 32:249-66. 2009
    ..Finally, we discuss technical and scientific challenges faced by these systems before they are widely adopted by severely motor-disabled patients...
  12. pmc Fast and slow oscillations in human primary motor cortex predict oncoming behaviorally relevant cues
    Maryam Saleh
    Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Neuron 65:461-71. 2010
    ..This result suggests that the beta amplitude and delta phase in MI reflect the subject's engagement with the rhythmically presented cues and work together to enhance sensitivity to predictable and task-relevant visual cues...
  13. ncbi request reprint Evidence against a single coordinate system representation in the motor cortex
    Wei Wu
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    Exp Brain Res 175:197-210. 2006
    ..These results suggest that the motor cortex employs a coordinate system that is yet to be discovered or perhaps that the motor cortex should not be viewed as a substrate for any coordinate system representation...
  14. pmc Exploiting multiple sensory modalities in brain-machine interfaces
    Aaron J Suminski
    Department of Organismal Biology and Anatomy and Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Neural Netw 22:1224-34. 2009
    ..Finally, we suggest how these playback-evoked responses may be used to improve BMI performance...
  15. pmc Single-unit stability using chronically implanted multielectrode arrays
    Adam S Dickey
    Committe on Computational Neuroscience, University of Chicago, Chicago, Illinois 60637, USA
    J Neurophysiol 102:1331-9. 2009
    ....
  16. ncbi request reprint Congruent activity during action and action observation in motor cortex
    Dennis Tkach
    Committee on Computational Neuroscience, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 27:13241-50. 2007
    ..Such congruent activity has proposed relevance to motor learning, mimicry, and communication and has practical applications for the development of motor-cortical neuroprostheses in paralyzed patients...
  17. ncbi request reprint Early visuomotor representations revealed from evoked local field potentials in motor and premotor cortical areas
    John G O'Leary
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    J Neurophysiol 96:1492-506. 2006
    ....
  18. doi request reprint The problem of parametric neural coding in the motor system
    Jacob Reimer
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    Adv Exp Med Biol 629:243-59. 2009
    ..When one considers the way this tuning space changes over time, the time-varying preferred parameter values of the neuron describe a small segment of movement that we call a "movement fragment"...
  19. pmc Bayesian inference of functional connectivity and network structure from spikes
    Ian H Stevenson
    Department of Physiology, Northwestern University, Chicago, IL 60611, USA
    IEEE Trans Neural Syst Rehabil Eng 17:203-13. 2009
    ..Groups of neurons in M1 and PMd show common patterns of input and output that may correspond to functional assemblies...
  20. pmc Observation-based learning for brain-machine interfaces
    Dennis Tkach
    Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Curr Opin Neurobiol 18:589-94. 2008
    ....
  21. doi request reprint Real-time decoding of nonstationary neural activity in motor cortex
    Wei Wu
    Department of Statistics, Florida State University, Tallahassee, FL 32306 USA
    IEEE Trans Neural Syst Rehabil Eng 16:213-22. 2008
    ..We also test the new methods in a simulated BMI experiment where the true hand motion is not known. The successful performance suggests these methods could be useful decoding algorithms for practical applications...
  22. ncbi request reprint Spatiotemporal tuning of motor cortical neurons for hand position and velocity
    Liam Paninski
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurophysiol 91:515-32. 2004
    ..Hand motion signals appear to be represented as a distributed code in which diverse information about position and velocity is available within small regions of MI...
  23. ncbi request reprint Superlinear population encoding of dynamic hand trajectory in primary motor cortex
    Liam Paninski
    Gatsby Computational Neuroscience Unit, University College London, London, United Kingdom WC1N 3AR
    J Neurosci 24:8551-61. 2004
    ..Nevertheless, this neighbor activity is approximately as informative as the hand velocity, supporting the view that neural encoding in MI is best understood at a population level...
  24. ncbi request reprint Statistical encoding model for a primary motor cortical brain-machine interface
    Shy Shoham
    Faculty of Biomedical Engineering, The Technion, Israel Institute of Technology, Haifa 32000, Israel
    IEEE Trans Biomed Eng 52:1312-22. 2005
    ..The statistical model is seamlessly integrated into a nearly-optimal recursive method for decoding movement from neural responses based on a Sequential Monte Carlo filter...
  25. ncbi request reprint Encoding in the motor cortex: was evarts right after all? Focus on "motor cortex neural correlates of output kinematics and kinetics during isometric-force and arm-reaching tasks"
    Nicholas G Hatsopoulos
    J Neurophysiol 94:2261-2. 2005
  26. ncbi request reprint Template-based spike pattern identification with linear convolution and dynamic time warping
    Zhiyi Chi
    Department of Statistics, University of Connecticut, 215 Glenbrook Rd, Storrs, CT 06269, USA
    J Neurophysiol 97:1221-35. 2007
    ....
  27. ncbi request reprint Coordinate system representations of movement direction in the premotor cortex
    Wei Wu
    Department of Statistics, Florida State University, Tallahassee, FL 32306 4330, USA
    Exp Brain Res 176:652-7. 2007
    ....
  28. pmc Biomimetic brain machine interfaces for the control of movement
    Andrew H Fagg
    School of Computer Science, University of Oklahoma, Norman, Oklahoma 73019, USA
    J Neurosci 27:11842-6. 2007
    ....

Research Grants8

  1. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2004
    ..In addition, this work has direct relevance towards the development of a neuro-motor prosthesis by which paralyzed patients may be able to control external devices by activating their cortex. ..
  2. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2005
    ..In addition, this work has direct relevance towards the development of a neuro-motor prosthesis by which paralyzed patients may be able to control external devices by activating their cortex. ..
  3. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2006
    ..In addition, this work has direct relevance towards the development of a neuro-motor prosthesis by which paralyzed patients may be able to control external devices by activating their cortex. ..
  4. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2005
    ..In addition, this work has direct relevance towards the development of a neuro-motor prosthesis by which paralyzed patients may be able to control external devices by activating their cortex. ..
  5. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2007
    ..In addition, this work has direct relevance towards the development of a neuro-motor prosthesis by which paralyzed patients may be able to control external devices by activating their cortex. ..
  6. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2009
    ....
  7. Coding of action by motor & premotor cortical ensembles
    Nicholas G Hatsopoulos; Fiscal Year: 2010
    ....