Nan E Hatch
Affiliation: University of Michigan
Hatch N. FGF signaling in craniofacial biological control and pathological craniofacial development. Crit Rev Eukaryot Gene Expr. 2010;20:295-311 pubmed
..In this review we will discuss recent in vitro and in vivo studies investigating biologic mechanisms by which signaling through FGFRs influences skeletal development and can lead to craniosynostosis...
Nam H, Vesela I, Siismets E, Hatch N. Tissue nonspecific alkaline phosphatase promotes calvarial progenitor cell cycle progression and cytokinesis via Erk1,2. Bone. 2018;120:125-136 pubmed publisher
..These results identify a novel mechanism by which TNAP promotes calvarial progenitor cell renewal and indicate that converging pathways exist downstream of FGF signaling and TNAP activity to control craniofacial skeletal development. ..
Liu J, Campbell C, Nam H, Caron A, Yadav M, MillÃ¡n J, et al
. Enzyme replacement for craniofacial skeletal defects and craniosynostosis in murine hypophosphatasia. Bone. 2015;78:203-11 pubmed publisher
Hatch N. Potential role of PC-1 expression and pyrophosphate elaboration in the molecular etiology of the FGFR-associated craniosynostosis syndromes. Orthod Craniofac Res. 2007;10:53-8 pubmed
..These results suggest that the expression of PC-1 downstream of FGF signaling is an integral aspect of osteoblastic function, and that pyrophosphate elaboration may play a significant role in the pathology of craniosynostosis. ..
Ramaswamy J, Nam H, Ramaraju H, Hatch N, Kohn D. Inhibition of osteoblast mineralization by phosphorylated phage-derived apatite-specific peptide. Biomaterials. 2015;73:120-30 pubmed publisher
Hatch N, Hudson M, Seto M, Cunningham M, Bothwell M. Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F. J Biol Chem. 2006;281:27292-305 pubmed
Hatch N, Franceschi R. Osteoblast differentiation stage-specific expression of the pyrophosphate-generating enzyme PC-1. Cells Tissues Organs. 2009;189:65-9 pubmed publisher
..These results also indicate that PC-1 may play multiple and distinct roles in the development of mineralized tissues. ..
Hatch N, Li Y, Franceschi R. FGF2 stimulation of the pyrophosphate-generating enzyme, PC-1, in pre-osteoblast cells is mediated by RUNX2. J Bone Miner Res. 2009;24:652-62 pubmed publisher
..Taken together, our results establish that FGF2 is a specific inducer of PC-1 in pre-osteoblast cells and that FGF2 induces PC-1 expression through a mechanism involving Runx2. ..