Nan E Hatch

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. request reprint
    Hatch N. FGF signaling in craniofacial biological control and pathological craniofacial development. Crit Rev Eukaryot Gene Expr. 2010;20:295-311 pubmed
    ..In this review we will discuss recent in vitro and in vivo studies investigating biologic mechanisms by which signaling through FGFRs influences skeletal development and can lead to craniosynostosis...
  2. request reprint
    Hatch N, Hudson M, Seto M, Cunningham M, Bothwell M. Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F. J Biol Chem. 2006;281:27292-305 pubmed
    ....
  3. Hatch N, Franceschi R. Osteoblast differentiation stage-specific expression of the pyrophosphate-generating enzyme PC-1. Cells Tissues Organs. 2009;189:65-9 pubmed publisher
    ..These results also indicate that PC-1 may play multiple and distinct roles in the development of mineralized tissues. ..
  4. Hatch N, Li Y, Franceschi R. FGF2 stimulation of the pyrophosphate-generating enzyme, PC-1, in pre-osteoblast cells is mediated by RUNX2. J Bone Miner Res. 2009;24:652-62 pubmed publisher
    ..Taken together, our results establish that FGF2 is a specific inducer of PC-1 in pre-osteoblast cells and that FGF2 induces PC-1 expression through a mechanism involving Runx2. ..

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Detail Information

Publications4

  1. request reprint
    Hatch N. FGF signaling in craniofacial biological control and pathological craniofacial development. Crit Rev Eukaryot Gene Expr. 2010;20:295-311 pubmed
    ..In this review we will discuss recent in vitro and in vivo studies investigating biologic mechanisms by which signaling through FGFRs influences skeletal development and can lead to craniosynostosis...
  2. request reprint
    Hatch N, Hudson M, Seto M, Cunningham M, Bothwell M. Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F. J Biol Chem. 2006;281:27292-305 pubmed
    ....
  3. Hatch N, Franceschi R. Osteoblast differentiation stage-specific expression of the pyrophosphate-generating enzyme PC-1. Cells Tissues Organs. 2009;189:65-9 pubmed publisher
    ..These results also indicate that PC-1 may play multiple and distinct roles in the development of mineralized tissues. ..
  4. Hatch N, Li Y, Franceschi R. FGF2 stimulation of the pyrophosphate-generating enzyme, PC-1, in pre-osteoblast cells is mediated by RUNX2. J Bone Miner Res. 2009;24:652-62 pubmed publisher
    ..Taken together, our results establish that FGF2 is a specific inducer of PC-1 in pre-osteoblast cells and that FGF2 induces PC-1 expression through a mechanism involving Runx2. ..