Marguerite Hatch

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Oxalobacter sp. reduces urinary oxalate excretion by promoting enteric oxalate secretion
    M Hatch
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    Kidney Int 69:691-8. 2006
  2. pmc Transcellular oxalate and Cl- absorption in mouse intestine is mediated by the DRA anion exchanger Slc26a3, and DRA deletion decreases urinary oxalate
    Robert W Freel
    Dept of Pathology, Immunology, and Laboratory Medicine, College of Medicine, Univ of Florida, Gainesville, FL 32610
    Am J Physiol Gastrointest Liver Physiol 305:G520-7. 2013
  3. pmc Enteric oxalate elimination is induced and oxalate is normalized in a mouse model of primary hyperoxaluria following intestinal colonization with Oxalobacter
    Marguerite Hatch
    Dept of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, USA
    Am J Physiol Gastrointest Liver Physiol 300:G461-9. 2011
  4. pmc Increased colonic sodium absorption in rats with chronic renal failure is partially mediated by AT1 receptor agonism
    Marguerite Hatch
    Dept of Pathology, Immunology, and Laboratory Medicine, P O Box 100275, 1600 SW Archer Rd, Gainesville, FL 32610, USA
    Am J Physiol Gastrointest Liver Physiol 295:G348-56. 2008
  5. pmc The roles and mechanisms of intestinal oxalate transport in oxalate homeostasis
    Marguerite Hatch
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Semin Nephrol 28:143-51. 2008
  6. ncbi request reprint Renal and intestinal handling of oxalate following oxalate loading in rats
    Marguerite Hatch
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Fla 32610, USA
    Am J Nephrol 23:18-26. 2003
  7. ncbi request reprint Angiotensin II involvement in adaptive enteric oxalate excretion in rats with chronic renal failure induced by hyperoxaluria
    Marguerite Hatch
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, 1600 SW Archer Road, PO Box 100275, Gainesville, FL 32610, USA
    Urol Res 31:426-32. 2003
  8. ncbi request reprint Intestinal transport of an obdurate anion: oxalate
    Marguerite Hatch
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, P O Box 100275, 1600 S W Archer Road, FL 32610, USA
    Urol Res 33:1-16. 2005
  9. pmc Sulfate secretion and chloride absorption are mediated by the anion exchanger DRA (Slc26a3) in the mouse cecum
    Jonathan M Whittamore
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Am J Physiol Gastrointest Liver Physiol 305:G172-84. 2013
  10. doi request reprint Butyrate and type 1 diabetes mellitus: can we fix the intestinal leak?
    Nan Li
    Department of Pediatrics, University of Florida, Gainesville, FL 32610 0296, USA
    J Pediatr Gastroenterol Nutr 51:414-7. 2010

Detail Information

Publications19

  1. ncbi request reprint Oxalobacter sp. reduces urinary oxalate excretion by promoting enteric oxalate secretion
    M Hatch
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    Kidney Int 69:691-8. 2006
    ..Whether Oxalobacter, or products of Oxalobacter, can therapeutically reduce urinary oxalate excretion and influence stone disease warrants further investigation in long-term studies in various patient populations...
  2. pmc Transcellular oxalate and Cl- absorption in mouse intestine is mediated by the DRA anion exchanger Slc26a3, and DRA deletion decreases urinary oxalate
    Robert W Freel
    Dept of Pathology, Immunology, and Laboratory Medicine, College of Medicine, Univ of Florida, Gainesville, FL 32610
    Am J Physiol Gastrointest Liver Physiol 305:G520-7. 2013
    ..The large reductions in urinary oxalate excretion underscore the importance of transcellular intestinal oxalate absorption, in general, and, more specifically, the importance of the DRA exchanger in oxalate homeostasis...
  3. pmc Enteric oxalate elimination is induced and oxalate is normalized in a mouse model of primary hyperoxaluria following intestinal colonization with Oxalobacter
    Marguerite Hatch
    Dept of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, USA
    Am J Physiol Gastrointest Liver Physiol 300:G461-9. 2011
    ....
  4. pmc Increased colonic sodium absorption in rats with chronic renal failure is partially mediated by AT1 receptor agonism
    Marguerite Hatch
    Dept of Pathology, Immunology, and Laboratory Medicine, P O Box 100275, 1600 SW Archer Rd, Gainesville, FL 32610, USA
    Am J Physiol Gastrointest Liver Physiol 295:G348-56. 2008
    ..We conclude that Na(+) absorption in CRF rat distal colon is increased due to elevated expression of proteins mediating electroneutral and electrogenic uptake and that it is partially mediated by AT(1) receptors...
  5. pmc The roles and mechanisms of intestinal oxalate transport in oxalate homeostasis
    Marguerite Hatch
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Semin Nephrol 28:143-51. 2008
    ..Finally, the significance of oxalate degrading bacteria to oxalate homeostasis is considered from basic and applied perspectives...
  6. ncbi request reprint Renal and intestinal handling of oxalate following oxalate loading in rats
    Marguerite Hatch
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Fla 32610, USA
    Am J Nephrol 23:18-26. 2003
    ..However, the renal and intestinal handling of oxalate has not been evaluated for other common models of hyperoxaluria that simulate primary hyperoxaluria or oxalate stone disease...
  7. ncbi request reprint Angiotensin II involvement in adaptive enteric oxalate excretion in rats with chronic renal failure induced by hyperoxaluria
    Marguerite Hatch
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, 1600 SW Archer Road, PO Box 100275, Gainesville, FL 32610, USA
    Urol Res 31:426-32. 2003
    ....
  8. ncbi request reprint Intestinal transport of an obdurate anion: oxalate
    Marguerite Hatch
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, P O Box 100275, 1600 S W Archer Road, FL 32610, USA
    Urol Res 33:1-16. 2005
    ..In addition, we review the role of the intestine in oxalate disease states and various factors affecting oxalate absorption...
  9. pmc Sulfate secretion and chloride absorption are mediated by the anion exchanger DRA (Slc26a3) in the mouse cecum
    Jonathan M Whittamore
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Am J Physiol Gastrointest Liver Physiol 305:G172-84. 2013
    ..With DRA linked to the pathogenesis of other gastrointestinal diseases extending its functional characterization offers a more complete picture of its role in the intestine...
  10. doi request reprint Butyrate and type 1 diabetes mellitus: can we fix the intestinal leak?
    Nan Li
    Department of Pediatrics, University of Florida, Gainesville, FL 32610 0296, USA
    J Pediatr Gastroenterol Nutr 51:414-7. 2010
    ..We hypothesized that enteral administration of sodium butyrate (NaB) in preweaned rats would result in differences in the development of diabetes associated with decreased inflammation and pancreatic β-cell destruction...
  11. ncbi request reprint Lipid peroxidation is not the underlying cause of renal injury in hyperoxaluric rats
    Mike L Green
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610 00275, USA
    Kidney Int 68:2629-38. 2005
    ..In the current study, we assess the role of oxidative stress in renal tubular damage in a rat model of chronic hyperoxaluria (HYP) and chronic renal failure induced by hyperoxaluria (HRF) compared to control rats...
  12. ncbi request reprint Ileal oxalate absorption and urinary oxalate excretion are enhanced in Slc26a6 null mice
    Robert W Freel
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, 32610 00275, USA
    Am J Physiol Gastrointest Liver Physiol 290:G719-28. 2006
    ..We conclude that PAT1 is DIDS sensitive and mediates a significant fraction of oxalate efflux across the apical membrane in exchange for Cl(-); as such, PAT1 represents a major apical membrane pathway mediating J(sm)(Ox)...
  13. ncbi request reprint Ethylene glycol induces hyperoxaluria without metabolic acidosis in rats
    Mike L Green
    Dept of Pathology, Immunology, and Laboratory Medicine, Univ of Florida, College of Medicine, PO Box 100275, Gainesville, FL 32610 00275, USA
    Am J Physiol Renal Physiol 289:F536-43. 2005
    ..We conclude that metabolic acidosis does not develop in conventional EG treatments but may ensue with renal insufficiency resulting from an oxalate load...
  14. pmc Hyperoxaluric rats do not exhibit alterations in renal expression patterns of Slc26a1 (SAT1) mRNA or protein
    Robert W Freel
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, P O Box 100275, Gainesville, FL 32610 00275, USA
    Urol Res 40:647-54. 2012
    ..Together, the results indicate that transcriptional modulation of the SAT1 gene is not a significant component of the hyperoxaluria observed in these rat models...
  15. pmc Enteric oxalate secretion is not directly mediated by the human CFTR chloride channel
    Robert W Freel
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, College of Medicine, P O Box 100275, Gainesville, FL 32610 00275, USA
    Urol Res 36:127-31. 2008
    ..We conclude that the human CFTR gene product does not directly mediate oxalate efflux in secretory epithelia and hence is not directly involved in oxalate homeostasis in humans...
  16. pmc Steatorrhea and hyperoxaluria occur after gastric bypass surgery in obese rats regardless of dietary fat or oxalate
    Benjamin K Canales
    Department of Urology, University of Florida, Gainesville, Florida 32610, USA
    J Urol 190:1102-9. 2013
    ..We determined the effect of dietary fat and oxalate on fecal fat excretion and urine parameters in a rat model of Roux-en-Y gastric bypass surgery...
  17. pmc Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26A6 reveals the role and properties of PAT-1
    Robert W Freel
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610 00275, USA
    Am J Physiol Gastrointest Liver Physiol 297:G918-29. 2009
    ..The overall symmetry of PAT-1-mediated oxalate exchange suggests that vectorial oxalate transport observed in vivo is principally dependent on the magnitude and direction of counterion gradients...
  18. ncbi request reprint Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes
    Josef Neu
    Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
    J Pediatr Gastroenterol Nutr 40:589-95. 2005
    ..In these studies, we examined both the physical and functional permeability characteristics of the small intestine in diabetes-prone and control rats...
  19. ncbi request reprint Serum oxalate in human beings and rats as determined with the use of ion chromatography
    Anastasia H Harris
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Lab Clin Med 144:45-52. 2004
    ....

Research Grants17

  1. ANGIOTENSIN II REGULATION OF ENTERIC OXALATE ELIMINATION
    Marguerite Hatch; Fiscal Year: 2001
    ..abstract_text> ..
  2. Probiotic-Induced Elimination of Oxalate to Treat Hyperoxaluria Associated with P
    Marguerite Hatch; Fiscal Year: 2010
    ....
  3. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2010
    ..Understanding oxalate handling in PH1 and the potential roles and interactions of PAT1 and Oxalobacter in modulating the excessive body burden of oxalate in this genetic disease are now possible. ..
  4. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
    ..Understanding oxalate handling in health and disease is essential for the development of potential pharmacological therapies. ..
  5. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2009
    ..Understanding oxalate handling in PH1 and the potential roles and interactions of PAT1 and Oxalobacter in modulating the excessive body burden of oxalate in this genetic disease are now possible. ..
  6. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2009
    ..Understanding oxalate handling in health and disease is essential for the development of potential pharmacological therapies. ..
  7. 8th International Primary Hyperoxaluria Workshop
    Marguerite Hatch; Fiscal Year: 2007
    ..g. pediatric and adult nephrology, transplant surgery, metabolic medicine, molecular and cell biology, clinical and molecular genetics) to discuss their common interest in Primary Hyperoxaluria. ..
  8. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2007
    ..Understanding oxalate handling in health and disease is essential for the development of potential pharmacological therapies. ..
  9. ANGIOTENSIN II REGULATION OF ENTERIC OXALATE ELIMINATION
    Marguerite Hatch; Fiscal Year: 2004
    ..abstract_text> ..
  10. ANGIOTENSIN II REGULATION OF ENTERIC OXALATE ELIMINATION
    Marguerite Hatch; Fiscal Year: 2003
    ..abstract_text> ..
  11. Enteric Elimination and Degradation of Oxalic Acid
    Marguerite Hatch; Fiscal Year: 2002
    ..The potential for the clinical application of a novel treatment strategy to reduce urinary oxalate excretion is broad-based and highly significant...
  12. ANGIOTENSIN II REGULATION OF ENTERIC OXALATE ELIMINATION
    Marguerite Hatch; Fiscal Year: 2002
    ..abstract_text> ..
  13. CALCIUM OXALATE IN BIOLOGICAL SYSTEMS
    Marguerite Hatch; Fiscal Year: 2002
    ..abstract_text> ..
  14. ANGIOTENSIN II REGULATION OF ENTERIC OXALATE ELIMINATION
    Marguerite Hatch; Fiscal Year: 2001
    ..abstract_text> ..
  15. ANGIOTENSIN II REGULATION OF ENTERIC OXALATE ELIMINATION
    Marguerite Hatch; Fiscal Year: 1999
    ..abstract_text> ..
  16. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
    ..Understanding oxalate handling in health and disease is essential for the development of potential pharmacological therapies. ..