P Hasty

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency
    Erwin Reiling
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 9:e93568. 2014
  2. pmc Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair
    Yong Jun Choi
    Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 9:e86358. 2014
  3. pmc Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes
    Lingchuan Hu
    Department of Molecular Medicine Institute of Biotechnology, The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245 3207, USA
    Nature 501:569-72. 2013
  4. pmc Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor
    Mariana Yaneva
    Lexicon Genetics Inc The Woodlands, TX 77381 4287, USA
    Nucleic Acids Res 33:5320-30. 2005
  5. pmc mTORC1 and p53: clash of the gods?
    Paul Hasty
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX, USA
    Cell Cycle 12:20-5. 2013
  6. ncbi request reprint Is NHEJ a tumor suppressor or an aging suppressor?
    Paul Hasty
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas, USA
    Cell Cycle 7:1139-45. 2008
  7. ncbi request reprint The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: observations in humans and mice
    Paul Hasty
    Department of Molecular Medicine, University of Texas, Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA
    Mech Ageing Dev 126:71-7. 2005
  8. ncbi request reprint Aging and genome maintenance: lessons from the mouse?
    Paul Hasty
    Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Science 299:1355-9. 2003
  9. ncbi request reprint Aging. Genomic priorities in aging
    Paul Hasty
    Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Science 296:1250-1. 2002
  10. ncbi request reprint The impact energy metabolism and genome maintenance have on longevity and senescence: lessons from yeast to mammals
    P Hasty
    Department of Molecular Medicine, Institute of Biotechnology, The University of Texas, Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Mech Ageing Dev 122:1651-62. 2001

Research Grants

  1. Discovering TREX1 and TREX2 Function in Mammalian Cells and Mice
    EDWARD PAUL HASTY; Fiscal Year: 2010
  2. XRCC5 MUTANT MICE AND CELL LINES
    EDWARD HASTY; Fiscal Year: 1999
  3. Discovering TREX1 and TREX2 Function in Mammalian Cells and Mice
    EDWARD HASTY; Fiscal Year: 2009
  4. Discovering TREX1 and TREX2 Function in Mammalian Cells and Mice
    EDWARD HASTY; Fiscal Year: 2007
  5. Investigation of xrcc5 Mutant Mice
    EDWARD HASTY; Fiscal Year: 2005
  6. Investigation of xrcc5 Mutant Mice
    EDWARD HASTY; Fiscal Year: 2004
  7. Investigation of xrcc5 Mutant Mice
    EDWARD HASTY; Fiscal Year: 2003
  8. Investigation of xrcc5 Mutant Mice
    EDWARD HASTY; Fiscal Year: 2002

Collaborators

  • Jan Vijg
  • Han Li
  • Judith Campisi
  • Martijn E T DollĂ©
  • Dong Hyun Kim
  • Robert W Sobol
  • EDWARD HASTY
  • EDWARD PAUL HASTY
  • Erwin Reiling
  • Yong Jun Choi
  • Harry van Steeg
  • MoonSook Lee
  • Mi Young Son
  • Lingchuan Hu
  • V B Holcomb
  • Mariana Yaneva
  • Jan H Hoeijmakers
  • Alain de Bruin
  • Bhawani Nagarajah
  • Jamie L Fornsaglio
  • Sandra Imholz
  • Piet de With
  • Xiao Hong Wang
  • Sameh A Youssef
  • Marianne Roodbergen
  • Cory L Holland
  • Tae Moon Kim
  • Satoshi Tateishi
  • Sung A Kim
  • P Renee Yew
  • Cristina Montagna
  • Lavinia C Dumitrache
  • T Marple
  • R W Kornegay
  • H Vogel
  • Teresa Marple

Detail Information

Publications13

  1. pmc The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency
    Erwin Reiling
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 9:e93568. 2014
    ..Presumably, the more severe degenerative effect of Ku80 inactivation on lifespan compared to DNA-PKCS inactivation is caused by additional functions of Ku80 or activity of free Ku70 since both Ku80 and DNA-PKCS are essential for NHEJ. ..
  2. pmc Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair
    Yong Jun Choi
    Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 9:e86358. 2014
    ..In addition, free Ku70 and free Ku80 bound to AP sites and in the case of Ku70 inhibited APE1 activity. These observations support a novel role for free Ku70 and free Ku80 in altering BER. ..
  3. pmc Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes
    Lingchuan Hu
    Department of Molecular Medicine Institute of Biotechnology, The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245 3207, USA
    Nature 501:569-72. 2013
    ..Interestingly, replication fork stalling induced fusion for identical and mismatched repeats, implicating faulty replication as a causal mechanism for both pathways. ..
  4. pmc Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor
    Mariana Yaneva
    Lexicon Genetics Inc The Woodlands, TX 77381 4287, USA
    Nucleic Acids Res 33:5320-30. 2005
    ....
  5. pmc mTORC1 and p53: clash of the gods?
    Paul Hasty
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX, USA
    Cell Cycle 12:20-5. 2013
    ..Here we discuss how these p53-mTORC1 interactions might play a role in the suppression of cancer and perhaps the development of cellular senescence and organismal aging...
  6. ncbi request reprint Is NHEJ a tumor suppressor or an aging suppressor?
    Paul Hasty
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas, USA
    Cell Cycle 7:1139-45. 2008
    ..Furthermore, NHEJ did not evolve to suppress tumors and any observed tumor suppression is merely circumstantial to unnatural laboratory conditions coupled with human bias that favors defining all DNA repair pathways as caretakers...
  7. ncbi request reprint The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: observations in humans and mice
    Paul Hasty
    Department of Molecular Medicine, University of Texas, Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA
    Mech Ageing Dev 126:71-7. 2005
    ....
  8. ncbi request reprint Aging and genome maintenance: lessons from the mouse?
    Paul Hasty
    Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Science 299:1355-9. 2003
    ..Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans...
  9. ncbi request reprint Aging. Genomic priorities in aging
    Paul Hasty
    Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Science 296:1250-1. 2002
  10. ncbi request reprint The impact energy metabolism and genome maintenance have on longevity and senescence: lessons from yeast to mammals
    P Hasty
    Department of Molecular Medicine, Institute of Biotechnology, The University of Texas, Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Mech Ageing Dev 122:1651-62. 2001
    ..In addition, sequence and functional similarities between Sir2 and other chromatin metabolism proteins present the possibility that genetic components for longevity and senescence are conserved from yeast to mammals...
  11. doi request reprint Deleting Ku70 is milder than deleting Ku80 in p53-mutant mice and cells
    H Li
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, 78245 3207, USA
    Oncogene 28:1875-8. 2009
    ..Thus, Ku80 may function outside the Ku heterodimer to influence DNA damage repair presenting the possibility that Ku80 influenced the open coding ends in a manner that suppressed a cancer-causing translocation...
  12. ncbi request reprint Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs
    V B Holcomb
    The Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, The Institute of Biotechnology, San Antonio, TX 78245 3207, USA
    Oncogene 25:7159-65. 2006
    ..Our observations are the first to show that Ku80 suppresses cancer caused by nonspecific DNA damage and we present a novel mouse model for medulloblastoma...

Research Grants10

  1. Discovering TREX1 and TREX2 Function in Mammalian Cells and Mice
    EDWARD PAUL HASTY; Fiscal Year: 2010
    ..Completion of this proposal will greatly facilitate our understanding of TREX1 and TREX2 for maintaining genome stability and for preventingcancer. ..
  2. XRCC5 MUTANT MICE AND CELL LINES
    EDWARD HASTY; Fiscal Year: 1999
    ..Completion of these aims will significantly impact the way we think about the dynamic nature of DNA and may impact therapy for cancer and immune deficiency. ..
  3. Discovering TREX1 and TREX2 Function in Mammalian Cells and Mice
    EDWARD HASTY; Fiscal Year: 2009
    ..Completion of this proposal will greatly facilitate our understanding of TREX1 and TREX2 for maintaining genome stability and for preventingcancer. ..
  4. Discovering TREX1 and TREX2 Function in Mammalian Cells and Mice
    EDWARD HASTY; Fiscal Year: 2007
    ..Completion of this proposal will greatly facilitate our understanding of TREX1 and TREX2 for maintaining genome stability and for preventing cancer. ..
  5. Investigation of xrcc5 Mutant Mice
    EDWARD HASTY; Fiscal Year: 2005
    ..The role of the tumor suppression protein, p53, will be analyzed for its impact on oncogenesis in ku80-mutant mice with specific attention given to mammary tissue in a defined mouse model. ..
  6. Investigation of xrcc5 Mutant Mice
    EDWARD HASTY; Fiscal Year: 2004
    ..The role of the tumor suppression protein, p53, will be analyzed for its impact on oncogenesis in ku80-mutant mice with specific attention given to mammary tissue in a defined mouse model. ..
  7. Investigation of xrcc5 Mutant Mice
    EDWARD HASTY; Fiscal Year: 2003
    ..The role of the tumor suppression protein, p53, will be analyzed for its impact on oncogenesis in ku80-mutant mice with specific attention given to mammary tissue in a defined mouse model. ..
  8. Investigation of xrcc5 Mutant Mice
    EDWARD HASTY; Fiscal Year: 2002
    ..The role of the tumor suppression protein, p53, will be analyzed for its impact on oncogenesis in ku80-mutant mice with specific attention given to mammary tissue in a defined mouse model. ..