T Hasson

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Molecular motors: sensing a function for myosin-VIIa
    T Hasson
    Department of Biology, University of California at San Diego, La Jolla, 92093 0368, USA
    Curr Biol 9:R838-41. 1999
  2. pmc Myo6 facilitates the translocation of endocytic vesicles from cell peripheries
    Laura Aschenbrenner
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA
    Mol Biol Cell 14:2728-43. 2003
  3. ncbi request reprint Myosin VI: two distinct roles in endocytosis
    Tama Hasson
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California at San Diego, 2129 Bonner Hall, MC 0368, 9500 Gilman Drive, La Jolla, CA 92093 0368, USA
    J Cell Sci 116:3453-61. 2003
  4. pmc Uncoated endocytic vesicles require the unconventional myosin, Myo6, for rapid transport through actin barriers
    Laura Aschenbrenner
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA
    Mol Biol Cell 15:2253-63. 2004
  5. ncbi request reprint Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator
    Agnieszka Swiatecka-Urban
    Dartmouth Medical School, Department of Physiology, Hanover, New Hampshire 03755, USA
    J Biol Chem 279:38025-31. 2004
  6. ncbi request reprint Mechanisms of motor protein reversal
    T Hasson
    Section of Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, California 92093 0368, USA
    Curr Opin Cell Biol 13:29-35. 2001
  7. ncbi request reprint Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression
    T Hasson
    Department of Biology, Yale University, New Haven, Connecticut 06520, USA
    Cell Motil Cytoskeleton 37:127-38. 1997
  8. pmc Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles
    Samia N Naccache
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 103:12735-40. 2006
  9. pmc Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B
    T Hasson
    Department of Biology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 92:9815-9. 1995
  10. ncbi request reprint Regulation of myosin-VI targeting to endocytic compartments
    Amber L Dance
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA
    Traffic 5:798-813. 2004

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Molecular motors: sensing a function for myosin-VIIa
    T Hasson
    Department of Biology, University of California at San Diego, La Jolla, 92093 0368, USA
    Curr Biol 9:R838-41. 1999
    ..Mutation of the Dictyostelium myosin-VII gene has now revealed a role for this unconventional myosin in phagocytic events, providing a possible clue to the role of mammalian myosin-VIIa in the inner ear and retina...
  2. pmc Myo6 facilitates the translocation of endocytic vesicles from cell peripheries
    Laura Aschenbrenner
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA
    Mol Biol Cell 14:2728-43. 2003
    ....
  3. ncbi request reprint Myosin VI: two distinct roles in endocytosis
    Tama Hasson
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California at San Diego, 2129 Bonner Hall, MC 0368, 9500 Gilman Drive, La Jolla, CA 92093 0368, USA
    J Cell Sci 116:3453-61. 2003
    ..Three distinct adapter proteins--GIPC, Dab2 and SAP97--that associate with the cargo-binding tail domain of myosin VI have been identified. These proteins may recruit myosin VI to its sites of action...
  4. pmc Uncoated endocytic vesicles require the unconventional myosin, Myo6, for rapid transport through actin barriers
    Laura Aschenbrenner
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA
    Mol Biol Cell 15:2253-63. 2004
    ..Therefore actin is a physical barrier impeding uncoated vesicle trafficking, and myo6 is recruited to move the vesicles through this barrier for fusion with the early endosome...
  5. ncbi request reprint Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator
    Agnieszka Swiatecka-Urban
    Dartmouth Medical School, Department of Physiology, Hanover, New Hampshire 03755, USA
    J Biol Chem 279:38025-31. 2004
    ..CFTR endocytosis was decreased by cytochalasin D, an actin-filament depolymerizing agent. Taken together, these data indicate that myosin VI and Dab2 facilitate CFTR endocytosis by a mechanism that requires actin filaments...
  6. ncbi request reprint Mechanisms of motor protein reversal
    T Hasson
    Section of Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, California 92093 0368, USA
    Curr Opin Cell Biol 13:29-35. 2001
    ....
  7. ncbi request reprint Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression
    T Hasson
    Department of Biology, Yale University, New Haven, Connecticut 06520, USA
    Cell Motil Cytoskeleton 37:127-38. 1997
    ..On the basis of these results, we propose that the mutations in myosin-VIIa in the sh1 alleles leads to both motor dysfunction and to a protein destabilization phenotype...
  8. pmc Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles
    Samia N Naccache
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 103:12735-40. 2006
    ....
  9. pmc Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B
    T Hasson
    Department of Biology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 92:9815-9. 1995
    ....
  10. ncbi request reprint Regulation of myosin-VI targeting to endocytic compartments
    Amber L Dance
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA
    Traffic 5:798-813. 2004
    ..Instead, our data suggest that myosin-VI recruitment to clathrin-coated pits may be an early step in the recruitment of GIPC to the vesicle surface...
  11. pmc Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism
    Michaella Velichkova
    University of California at San Diego, Division of Biological Sciences, Section of Cell and Developmental Biology, 2129 Bonner Hall, MC 0368, 9500 Gilman Drive, La Jolla, CA 92093 0368, USA
    Mol Cell Biol 25:4501-13. 2005
    ..Oxidative stress inactivates Keap1's NES, allowing entry of both Keap1 and Nrf2 into the nucleus and transcriptional transactivation of ARE genes...
  12. ncbi request reprint Keap1 in adhesion complexes
    Michaella Velichkova
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093 0368, USA
    Cell Motil Cytoskeleton 56:109-19. 2003
    ..As Keap1 homologues are actin-bundling proteins, we hypothesize that Keap1's function is to bundle F-actin within these diverse types of cell adhesion components...
  13. ncbi request reprint A human homologue of Drosophila kelch associates with myosin-VIIa in specialized adhesion junctions
    Michaella Velichkova
    Division of Biology, Section of Cell and Developmental Biology, University of California at San Diego, La Jolla 92093, USA
    Cell Motil Cytoskeleton 51:147-64. 2002
    ..Keap1 and myosin-VIIa overlapped in expression in the inner hair cells of the cochlea, suggesting that Keap1 may be a part of a family of actin-binding proteins that could be important for myosin-VIIa function in testis and inner ear...
  14. ncbi request reprint Vertebrate unconventional myosins
    T Hasson
    Department of Biology, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 271:16431-4. 1996
  15. ncbi request reprint The growing family of myosin motors and their role in neurons and sensory cells
    T Hasson
    Department of Biology, Yale University 266 Whitney Avenue, Room 342, Kline Biology Tower, New Haven, Connecticut 06520, USA
    Curr Opin Neurobiol 7:615-23. 1997
    ..In the past few years, this premise has been supported by genetic evidence that has shown that unconventional myosins are essential for the proper functioning of neurons, retina and the sensory cells of the inner ear...
  16. ncbi request reprint Myosin VI altered at threonine 406 stabilizes actin filaments in vivo
    Samia N Naccache
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA
    Cell Motil Cytoskeleton 63:633-45. 2006
    ..Our study suggests that phosphorylation at T406 changes the nature of myosin VI's interaction with actin in vivo...
  17. ncbi request reprint Expression of myosin VI within the early endocytic pathway in adult and developing proximal tubules
    Daniel Biemesderfer
    Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut 06520 8029, USA
    Am J Physiol Renal Physiol 282:F785-94. 2002
    ..These studies support a model for myosin VI function in the endocytic process of the proximal tubule...
  18. pmc Precise positioning of myosin VI on endocytic vesicles in vivo
    David Altman
    Department of Biochemistry, Stanford University Medical Center, Stanford, California, United States of America
    PLoS Biol 5:e210. 2007
    ..Our results are therefore consistent with vesicle-associated myosin VI existing as a processive dimer, capable of its known trafficking function...
  19. pmc Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells
    Mathias Senften
    Department of Cell Biology, The Scripps Research Institute, Institute for Childhood and Neglected Disease, La Jolla, California 92037, USA
    J Neurosci 26:2060-71. 2006
    ..Together, our findings suggest that PCDH15 and MYO7A cooperate to regulate the development and function of the mechanically sensitive hair bundle...
  20. pmc The unconventional myosin-VIIa associates with lysosomes
    Lily E Soni
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093 0368, USA
    Cell Motil Cytoskeleton 62:13-26. 2005
    ..Myosin-VIIa copurified with lysosomes on density gradients, and fractionation and extraction experiments suggested that it was tightly associated with the lysosome surface. These studies suggest that myosin-VIIa is a lysosome motor...
  21. pmc A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells
    Ronna Hertzano
    Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel
    PLoS Genet 4:e1000207. 2008
    ....