DANIEL HASSETT

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Catalase (KatA) plays a role in protection against anaerobic nitric oxide in Pseudomonas aeruginosa
    Shengchang Su
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e91813. 2014
  2. doi request reprint Chronic obstructive pulmonary disease (COPD): evaluation from clinical, immunological and bacterial pathogenesis perspectives
    Daniel J Hassett
    Departments of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA
    J Microbiol 52:211-26. 2014
  3. doi request reprint Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies
    Daniel J Hassett
    University of Cincinnati College of Medicine, Department of Molecular Genetics, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
    Expert Opin Ther Targets 14:117-30. 2010
  4. ncbi request reprint Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets
    Daniel J Hassett
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
    Adv Drug Deliv Rev 54:1425-43. 2002
  5. ncbi request reprint Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide
    D J Hassett
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Mol Microbiol 34:1082-93. 1999
  6. ncbi request reprint Bactericidal antibiotics and oxidative stress: a radical proposal
    Daniel J Hassett
    Department of Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45221, USA
    ACS Chem Biol 2:708-10. 2007
  7. pmc Hydrogen peroxide sensitivity of catechol-2,3-dioxygenase: a cautionary note on use of xylE reporter fusions under aerobic conditions
    D J Hassett
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Appl Environ Microbiol 66:4119-23. 2000
  8. pmc A protease-resistant catalase, KatA, released upon cell lysis during stationary phase is essential for aerobic survival of a Pseudomonas aeruginosa oxyR mutant at low cell densities
    D J Hassett
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Bacteriol 182:4557-63. 2000
  9. doi request reprint Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways
    Daniel J Hassett
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Trends Microbiol 17:130-8. 2009
  10. pmc Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions
    Sang Sun Yoon
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Clin Invest 116:436-46. 2006

Research Grants

Collaborators

Detail Information

Publications41

  1. pmc Catalase (KatA) plays a role in protection against anaerobic nitric oxide in Pseudomonas aeruginosa
    Shengchang Su
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e91813. 2014
    ..We proposed that such protective effects of KatA may involve buffering of free NO when potentially toxic concentrations of NO are approached. ..
  2. doi request reprint Chronic obstructive pulmonary disease (COPD): evaluation from clinical, immunological and bacterial pathogenesis perspectives
    Daniel J Hassett
    Departments of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA
    J Microbiol 52:211-26. 2014
    ..We offer a non-conventional, biocidal treatment that may be effective for COPD airway infections as well as with combinations of current antibiotic regimens for more effective treatment outcomes and relief for patients with COPD. ..
  3. doi request reprint Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies
    Daniel J Hassett
    University of Cincinnati College of Medicine, Department of Molecular Genetics, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
    Expert Opin Ther Targets 14:117-30. 2010
    ..Better understanding of the mechanisms used by P. aeruginosa to circumvent host defenses and therapeutic intervention strategies is critical for advancing novel treatment strategies...
  4. ncbi request reprint Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets
    Daniel J Hassett
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
    Adv Drug Deliv Rev 54:1425-43. 2002
    ..aeruginosa for more effective treatment of chronic CF lung infections...
  5. ncbi request reprint Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide
    D J Hassett
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Mol Microbiol 34:1082-93. 1999
    ....
  6. ncbi request reprint Bactericidal antibiotics and oxidative stress: a radical proposal
    Daniel J Hassett
    Department of Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45221, USA
    ACS Chem Biol 2:708-10. 2007
    ..This proposal represents an abrupt departure from conventional models, and it will attract further experimental tests...
  7. pmc Hydrogen peroxide sensitivity of catechol-2,3-dioxygenase: a cautionary note on use of xylE reporter fusions under aerobic conditions
    D J Hassett
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Appl Environ Microbiol 66:4119-23. 2000
    ..Our results suggest using caution in interpreting data derived from xylE reporter fusions under aerobic conditions, especially where oxidative stress is present or when catalase-deficient strains are used...
  8. pmc A protease-resistant catalase, KatA, released upon cell lysis during stationary phase is essential for aerobic survival of a Pseudomonas aeruginosa oxyR mutant at low cell densities
    D J Hassett
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Bacteriol 182:4557-63. 2000
    ..Taken together, our results indicate that inactivation of OxyR renders P. aeruginosa exquisitely sensitive to both H(2)O(2) and aminoglycosides, which are clinically and environmentally important antimicrobials...
  9. doi request reprint Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways
    Daniel J Hassett
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Trends Microbiol 17:130-8. 2009
    ..Mutants lacking these factors might be uniquely susceptible to nitrogen oxide, specifically the nitrite anion (NO(2)(-)), in the treatment of P. aeruginosa airway infections in CF...
  10. pmc Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions
    Sang Sun Yoon
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Clin Invest 116:436-46. 2006
    ..In summary, selective killing by HNO2 may provide novel insights into the important clinical goal of eradicating mucoid P. aeruginosa from the CF airways...
  11. pmc Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration
    Sang Sun Yoon
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    EMBO J 26:3662-72. 2007
    ..These data suggest that protection of a P. aeruginosa norCB mutant against anaerobic NO toxicity occurs by both control of NO supply and reassignment of metabolic enzymes to the task of NO sequestration...
  12. pmc Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice
    Gee W Lau
    Division of Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, MSB 6006, Cincinnati, OH 45267 0564, USA
    Infect Immun 72:4275-8. 2004
    ..Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection...
  13. ncbi request reprint Chronic Pseudomonas aeruginosa infection in cystic fibrosis airway disease: metabolic changes that unravel novel drug targets
    Sang Sun Yoon
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH 45267 0524, USA
    Expert Rev Anti Infect Ther 2:611-23. 2004
    ..Finally, a new hypothesis, that P. aeruginosa thrives as biofilms within the thickened anaerobic mucus layers, will be developed...
  14. pmc Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis
    Charles C Caldwell
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Am J Pathol 175:2473-88. 2009
    ..In summary, this study establishes that PCN is an important P. aeruginosa virulence factor capable of directly inducing pulmonary pathophysiology in mice, consistent with changes observed in CF and other bronchiectasis lungs...
  15. ncbi request reprint Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis
    Sang Sun Yoon
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Dev Cell 3:593-603. 2002
    ..Thus, future investigations of CF pathogenesis and therapy should include a better understanding of anaerobic metabolism and biofilm development by P. aeruginosa...
  16. ncbi request reprint Modulation of lung epithelial functions by Pseudomonas aeruginosa
    Gee W Lau
    Department of Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0557, USA
    Trends Microbiol 13:389-97. 2005
    ..Understanding the complex interactions between the lung epithelium and P. aeruginosa might enable more effective therapeutic strategies against infection in cystic fibrosis and immuno-compromised individuals...
  17. pmc Pseudomonas aeruginosa OxyR is required for full virulence in rodent and insect models of infection and for resistance to human neutrophils
    Gee W Lau
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    Infect Immun 73:2550-3. 2005
  18. ncbi request reprint The role of pyocyanin in Pseudomonas aeruginosa infection
    Gee W Lau
    Division of Pulmonary and Critical Care Medicine, and Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0564, USA
    Trends Mol Med 10:599-606. 2004
    ..aeruginosa during infection. In addition, few cellular pathways that are affected by PCN are known. This review briefly highlights recent advances that might clarify the role of PCN in P. aeruginosa pathogenesis...
  19. pmc The peptidoglycan-associated lipoprotein OprL helps protect a Pseudomonas aeruginosa mutant devoid of the transactivator OxyR from hydrogen peroxide-mediated killing during planktonic and biofilm culture
    Warunya Panmanee
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
    J Bacteriol 190:3658-69. 2008
    ....
  20. pmc NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection
    Scott C Wesselkamper
    Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 181:5481-9. 2008
    ..aeruginosa respiratory infection...
  21. ncbi request reprint Differential roles of OxyR-controlled antioxidant enzymes alkyl hydroperoxide reductase (AhpCF) and catalase (KatB) in the protection of Pseudomonas aeruginosa against hydrogen peroxide in biofilm vs. planktonic culture
    Warunya Panmanee
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    FEMS Microbiol Lett 295:238-44. 2009
    ..planktonic culture upon exposure to hydrogen peroxide. AhpCF was found to be critical for survival of biofilm bacteria while KatB was more important for survival of planktonic free-swimming organisms...
  22. pmc Human targets of Pseudomonas aeruginosa pyocyanin
    Huimin Ran
    Division of Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0564, USA
    Proc Natl Acad Sci U S A 100:14315-20. 2003
    ..We discuss how the inactivation of V-ATPase may negatively impact the lung function of cystic fibrosis patients...
  23. ncbi request reprint Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vacuolar ATPase-dependent cystic fibrosis transmembrane conductance regulator expression and localization
    Fansheng Kong
    Division of Pulmonary and Critical Care Medicine, Cincinnati Children s Hospital, Cincinnati, OH, USA
    Cell Microbiol 8:1121-33. 2006
    ..Our study supports the notion that PCN contributes significantly to the pathogenesis of CF and other bronchiectasis patients infected by PA...
  24. pmc A zinc-dependent adhesion module is responsible for intercellular adhesion in staphylococcal biofilms
    Deborah G Conrady
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    Proc Natl Acad Sci U S A 105:19456-61. 2008
    ..Zn(2+) chelation represents a potential therapeutic approach for combating biofilm growth in a wide range of bacterial biofilm-related infections...
  25. pmc Global analysis of cellular factors and responses involved in Pseudomonas aeruginosa resistance to arsenite
    Kislay Parvatiyar
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH 45267 0524, USA
    J Bacteriol 187:4853-64. 2005
    ..SOD appears to be involved, but its function may be in the protection of superoxide-sensitive sulfhydryl groups...
  26. pmc Gallium disrupts iron uptake by intracellular and extracellular Francisella strains and exhibits therapeutic efficacy in a murine pulmonary infection model
    Oyebode Olakanmi
    Medical Service, VA Medical Center Cincinnati, Cincinnati, Ohio 45220, USA
    Antimicrob Agents Chemother 54:244-53. 2010
    ..These data support the potential utility of Ga as a therapy for F. tularensis infection of the lung...
  27. ncbi request reprint The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-gamma-mediated macrophage killing
    Jeff G Leid
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA
    J Immunol 175:7512-8. 2005
    ..aeruginosa biofilm bacteria from the human immune system...
  28. pmc Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa
    Nicolas Barraud
    School of Biotechnology and Biomolecular Sciences and Centre for Marine Biofouling and Bio Innovation, Biological Sciences Building, University of New South Wales, Kensington, Sydney, NSW 2052, Australia
    J Bacteriol 188:7344-53. 2006
    ..aeruginosa biofilms from a glass surface. Combined exposure to both NO and antimicrobial agents may therefore offer a novel strategy to control preestablished, persistent P. aeruginosa biofilms and biofilm-related infections...
  29. ncbi request reprint Static growth of mucoid Pseudomonas aeruginosa selects for non-mucoid variants that have acquired flagellum-dependent motility
    Timna J O Wyckoff
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1064, USA
    Microbiology 148:3423-30. 2002
    ..This may afford P. aeruginosa the ability to swim towards areas of higher oxygen concentrations. Subsequent to this, algT mutations are likely to secure the motile phenotype...
  30. pmc Transcriptome analysis of Pseudomonas aeruginosa after interaction with human airway epithelial cells
    Anders Frisk
    Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Louisiana Center for Lung Biology and Immunotherapy, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Infect Immun 72:5433-8. 2004
    ..Gene expression profiles indicated that various genes involved in phosphate acquisition and iron scavenging were differentially regulated...
  31. pmc The transcriptional regulator AlgR controls cyanide production in Pseudomonas aeruginosa
    Alexander J Carterson
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112 2699, USA
    J Bacteriol 186:6837-44. 2004
    ..aeruginosa CF isolates are more hypercyanogenic than nonmucoid laboratory strains. Taken together, cyanide production may be a relevant virulence factor in CF lung disease, the production of which is regulated, in part, by AlgR...
  32. pmc Proteomic, microarray, and signature-tagged mutagenesis analyses of anaerobic Pseudomonas aeruginosa at pH 6.5, likely representing chronic, late-stage cystic fibrosis airway conditions
    Mark D Platt
    Department of Chemistry, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    J Bacteriol 190:2739-58. 2008
    ..aeruginosa to limit the growth of this important CF pathogen when it is either limited or completely restricted in its oxygen supply...
  33. pmc Pseudomonas aeruginosa AlgR represses the Rhl quorum-sensing system in a biofilm-specific manner
    Lisa A Morici
    Tulane University Health Sciences Center, Department of Microbiology and Immunology, New Orleans, LA 70112, USA
    J Bacteriol 189:7752-64. 2007
    ..These data also suggest that AlgR may control transcription in a contact-dependent or biofilm-specific manner...
  34. ncbi request reprint The mobA gene is required for assimilatory and respiratory nitrate reduction but not xanthine dehydrogenase activity in Pseudomonas aeruginosa
    Chris Noriega
    Department of Biology, University of Dayton, Dayton, OH 45469, USA
    Curr Microbiol 51:419-24. 2005
    ....
  35. pmc BdlA, a chemotaxis regulator essential for biofilm dispersion in Pseudomonas aeruginosa
    Ryan Morgan
    Department of Biological Sciences, Binghamton University, SUNY at Binghamton, 104 Science III, NY 13902, USA
    J Bacteriol 188:7335-43. 2006
    ..Our findings suggest that BdlA may be a link between sensing environmental cues, c-di-GMP levels, and detachment. Based on our findings, a possible involvement of BdlA in a signaling cascade resulting in biofilm dispersion is discussed...
  36. ncbi request reprint Subinhibitory bismuth-thiols reduce virulence of Pseudomonas aeruginosa
    Chieh Liang Wu
    CardioPulmonary Research Institute, Division of Pulmonary and Critical Care Medicine, Winthrop University Hospital, SUNY School of Medicine at Stony Brook, Mineola, New York 11501, USA
    Am J Respir Cell Mol Biol 26:731-8. 2002
    ..In summary, low BT concentrations affect P. aeruginosa in a variety of ways, the combination of which may help prevent or resolve respiratory tract infection...
  37. pmc A Na+:H+ antiporter and a molybdate transporter are essential for arsenite oxidation in Agrobacterium tumefaciens
    Des R Kashyap
    Department of Land Resources and Environmental Sciences, Montana State University, Bozeman, Montana 59717, USA
    J Bacteriol 188:1577-84. 2006
    ..In each mutant, the loss of As(III)-oxidizing capacity resulted in conversion to an arsenate [As(V)]-reducing phenotype. Neither mutant was more sensitive to As(III) than the parental strain...
  38. ncbi request reprint Bacterial biofilms of importance to medicine and bioterrorism: proteomic techniques to identify novel vaccine components and drug targets
    Daniel J Hassett
    Expert Opin Biol Ther 3:1201-7. 2003
    ..The other is referred to as persistent 'bioterrorist agent biofilms' in which Francisella tularensis can grow on surfaces where environmental amoeba can phagocytose them, allowing for growth of F. tularensis within the amoebae...
  39. ncbi request reprint The Pseudomonas aeruginosa type IV pilin receptor binding domain functions as an adhesin for both biotic and abiotic surfaces
    Carmen L Giltner
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Mol Microbiol 59:1083-96. 2006
    ..Therefore, the C-terminal receptor binding domain appears to have evolved for binding a variety of surfaces...
  40. pmc MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival
    Crystal M Lauriano
    Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Proc Natl Acad Sci U S A 101:4246-9. 2004
    ..Thus, MglA regulates the transcription of virulence factors of F. tularensis that contribute to intramacrophage and intraamoebae survival...
  41. pmc Cytotoxicity of Pseudomonas secreted exotoxins requires OxyR expression
    Kurt A Melstrom
    Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Surg Res 143:50-7. 2007
    ..Pseudomonas aeruginosa combats host-initiated oxidant stress through expression of the transactivating factor, OxyR. Here we have tested the premise that OxyR regulates Pseudomonal cytotoxicity through secreted exotoxin production...

Research Grants11

  1. Role of OxyR in P. aeruginosa Biofilm Resistance to H202
    DANIEL HASSETT; Fiscal Year: 2006
    ....
  2. Role of OxyR in P. aeruginosa Biofilm Resistance to H202
    DANIEL HASSETT; Fiscal Year: 2005
    ....
  3. Role of OxyR in P. aeruginosa Biofilm Resistance to H202
    DANIEL HASSETT; Fiscal Year: 2004
    ....
  4. B.pseudomallei bioterrorism and quorum sensing
    DANIEL HASSETT; Fiscal Year: 2003
    ..These studies will provide important information that will lead to countermeasures against a potential bioterrorist attack using the potentially lethal gram-negative bacterium, B. pseudomallei. ..
  5. Proteogenome of Anaerobic P. aeruginosa in CF Mucus
    DANIEL HASSETT; Fiscal Year: 2003
    ..Our LONG TERM GOAL is to identify cellular targets that inhibit or significantly compromise the denitrification process that is occurring by P. aeruginosa in the CF airways. ..
  6. IRON, FUR AND ALGINATE PRODUCTION IN P AERUGINOSA
    DANIEL HASSETT; Fiscal Year: 2002
    ..Information derived from the studies proposed herein will advance the current knowledge about the role of these factors in the pathogenesis of P. aeruginosa infections in CF. ..
  7. IRON, FUR AND ALGINATE PRODUCTION IN P AERUGINOSA
    DANIEL HASSETT; Fiscal Year: 2001
    ..Information derived from the studies proposed herein will advance the current knowledge about the role of these factors in the pathogenesis of P. aeruginosa infections in CF. ..
  8. IRON, FUR AND ALGINATE PRODUCTION IN P AERUGINOSA
    DANIEL HASSETT; Fiscal Year: 2000
    ..Information derived from the studies proposed herein will advance the current knowledge about the role of these factors in the pathogenesis of P. aeruginosa infections in CF. ..
  9. IRON, FUR AND ALGINATE PRODUCTION IN P AERUGINOSA
    DANIEL HASSETT; Fiscal Year: 1999
    ..Information derived from the studies proposed herein will advance the current knowledge about the role of these factors in the pathogenesis of P. aeruginosa infections in CF. ..
  10. Role of OxyR in P. aeruginosa Biofilm Resistance to H202
    DANIEL HASSETT; Fiscal Year: 2007
    ....