W L Hasler

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint The irritable bowel syndrome during pregnancy
    William L Hasler
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI, USA
    Gastroenterol Clin North Am 32:385-406, viii. 2003
  2. ncbi request reprint Emerging drugs for the treatment of gastroparesis
    William L Hasler
    University of Michigan Health System, Division of Gastroenterology, 3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109, USA 1 734 936 4780 1 734 936 7392
    Expert Opin Emerg Drugs 19:261-79. 2014
  3. doi request reprint Pathology of emesis: its autonomic basis
    William L Hasler
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA Electronic address
    Handb Clin Neurol 117:337-52. 2013
  4. ncbi request reprint Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting
    W L Hasler
    University of Michigan, Ann Arbor, Michigan, USA
    Neurogastroenterol Motil 25:427-38, e300-1. 2013
  5. doi request reprint Gastroparesis
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Curr Opin Gastroenterol 28:621-8. 2012
  6. pmc Gastroparesis--current concepts and considerations
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Medscape J Med 10:16. 2008
  7. ncbi request reprint Gastroparesis: symptoms, evaluation, and treatment
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, University of Michigan Hospital, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109, USA
    Gastroenterol Clin North Am 36:619-47, ix. 2007
  8. ncbi request reprint Type 1 diabetes and gastroparesis: diagnosis and treatment
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109, USA
    Curr Gastroenterol Rep 9:261-9. 2007
  9. ncbi request reprint Irritable bowel syndrome and bloating
    William L Hasler
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48170, USA
    Best Pract Res Clin Gastroenterol 21:689-707. 2007
  10. ncbi request reprint Nausea, gastroparesis, and aerophagia
    William L Hasler
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Clin Gastroenterol 39:S223-9. 2005

Detail Information

Publications48

  1. ncbi request reprint The irritable bowel syndrome during pregnancy
    William L Hasler
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI, USA
    Gastroenterol Clin North Am 32:385-406, viii. 2003
    ..Nine percent to 22% of the population report symptoms consistent with IBS. IBS is the most prevalent digestive disease, representing 12% of visits to primary care physicians and 28% of referrals to gastroenterologists...
  2. ncbi request reprint Emerging drugs for the treatment of gastroparesis
    William L Hasler
    University of Michigan Health System, Division of Gastroenterology, 3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109, USA 1 734 936 4780 1 734 936 7392
    Expert Opin Emerg Drugs 19:261-79. 2014
    ....
  3. doi request reprint Pathology of emesis: its autonomic basis
    William L Hasler
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA Electronic address
    Handb Clin Neurol 117:337-52. 2013
    ..Likewise, non-medication therapies may act in part via modulation of some of these same autonomic pathways. ..
  4. ncbi request reprint Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting
    W L Hasler
    University of Michigan, Ann Arbor, Michigan, USA
    Neurogastroenterol Motil 25:427-38, e300-1. 2013
    ..This study related pain to clinical factors in gastroparesis and contrasted pain/discomfort- with nausea/vomiting-predominant disease...
  5. doi request reprint Gastroparesis
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Curr Opin Gastroenterol 28:621-8. 2012
    ..This review provides updated information on gastroparesis focusing on new findings from the past few years...
  6. pmc Gastroparesis--current concepts and considerations
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Medscape J Med 10:16. 2008
  7. ncbi request reprint Gastroparesis: symptoms, evaluation, and treatment
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, University of Michigan Hospital, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109, USA
    Gastroenterol Clin North Am 36:619-47, ix. 2007
    ..Current therapies rely on dietary modifications, medications to stimulate gastric evacuation, and agents to reduce vomiting. Endoscopic and surgical options are increasingly used for cases refractory to medication treatment...
  8. ncbi request reprint Type 1 diabetes and gastroparesis: diagnosis and treatment
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109, USA
    Curr Gastroenterol Rep 9:261-9. 2007
    ..Current therapy relies on dietary modifications, medications to stimulate gastric evacuation, and agents to reduce vomiting. Endoscopic and surgical options are increasingly used in patients who are refractory to drug treatment...
  9. ncbi request reprint Irritable bowel syndrome and bloating
    William L Hasler
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48170, USA
    Best Pract Res Clin Gastroenterol 21:689-707. 2007
    ..Available therapies include lifestyle alterations, dietary modifications, enzyme preparations, adsorbents and agents which reduce surface tension, treatments that alter gut flora, and drugs that modulate gut transit...
  10. ncbi request reprint Nausea, gastroparesis, and aerophagia
    William L Hasler
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Clin Gastroenterol 39:S223-9. 2005
    ..There are no pharmaceutical remedies for this condition; thus, therapy relies on behavioral treatments...
  11. doi request reprint Differences in intragastric pH in diabetic vs. idiopathic gastroparesis: relation to degree of gastric retention
    William L Hasler
    Division of Gastroenterology, Univ of Michigan Health System, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1384-91. 2008
    ..those with mild delays. Thus both etiology and degree of gastric stasis determine gastric acidity in gastroparesis...
  12. doi request reprint Management of gastroparesis
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109, USA
    Expert Rev Gastroenterol Hepatol 2:411-23. 2008
    ..Future pharmaceuticals will target the contractile and nonmotor defects via novel pathways. Novel electrical stimulation techniques will be employed either alone or in combination with medications...
  13. doi request reprint Methods of gastric electrical stimulation and pacing: a review of their benefits and mechanisms of action in gastroparesis and obesity
    W L Hasler
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Neurogastroenterol Motil 21:229-43. 2009
    ..Current research is focusing on novel stimulation methods to better control symptoms in gastroparesis and promote weight reduction in morbid obesity...
  14. ncbi request reprint Serotonin and the GI tract
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Curr Gastroenterol Rep 11:383-91. 2009
    ..Novel agents are in testing, which may exhibit efficacy without significant toxicity...
  15. doi request reprint Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS
    William L Hasler
    University of Michigan Health System, Ann Arbor, Michigan, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1107-14. 2009
    ..Constipated patients with normal or moderately delayed transit show increased motor activity that is partly explained by IBS. These findings emphasize differential effects on transit and motility in different constipation subtypes...
  16. pmc Psychological dysfunction is associated with symptom severity but not disease etiology or degree of gastric retention in patients with gastroparesis
    William L Hasler
    Department of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Gastroenterol 105:2357-67. 2010
    ..Gastroparesis patients may have associated psychological distress. This study aimed to measure depression and anxiety in gastroparesis in relation to disease severity, etiology, and gastric retention...
  17. pmc Bloating in gastroparesis: severity, impact, and associated factors
    William L Hasler
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Gastroenterol 106:1492-502. 2011
    ..We aimed to quantify the prevalence of bloating in gastroparesis and relate its severity to clinical factors and quality of life...
  18. doi request reprint Gastroparesis: pathogenesis, diagnosis and management
    William L Hasler
    Division of Gastroenterology, University of Michigan Hospital, 3912 Taubman Center, Ann Arbor, MI 5362, USA
    Nat Rev Gastroenterol Hepatol 8:438-53. 2011
    ..The natural history of this condition is poorly understood. Active ongoing research is providing important insights into the pathogenesis, diagnosis, treatment and outcomes of this disease...
  19. ncbi request reprint Safety profile of tegaserod, a 5-HT4 receptor agonist, for the treatment of irritable bowel syndrome
    William L Hasler
    Division of Gastroenterology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Drug Saf 27:619-31. 2004
    ..Diarrhoea is the most common adverse event associated with tegaserod use. Continued post-US marketing surveillance will further define the safety and tolerability profile of tegaserod...
  20. ncbi request reprint Systematic review: Abdominal and pelvic surgery in patients with irritable bowel syndrome
    W L Hasler
    Division of Gastroenterology, University of Michigan School of Medicine, Ann Arbor, 48109, USA
    Aliment Pharmacol Ther 17:997-1005. 2003
    ..To systematically review research on the prevalence of abdominal and pelvic surgery in patients with irritable bowel syndrome...
  21. ncbi request reprint The irritable bowel syndrome
    William L Hasler
    Division of Gastroenterology, Department of Medicine, University of Michigan Medical Center, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109, USA
    Med Clin North Am 86:1525-51. 2002
    ..Therapeutic options include dietary modifications, counseling, medications, and psychologic treatments. Novel therapies are being investigated to correct potentially pathogenetic peripheral and CNS abnormalities in IBS...
  22. ncbi request reprint Pharmacotherapy for intestinal motor and sensory disorders
    William L Hasler
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109, USA
    Gastroenterol Clin North Am 32:707-32, viii-ix. 2003
    ..Finally, some patients may benefit from initiation of nonspecific therapies, which have no appreciable effect on gut motor or sensory function...
  23. doi request reprint Traditional thoughts on the pathophysiology of irritable bowel syndrome
    William L Hasler
    Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, 5362, Ann Arbor, MI 48109, USA
    Gastroenterol Clin North Am 40:21-43. 2011
    ..Contributions from psychosocial disturbances are observed in patients from tertiary centers and primary practice. Proof of causation of symptom genesis for most of these factors is limited...
  24. ncbi request reprint Effects of nutrients and serotonin 5-HT3 antagonism on symptoms evoked by distal gastric distension in humans
    U Ladabaum
    Division of Gastroenterology, Department of Internal Medicine, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 0362, USA
    Am J Physiol Gastrointest Liver Physiol 280:G201-8. 2001
    ..In conclusion, isobaric distal gastric distension produces more intense symptoms during duodenal lipid compared with saline perfusion. Symptom perception during distal gastric distension is unaffected by 5-HT3 receptor antagonism...
  25. ncbi request reprint Gastric distention correlates with activation of multiple cortical and subcortical regions
    U Ladabaum
    Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 120:369-76. 2001
    ..However, the cerebral loci that process sensory information from the stomach are unknown. The aim of this study was to localize the human brain regions that are activated by gastric distention...
  26. ncbi request reprint Impaired gastrocolonic response and peristaltic reflex in slow-transit constipation: role of 5-HT(3) pathways
    Einar S Björnsson
    Division of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, S 41345 Gothenburg, Sweden
    Am J Physiol Gastrointest Liver Physiol 283:G400-7. 2002
    ..Thus abnormalities of neural reflex modulation of colonic motor function may play pathophysiological roles in slow-transit constipation...
  27. ncbi request reprint Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. VI. Pathogenesis and therapeutic approaches to human gastric dysrhythmias
    Chung Owyang
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Physiol Gastrointest Liver Physiol 283:G8-15. 2002
    ..Finally direct gastric electrical stimulation using a surgically implanted neurostimulator has shown promise in reducing emesis in patients with gastroparesis and gastric dysrhythmias...
  28. ncbi request reprint Electrogastrography: a document prepared by the gastric section of the American Motility Society Clinical GI Motility Testing Task Force
    H P Parkman
    GI Section, Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA
    Neurogastroenterol Motil 15:89-102. 2003
    ..Proposed clinical indications for performance of EGG in patients with unexplained nausea, vomiting and dyspeptic symptoms must be validated by prospective controlled investigations...
  29. doi request reprint Coupling and propagation of normal and dysrhythmic gastric slow waves during acute hyperglycaemia in healthy humans
    R Coleski
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI, USA
    Neurogastroenterol Motil 21:492-9, e1-2. 2009
    ..Hyperglycaemia elicits isolated tachygastrias and uncoupling of normal slow waves that are most prominent distally. These findings provide a foundation for studying slow wave conduction defects in diabetic gastropathy...
  30. ncbi request reprint Nizatidine enhances the gastrocolonic response and the colonic peristaltic reflex in humans
    W M Sun
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Pharmacol Exp Ther 299:159-63. 2001
    ..Further research on the prokinetic action of nizatidine in the colon may lead to novel treatments for idiopathic constipation...
  31. ncbi request reprint Low- versus high-dose azithromycin triple therapy for Helicobacter pylori infection
    W D Chey
    Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Aliment Pharmacol Ther 12:1263-7. 1998
    ..We report a clinical trial which evaluated the effectiveness of triple therapy containing low- and high-dose azithromycin to treat Helicobacter pylori infection...
  32. ncbi request reprint Modulation of intestinal gas dynamics in healthy human volunteers by the 5-HT receptor agonist tegaserod
    Radoslav Coleski
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Am J Gastroenterol 101:1858-65. 2006
    ..We hypothesized that 5-HT4 activation by tegaserod stimulates gas transit in healthy individuals...
  33. ncbi request reprint Directed endoscopic mucosal mapping of normal and dysrhythmic gastric slow waves in healthy humans
    R Coleski
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Neurogastroenterol Motil 16:557-65. 2004
    ..This method provides insight into the mechanisms of action of gastric slow wave dysrhythmic stimuli...
  34. ncbi request reprint Nutrient modulation of intestinal gas dynamics in healthy humans: dependence on caloric content and meal consistency
    Sutep Gonlachanvit
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 291:G389-95. 2006
    ..Solids stimulate early postprandial gas dynamics to the same extent as liquid meals of similar caloric content. Thus modulatory effects of meals on intestinal gas transit depend on their caloric content but not their consistency...
  35. ncbi request reprint Ginger reduces hyperglycemia-evoked gastric dysrhythmias in healthy humans: possible role of endogenous prostaglandins
    Sutep Gonlachanvit
    Division of Gastroenterology, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109, USA
    J Pharmacol Exp Ther 307:1098-103. 2003
    ..These findings suggest novel mechanisms for the traditional Chinese herbal remedy ginger...
  36. ncbi request reprint Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipation
    Satish S C Rao
    Department of Medicine, University of Iowa, Iowa City, Iowa 52242 1009, USA
    Clin Gastroenterol Hepatol 7:537-44. 2009
    ..We assessed regional and CTT with the SmartPill (SmartPill Corporation, Buffalo, NY), a new wireless pH and pressure recording capsule, in constipated and healthy subjects and compared this with ROM...
  37. ncbi request reprint Nausea and vomiting
    William L Hasler
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, 48109, USA
    Gastroenterology 125:1860-7. 2003
  38. ncbi request reprint Selective reversal of hyperglycemia-evoked gastric myoelectric dysrhythmias by nitrergic stimulation in healthy humans
    Radoslav Coleski
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    J Pharmacol Exp Ther 312:103-11. 2005
    ..These findings are consistent with selective impairment of nitrergic function in this model of diabetic gastropathy and suggest that NO donors and other agents that increase NO activity may be useful for treating diabetic dysrhythmias...
  39. ncbi request reprint American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis
    Henry P Parkman
    Temple University School of Medicine, Philadelphia, PA, USA
    Gastroenterology 127:1592-622. 2004
    ..The paper was approved by the Committee on May 16, 2004, and by the AGA Governing Board on September 23, 2004...
  40. ncbi request reprint Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine
    Thomas L Abell
    Gastroenterology, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Gastroenterol 103:753-63. 2008
    ..Adoption of this standardized protocol will resolve the lack of uniformity of testing, add reliability and credibility to the results, and improve the clinical utility of the GE test...
  41. ncbi request reprint The stomach and weight reduction: the role of ghrelin
    William L Hasler
    Gastroenterology 124:575-7. 2003
  42. ncbi request reprint Gastric neurostimulation for gastroparesis: time to pick up the pace
    William L Hasler
    Gastroenterology 125:979-81; discussion 981. 2003
  43. ncbi request reprint Celiac sprue as a possible cause of symptoms in presumed irritable bowel syndrome
    William L Hasler
    Gastroenterology 122:2086-7. 2002
  44. ncbi request reprint Air apparent: studies of gas and bloating in IBS
    William L Hasler
    Gastroenterology 122:576-7; discussion 577-8. 2002
  45. ncbi request reprint American Gastroenterological Association medical position statement: diagnosis and treatment of gastroparesis
    Henry P Parkman
    Temple University School of Medicine, Philadelphia, PA, USA
    Gastroenterology 127:1589-91. 2004
    ..It was approved by the Clinical Practice Committee on May 16, 2004, and by the AGA Governing Board on September 23, 2004...
  46. ncbi request reprint Fecal flora in irritable bowel syndrome: characterization using molecular methods
    William L Hasler
    Gastroenterology 129:759-61. 2005
  47. ncbi request reprint Preventing postoperative nausea and vomiting: a comprehensive comparison of treatments
    William L Hasler
    Gastroenterology 128:509-10; author reply 510-1. 2005
  48. ncbi request reprint Lactulose breath testing, bacterial overgrowth, and IBS: just a lot of hot air?
    William L Hasler
    Gastroenterology 125:1898-900; discussion 1900. 2003