W L Hasler


Affiliation: University of Michigan
Country: USA


  1. Hasler W, Wilson L, Nguyen L, Snape W, Abell T, Koch K, et al. Opioid Use and Potency Are Associated With Clinical Features, Quality of Life, and Use of Resources in Patients With Gastroparesis. Clin Gastroenterol Hepatol. 2018;: pubmed publisher
    ..These findings form a basis for studies to characterize adverse outcomes of opioid use in patients with gastroparesis and to help identify those who might benefit from interventions to prevent opioid overuse. ..
  2. Hasler W. Gastroparesis: pathogenesis, diagnosis and management. Nat Rev Gastroenterol Hepatol. 2011;8:438-53 pubmed publisher
    ..The natural history of this condition is poorly understood. Active ongoing research is providing important insights into the pathogenesis, diagnosis, treatment and outcomes of this disease. ..
  3. Hasler W. Methods of gastric electrical stimulation and pacing: a review of their benefits and mechanisms of action in gastroparesis and obesity. Neurogastroenterol Motil. 2009;21:229-43 pubmed publisher
    ..Current research is focusing on novel stimulation methods to better control symptoms in gastroparesis and promote weight reduction in morbid obesity. ..
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    Hasler W. Gastroparesis: symptoms, evaluation, and treatment. Gastroenterol Clin North Am. 2007;36:619-47, ix pubmed
    ..Current therapies rely on dietary modifications, medications to stimulate gastric evacuation, and agents to reduce vomiting. Endoscopic and surgical options are increasingly used for cases refractory to medication treatment. ..
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    Hasler W, Schoenfeld P. Systematic review: Abdominal and pelvic surgery in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2003;17:997-1005 pubmed
  6. Hasler W. Gastroparesis--current concepts and considerations. Medscape J Med. 2008;10:16 pubmed
  7. Hasler W. Symptomatic management for gastroparesis: antiemetics, analgesics, and symptom modulators. Gastroenterol Clin North Am. 2015;44:113-26 pubmed publisher
    ..Neurologic and cardiac toxicities of these medications are recognized. Additional controlled study is warranted to define antiemetic, analgesic, and neuromodulator usefulness in gastroparesis. ..
  8. Hasler W, Wilson L, Parkman H, Nguyen L, Abell T, Koch K, et al. Bloating in gastroparesis: severity, impact, and associated factors. Am J Gastroenterol. 2011;106:1492-502 pubmed publisher
    ..Antiemetics, probiotics, and antidepressants with significant norepinephrine reuptake inhibitor activity may affect reports of bloating. These findings provide insight into this underappreciated symptom of gastroparesis. ..
  9. Hasler W, Li B, Koch K, Parkman H, Kovacic K, McCallum R. Methodologic considerations for studies of chronic nausea and vomiting in adults and children. Auton Neurosci. 2017;202:28-39 pubmed publisher

More Information


  1. Hasler W. Traditional thoughts on the pathophysiology of irritable bowel syndrome. Gastroenterol Clin North Am. 2011;40:21-43 pubmed publisher
    ..Contributions from psychosocial disturbances are observed in patients from tertiary centers and primary practice. Proof of causation of symptom genesis for most of these factors is limited. ..
  2. Hasler W. Newest Drugs for Chronic Unexplained Nausea and Vomiting. Curr Treat Options Gastroenterol. 2016;14:371-385 pubmed
    ..This current research may broaden the treatment options for refractory cases of unexplained nausea and vomiting. ..
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    Lee A, Hasler W. Opioids and GI Motility-Friend or Foe?. Curr Treat Options Gastroenterol. 2016;14:478-494 pubmed
    ..This chapter will review the pathophysiology of OBD, including OINV and OIC, and treatment options available. ..
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    Hasler W. Nausea, gastroparesis, and aerophagia. J Clin Gastroenterol. 2005;39:S223-9 pubmed
    ..There are no pharmaceutical remedies for this condition; thus, therapy relies on behavioral treatments...
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    Hasler W. The irritable bowel syndrome. Med Clin North Am. 2002;86:1525-51 pubmed
    ..Therapeutic options include dietary modifications, counseling, medications, and psychologic treatments. Novel therapies are being investigated to correct potentially pathogenetic peripheral and CNS abnormalities in IBS...
  6. Hasler W, Wilson L, Parkman H, Koch K, Abell T, Nguyen L, et al. Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting. Neurogastroenterol Motil. 2013;25:427-38, e300-1 pubmed publisher
    ..This study related pain to clinical factors in gastroparesis and contrasted pain/discomfort- with nausea/vomiting-predominant disease...
  7. Coleski R, Baker J, Hasler W. Endoscopic Gastric Food Retention in Relation to Scintigraphic Gastric Emptying Delays and Clinical Factors. Dig Dis Sci. 2016;61:2593-601 pubmed publisher
    ..Gastric emptying delays correlate with amounts of retained food on endoscopy. Retention is influenced by opiates, but not other medications. These analyses delineate pathogenic factors promoting gastric food retention. ..
  8. Lee A, Hasler W. Diabetes and the Stomach. Curr Treat Options Gastroenterol. 2017;15:441-459 pubmed publisher
    ..This article will review the pathophysiology, new insights into disease mechanism, and treatment options for diabetic gastroparesis. ..