Research Topics
| Jeffrey HasdaySummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
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Detail Information
Publications
Febrile-range hyperthermia augments neutrophil accumulation and enhances lung injury in experimental gram-negative bacterial pneumoniaPenelope Rice
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Immunol 174:3676-85. 2005..The ultimate effect of FRH is determined by the balance between accelerated pathogen clearance and collateral tissue injury, which is determined, in part, by the site of infection...
Hyperthermia promotes and prevents respiratory epithelial apoptosis through distinct mechanismsAshish Nagarsekar
Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Am J Respir Cell Mol Biol 47:824-33. 2012..Thus, depending on the temperature and timing relative to death receptor activation, hyperthermia can exert pro- and antiapoptotic effects through distinct mechanisms...- Febrile-range hyperthermia modifies endothelial and neutrophilic functions to promote extravasationMohan E Tulapurkar
Division of Pulmonary and Critical Care, Department of Medicine, School of Medicine, University of Maryland, 20 Penn St, Baltimore, MD 21201, USA
Am J Respir Cell Mol Biol 46:807-14. 2012.... - Bacterial endotoxin is an active component of cigarette smokeJ D Hasday
Division of Pulmonary and Critical Care Medicine, University of Maryland Medical School, Baltimore, USA
Chest 115:829-35. 1999..Experimental LPS inhalation mimics many of the acute effects of cigarette smoke in the lower airway. Therefore, we reasoned that LPS may be a biologically active component of cigarette smoke... - Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmaticsJ D Hasday
Pulmonary and Critical Care Division of the Department of Medicine, Center for Genetics of Asthma and Complex Diseases, University of Maryland Medical School, The Medical Service of the Baltimore VA Medical Center, 21201, USA
Am J Respir Crit Care Med 161:1229-36. 2000..These data suggest that leukotriene inhibition may be more effective in a subset of asthmatics in whom leukotrienes are a major contributory factor in causing allergic inflammation... - Antipyretic therapy in patients with sepsisJ D Hasday
Medical Care Clinical Center, Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA
Clin Infect Dis 31:S234-41. 2000.... - The role of fever in the infected hostJ D Hasday
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, and the Medicine Services of the Baltimore Veterans Affairs Centre, MD 21201, USA
Microbes Infect 2:1891-904. 2000..This paper reviews the state of our knowledge concerning the biological effects of fever in infected hosts and the influence of fever and antipyretic therapy on survival during sepsis in experimental models and in man... - Fever and the heat shock response: distinct, partially overlapping processesJ D Hasday
Department of Medicine, University of Maryland School of Medicine and the Medicine and Research Services of the Baltimore VA Medical Center, 21201, USA
Cell Stress Chaperones 5:471-80. 2000..The relationship between fever and the heat shock response is an illuminating example of how a more recently evolved response might exploit preexisting biochemical pathways for a new function... - Febrile-range hyperthermia augments pulmonary neutrophil recruitment and amplifies pulmonary oxygen toxicityJeffrey D Hasday
Divisions of Pulmonary and Critical Care Medicine, Department of Pathology, University of Maryland, Baltimore, Maryland 21201, USA
Am J Pathol 162:2005-17. 2003..In certain conditions, such as in the hyperoxic lung, this process may be deleterious... - Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-{kappa}B recruitment to cytokine gene promotersZachary A Cooper
Univ of Maryland School of Medicine, Health Science Facility II, Rm S311, 20 Penn St, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 298:C171-81. 2010..These data suggest that FRT exerts its effects on cytokine gene expression in a gene-specific manner through distal effects on promoter activation rather than proximal receptor activation and signal transduction... - Bacterial endotoxin modifies heat shock factor-1 activity in RAW 264.7 cells: implications for TNF-alpha regulation during exposure to febrile range temperaturesIshwar S Singh
Department of Medicine, University of Maryland and Medical and Research Services of the Baltimore VA Medical Center, Baltimore, Maryland 21201, USA
J Endotoxin Res 10:175-84. 2004.... - Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemiaVishwas D Joshi
Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore 21201, USA
Infect Immun 70:6896-903. 2002..Thus, Cas-1 is essential for innate antibacterial host defenses and may represent a mechanism of innate immunity that upon excessive stimulation by microbial components may lead to endotoxic shock... - Core temperature correlates with expression of selected stress and immunomodulatory genes in febrile patients with sepsis and noninfectious SIRSLarry A Sonna
University of Maryland School of Medicine, Baltimore, MD 21201, USA
Cell Stress Chaperones 15:55-66. 2010..For some genes, it appears that clinical condition can alter temperature-sensitive gene expression. Collectively, these data underscore the potential importance of body temperature in shaping the immune response to infection and injury... - Surfactant protein-A limits Ureaplasma-mediated lung inflammation in a murine pneumonia modelMobolaji E Famuyide
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Pediatr Res 66:162-7. 2009..SP-A deficiency may contribute to the prolonged inflammatory response in the Ureaplasma-infected preterm lung, but other factors may contribute to the impaired Ureaplasma clearance... - Antenatal Ureaplasma urealyticum respiratory tract infection stimulates proinflammatory, profibrotic responses in the preterm baboon lungRose M Viscardi
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Pediatr Res 60:141-6. 2006..Collectively, these data suggest that a prolonged proinflammatory response initiated by intrauterine Ureaplasma infection contributes to early fibrosis and altered developmental signaling in the immature lung... - Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-kappaB in alveolar macrophages stimulated with TLR2 and TLR4 agonistsHaiyan Chen
Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, MD 21201, USA
J Immunol 179:6097-106. 2007.... - Splice isoforms of human interleukin-4 are functionally active in mice in vivoIrina G Luzina
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Immunology 132:385-93. 2011..These findings suggest that splice isoforms of human IL-4 are functionally active in vivo in mice, and partially share the effects of the corresponding species-specific isoforms... - Febrile range temperature represses TNF-alpha gene expression in LPS-stimulated macrophages by selectively blocking recruitment of Sp1 to the TNF-alpha promoterZachary A Cooper
Division of Pulmonary and Critical Care, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Cell Stress Chaperones 15:665-73. 2010.... - Role of Ureaplasma species in neonatal chronic lung disease: epidemiologic and experimental evidenceROSE MARIE VISCARDI
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Pediatr Res 65:84R-90R. 2009..Potential strategies to prevent or ameliorate the effects of Ureaplasma infection in utero and in the preterm lung are discussed... - Characterization of a murine model of Ureaplasma urealyticum pneumoniaRose M Viscardi
Department of Pediatrics, University of Maryland School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland, USA
Infect Immun 70:5721-9. 2002.... - Tolerance to microbial TLR ligands: molecular mechanisms and relevance to diseaseAndrei E Medvedev
Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, Baltimore, Maryland 21201, USA
J Endotoxin Res 12:133-50. 2006..In this review, we present current theories of the molecular mechanisms that underlie induction and maintenance of 'microbial tolerance', and discuss the possible relevance of tolerance to several infectious and non-infectious diseases... - Variable prevalence of pulmonary hypertension in patients with advanced interstitial pneumoniaNevins W Todd
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Heart Lung Transplant 29:188-94. 2010..We sought to determine the prevalence of pulmonary hypertension in sub-groups of patients with interstitial pneumonia and to investigate possible associations between pulmonary vascular hemodynamics and pulmonary function... - Disordered pulmonary myofibroblast distribution and elastin expression in preterm infants with Ureaplasma urealyticum pneumonitisRose Viscardi
Department of Pediatrics, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, 21201, USA
Pediatr Dev Pathol 9:143-51. 2006.... - Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxiaLing Chen
Div of Pulmonary and Critical Care Medicine, Univ of Maryland, Baltimore, 685 West Baltimore St, MSTF 816, Baltimore, MD 21201, USA
J Appl Physiol 104:218-23. 2008..In conclusion, CIH-mediated LV global dysfunction is associated with myocyte hypertrophy and apoptosis at the cellular level... - A high affinity HSF-1 binding site in the 5'-untranslated region of the murine tumor necrosis factor-alpha gene is a transcriptional repressorIshwar S Singh
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 277:4981-8. 2002..5 degrees C. This suggests that HSF-1 might repress TNFalpha transcription through redundant mechanisms, some of which might not require high affinity binding of HSF-1... - CCL18-stimulated upregulation of collagen production in lung fibroblasts requires Sp1 signaling and basal Smad3 activityIrina G Luzina
Department of Medicine, University of Maryland School of Medicine, Baltimore VA Medical Center, Baltimore, Maryland 21201, USA
J Cell Physiol 206:221-8. 2006..These observations suggest that both CCL18 signaling in pulmonary fibroblasts and basal Smad3 activity are independent of autocrine TGF-beta... - Hypothermia prolongs activation of NF-kappaB and augments generation of inflammatory cytokinesKaren D Fairchild
Department of Pediatrics, Division of Neonatology, Rm N5W68, University of Maryland Hospital, 22 S Greene Street, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 287:C422-31. 2004.... - Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infantsRose M Viscardi
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Pediatr Res 55:1009-17. 2004..05 each case) but not >/=28 wk GA. These data suggest that in infants </=28 wks GA, BPD may be initiated by inflammatory mediators in amniotic fluid, but brain injury may involve variations in the systemic inflammatory response... - Heat shock co-activates interleukin-8 transcriptionIshwar S Singh
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
Am J Respir Cell Mol Biol 39:235-42. 2008..We speculate that during evolution the CXC chemokine genes may have co-opted elements of the HS response to amplify their expression and enhance neutrophil delivery during febrile illnesses... 
Differential expression of toll-like receptor genes: sepsis compared with sterile inflammation 1 day before sepsis diagnosisMatthew E Lissauer
Department of Surgical Critical Care, University of Maryland Medical Center, Room S4D07, 22 S Greene St, Baltimore, MD 21201, USA
Shock 31:238-44. 2009..These expression differences occur before phenotypic-based diagnosis of clinical sepsis...- IL-18 levels and the outcome of innate immune response to lipopolysaccharide: importance of a positive feedback loop with caspase-1 in IL-18 expressionVishwas D Joshi
Department of Medicine, Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore 21201, USA
J Immunol 169:2536-44. 2002..We conclude that the regulation of serum IL-18 expression is critical to the outcome of innate immune responses to LPS... - Febrile-range hyperthermia accelerates caspase-dependent apoptosis in human neutrophilsAshish Nagarsekar
Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Immunol 181:2636-43. 2008..5 degrees C) doubled the proportion of bronchoalveolar PMNs undergoing apoptosis compared with euthermic mice. This process may play an important role in limiting inflammation and tissue injury during febrile illnesses... - Hyperthermia in the febrile range induces HSP72 expression proportional to exposure temperature but not to HSF-1 DNA-binding activity in human lung epithelial A549 cellsMohan E Tulapurkar
Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Cell Stress Chaperones 14:499-508. 2009..Instead, HSF-1-mediated HSP expression following hyperthermia and heat shock appears to be mediated, in addition to HSF-1 activation, by posttranslational modifications of HSF-1 protein... - Costimulation modulation uncouples protection from immunopathology in memory T cell responses to influenza virusJohn R Teijaro
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Immunol 182:6834-43. 2009.... - Oxidative stress and left ventricular function with chronic intermittent hypoxia in ratsLing Chen
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland, 685 West Baltimore Street, MSTF 800, Baltimore, MD, USA
Am J Respir Crit Care Med 172:915-20. 2005..05) and LV myocardial superoxide dismutase levels were lower (CIH, 10.3+/-4.9; HC, 18.6+/-8.2 U/mg protein; p<0.05) with CIH. CONCLUSIONS: CIH leads to oxidative stress and LV myocardial dysfunction... - Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endotheliaXiu Fen Sui
Department of Medicine and Pathology, Division of Infectious Diseases and Pulmonary Medicine, Mucosal Biology Research Center, University of Maryland School of Medicine, 22 Penn St, Baltimore, MD 21201, USA
Am J Pathol 166:1247-58. 2005..Therefore, PTPmu is expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity... - CXC chemokines: a new family of heat-shock proteins?Ashish Nagarsekar
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
Immunol Invest 34:381-98. 2005.... - An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunityXiao Ling Li
Graduate Program in Molecular Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 105:20816-21. 2008..As a regulator of fundamental components of the innate immune response, RNase-L represents a viable therapeutic target to augment host defense against diverse microbial pathogens... - Acetaminophen has limited antipyretic activity in critically ill patientsRachel S Greenberg
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore VA Medical Center, Baltimore, MD 21201, USA
J Crit Care 25:363.e1-7. 2010..The objective of this study was to analyze the antipyretic activity of acetaminophen in critically ill patients... - Hypothermia enhances phosphorylation of I{kappa}B kinase and prolongs nuclear localization of NF-{kappa}B in lipopolysaccharide-activated macrophagesKaren D Fairchild
Department of Pediatrics, University of Virginia Health System, Box 800386, Charlottesville, VA 22908, USA
Am J Physiol Cell Physiol 289:C1114-21. 2005..Enhanced NF-kappaB activation may contribute to the immunomodulatory effects of HT in various clinical settings... - Effect of moderate hypothermia on gene expression by THP-1 cells: a DNA microarray studyLarry A Sonna
Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
Physiol Genomics 26:91-8. 2006..These in vitro findings suggest that prolonged hypothermia in vivo might be capable of producing physiologically relevant changes in gene expression by circulating leukocytes... - Exercise-heat acclimation in humans alters baseline levels and ex vivo heat inducibility of HSP72 and HSP90 in peripheral blood mononuclear cellsJames P McClung
US Army Research Institute of Environmental Medicine, Natick, MA, USA
Am J Physiol Regul Integr Comp Physiol 294:R185-91. 2008..These data demonstrate that physiological adaptations in humans undergoing HA are accompanied by both increases in baseline levels and changes in regulation of cytoprotective HSPs... - Protein tyrosine phosphatase activity regulates endothelial cell-cell interactions, the paracellular pathway, and capillary tube stabilityBradford A Young
Division of Infectious Diseases, Department of Veterans Affairs Medical Center, Baltimore 21201, USA
Am J Physiol Lung Cell Mol Physiol 285:L63-75. 2003....
Research Grants
- The contribution of heat shock/stress pathways to acute lung injuryJeffrey D Hasday; Fiscal Year: 2010..Ablating fever may eliminate its beneficial as well as its harmful effects. We expect that a better understanding of its molecular mechanisms will allow us to selectively block the harmful effects of fever/hyperthermia. ..
- The contribution of heat shock/stress pathways to acute lung injuryJeffrey Hasday; Fiscal Year: 2007..Ablating fever may eliminate its beneficial as well as its harmful effects. We expect that a better understanding of its molecular mechanisms will allow us to selectively block the harmful effects of fever/hyperthermia. ..
- Mechanisms of HSF1-mediated Repression of TNF-alphaJeffrey Hasday; Fiscal Year: 2007..The proposed studies will provide new insight into how the biochemical events that regulate host defenses is modified by the temperature increase that occurs during fever. ..
- Mechanisms of Fever-Enhanced Hyperoxic Lung InjuryJeffrey Hasday; Fiscal Year: 2006..The proposed studies will provide new insights about the unanticipated consequences of fever in critically ill patients, and expand our knowledge about the mechanisms through which fever modifies the immune response. ..
- BODY TEMPERATURE AND REGULATING HOST DEFENSESJeffrey Hasday; Fiscal Year: 2001..abstract_text> ..
- Mechanisms of Fever-Enhanced Acute Lung InjuryJeffrey D Hasday; Fiscal Year: 2010..The same knowledge will help us develop better therapies to prevent the complications of heat stroke, a growing global health problem. ..