Jeffrey Hasday

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Febrile-range hyperthermia augments neutrophil accumulation and enhances lung injury in experimental gram-negative bacterial pneumonia
    Penelope Rice
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 174:3676-85. 2005
  2. pmc Hyperthermia promotes and prevents respiratory epithelial apoptosis through distinct mechanisms
    Ashish Nagarsekar
    Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Respir Cell Mol Biol 47:824-33. 2012
  3. pmc Febrile-range hyperthermia modifies endothelial and neutrophilic functions to promote extravasation
    Mohan E Tulapurkar
    Division of Pulmonary and Critical Care, Department of Medicine, School of Medicine, University of Maryland, 20 Penn St, Baltimore, MD 21201, USA
    Am J Respir Cell Mol Biol 46:807-14. 2012
  4. ncbi request reprint Bacterial endotoxin is an active component of cigarette smoke
    J D Hasday
    Division of Pulmonary and Critical Care Medicine, University of Maryland Medical School, Baltimore, USA
    Chest 115:829-35. 1999
  5. ncbi request reprint Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics
    J D Hasday
    Pulmonary and Critical Care Division of the Department of Medicine, Center for Genetics of Asthma and Complex Diseases, University of Maryland Medical School, The Medical Service of the Baltimore VA Medical Center, 21201, USA
    Am J Respir Crit Care Med 161:1229-36. 2000
  6. ncbi request reprint Antipyretic therapy in patients with sepsis
    J D Hasday
    Medical Care Clinical Center, Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA
    Clin Infect Dis 31:S234-41. 2000
  7. ncbi request reprint The role of fever in the infected host
    J D Hasday
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, and the Medicine Services of the Baltimore Veterans Affairs Centre, MD 21201, USA
    Microbes Infect 2:1891-904. 2000
  8. pmc Fever and the heat shock response: distinct, partially overlapping processes
    J D Hasday
    Department of Medicine, University of Maryland School of Medicine and the Medicine and Research Services of the Baltimore VA Medical Center, 21201, USA
    Cell Stress Chaperones 5:471-80. 2000
  9. pmc Febrile-range hyperthermia augments pulmonary neutrophil recruitment and amplifies pulmonary oxygen toxicity
    Jeffrey D Hasday
    Divisions of Pulmonary and Critical Care Medicine, Department of Pathology, University of Maryland, Baltimore, Maryland 21201, USA
    Am J Pathol 162:2005-17. 2003
  10. pmc Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-{kappa}B recruitment to cytokine gene promoters
    Zachary A Cooper
    Univ of Maryland School of Medicine, Health Science Facility II, Rm S311, 20 Penn St, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 298:C171-81. 2010

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Febrile-range hyperthermia augments neutrophil accumulation and enhances lung injury in experimental gram-negative bacterial pneumonia
    Penelope Rice
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 174:3676-85. 2005
    ..The ultimate effect of FRH is determined by the balance between accelerated pathogen clearance and collateral tissue injury, which is determined, in part, by the site of infection...
  2. pmc Hyperthermia promotes and prevents respiratory epithelial apoptosis through distinct mechanisms
    Ashish Nagarsekar
    Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Respir Cell Mol Biol 47:824-33. 2012
    ..Thus, depending on the temperature and timing relative to death receptor activation, hyperthermia can exert pro- and antiapoptotic effects through distinct mechanisms...
  3. pmc Febrile-range hyperthermia modifies endothelial and neutrophilic functions to promote extravasation
    Mohan E Tulapurkar
    Division of Pulmonary and Critical Care, Department of Medicine, School of Medicine, University of Maryland, 20 Penn St, Baltimore, MD 21201, USA
    Am J Respir Cell Mol Biol 46:807-14. 2012
    ....
  4. ncbi request reprint Bacterial endotoxin is an active component of cigarette smoke
    J D Hasday
    Division of Pulmonary and Critical Care Medicine, University of Maryland Medical School, Baltimore, USA
    Chest 115:829-35. 1999
    ..Experimental LPS inhalation mimics many of the acute effects of cigarette smoke in the lower airway. Therefore, we reasoned that LPS may be a biologically active component of cigarette smoke...
  5. ncbi request reprint Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics
    J D Hasday
    Pulmonary and Critical Care Division of the Department of Medicine, Center for Genetics of Asthma and Complex Diseases, University of Maryland Medical School, The Medical Service of the Baltimore VA Medical Center, 21201, USA
    Am J Respir Crit Care Med 161:1229-36. 2000
    ..These data suggest that leukotriene inhibition may be more effective in a subset of asthmatics in whom leukotrienes are a major contributory factor in causing allergic inflammation...
  6. ncbi request reprint Antipyretic therapy in patients with sepsis
    J D Hasday
    Medical Care Clinical Center, Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA
    Clin Infect Dis 31:S234-41. 2000
    ....
  7. ncbi request reprint The role of fever in the infected host
    J D Hasday
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, and the Medicine Services of the Baltimore Veterans Affairs Centre, MD 21201, USA
    Microbes Infect 2:1891-904. 2000
    ..This paper reviews the state of our knowledge concerning the biological effects of fever in infected hosts and the influence of fever and antipyretic therapy on survival during sepsis in experimental models and in man...
  8. pmc Fever and the heat shock response: distinct, partially overlapping processes
    J D Hasday
    Department of Medicine, University of Maryland School of Medicine and the Medicine and Research Services of the Baltimore VA Medical Center, 21201, USA
    Cell Stress Chaperones 5:471-80. 2000
    ..The relationship between fever and the heat shock response is an illuminating example of how a more recently evolved response might exploit preexisting biochemical pathways for a new function...
  9. pmc Febrile-range hyperthermia augments pulmonary neutrophil recruitment and amplifies pulmonary oxygen toxicity
    Jeffrey D Hasday
    Divisions of Pulmonary and Critical Care Medicine, Department of Pathology, University of Maryland, Baltimore, Maryland 21201, USA
    Am J Pathol 162:2005-17. 2003
    ..In certain conditions, such as in the hyperoxic lung, this process may be deleterious...
  10. pmc Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-{kappa}B recruitment to cytokine gene promoters
    Zachary A Cooper
    Univ of Maryland School of Medicine, Health Science Facility II, Rm S311, 20 Penn St, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 298:C171-81. 2010
    ..These data suggest that FRT exerts its effects on cytokine gene expression in a gene-specific manner through distal effects on promoter activation rather than proximal receptor activation and signal transduction...
  11. ncbi request reprint Bacterial endotoxin modifies heat shock factor-1 activity in RAW 264.7 cells: implications for TNF-alpha regulation during exposure to febrile range temperatures
    Ishwar S Singh
    Department of Medicine, University of Maryland and Medical and Research Services of the Baltimore VA Medical Center, Baltimore, Maryland 21201, USA
    J Endotoxin Res 10:175-84. 2004
    ....
  12. pmc Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemia
    Vishwas D Joshi
    Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 70:6896-903. 2002
    ..Thus, Cas-1 is essential for innate antibacterial host defenses and may represent a mechanism of innate immunity that upon excessive stimulation by microbial components may lead to endotoxic shock...
  13. pmc Core temperature correlates with expression of selected stress and immunomodulatory genes in febrile patients with sepsis and noninfectious SIRS
    Larry A Sonna
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cell Stress Chaperones 15:55-66. 2010
    ..For some genes, it appears that clinical condition can alter temperature-sensitive gene expression. Collectively, these data underscore the potential importance of body temperature in shaping the immune response to infection and injury...
  14. pmc Surfactant protein-A limits Ureaplasma-mediated lung inflammation in a murine pneumonia model
    Mobolaji E Famuyide
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Pediatr Res 66:162-7. 2009
    ..SP-A deficiency may contribute to the prolonged inflammatory response in the Ureaplasma-infected preterm lung, but other factors may contribute to the impaired Ureaplasma clearance...
  15. ncbi request reprint Antenatal Ureaplasma urealyticum respiratory tract infection stimulates proinflammatory, profibrotic responses in the preterm baboon lung
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Pediatr Res 60:141-6. 2006
    ..Collectively, these data suggest that a prolonged proinflammatory response initiated by intrauterine Ureaplasma infection contributes to early fibrosis and altered developmental signaling in the immature lung...
  16. ncbi request reprint Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-kappaB in alveolar macrophages stimulated with TLR2 and TLR4 agonists
    Haiyan Chen
    Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, MD 21201, USA
    J Immunol 179:6097-106. 2007
    ....
  17. pmc Splice isoforms of human interleukin-4 are functionally active in mice in vivo
    Irina G Luzina
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Immunology 132:385-93. 2011
    ..These findings suggest that splice isoforms of human IL-4 are functionally active in vivo in mice, and partially share the effects of the corresponding species-specific isoforms...
  18. pmc Febrile range temperature represses TNF-alpha gene expression in LPS-stimulated macrophages by selectively blocking recruitment of Sp1 to the TNF-alpha promoter
    Zachary A Cooper
    Division of Pulmonary and Critical Care, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cell Stress Chaperones 15:665-73. 2010
    ....
  19. pmc Role of Ureaplasma species in neonatal chronic lung disease: epidemiologic and experimental evidence
    ROSE MARIE VISCARDI
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Pediatr Res 65:84R-90R. 2009
    ..Potential strategies to prevent or ameliorate the effects of Ureaplasma infection in utero and in the preterm lung are discussed...
  20. pmc Characterization of a murine model of Ureaplasma urealyticum pneumonia
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland, USA
    Infect Immun 70:5721-9. 2002
    ....
  21. ncbi request reprint Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease
    Andrei E Medvedev
    Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, Baltimore, Maryland 21201, USA
    J Endotoxin Res 12:133-50. 2006
    ..In this review, we present current theories of the molecular mechanisms that underlie induction and maintenance of 'microbial tolerance', and discuss the possible relevance of tolerance to several infectious and non-infectious diseases...
  22. pmc Variable prevalence of pulmonary hypertension in patients with advanced interstitial pneumonia
    Nevins W Todd
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Heart Lung Transplant 29:188-94. 2010
    ..We sought to determine the prevalence of pulmonary hypertension in sub-groups of patients with interstitial pneumonia and to investigate possible associations between pulmonary vascular hemodynamics and pulmonary function...
  23. ncbi request reprint Disordered pulmonary myofibroblast distribution and elastin expression in preterm infants with Ureaplasma urealyticum pneumonitis
    Rose Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, 21201, USA
    Pediatr Dev Pathol 9:143-51. 2006
    ....
  24. ncbi request reprint Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia
    Ling Chen
    Div of Pulmonary and Critical Care Medicine, Univ of Maryland, Baltimore, 685 West Baltimore St, MSTF 816, Baltimore, MD 21201, USA
    J Appl Physiol (1985) 104:218-23. 2008
    ..In conclusion, CIH-mediated LV global dysfunction is associated with myocyte hypertrophy and apoptosis at the cellular level...
  25. ncbi request reprint A high affinity HSF-1 binding site in the 5'-untranslated region of the murine tumor necrosis factor-alpha gene is a transcriptional repressor
    Ishwar S Singh
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 277:4981-8. 2002
    ..5 degrees C. This suggests that HSF-1 might repress TNFalpha transcription through redundant mechanisms, some of which might not require high affinity binding of HSF-1...
  26. ncbi request reprint CCL18-stimulated upregulation of collagen production in lung fibroblasts requires Sp1 signaling and basal Smad3 activity
    Irina G Luzina
    Department of Medicine, University of Maryland School of Medicine, Baltimore VA Medical Center, Baltimore, Maryland 21201, USA
    J Cell Physiol 206:221-8. 2006
    ..These observations suggest that both CCL18 signaling in pulmonary fibroblasts and basal Smad3 activity are independent of autocrine TGF-beta...
  27. ncbi request reprint Hypothermia prolongs activation of NF-kappaB and augments generation of inflammatory cytokines
    Karen D Fairchild
    Department of Pediatrics, Division of Neonatology, Rm N5W68, University of Maryland Hospital, 22 S Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 287:C422-31. 2004
    ....
  28. ncbi request reprint Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Pediatr Res 55:1009-17. 2004
    ..05 each case) but not >/=28 wk GA. These data suggest that in infants </=28 wks GA, BPD may be initiated by inflammatory mediators in amniotic fluid, but brain injury may involve variations in the systemic inflammatory response...
  29. pmc Heat shock co-activates interleukin-8 transcription
    Ishwar S Singh
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 39:235-42. 2008
    ..We speculate that during evolution the CXC chemokine genes may have co-opted elements of the HS response to amplify their expression and enhance neutrophil delivery during febrile illnesses...
  30. doi request reprint Differential expression of toll-like receptor genes: sepsis compared with sterile inflammation 1 day before sepsis diagnosis
    Matthew E Lissauer
    Department of Surgical Critical Care, University of Maryland Medical Center, Room S4D07, 22 S Greene St, Baltimore, MD 21201, USA
    Shock 31:238-44. 2009
    ..These expression differences occur before phenotypic-based diagnosis of clinical sepsis...
  31. ncbi request reprint IL-18 levels and the outcome of innate immune response to lipopolysaccharide: importance of a positive feedback loop with caspase-1 in IL-18 expression
    Vishwas D Joshi
    Department of Medicine, Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore 21201, USA
    J Immunol 169:2536-44. 2002
    ..We conclude that the regulation of serum IL-18 expression is critical to the outcome of innate immune responses to LPS...
  32. pmc Febrile-range hyperthermia accelerates caspase-dependent apoptosis in human neutrophils
    Ashish Nagarsekar
    Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 181:2636-43. 2008
    ..5 degrees C) doubled the proportion of bronchoalveolar PMNs undergoing apoptosis compared with euthermic mice. This process may play an important role in limiting inflammation and tissue injury during febrile illnesses...
  33. pmc Hyperthermia in the febrile range induces HSP72 expression proportional to exposure temperature but not to HSF-1 DNA-binding activity in human lung epithelial A549 cells
    Mohan E Tulapurkar
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Cell Stress Chaperones 14:499-508. 2009
    ..Instead, HSF-1-mediated HSP expression following hyperthermia and heat shock appears to be mediated, in addition to HSF-1 activation, by posttranslational modifications of HSF-1 protein...
  34. doi request reprint Costimulation modulation uncouples protection from immunopathology in memory T cell responses to influenza virus
    John R Teijaro
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 182:6834-43. 2009
    ....
  35. ncbi request reprint Oxidative stress and left ventricular function with chronic intermittent hypoxia in rats
    Ling Chen
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland, 685 West Baltimore Street, MSTF 800, Baltimore, MD, USA
    Am J Respir Crit Care Med 172:915-20. 2005
    ..Obstructive sleep apnea (OSA) is associated with oxidative stress and myocardial dysfunction. We hypothesized that the chronic intermittent hypoxia (CIH) component of OSA is sufficient to lead to these adverse effects...
  36. pmc Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia
    Xiu Fen Sui
    Department of Medicine and Pathology, Division of Infectious Diseases and Pulmonary Medicine, Mucosal Biology Research Center, University of Maryland School of Medicine, 22 Penn St, Baltimore, MD 21201, USA
    Am J Pathol 166:1247-58. 2005
    ..Therefore, PTPmu is expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity...
  37. ncbi request reprint CXC chemokines: a new family of heat-shock proteins?
    Ashish Nagarsekar
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Immunol Invest 34:381-98. 2005
    ....
  38. pmc An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity
    Xiao Ling Li
    Graduate Program in Molecular Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 105:20816-21. 2008
    ..As a regulator of fundamental components of the innate immune response, RNase-L represents a viable therapeutic target to augment host defense against diverse microbial pathogens...
  39. pmc Acetaminophen has limited antipyretic activity in critically ill patients
    Rachel S Greenberg
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore VA Medical Center, Baltimore, MD 21201, USA
    J Crit Care 25:363.e1-7. 2010
    ..The objective of this study was to analyze the antipyretic activity of acetaminophen in critically ill patients...
  40. ncbi request reprint Hypothermia enhances phosphorylation of I{kappa}B kinase and prolongs nuclear localization of NF-{kappa}B in lipopolysaccharide-activated macrophages
    Karen D Fairchild
    Department of Pediatrics, University of Virginia Health System, Box 800386, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 289:C1114-21. 2005
    ..Enhanced NF-kappaB activation may contribute to the immunomodulatory effects of HT in various clinical settings...
  41. ncbi request reprint Effect of moderate hypothermia on gene expression by THP-1 cells: a DNA microarray study
    Larry A Sonna
    Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
    Physiol Genomics 26:91-8. 2006
    ..These in vitro findings suggest that prolonged hypothermia in vivo might be capable of producing physiologically relevant changes in gene expression by circulating leukocytes...
  42. ncbi request reprint Exercise-heat acclimation in humans alters baseline levels and ex vivo heat inducibility of HSP72 and HSP90 in peripheral blood mononuclear cells
    James P McClung
    US Army Research Institute of Environmental Medicine, Natick, MA, USA
    Am J Physiol Regul Integr Comp Physiol 294:R185-91. 2008
    ..These data demonstrate that physiological adaptations in humans undergoing HA are accompanied by both increases in baseline levels and changes in regulation of cytoprotective HSPs...
  43. ncbi request reprint Protein tyrosine phosphatase activity regulates endothelial cell-cell interactions, the paracellular pathway, and capillary tube stability
    Bradford A Young
    Division of Infectious Diseases, Department of Veterans Affairs Medical Center, Baltimore 21201, USA
    Am J Physiol Lung Cell Mol Physiol 285:L63-75. 2003
    ....

Research Grants19

  1. BODY TEMPERATURE AND REGULATING HOST DEFENSES
    Jeffrey Hasday; Fiscal Year: 1999
    ..abstract_text> ..
  2. The contribution of heat shock/stress pathways to acute lung injury
    Jeffrey D Hasday; Fiscal Year: 2010
    ..Ablating fever may eliminate its beneficial as well as its harmful effects. We expect that a better understanding of its molecular mechanisms will allow us to selectively block the harmful effects of fever/hyperthermia. ..
  3. Mechanisms of Fever-Enhanced Acute Lung Injury
    Jeffrey Hasday; Fiscal Year: 2009
    ..The same knowledge will help us develop better therapies to prevent the complications of heat stroke, a growing global health problem. ..
  4. The contribution of heat shock/stress pathways to acute lung injury
    Jeffrey Hasday; Fiscal Year: 2009
    ..Ablating fever may eliminate its beneficial as well as its harmful effects. We expect that a better understanding of its molecular mechanisms will allow us to selectively block the harmful effects of fever/hyperthermia. ..
  5. The contribution of heat shock/stress pathways to acute lung injury
    Jeffrey Hasday; Fiscal Year: 2007
    ..Ablating fever may eliminate its beneficial as well as its harmful effects. We expect that a better understanding of its molecular mechanisms will allow us to selectively block the harmful effects of fever/hyperthermia. ..
  6. Mechanisms of HSF1-mediated Repression of TNF-alpha
    Jeffrey Hasday; Fiscal Year: 2007
    ..The proposed studies will provide new insight into how the biochemical events that regulate host defenses is modified by the temperature increase that occurs during fever. ..
  7. Mechanisms of HSF1-mediated Repression of TNF-alpha
    Jeffrey Hasday; Fiscal Year: 2005
    ..The proposed studies will provide new insight into how the biochemical events that regulate host defenses is modified by the temperature increase that occurs during fever. ..
  8. Mechanisms of HSF1-mediated Repression of TNF-alpha
    Jeffrey Hasday; Fiscal Year: 2006
    ..The proposed studies will provide new insight into how the biochemical events that regulate host defenses is modified by the temperature increase that occurs during fever. ..
  9. Mechanisms of Fever-Enhanced Hyperoxic Lung Injury
    Jeffrey Hasday; Fiscal Year: 2006
    ..The proposed studies will provide new insights about the unanticipated consequences of fever in critically ill patients, and expand our knowledge about the mechanisms through which fever modifies the immune response. ..
  10. Mechanisms of HSF1-mediated Repression of TNF-alpha
    Jeffrey Hasday; Fiscal Year: 2005
    ..The proposed studies will provide new insight into how the biochemical events that regulate host defenses is modified by the temperature increase that occurs during fever. ..
  11. Mechanisms of Fever-Enhanced Hyperoxic Lung Injury
    Jeffrey Hasday; Fiscal Year: 2005
    ..The proposed studies will provide new insights about the unanticipated consequences of fever in critically ill patients, and expand our knowledge about the mechanisms through which fever modifies the immune response. ..
  12. Mechanisms of HSF1-mediated Repression of TNF-alpha
    Jeffrey Hasday; Fiscal Year: 2004
    ..The proposed studies will provide new insight into how the biochemical events that regulate host defenses is modified by the temperature increase that occurs during fever. ..
  13. Mechanisms of Fever-Enhanced Hyperoxic Lung Injury
    Jeffrey Hasday; Fiscal Year: 2004
    ..The proposed studies will provide new insights about the unanticipated consequences of fever in critically ill patients, and expand our knowledge about the mechanisms through which fever modifies the immune response. ..
  14. Mechanisms of Fever-Enhanced Hyperoxic Lung Injury
    Jeffrey Hasday; Fiscal Year: 2003
    ..The proposed studies will provide new insights about the unanticipated consequences of fever in critically ill patients, and expand our knowledge about the mechanisms through which fever modifies the immune response. ..
  15. BODY TEMPERATURE AND REGULATING HOST DEFENSES
    Jeffrey Hasday; Fiscal Year: 2001
    ..abstract_text> ..
  16. BODY TEMPERATURE AND REGULATING HOST DEFENSES
    Jeffrey Hasday; Fiscal Year: 2000
    ..abstract_text> ..
  17. Mechanisms of Fever-Enhanced Acute Lung Injury
    Jeffrey D Hasday; Fiscal Year: 2010
    ..The same knowledge will help us develop better therapies to prevent the complications of heat stroke, a growing global health problem. ..