Grant A Hartzog

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Just the FACTs: histone H2B ubiquitylation and nucleosome dynamics
    Grant A Hartzog
    Department of MCD Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Mol Cell 31:2-4. 2008
  2. ncbi request reprint Transcript elongation on a nucleoprotein template
    Grant A Hartzog
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    Biochim Biophys Acta 1577:276-86. 2002
  3. ncbi request reprint Transcription elongation by RNA polymerase II
    Grant A Hartzog
    Department of MCD Biology, University of California, Santa Cruz, California 95064, USA
    Curr Opin Genet Dev 13:119-26. 2003
  4. ncbi request reprint Competing for the clamp: promoting RNA polymerase processivity and managing the transition from initiation to elongation
    Grant A Hartzog
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    Mol Cell 43:161-3. 2011
  5. pmc The Paf1 complex physically and functionally associates with transcription elongation factors in vivo
    Sharon L Squazzo
    Department of MCD Biology, University of California, Santa Cruz, CA 95064, USA
    EMBO J 21:1764-74. 2002
  6. pmc The Spt4-Spt5 complex: a multi-faceted regulator of transcription elongation
    Grant A Hartzog
    Department of MCD Biology, University of California, Santa Cruz, CA 95064, USA
    Biochim Biophys Acta 1829:105-15. 2013
  7. ncbi request reprint A new role for histone tail modifications in transcription elongation
    Grant A Hartzog
    Department of Molecular, Cell, and Developmental Biology, University of California at Santa Cruz, Santa Cruz, California 95064, USA
    Genes Dev 21:3209-13. 2007
  8. pmc Confirmation of the cellular targets of benomyl and rapamycin using next-generation sequencing of resistant mutants in S. cerevisiae
    Dustin A Wride
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, USA
    Mol Biosyst 10:3179-87. 2014
  9. pmc Structural determination of NSC 670224, synthesis of analogues and biological evaluation
    Nathaniel B Zuckerman
    Department of Chemistry and Biochemistry, University of California, Santa Cruz UCSC, Santa Cruz, CA 95064, USA
    ChemMedChem 7:761-5. 2012
  10. pmc Analysis of a splice array experiment elucidates roles of chromatin elongation factor Spt4-5 in splicing
    Yuanyuan Xiao
    Department of Epidemiology and Biostatistics, Center for Bioinformatics and Molecular Biostatistics, University of California, San Francisco, California, United States of America
    PLoS Comput Biol 1:e39. 2005

Research Grants

  1. Functions of Spt4-Spt5 in Gene Expression
    Grant Hartzog; Fiscal Year: 2008

Collaborators

  • Nader Pourmand
  • Craig D Kaplan
  • Karen M Arndt
  • JOHN WALTER TAMKUN
  • Mark R Segal
  • Dustin A Wride
  • Walter M Bray
  • R Scott Lokey
  • Tiffani K Quan
  • Nathaniel B Zuckerman
  • Rajna Simic
  • Yuanyuan Xiao
  • Derek L Lindstrom
  • Patrick J Costa
  • Sol Katzman
  • Sean C Nisam
  • Jacob J Kosarchuk
  • Sharon L Squazzo
  • Carlos E Dobkin
  • Ray F Berkeley
  • Andrew S Myers
  • Joseph P Konopelski
  • Todd A Burckin
  • Lily Shiue
  • Yee H Yang
  • Kelli L Roinick
  • Hien G Tran
  • Alexander D Johnson
  • Kathryn E Kumer
  • Andrew J Link
  • Jennifer L Jennings

Detail Information

Publications12

  1. doi request reprint Just the FACTs: histone H2B ubiquitylation and nucleosome dynamics
    Grant A Hartzog
    Department of MCD Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Mol Cell 31:2-4. 2008
    ....
  2. ncbi request reprint Transcript elongation on a nucleoprotein template
    Grant A Hartzog
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    Biochim Biophys Acta 1577:276-86. 2002
    ..The C-terminal repeated domain (CTD) of Pol II may also play a role in regulating elongation through chromatin...
  3. ncbi request reprint Transcription elongation by RNA polymerase II
    Grant A Hartzog
    Department of MCD Biology, University of California, Santa Cruz, California 95064, USA
    Curr Opin Genet Dev 13:119-26. 2003
    ..Finally, a combination of genetic analysis and the localization of factors on transcribed chromatin is being used to confirm a role for factors in elongation...
  4. ncbi request reprint Competing for the clamp: promoting RNA polymerase processivity and managing the transition from initiation to elongation
    Grant A Hartzog
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    Mol Cell 43:161-3. 2011
    ..This work highlights the RNA polymerase clamp as a target for regulation and points to dynamic interactions between initiation and elongation machineries...
  5. pmc The Paf1 complex physically and functionally associates with transcription elongation factors in vivo
    Sharon L Squazzo
    Department of MCD Biology, University of California, Santa Cruz, CA 95064, USA
    EMBO J 21:1764-74. 2002
    ..Taken together, these data suggest that the Paf1 complex functions during the elongation phase of transcription in conjunction with Spt4-Spt5 and Spt16-Pob3...
  6. pmc The Spt4-Spt5 complex: a multi-faceted regulator of transcription elongation
    Grant A Hartzog
    Department of MCD Biology, University of California, Santa Cruz, CA 95064, USA
    Biochim Biophys Acta 1829:105-15. 2013
    ..This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation...
  7. ncbi request reprint A new role for histone tail modifications in transcription elongation
    Grant A Hartzog
    Department of Molecular, Cell, and Developmental Biology, University of California at Santa Cruz, Santa Cruz, California 95064, USA
    Genes Dev 21:3209-13. 2007
  8. pmc Confirmation of the cellular targets of benomyl and rapamycin using next-generation sequencing of resistant mutants in S. cerevisiae
    Dustin A Wride
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, USA
    Mol Biosyst 10:3179-87. 2014
    ..We call our approach "Mutagenesis to Uncover Targets by deep Sequencing", or "MUTseq", and show through this proof-of-concept study its potential utility in characterizing MOAs and targets of novel compounds. ..
  9. pmc Structural determination of NSC 670224, synthesis of analogues and biological evaluation
    Nathaniel B Zuckerman
    Department of Chemistry and Biochemistry, University of California, Santa Cruz UCSC, Santa Cruz, CA 95064, USA
    ChemMedChem 7:761-5. 2012
    ..The structure of NSC 670224, previously thought to be a 2,4-dichloro arene, was established as the 3,4-dichloro arene, and a focused library of analogues were synthesized and biologically evaluated...
  10. pmc Analysis of a splice array experiment elucidates roles of chromatin elongation factor Spt4-5 in splicing
    Yuanyuan Xiao
    Department of Epidemiology and Biostatistics, Center for Bioinformatics and Molecular Biostatistics, University of California, San Francisco, California, United States of America
    PLoS Comput Biol 1:e39. 2005
    ..Our results suggest that the Spt4-Spt5 complex may help coordinate splicing with transcription under conditions that present kinetic challenges to spliceosome assembly or function...
  11. pmc Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes
    Rajna Simic
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    EMBO J 22:1846-56. 2003
    ..Collectively, these findings suggest an important role for Chd1 and chromatin remodeling in the control of transcription elongation...

Research Grants1

  1. Functions of Spt4-Spt5 in Gene Expression
    Grant Hartzog; Fiscal Year: 2008
    ..Studies here include biochemical and genetic analyses of splicing in spt mutants and tests of the influence of Spt4-Spt5 on the assembly of RNA export proteins onto mRNA. ..