John Harty

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc The relevance of non-human primate and rodent malaria models for humans
    Jean Langhorne
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Malar J 10:23. 2011
  2. pmc CD8 T-cell recognition of macrophages and hepatocytes results in immunity to Listeria monocytogenes
    J T Harty
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    Infect Immun 64:3632-40. 1996
  3. doi request reprint Shaping and reshaping CD8+ T-cell memory
    John T Harty
    Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, USA
    Nat Rev Immunol 8:107-19. 2008
  4. ncbi request reprint CD8+ T cell effector mechanisms in resistance to infection
    J T Harty
    Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, USA
    Annu Rev Immunol 18:275-308. 2000
  5. pmc Primary and secondary immune responses to Listeria monocytogenes
    J T Harty
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Curr Opin Immunol 8:526-30. 1996
  6. ncbi request reprint Responses of CD8(+) T cells to intracellular bacteria
    J T Harty
    Department of Microbiology, Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City 52242, USA
    Curr Opin Immunol 11:89-93. 1999
  7. pmc Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function
    Hai Hui Xue
    Department of Microbiology, University of Iowa, 51 Newton Road, BSB 3 710, Iowa City, IA 52246, USA
    Mol Cell Biol 28:4300-9. 2008
  8. ncbi request reprint T cells undergo rapid ON/OFF but not ON/OFF/ON cycling of cytokine production in response to antigen
    Gail A Corbin
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    J Immunol 174:718-26. 2005
  9. ncbi request reprint Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination
    Vladimir P Badovinac
    Department of Microbiology, 3 512 Bowen Science Building, 51 Newton Road, University of Iowa, Iowa City, Iowa 52240, USA
    Nat Med 11:748-56. 2005
  10. ncbi request reprint Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection
    Jodie S Haring
    Department of Microbiology, Carver School of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 180:2855-62. 2008

Collaborators

  • Noah S Butler
  • GAIL BISHOP
  • Hai Hui Xue
  • STEVEN VARGA
  • W J Leonard
  • Werner Held
  • Claire L Hutchings
  • Arturo Reyes-Sandoval
  • D K Meyerholz
  • Keith S Bahjat
  • Anne C Moore
  • THOMAS GRIFFITH
  • Stephen M Todryk
  • Hildegund Cj Ertl
  • Vladimir P Badovinac
  • Jodie S Haring
  • Ali Jabbari
  • Thomas C Wirth
  • Aaruni Khanolkar
  • Sara E Hamilton
  • Nhat Long L Pham
  • Nathan W Schmidt
  • Gail A Corbin
  • Brandon B Porter
  • Kelly A Nordyke Messingham
  • Xinyuan Zhou
  • Dong Mei Zhao
  • Deepa Rai
  • Amy R Tvinnereim
  • Kelly A N Messingham
  • Jeffrey C Nolz
  • Jean Langhorne
  • Shuyang Yu
  • Lecia L Epping
  • Troy D Humphreys
  • Kevin L Legge
  • Fabio R Santori
  • Gabriel R Starbeck-Miller
  • Maria M Mota
  • Eleanor Riley
  • Mary Galinski
  • Patrick Duffy
  • Pierre Buffet
  • Erica Pasini
  • Didier Leroy
  • Michael Good
  • Monique Stins
  • Laurent Renia
  • Lecia L Pewe
  • Ryan A Langlois
  • Jaime T Sabel
  • Ross B Fulton
  • Tom Bair
  • Dilea Tifrea
  • Nhat Long Pham
  • Courtney J Fleenor
  • Brayton A Haag
  • Stacey M Hartwig
  • MORRIS O DAILEY
  • Lichao Zhao
  • Adrian V Hill
  • Lyric C Bartholomay
  • Brad J Tucker
  • Sarah C Gilbert
  • Rebecca L Podyminogin
  • Julie Bollenbacher-Reilley
  • Peter Lauer
  • Xuefang Jing
  • Stanislav Vukmanovic
  • Sasa Radoja
  • Courtney Smith
  • Zoran Popmihajlov

Detail Information

Publications61

  1. pmc The relevance of non-human primate and rodent malaria models for humans
    Jean Langhorne
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Malar J 10:23. 2011
    ..The major conclusions of the session were that experimental and human studies should be more closely linked so that they inform each other, and that there should be wider access to relevant clinical material...
  2. pmc CD8 T-cell recognition of macrophages and hepatocytes results in immunity to Listeria monocytogenes
    J T Harty
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    Infect Immun 64:3632-40. 1996
    ..In addition, Listeria-specific CD8 T cells lyse Listeria-infected hepatocyte-like cells in vitro. Thus, Listeria-infected hepatocytes can be recognized by CD8 T cells in vivo and in vitro...
  3. doi request reprint Shaping and reshaping CD8+ T-cell memory
    John T Harty
    Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, USA
    Nat Rev Immunol 8:107-19. 2008
    ..Here, we dissect the input signals that shape the characteristics of the memory CD8+ T-cell response and discuss how manipulation of these signals has the potential to reshape CD8+ T-cell memory and improve the efficacy of vaccination...
  4. ncbi request reprint CD8+ T cell effector mechanisms in resistance to infection
    J T Harty
    Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, USA
    Annu Rev Immunol 18:275-308. 2000
    ..Finally, recent studies of human CD8(+) T cells reveal the potential for novel effector mechanisms in resistance to infection...
  5. pmc Primary and secondary immune responses to Listeria monocytogenes
    J T Harty
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Curr Opin Immunol 8:526-30. 1996
    ....
  6. ncbi request reprint Responses of CD8(+) T cells to intracellular bacteria
    J T Harty
    Department of Microbiology, Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City 52242, USA
    Curr Opin Immunol 11:89-93. 1999
    ..These results, together with advances in our understanding of nonclassical MHC class I presentation, reveal the impact of pathogen biology on host immunity to infection...
  7. pmc Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function
    Hai Hui Xue
    Department of Microbiology, University of Iowa, 51 Newton Road, BSB 3 710, Iowa City, IA 52246, USA
    Mol Cell Biol 28:4300-9. 2008
    ..Our findings argue against such a possibility and rather suggest that GABPbeta1S has a critical role in maintaining the transcriptional activity of the GABPalpha/beta complex...
  8. ncbi request reprint T cells undergo rapid ON/OFF but not ON/OFF/ON cycling of cytokine production in response to antigen
    Gail A Corbin
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    J Immunol 174:718-26. 2005
    ..Thus, T cells are not able to undergo rapid ON/OFF/ON cytokine cycling in vitro in response to Ag...
  9. ncbi request reprint Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination
    Vladimir P Badovinac
    Department of Microbiology, 3 512 Bowen Science Building, 51 Newton Road, University of Iowa, Iowa City, Iowa 52240, USA
    Nat Med 11:748-56. 2005
    ....
  10. ncbi request reprint Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection
    Jodie S Haring
    Department of Microbiology, Carver School of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 180:2855-62. 2008
    ..These results indicate that expression of IL-7Ralpha alone does not support increased survival of effector Ag-specific CD4 or CD8 T cells into the memory phase following bacterial infection...
  11. ncbi request reprint Manipulating the rate of memory CD8+ T cell generation after acute infection
    Vladimir P Badovinac
    Interdisciplinary Graduate Program in Immunology, Department of Microbiology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    J Immunol 179:53-63. 2007
    ....
  12. ncbi request reprint CD8 T cell memory development: CD4 T cell help is appreciated
    Aaruni Khanolkar
    Department of Microbiology, University of Iowa, 3 512 Bowen Science Building, Iowa City, IA 52242, USA
    Immunol Res 39:94-104. 2007
    ..In recent years it has been determined that CD4 T cells play a vital role in the survival and functional responsiveness of memory CD8 T cells. However, the mechanism(s) of this interaction are still unclear...
  13. pmc Constitutive activation of Wnt signaling favors generation of memory CD8 T cells
    Dong Mei Zhao
    Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 184:1191-9. 2010
    ..Thus, constitutive activation of the canonical Wnt pathway favors memory CD8 T cell formation during initial immunization, resulting in enhanced immunity upon second encounter with the same pathogen...
  14. pmc Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts
    Deepa Rai
    Department of Pathology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 183:7672-81. 2009
    ..This concept has direct relevance to development of vaccines in outbred humans...
  15. pmc Generation and maintenance of Listeria-specific CD8+ T cell responses in perforin-deficient mice chronically infected with LCMV
    Troy D Humphreys
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Virology 370:310-22. 2008
    ....
  16. ncbi request reprint Simultaneous assessment of antigen-stimulated cytokine production and memory subset composition of memory CD8 T cells
    Ali Jabbari
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, USA
    J Immunol Methods 313:161-8. 2006
    ..Using this method, we directly identify differences in IL-2 production capacity by CD62L(hi)- and CD62L(lo)-expressing antigen-specific memory CD8 T cell populations...
  17. ncbi request reprint Inflaming the CD8+ T cell response
    Jodie S Haring
    Department of Microbiology, University of Iowa, Iowa City, 52242, USA
    Immunity 25:19-29. 2006
    ..These data may suggest new strategies for manipulating vaccine efficacy in the quest to protect against pathogenic microbes...
  18. doi request reprint High initial frequency of TCR-transgenic CD8 T cells alters inflammation and pathogen clearance without affecting memory T cell function
    Thomas C Wirth
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Mol Immunol 47:71-8. 2009
    ..Our results confirm the necessity to use low numbers of naïve precursors to mimic endogenous immune responses but show at the same time that memory CD8 T cell function in adoptive transfers is independent of input numbers...
  19. doi request reprint Differentiation of central memory CD8 T cells is independent of CD62L-mediated trafficking to lymph nodes
    Thomas C Wirth
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 182:6195-206. 2009
    ..Our results suggest that CD62L is not a deterministic marker of central memory T cell differentiation, thus providing new insight into the process of memory CD8 T cell generation...
  20. pmc Modulating numbers and phenotype of CD8+ T cells in secondary immune responses
    Thomas C Wirth
    Department of Microbiology, University of Iowa, Iowa City, IA, USA
    Eur J Immunol 40:1916-26. 2010
    ..Therefore, our study has important implications for the design of prime-boost regimens that aim to generate protective CD8(+) T-cell-mediated immunity...
  21. ncbi request reprint CD8(+) T-cell homeostasis after infection: setting the 'curve'
    Vladimir P Badovinac
    Department of Microbiology, University of Iowa, 3 512 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA
    Microbes Infect 4:441-7. 2002
    ..The possibility that early events after infection regulate major features of Ag-specific CD8(+) T-cell homeostasis will be discussed here...
  22. ncbi request reprint CD8+ T cell contraction is controlled by early inflammation
    Vladimir P Badovinac
    Department of Microbiology, University of Iowa, Iowa City, Iowa, USA
    Nat Immunol 5:809-17. 2004
    ..Thus, contraction is controlled by early inflammation but is not essential for the generation of protective memory CD8(+) T cells after infection...
  23. ncbi request reprint Quantitation of CD8+ T cell expansion, memory, and protective immunity after immunization with peptide-coated dendritic cells
    Sara E Hamilton
    Interdisciplinary Program in Immunology and Department of Microbiology, University of Iowa, Iowa City 52242, USA
    J Immunol 169:4936-44. 2002
    ..This protection was enhanced by diversifying the memory CD8(+) T cell compartment, even in the absence of a large increase in Ag-specific CD8(+) memory T cells...
  24. ncbi request reprint The role of inflammation in the generation and maintenance of memory T cells
    Noah S Butler
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    Adv Exp Med Biol 684:42-56. 2010
    ..Herein, we discuss our current understanding of how inflammation shapes not only the quantity and quality of memory T cells, but also the rate at which functional memory T-cell populations develop...
  25. pmc Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1
    Xinyuan Zhou
    Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Immunity 33:229-40. 2010
    ..Our studies thus identify TCF-1 as a critical player in a transcriptional program that regulates memory CD8 differentiation and longevity...
  26. ncbi request reprint Regulation of CD8+ T cells undergoing primary and secondary responses to infection in the same host
    Vladimir P Badovinac
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 170:4933-42. 2003
    ....
  27. pmc CD8(+)-T-cell response to secreted and nonsecreted antigens delivered by recombinant Listeria monocytogenes during secondary infection
    Amy R Tvinnereim
    Department of Microbiology, Interdisciplinary Graduate Program in Immunology, The University of Iowa, Iowa City, Iowa 52242, USA
    Infect Immun 70:153-62. 2002
    ..monocytogenes replication. Thus, the level of antivector immunity impacts the control of infection and efficiency of priming responses against new antigens introduced with the same vector...
  28. ncbi request reprint Duration of infection and antigen display have minimal influence on the kinetics of the CD4+ T cell response to Listeria monocytogenes infection
    Gail A Corbin
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 173:5679-87. 2004
    ....
  29. pmc Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation
    Thomas C Wirth
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Immunity 33:128-40. 2010
    ..These results reveal the complex regulation of memory CD8(+) T cell differentiation and identify potential new molecular targets to dissect the function of memory cells generated by repeated antigen stimulation...
  30. pmc Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites
    Nathan W Schmidt
    Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Pathog 6:e1000998. 2010
    ..These data provide new insights into protective CD8 T cell responses elicited by RAS-immunization in genetically diverse hosts, information with relevance to developing attenuated whole-parasite vaccines...
  31. pmc Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites
    Noah S Butler
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 184:2528-38. 2010
    ..Our studies also show that the effector pathways that memory CD8 T cells use to eliminate liver stage infection are, in part, Plasmodium species specific...
  32. pmc T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts
    Aaruni Khanolkar
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:1132-41. 2010
    ..Thus, identification of novel CD4 and CD8 T cell epitopes for MHV-1 permitted high-resolution analyses of pulmonary T cell responses in a mouse model of SARS...
  33. pmc Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly
    Nhat Long L Pham
    Departments of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 107:12198-203. 2010
    ..Thus, accelerated CD8 T-cell memory after in vivo cross-priming in the absence of adjuvant is generalizable and can be exploited to generate protective immunity rapidly...
  34. pmc Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria
    Nathan W Schmidt
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:14017-22. 2008
    ..Furthermore, the extremely large threshold in memory CD8 T cell frequencies required for long-term protection in mice may have important implications for development of effective malaria vaccines...
  35. pmc Interleukin-18-related genes are induced during the contraction phase but do not play major roles in regulating the dynamics or function of the T-cell response to Listeria monocytogenes infection
    Jodie S Haring
    Department of Microbiology, 3 512 BSB, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    Infect Immun 77:1894-903. 2009
    ..monocytogenes infection...
  36. pmc CD8 T cell immunity to Plasmodium permits generation of protective antibodies after repeated sporozoite challenge
    Nathan W Schmidt
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, United States
    Vaccine 27:6103-6. 2009
    ..Therefore, initial protection by a CD8 T cell-targeted liver stage subunit vaccine allows the generation of enhanced sterilizing immune responses from repeated exposure to Plasmodium parasites...
  37. pmc A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigen-driven proliferation
    Nhat Long L Pham
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 183:2337-48. 2009
    ..These data suggest that a default pathway of memory CD8 T cell differentiation is deflected toward sustained effector commitment by encounter with inflammatory cytokines during Ag-driven proliferation...
  38. pmc Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome
    Aaruni Khanolkar
    Department of Microbiology, University of Iowa, Iowa City, 52242, USA
    J Virol 83:9258-72. 2009
    ..Overall, our findings highlight the role of the host immune response in contributing to the pathogenesis of coronavirus-induced respiratory disease...
  39. ncbi request reprint The generation and modulation of antigen-specific memory CD8 T cell responses
    Ali Jabbari
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, 52242, USA
    J Leukoc Biol 80:16-23. 2006
    ..The generation of antigen-specific CD8 T cells, therefore, is a potential approach in the design of vaccines, especially for those pathogens in which the humoral response is insufficient to protect the host...
  40. ncbi request reprint Influence of effector molecules on the CD8(+) T cell response to infection
    John T Harty
    Department of Microbiology, and Interdisciplinary Graduate Program in Immunology, University of Iowa, 3 512 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA
    Curr Opin Immunol 14:360-5. 2002
    ..Recent evidence demonstrates that anti-microbial effector molecules such as perforin and IFN-gamma regulate specific aspects of CD8(+) T cell homeostasis by mechanisms that may be dependent or independent of pathogen clearance...
  41. ncbi request reprint Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice
    Vladimir P Badovinac
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    Immunity 18:463-74. 2003
    ..Thus, perforin was essential for resistance to secondary LCMV infection, and, in the absence of perforin, vaccination resulted in lethal disease mediated by dysregulated CD8(+) T cell expansion and cytokine production...
  42. ncbi request reprint Deficient anti-listerial immunity in the absence of perforin can be restored by increasing memory CD8+ T cell numbers
    Kelly A Nordyke Messingham
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 171:4254-62. 2003
    ..Thus, increasing the number of memory CD8(+) T cells can overcome diminished per-cell protective immunity in the absence of perforin...
  43. ncbi request reprint MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory response
    Sara E Hamilton
    Interdisciplinary Program in Immunology, The University of Iowa, Iowa City, IA 52242, USA
    Nat Immunol 5:159-68. 2004
    ..Thus, protective immunity by H2-M3-restricted T cells is limited to primary infection, indicating that memory MHC class Ia-restricted T cells prevent nonessential immune responses during secondary infection...
  44. ncbi request reprint Dynamic regulation of IFN-gamma signaling in antigen-specific CD8+ T cells responding to infection
    Jodie S Haring
    Department of Microbiology, University of Iowa, Iowa City, 52242, USA
    J Immunol 174:6791-802. 2005
    ....
  45. ncbi request reprint Cutting edge: differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation
    Ali Jabbari
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 175:4829-33. 2005
    ..These findings suggest a differential requirement for spMHC signals for maintenance of CD8 T cell function and homeostatic proliferation...
  46. pmc Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype
    Ali Jabbari
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Exp Med 203:919-32. 2006
    ..Thus, primary and secondary memory CD8 T cells are functionally distinct, and the number of encounters with antigen influences memory CD8 T cell function...
  47. ncbi request reprint TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells
    Vladimir P Badovinac
    Department of Microbiology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    J Immunol 177:999-1006. 2006
    ....
  48. ncbi request reprint Programming, demarcating, and manipulating CD8+ T-cell memory
    Vladimir P Badovinac
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    Immunol Rev 211:67-80. 2006
    ..Finally, we discuss experimental approaches to manipulate and accelerate generation of CD8+ T cells with memory characteristics, and how these systems can inform both basic and applied immunology...
  49. ncbi request reprint T cell conditioning explains early disappearance of the memory CD8 T cell response to infection
    Ali Jabbari
    Interdisciplinary Graduate Program in Immunology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 177:3012-8. 2006
    ..Conventional analyses of memory CD8 T cell populations early after infection and possibly in the presence of low levels of Ag (as during chronic infections) may exclude significant numbers of the responding CD8 T cell population...
  50. ncbi request reprint A role for IFN-gamma from antigen-specific CD8+ T cells in protective immunity to Listeria monocytogenes
    Kelly A N Messingham
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 179:2457-66. 2007
    ....
  51. pmc Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection
    Vladimir P Badovinac
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Immunity 26:827-41. 2007
    ..These data strongly suggest that modeling the endogenous T cell response with TCR-tg cells will require every effort to approximate the endogenous precursor frequency...
  52. pmc Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor
    Jodie S Haring
    Department of Microbiology, 3 512 BSB, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    Infect Immun 74:6252-63. 2006
    ..From these data we conclude that IFN-gamma regulates the contraction, phenotype, and function of Ag-specific CD4 T cells generated after infection...
  53. pmc Naive, effector and memory CD8 T-cell trafficking: parallels and distinctions
    Jeffrey C Nolz
    Department of Microbiology, 3 512 Bowen Science Building, 51 Newton Rd, Iowa City, IA 52242, USA
    Immunotherapy 3:1223-33. 2011
    ..In this article, we discuss recent advances in understanding how antigenic stimulation influences expression of various trafficking receptors and ligands, and how this determines the tissue localization of CD8 T cells...
  54. ncbi request reprint Neutrophil involvement in cross-priming CD8+ T cell responses to bacterial antigens
    Amy R Tvinnereim
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 173:1994-2002. 2004
    ..In addition, cross-presentation of bacterial Ags from neutrophils may explain how CD8(+) T cell responses are generated against Ags from extracellular bacterial pathogens...
  55. pmc The onset of CD8+-T-cell contraction is influenced by the peak of Listeria monocytogenes infection and antigen display
    Brandon B Porter
    Interdisciplinary Program in Immunology, University of Iowa, 3 512 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA
    Infect Immun 74:1528-36. 2006
    ..These results demonstrate a direct relationship between the course of infection and Ag display and that the timing of these events is important in shaping the T-cell response to infection...
  56. ncbi request reprint Listeriolysin O-deficient Listeria monocytogenes as a vaccine delivery vehicle: antigen-specific CD8 T cell priming and protective immunity
    Sara E Hamilton
    Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 177:4012-20. 2006
    ..We conclude that the generation of protective immunity by LLO-deficient strains of LM does in fact occur and that this highly attenuated LM strain may be a useful platform for vaccine delivery...
  57. ncbi request reprint Programmed contraction of CD8(+) T cells after infection
    Vladimir P Badovinac
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Nat Immunol 3:619-26. 2002
    ..Thus, major features of antigen-specific CD8(+) T cell homeostasis, including the contraction phase of an immune response, may be programmed early after infection...
  58. pmc Viral vector vaccines make memory T cells against malaria
    Arturo Reyes-Sandoval
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Immunology 121:158-65. 2007
    ..Being able to influence the memory T-cell make-up in a rational manner may allow us to develop more efficacious vaccines...
  59. ncbi request reprint TCR beta chain that forms peptide-independent alloreactive TCR transfers reduced reactivity with irrelevant peptide/MHC complex
    Fabio R Santori
    Michael Heidelberger Division of Immunology, Department of Pathology and New York University Cancer Center, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 178:6109-14. 2007
    ..In addition, these findings demonstrate that reactivity to peptides is preferred over the reactivity to MHC during the formation of the TCR repertoire...
  60. ncbi request reprint Memory lanes
    Vladimir P Badovinac
    Nat Immunol 4:212-3. 2003
  61. doi request reprint Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei
    Arturo Reyes-Sandoval
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Eur J Immunol 38:732-41. 2008
    ..Our data suggest that T(EM) cells are important as a first line of defense against fast-replicating pathogens such as murine Plasmodium and demonstrate the potential of replication-defective SAd as future malaria vaccines for humans...

Research Grants34

  1. CD8+T cell effector mechansisms against L. monocytogenes
    John Harty; Fiscal Year: 2007
    ..Aim-3. Investigate the mechanisms responsible for prolonged contraction of CD8+ T cells during the secondary response to infection. ..
  2. Accelerated CD8 T cell memory after DC vaccination
    John Harty; Fiscal Year: 2007
    ..Aim 3. Determine if accelerated memory and prime-boost after DC immunization improves immunotherapy against established tumors and protection against malaria and leishmaniasis. ..
  3. Regulation of T cell homeostasis by IFN-gamma
    John Harty; Fiscal Year: 2007
    ..Specific Aim 2. Determine if IFN-gamma regulates T cell contraction through p53 and/or IL-18 signaling. Specific Aim 3. Determine the requirements for IFN-alpha-beta and IFN-gamma signaling in regulating CDS T cell expansion. ..
  4. CTL pathogenesis after infection of vaccinated host
    John Harty; Fiscal Year: 2009
    ..Aim 3. Analyze CD8+ T cell and pathogen parameters that determine the outcome of LCMV infection in vaccinated PKO mice. Aim 4. Determine if vaccination-associated mortality extends to other immunodeficiencies or pathogens. ..
  5. Regulation of T cell homeostasis by IFN-gamma
    John T Harty; Fiscal Year: 2010
    ..Determine if IFN-gamma regulates T cell contraction through p53 and/or IL-18 signaling. Specific Aim 3. Determine the requirements for IFN-alpha-beta and IFN-gamma signaling in regulating CDS T cell expansion. ..
  6. Accelerated CD8 T cell memory after DC vaccination
    John T Harty; Fiscal Year: 2010
    ..Aim 3. Determine if accelerated memory and prime-boost after DC immunization improves immunotherapy against established tumors and protection against malaria and leishmaniasis. ..
  7. Regulation of T cell homeostasis by IFN-gamma
    John Harty; Fiscal Year: 2005
    ....
  8. CD8+ T CELL EFFECTOR MECHANISMS AGAINST L MONOCYTOGENES
    John Harty; Fiscal Year: 2001
    ..The results of these studies will provide important information for vaccine design strategies and emerging approaches to the immunotherapy of human infectious diseases. ..
  9. Presentation of Listeria antigens to CD8+ T cells
    John Harty; Fiscal Year: 2005
    ..Such basic information will impact evolving strategies for rational vaccine design, addressing the utility of the various antigen presentation pathways for vaccine delivery and for providing targets for protective immunity. ..
  10. Memory CD8 T cell immunity to Plasmodium liver stage infec
    John T Harty; Fiscal Year: 2010
    ..Addressing this knowledge gap would aid in the rational design of malaria vaccines and is the goal of this proposal. ..