M Elizabeth Hartnett

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Perceived barriers to diabetic eye care: qualitative study of patients and physicians
    M Elizabeth Hartnett
    Department of Ophthalmology, The University of North Carolina at Chapel Hill, 27599 7040, USA
    Arch Ophthalmol 123:387-91. 2005
  2. pmc Neutralizing antibody to VEGF reduces intravitreous neovascularization and may not interfere with ongoing intraretinal vascularization in a rat model of retinopathy of prematurity
    P Geisen
    Department of Ophthalmology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
    Mol Vis 14:345-57. 2008
  3. pmc Increased angiogenic factors associated with peripheral avascular retina and intravitreous neovascularization: a model of retinopathy of prematurity
    Steven J Budd
    Department of Ophthalmology, School of Medicine, University of North Carolina, 130 Mason Farm Rd, Campus Box 7040, Chapel Hill, NC 27599 7040, USA
    Arch Ophthalmol 128:589-95. 2010
  4. pmc Aqueous vascular endothelial growth factor as a predictor of macular thickening following cataract surgery in patients with diabetes mellitus
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Ophthalmol 148:895-901.e1. 2009
  5. pmc The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR model
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 130 Mason Farm Road, Chapel Hill, NC 27599 7040, USA
    Doc Ophthalmol 120:25-39. 2010
  6. pmc Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in a rat model of ROP: relevance to plus disease
    M Elizabeth Hartnett
    Department of Ophthalmology, The University of North Carolina, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 49:3107-14. 2008
  7. doi Subretinal hemorrhage after lens-sparing vitrectomy in infants born at or under 24 weeks gestation
    M Elizabeth Hartnett
    University of North Carolina, Chapel Hill, North Carolina, USA
    Retina 28:S69-74. 2008
  8. pmc Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 6109A Neuroscience Research Building, Chapel Hill, NC 27599, USA
    Invest Ophthalmol Vis Sci 47:4975-82. 2006
  9. pmc Fibrovascular organization in the vitreous following laser for ROP: implications for prognosis
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7040, USA
    Retina 26:S24-31. 2006
  10. ncbi Comparison of retinal outcomes after scleral buckle or lens-sparing vitrectomy for stage 4 retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599 7040, USA
    Retina 24:753-7. 2004

Research Grants

  1. Endothelial Transmigration Across the RPE Barrier
    Mary Elizabeth Hartnett; Fiscal Year: 2005
  2. Endothelial Transmigration in Neovascular Age-related Macular Degeneration
    Mary Elizabeth Hartnett; Fiscal Year: 2007

Collaborators

Detail Information

Publications36

  1. ncbi Perceived barriers to diabetic eye care: qualitative study of patients and physicians
    M Elizabeth Hartnett
    Department of Ophthalmology, The University of North Carolina at Chapel Hill, 27599 7040, USA
    Arch Ophthalmol 123:387-91. 2005
    ..To address inadequate retinopathy screening at a largely indigent clinic and to explore perceived barriers, using qualitative techniques...
  2. pmc Neutralizing antibody to VEGF reduces intravitreous neovascularization and may not interfere with ongoing intraretinal vascularization in a rat model of retinopathy of prematurity
    P Geisen
    Department of Ophthalmology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
    Mol Vis 14:345-57. 2008
    ....
  3. pmc Increased angiogenic factors associated with peripheral avascular retina and intravitreous neovascularization: a model of retinopathy of prematurity
    Steven J Budd
    Department of Ophthalmology, School of Medicine, University of North Carolina, 130 Mason Farm Rd, Campus Box 7040, Chapel Hill, NC 27599 7040, USA
    Arch Ophthalmol 128:589-95. 2010
    ..To determine expression of vascular endothelial growth factor (VEGF), pigment epithelium-derived factor, and their respective receptors in retinas using a model of retinopathy of prematurity...
  4. pmc Aqueous vascular endothelial growth factor as a predictor of macular thickening following cataract surgery in patients with diabetes mellitus
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Ophthalmol 148:895-901.e1. 2009
    ....
  5. pmc The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR model
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 130 Mason Farm Road, Chapel Hill, NC 27599 7040, USA
    Doc Ophthalmol 120:25-39. 2010
    ..Increased signaling of VEGF appears important to the development of both avascular retina and intravitreous neovascularization...
  6. pmc Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in a rat model of ROP: relevance to plus disease
    M Elizabeth Hartnett
    Department of Ophthalmology, The University of North Carolina, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 49:3107-14. 2008
    ..To study the effects of vascular endothelial growth factor (VEGF) on endothelial nitric oxide synthetase (eNOS) and retinal vascular tortuosity and cleavage planes in a rat model of retinopathy of prematurity (ROP)...
  7. doi Subretinal hemorrhage after lens-sparing vitrectomy in infants born at or under 24 weeks gestation
    M Elizabeth Hartnett
    University of North Carolina, Chapel Hill, North Carolina, USA
    Retina 28:S69-74. 2008
    ..To describe short term outcomes in a case series of infants with rapidly progressive retinopathy of prematurity (ROP) requiring laser and lens-sparing vitrectomies (LSV) at early postmenstrual ages (PMAs)...
  8. pmc Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 6109A Neuroscience Research Building, Chapel Hill, NC 27599, USA
    Invest Ophthalmol Vis Sci 47:4975-82. 2006
    ..To study the effects of intravitreous triamcinolone acetonide (TA) on neovascularization (NV), capillary density, and retinal endothelial cell (REC) viability in a model of oxygen-induced retinopathy (OIR)...
  9. pmc Fibrovascular organization in the vitreous following laser for ROP: implications for prognosis
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7040, USA
    Retina 26:S24-31. 2006
    ..To study associations between surgical outcome and mean postmenstrual age (PMA) when fibrovascular organization is detected between vascular and avascular retina following laser for acute retinopathy of prematurity (ROP)...
  10. ncbi Comparison of retinal outcomes after scleral buckle or lens-sparing vitrectomy for stage 4 retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599 7040, USA
    Retina 24:753-7. 2004
    ..To compare anatomic outcomes after lens-sparing vitrectomy (LSV) or scleral buckle (SB) for stage 4 retinopathy of prematurity (ROP)...
  11. ncbi Features associated with surgical outcome in patients with stages 4 and 5 retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, 27599, USA
    Retina 23:322-9. 2003
    ..To present ocular features associated with surgical outcomes in infants with stages 4 and 5 retinopathy of prematurity (ROP)...
  12. ncbi Long-term vision results measured with Teller Acuity Cards and a new Light Perception/Projection Scale after management of late stages of retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill 27599 7040, USA
    Arch Ophthalmol 121:991-6. 2003
    ....
  13. pmc Retinal features predictive of progressive stage 4 retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Retina 24:237-41. 2004
    ..To determine the retinal features predictive of progressive stage 4 retinopathy of prematurity (ROP) after laser treatment for threshold ROP...
  14. pmc The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model
    Grace Byfield
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599 7041, USA
    Invest Ophthalmol Vis Sci 50:3360-5. 2009
    ....
  15. pmc Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity
    Yuta Saito
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 13:840-53. 2007
    ....
  16. pmc The role of vascular endothelial growth factor-induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularization
    Elizabeth Monaghan-Benson
    Department of Cell and Developmental Biology, University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, USA
    Am J Pathol 177:2091-102. 2010
    ..These steps may contributed to the pathology of neovascular age-related macular degeneration...
  17. pmc Association of retinal vascular endothelial growth factor with avascular retina in a rat model of retinopathy of prematurity
    Steven J Budd
    Department of Ophthalmology, University of North Carolina, Chapel Hill, USA
    Arch Ophthalmol 128:1014-21. 2010
    ..To study the effects of oxygen fluctuations on rat vascular endothelial growth factor (VEGF), VEGF receptor 1(VEGFR1), and VEGFR2 in a model of retinopathy of prematurity (ROP)...
  18. pmc Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity
    John S Hartmann
    University of North Carolina, Department of Ophthalmology, Chapel Hill, NC, USA
    Mol Vis 17:1577-87. 2011
    ..To determine the effects of oxygen fluctuations on pigment epithelial-derived factor (PEDF) and vascular endothelial growth factor (VEGF)/PEDF ratios in a relevant rat model of retinopathy of prematurity (ROP)...
  19. pmc VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP
    Janet R McColm
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 10:512-20. 2004
    ..We also determined whether pigment epithelium-derived factor (PEDF) was dysregulated by oxygen fluctuations perhaps contributing to a delay in normal retinal vascular development...
  20. pmc Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis
    Janet R McColm
    Department of Ophthalmology, University of North Carolina, 6135 Neuroscience Research Building, 103 Mason Farm Road, Chapel Hill, NC 27599 7041, USA
    Exp Eye Res 83:438-46. 2006
    ..Antibody to LIF restored the cell counts to untreated levels. LIF reduced the number of cells in S phase. LIF attenuates retinal vascular development in vivo through growth arrest, and not apoptosis, of endothelial cells...
  21. pmc Upregulation of CCR3 by age-related stresses promotes choroidal endothelial cell migration via VEGF-dependent and -independent signaling
    Haibo Wang
    Department of Ophthalmology, The John Moran Eye Center, University of Utah, Salt Lake City, Utah, USA
    Invest Ophthalmol Vis Sci 52:8271-7. 2011
    ....
  22. pmc Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1
    Lynda J Peterson
    Department of Ophthalmology, 6135 Neuroscience Research Building, University of North Carolina, 103 Mason Farm Road, CB 7041, 6135 NSRB, Chapel Hill, NC 27599 7041, USA
    Exp Eye Res 84:737-44. 2007
    ..We hypothesize that contact between CECs and RPE stimulates a signaling pathway involving PI 3-K, Akt1, and Rac1 that facilitates CEC transmigration across the RPE barrier, an important step in the development of neovascular AMD...
  23. pmc Anti-VEGF antibody leads to later atypical intravitreous neovascularization and activation of angiogenic pathways in a rat model of retinopathy of prematurity
    Manabu McCloskey
    Department of Ophthalmology, The John Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 54:2020-6. 2013
    ..We sought to understand causes of late-onset IVNV and AVA following anti-VEGF using an ROP model...
  24. pmc The role of RPE cell-associated VEGF₁₈₉ in choroidal endothelial cell transmigration across the RPE
    Haibo Wang
    Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 52:570-8. 2011
    ..To determine the role of vascular endothelial growth factor 189 (VEGF₁₈₉) in choroidal endothelial cell (CEC) migration across the retinal pigment epithelium (RPE) and to explore the molecular mechanisms involved...
  25. ncbi Characterization of barrier properties and inducible VEGF expression of several types of retinal pigment epithelium in medium-term culture
    Pete Geisen
    Department of Ophthalmology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Curr Eye Res 31:739-48. 2006
    ..To investigate and compare the characteristics of four different types of retinal pigment epithelium (RPE) cells cultured for 2 to 5 weeks to provide guidance when choosing RPE cells for experimentation...
  26. ncbi Quantification of macular and optic disc hyperfluorescence after phacoemulsification in diabetes mellitus
    George K Escaravage
    Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Cataract Refract Surg 32:803-11. 2006
    ....
  27. ncbi Choroidal endothelial cells transmigrate across the retinal pigment epithelium but do not proliferate in response to soluble vascular endothelial growth factor
    Pete Geisen
    Department of Ophthalmology, University of North Carolina Chapel Hill, 103 Mason Farm Road, CB No 7041, 6135 NSRB, Chapel Hill, NC 27599, USA
    Exp Eye Res 82:608-19. 2006
    ..These findings may have relevance to the transformation of occult CNV into CNV within the neurosensory retina in AMD...
  28. pmc Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo
    Erika S Wittchen
    Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e73070. 2013
    ....
  29. pmc Chloride intracellular channel protein-4 functions in angiogenesis by supporting acidification of vacuoles along the intracellular tubulogenic pathway
    Barbara Ulmasov
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27514 7155, USA
    Am J Pathol 174:1084-96. 2009
    ..We conclude that CLIC4 plays a critical role in angiogenesis by supporting acidification of vacuoles along the cell-hollowing tubulogenic pathway...
  30. pmc The small GTPase Rap1 is a novel regulator of RPE cell barrier function
    Erika S Wittchen
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 52:7455-63. 2011
    ..To determine whether the small GTPase Rap1 regulates the formation and maintenance of the retinal pigment epithelial (RPE) cell junctional barrier...
  31. pmc Soluble mediators of diabetic macular edema: the diagnostic role of aqueous VEGF and cytokine levels in diabetic macular edema
    Leah A Owen
    Department of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Curr Diab Rep 13:476-80. 2013
    ..Further studies targeting individual cytokine activity will be important to our understanding of the pathogenesis and treatment. ..
  32. pmc New-onset maternal gestational hypertension and risk of retinopathy of prematurity
    Mohamed A Zayed
    Department of Ophthalmology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 51:4983-8. 2010
    ..To evaluate associations between conditions of maternal new-onset gestational hypertension (mHTN) and the features imparting risk of severe retinopathy of prematurity (ROP) in preterm infants...
  33. pmc Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes
    Robyn Reynolds
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:5818-27. 2009
    ..This study was conducted to determine whether alterations in circulating levels of these markers of complement activation and regulation are also independently associated with advanced AMD and whether they are related to AMD genotypes...
  34. ncbi Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 5109D Bioinformatics Building, 130 Mason Farm Road, CB 7040, Chapel Hill, NC 27599 7040, USA
    Exp Eye Res 77:593-9. 2003
    ..To investigate the effect of endothelial cells (EC) on the barrier function of the retinal pigment epithelium (RPE)...
  35. ncbi CIB1 regulates endothelial cells and ischemia-induced pathological and adaptive angiogenesis
    Mohamed A Zayed
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Circ Res 101:1185-93. 2007
    ..These data therefore reveal a critical role for CIB1 in ischemia-induced pathological and adaptive angiogenesis...
  36. ncbi Antiphospholipid antibody syndrome in a six-year-old female patient
    M Elizabeth Hartnett
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Ophthalmol 135:542-4. 2003
    ..To report the first instance of primary antiphospholipid antibody (APA) syndrome in an otherwise healthy 6-year-old female patient with retinal venous thromboses...

Research Grants2

  1. Endothelial Transmigration Across the RPE Barrier
    Mary Elizabeth Hartnett; Fiscal Year: 2005
    ..Increased knowledge of the mechanisms that cause this destructive phenomenon may lead to future means to prevent CNV in the neurosensory retina, and thus, reduce vision loss in AMD. ..
  2. Endothelial Transmigration in Neovascular Age-related Macular Degeneration
    Mary Elizabeth Hartnett; Fiscal Year: 2007
    ..Effective management will require treatments targeting different steps in the disease pathogenesis, including prevention. Our goal is to determine mechanisms to prevent neurosensory CNV. ..