John L Hartman Iv

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Global analysis of phase locking in gene expression during cell cycle: the potential in network modeling
    Shouguo Gao
    Department of Physics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    BMC Syst Biol 4:167. 2010
  2. pmc Accurate, precise modeling of cell proliferation kinetics from time-lapse imaging and automated image analysis of agar yeast culture arrays
    Najaf A Shah
    Department of Genetics, University of Alabama School of Medicine, Birmingham, Alabama 35294, USA
    BMC Syst Biol 1:3. 2007
  3. pmc Buffering of deoxyribonucleotide pool homeostasis by threonine metabolism
    John L Hartman
    Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:11700-5. 2007
  4. pmc Stringent mating-type-regulated auxotrophy increases the accuracy of systematic genetic interaction screens with Saccharomyces cerevisiae mutant arrays
    Indira Singh
    Department of Genetics, University of Alabama, Birmingham, Alabama 35294, USA
    Genetics 181:289-300. 2009
  5. pmc Recursive expectation-maximization clustering: a method for identifying buffering mechanisms composed of phenomic modules
    Jingyu Guo
    Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Chaos 20:026103. 2010
  6. pmc Defining genetic interaction
    Ramamurthy Mani
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:3461-6. 2008
  7. pmc Systematic quantification of gene interactions by phenotypic array analysis
    John L Hartman
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Genome Biol 5:R49. 2004

Research Grants

  1. Molecular Buffering of Replication in Yeast
    JOHN HARTMAN; Fiscal Year: 2006

Collaborators

  • JOHN HARTMAN
  • L P Zhao
  • Brett A McKinney
  • Shouguo Gao
  • Jingyu Guo
  • Indira Singh
  • Ramamurthy Mani
  • Najaf A Shah
  • Dehua Tian
  • Justin L Carter
  • Martin J Hessner
  • Xujing Wang
  • John W Rodgers
  • Sine Ozmen Togay
  • Rebecca Pass
  • Guri Giaever
  • Robert P St Onge
  • Frederick P Roth
  • Bradley Wardman
  • Richard J Laws

Detail Information

Publications7

  1. pmc Global analysis of phase locking in gene expression during cell cycle: the potential in network modeling
    Shouguo Gao
    Department of Physics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    BMC Syst Biol 4:167. 2010
    ..Conversely, the synchrony information can be utilized to infer interaction. Increasing evidence suggests that frequency modulation is also common in transcription regulation...
  2. pmc Accurate, precise modeling of cell proliferation kinetics from time-lapse imaging and automated image analysis of agar yeast culture arrays
    Najaf A Shah
    Department of Genetics, University of Alabama School of Medicine, Birmingham, Alabama 35294, USA
    BMC Syst Biol 1:3. 2007
    ..To improve HTCP performance and advance capabilities for quantifying interactions, YeastXtract software was developed for automated analysis of cell array images...
  3. pmc Buffering of deoxyribonucleotide pool homeostasis by threonine metabolism
    John L Hartman
    Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:11700-5. 2007
    ..Validation of these hypotheses substantiates the added benefit of quantitative phenotyping for identifying subtleties in gene interaction networks that modulate cellular phenotypes...
  4. pmc Stringent mating-type-regulated auxotrophy increases the accuracy of systematic genetic interaction screens with Saccharomyces cerevisiae mutant arrays
    Indira Singh
    Department of Genetics, University of Alabama, Birmingham, Alabama 35294, USA
    Genetics 181:289-300. 2009
    ..Modifications engineered to reduce haploid MRA escape reduced false negative results in SGA-type analysis, resulting in >95% sensitivity for detecting gene-gene interactions...
  5. pmc Recursive expectation-maximization clustering: a method for identifying buffering mechanisms composed of phenomic modules
    Jingyu Guo
    Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Chaos 20:026103. 2010
    ..It facilitates identification of phenomic modules, which contribute to buffering mechanisms that underlie cellular homeostasis and the regulation of phenotypic expression...
  6. pmc Defining genetic interaction
    Ramamurthy Mani
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:3461-6. 2008
    ..Additionally, we show that the Additive and Log definitions, each commonly used in population genetics, lead to differing conclusions related to the selective advantages of sexual reproduction...
  7. pmc Systematic quantification of gene interactions by phenotypic array analysis
    John L Hartman
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Genome Biol 5:R49. 2004
    ..The work provides an example of, and a general experimental framework for, quantitative analysis of gene interaction networks that buffer cell growth...

Research Grants1

  1. Molecular Buffering of Replication in Yeast
    JOHN HARTMAN; Fiscal Year: 2006
    ....