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Genomes and GenesSpecies | L G HarshmanSummaryAffiliation: University of Nebraska Country: USA Publications
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Publications
The cost of reproduction: the devil in the detailsLawrence G Harshman
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
Trends Ecol Evol 22:80-6. 2007..These studies not only provide new information about mechanisms that comprise 'the cost', but also hint at an underlying evolutionarily conserved causal mechanism...- Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogasterAnette Landenberger
Department of Nutrition and Health Sciences, University of Nebraska at Lincoln, 316 Ruth Leverton Hall, Lincoln, NE 68583-0806, USA
J Nutr Biochem 15:591-600. 2004..These findings are consistent with the hypothesis that biotin affects life span, stress resistance, and fertility in fruit flies... 
The symmetry of longevityLawrence G Harshman
School of Biological Sciences, University of Nebraska Lincoln, 68588, USA
J Gerontol A Biol Sci Med Sci 60:1233-7. 2005..Wing symmetry of females and males proved to be a statistically significant predictor of life span, especially for males...- Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogasterSergey V Nuzhdin
Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
BMC Genomics 10:124. 2009..We focus on the latter problem by describing genetic variation in transcript levels of genes in the InR/TOR pathway among 72 Drosophila melanogaster genotypes... 
Transcriptional profiling of the sperm storage organs of Drosophila melanogasterA M Prokupek
School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska, USA
Insect Mol Biol 18:465-75. 2009..Differences in functional gene categories indicate that these organs play unique roles in sperm storage...- Sex-specific expression of alternative transcripts in DrosophilaLauren M McIntyre
Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32611, USA
Genome Biol 7:R79. 2006..Here, we describe a genome-wide analysis of sex-specific expression of alternative transcripts in Drosophila melanogaster... - Environmental stress and reproduction in Drosophila melanogaster: starvation resistance, ovariole numbers and early age egg productionMarta L Wayne
Department of Zoology, University of Florida, Gainesville, FL32611, USA
BMC Evol Biol 6:57. 2006..melanogaster. Thus, one might expect that a negative genetic correlation between starvation resistance and early fecundity would be accompanied by a decrease in ovariole number... - Oxidative stress resistance: a robust correlated response to selection in extended longevity lines of Drosophila melanogaster?L G Harshman
School of Biological Sciences, University of Nebraska Lincoln, 68588, USA
J Gerontol A Biol Sci Med Sci 55:B415-7. 2000..Increased oxidative stress resistance appears to be a relatively robust correlated response to laboratory selection for late-life reproduction and extended longevity... - A cost of reproduction: oxidative stress susceptibility is associated with increased egg production in Drosophila melanogasterY Wang
School of Biological Sciences, 348 Manter Hall, University of Nebraska-Lincoln, Lincoln, NE 68588-0118, USA
Exp Gerontol 36:1349-59. 2001..Added yeast was associated with stress susceptibility of fertile females but not of sterile females. The results of the present study suggest that oxidative stress susceptibility is a physiological cost of reproduction... - Stress resistance and longevity in selected lines of Drosophila melanogasterL G Harshman
School of Biological Sciences, University of Nebraska Lincoln, 68588, USA
Neurobiol Aging 20:521-9. 1999..Neither females nor males from the selected lines were relatively long-lived. In at least some cases, stress resistance may be necessary, but not sufficient, for longevity... - A cost of reproduction in Drosophila melanogaster: stress susceptibilityA B Salmon
School of Biological Sciences, University of Nebraska Lincoln, 68588, USA
Evolution 55:1600-8. 2001..The results of the present study support the hypothesis that stress susceptibility is a cost of reproduction... - Molecular evolutionary analysis of seminal receptacle sperm storage organ genes of Drosophila melanogasterA M Prokupek
School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68588, USA
J Evol Biol 23:1386-98. 2010..These candidates belong to protein classes such as muscle contraction, odorant binding and odorant receptor, protease inhibitor and immunity... - Differential gene expression in insects: transcriptional controlL G Harshman
School of Biological Sciences, University of Nebraska Lincoln 68588 0118, USA
Annu Rev Entomol 43:671-700. 1998..Once this deficiency is addressed, the full impact of research on transcription control will be realized throughout the field of entomology... - Investigation of the endocrine system in extended longevity lines of Drosophila melanogasterL G Harshman
School of Biological Sciences, University of Nebraska Lincoln, 68588, USA
Exp Gerontol 34:997-1006. 1999..There was no difference between selected and control lines in the specific activity of either class of enzymes that metabolize juvenile hormone... - Extended longevity lines of Drosophila melanogaster: abundance of yolk protein gene mRNA in fat body and ovaryK A Carlson
School of Biological Sciences, University of Nebraska Lincoln, 68588 0118, USA
Exp Gerontol 34:173-84. 1999..On medium without supplemental yeast, the relatively low abundance of fat body yolk-protein gene mRNA in the selected lines on day 4 posteclosion corresponds to a prediction derived from the disposable soma theory... - Jhe in Gryllus assimilis: cloning, sequence-activity associations and phylogenyE J Crone
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588 0118, USA
Insect Biochem Mol Biol 37:1359-65. 2007..Phylogenetic analyses localised the G. assimilis JHE to a clade containing dipteran and coleopteran JHEs, with lepidopteran JHEs occurring in a separate clade... - Evolution of starvation resistance in Drosophila melanogaster: measurement of direct and correlated responses to artificial selectionT E Schwasinger-Schmidt
The University of Kansas School of Medicine, Kansas City, KS, USA
J Evol Biol 25:378-87. 2012.... - Superoxide dismutase activities in long-lived Drosophila melanogaster females: chico1 genotypes and dietary dilutionHadise Kabil
School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE, 68588, USA
Biogerontology 8:201-8. 2007..Results from the present study indicate that elevated CuZn SOD activity, not Mn SOD, is the basis for the relatively high level of SOD activity in the chico (1) homozygotes... - Quantitative trait loci for lipid content in Drosophila melanogasterMei-Hui Wang
School of Biological Sciences, University of Nebraska, Lincoln, USA
Obes Res 13:1891-7. 2005..Candidate genes are discussed in relationship to lipid abundance, lipid proportion, and starvation resistance... - Environment-dependent survival of Drosophila melanogaster: a quantitative genetic analysisMei-Hui Wang
School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588, USA
Aging Cell 3:133-40. 2004..One such linkage group on the second chromosome conferred starvation resistance and longevity, supporting the hypothesis of an association between starvation resistance and lifespan... - Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and lifespan and alters gene expression and histone biotinylation patternsErin M Smith
Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE 68583 0806, USA
J Nutr 137:2006-12. 2007..Biotinylation of histones was barely detectable in biotin-deprived flies, suggesting that epigenetic events might have contributed to effects of biotin deprivation... - Bioassays of compounds with potential juvenoid activity on Drosophila melanogaster: juvenile hormone III, bisepoxide juvenile hormone III and methyl farnesoatesLawrence G Harshman
School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68588, United States
J Insect Physiol 56:1465-70. 2010..One possible explanation for the results is that methyl farnesoate is active as a hormone in larval stages, but has little activity at the pupal stage where only juvenile hormone has a major effect... - Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly agingValentina A Shchedrina
Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588, USA
Mech Ageing Dev 130:429-43. 2009..Thus, MsrA and MsrB, the two proteins with similar function in antioxidant protein repair, have different effects on aging in fruit flies... - A quantitative trait locus analysis of natural genetic variation for Drosophila melanogaster oxidative stress survivalYue Wang
Department of Statistics, University of Nebraska-Lincoln, Lincoln, NE 68583-0963, USA
J Hered 97:355-66. 2006..We also determined early-age egg production and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production... - Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovaryDavid S Richard
Department of Biology, Susquehanna University, Selinsgrove, PA 17870, USA
J Insect Physiol 51:455-64. 2005..The ovary transplant experiments corroborate the endocrine results and demonstrate that insulin/insulin-like signaling (IIS) is necessary for vitellogenesis even when sufficient levels of JH, ecdysteroids or other factors are present... - Longevity-fertility trade-offs in the tephritid fruit fly, Anastrepha ludens, across dietary-restriction gradientsJames R Carey
Department of Entomology, University of California, Davis, Davis, CA 95616, USA
Aging Cell 7:470-7. 2008....