L G Harshman

Summary

Affiliation: University of Nebraska
Country: USA

Publications

  1. ncbi request reprint The cost of reproduction: the devil in the details
    Lawrence G Harshman
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Trends Ecol Evol 22:80-6. 2007
  2. ncbi request reprint Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster
    Anette Landenberger
    Department of Nutrition and Health Sciences, University of Nebraska at Lincoln, 316 Ruth Leverton Hall, Lincoln, NE 68583 0806, USA
    J Nutr Biochem 15:591-600. 2004
  3. pmc The symmetry of longevity
    Lawrence G Harshman
    School of Biological Sciences, University of Nebraska Lincoln, 68588, USA
    J Gerontol A Biol Sci Med Sci 60:1233-7. 2005
  4. pmc Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster
    Sergey V Nuzhdin
    Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
    BMC Genomics 10:124. 2009
  5. doi request reprint Transcriptional profiling of the sperm storage organs of Drosophila melanogaster
    A M Prokupek
    School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska, USA
    Insect Mol Biol 18:465-75. 2009
  6. pmc Drosophila melanogaster Selection for Survival after Infection with Bacillus cereus Spores: Evolutionary Genetic and Phenotypic Investigations of Respiration and Movement
    Junjie Ma
    Department of Food Science and Technology, University of Nebraska Lincoln, Lincoln, NE 68583, USA
    Int J Evol Biol 2013:576452. 2013
  7. pmc Sex-specific expression of alternative transcripts in Drosophila
    Lauren M McIntyre
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32611, USA
    Genome Biol 7:R79. 2006
  8. pmc Environmental stress and reproduction in Drosophila melanogaster: starvation resistance, ovariole numbers and early age egg production
    Marta L Wayne
    Department of Zoology, University of Florida, Gainesville, FL32611, USA
    BMC Evol Biol 6:57. 2006
  9. ncbi request reprint Oxidative stress resistance: a robust correlated response to selection in extended longevity lines of Drosophila melanogaster?
    L G Harshman
    School of Biological Sciences, University of Nebraska Lincoln, 68588, USA
    J Gerontol A Biol Sci Med Sci 55:B415-7. 2000
  10. ncbi request reprint A cost of reproduction: oxidative stress susceptibility is associated with increased egg production in Drosophila melanogaster
    Y Wang
    School of Biological Sciences, 348 Manter Hall, University of Nebraska-Lincoln, Lincoln, NE 68588-0118, USA
    Exp Gerontol 36:1349-59. 2001

Collaborators

Detail Information

Publications27

  1. ncbi request reprint The cost of reproduction: the devil in the details
    Lawrence G Harshman
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Trends Ecol Evol 22:80-6. 2007
    ..These studies not only provide new information about mechanisms that comprise 'the cost', but also hint at an underlying evolutionarily conserved causal mechanism...
  2. ncbi request reprint Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster
    Anette Landenberger
    Department of Nutrition and Health Sciences, University of Nebraska at Lincoln, 316 Ruth Leverton Hall, Lincoln, NE 68583 0806, USA
    J Nutr Biochem 15:591-600. 2004
    ..These findings are consistent with the hypothesis that biotin affects life span, stress resistance, and fertility in fruit flies...
  3. pmc The symmetry of longevity
    Lawrence G Harshman
    School of Biological Sciences, University of Nebraska Lincoln, 68588, USA
    J Gerontol A Biol Sci Med Sci 60:1233-7. 2005
    ..Wing symmetry of females and males proved to be a statistically significant predictor of life span, especially for males...
  4. pmc Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster
    Sergey V Nuzhdin
    Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
    BMC Genomics 10:124. 2009
    ..We focus on the latter problem by describing genetic variation in transcript levels of genes in the InR/TOR pathway among 72 Drosophila melanogaster genotypes...
  5. doi request reprint Transcriptional profiling of the sperm storage organs of Drosophila melanogaster
    A M Prokupek
    School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska, USA
    Insect Mol Biol 18:465-75. 2009
    ..Differences in functional gene categories indicate that these organs play unique roles in sperm storage...
  6. pmc Drosophila melanogaster Selection for Survival after Infection with Bacillus cereus Spores: Evolutionary Genetic and Phenotypic Investigations of Respiration and Movement
    Junjie Ma
    Department of Food Science and Technology, University of Nebraska Lincoln, Lincoln, NE 68583, USA
    Int J Evol Biol 2013:576452. 2013
    ..Relatively low movement of females indicated that their elevated respiration after mating was not due to a change in locomotion...
  7. pmc Sex-specific expression of alternative transcripts in Drosophila
    Lauren M McIntyre
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32611, USA
    Genome Biol 7:R79. 2006
    ..Here, we describe a genome-wide analysis of sex-specific expression of alternative transcripts in Drosophila melanogaster...
  8. pmc Environmental stress and reproduction in Drosophila melanogaster: starvation resistance, ovariole numbers and early age egg production
    Marta L Wayne
    Department of Zoology, University of Florida, Gainesville, FL32611, USA
    BMC Evol Biol 6:57. 2006
    ..melanogaster. Thus, one might expect that a negative genetic correlation between starvation resistance and early fecundity would be accompanied by a decrease in ovariole number...
  9. ncbi request reprint Oxidative stress resistance: a robust correlated response to selection in extended longevity lines of Drosophila melanogaster?
    L G Harshman
    School of Biological Sciences, University of Nebraska Lincoln, 68588, USA
    J Gerontol A Biol Sci Med Sci 55:B415-7. 2000
    ..Increased oxidative stress resistance appears to be a relatively robust correlated response to laboratory selection for late-life reproduction and extended longevity...
  10. ncbi request reprint A cost of reproduction: oxidative stress susceptibility is associated with increased egg production in Drosophila melanogaster
    Y Wang
    School of Biological Sciences, 348 Manter Hall, University of Nebraska-Lincoln, Lincoln, NE 68588-0118, USA
    Exp Gerontol 36:1349-59. 2001
    ..Added yeast was associated with stress susceptibility of fertile females but not of sterile females. The results of the present study suggest that oxidative stress susceptibility is a physiological cost of reproduction...
  11. ncbi request reprint Stress resistance and longevity in selected lines of Drosophila melanogaster
    L G Harshman
    School of Biological Sciences, University of Nebraska Lincoln, 68588, USA
    Neurobiol Aging 20:521-9. 1999
    ..Neither females nor males from the selected lines were relatively long-lived. In at least some cases, stress resistance may be necessary, but not sufficient, for longevity...
  12. ncbi request reprint A cost of reproduction in Drosophila melanogaster: stress susceptibility
    A B Salmon
    School of Biological Sciences, University of Nebraska Lincoln, 68588, USA
    Evolution 55:1600-8. 2001
    ..The results of the present study support the hypothesis that stress susceptibility is a cost of reproduction...
  13. ncbi request reprint Molecular evolutionary analysis of seminal receptacle sperm storage organ genes of Drosophila melanogaster
    A M Prokupek
    School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68588, USA
    J Evol Biol 23:1386-98. 2010
    ..These candidates belong to protein classes such as muscle contraction, odorant binding and odorant receptor, protease inhibitor and immunity...
  14. ncbi request reprint Differential gene expression in insects: transcriptional control
    L G Harshman
    School of Biological Sciences, University of Nebraska Lincoln 68588 0118, USA
    Annu Rev Entomol 43:671-700. 1998
    ..Once this deficiency is addressed, the full impact of research on transcription control will be realized throughout the field of entomology...
  15. ncbi request reprint Extended longevity lines of Drosophila melanogaster: abundance of yolk protein gene mRNA in fat body and ovary
    K A Carlson
    School of Biological Sciences, University of Nebraska Lincoln, 68588 0118, USA
    Exp Gerontol 34:173-84. 1999
    ..On medium without supplemental yeast, the relatively low abundance of fat body yolk-protein gene mRNA in the selected lines on day 4 posteclosion corresponds to a prediction derived from the disposable soma theory...
  16. ncbi request reprint Investigation of the endocrine system in extended longevity lines of Drosophila melanogaster
    L G Harshman
    School of Biological Sciences, University of Nebraska Lincoln, 68588, USA
    Exp Gerontol 34:997-1006. 1999
    ..There was no difference between selected and control lines in the specific activity of either class of enzymes that metabolize juvenile hormone...
  17. doi request reprint Evolution of starvation resistance in Drosophila melanogaster: measurement of direct and correlated responses to artificial selection
    T E Schwasinger-Schmidt
    The University of Kansas School of Medicine, Kansas City, KS, USA
    J Evol Biol 25:378-87. 2012
    ....
  18. ncbi request reprint Jhe in Gryllus assimilis: cloning, sequence-activity associations and phylogeny
    E J Crone
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588 0118, USA
    Insect Biochem Mol Biol 37:1359-65. 2007
    ..Phylogenetic analyses localised the G. assimilis JHE to a clade containing dipteran and coleopteran JHEs, with lepidopteran JHEs occurring in a separate clade...
  19. pmc Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and lifespan and alters gene expression and histone biotinylation patterns
    Erin M Smith
    Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE 68583 0806, USA
    J Nutr 137:2006-12. 2007
    ..Biotinylation of histones was barely detectable in biotin-deprived flies, suggesting that epigenetic events might have contributed to effects of biotin deprivation...
  20. ncbi request reprint Superoxide dismutase activities in long-lived Drosophila melanogaster females: chico1 genotypes and dietary dilution
    Hadise Kabil
    School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE, 68588, USA
    Biogerontology 8:201-8. 2007
    ..Results from the present study indicate that elevated CuZn SOD activity, not Mn SOD, is the basis for the relatively high level of SOD activity in the chico (1) homozygotes...
  21. ncbi request reprint Quantitative trait loci for lipid content in Drosophila melanogaster
    Mei Hui Wang
    School of Biological Sciences, University of Nebraska, Lincoln, USA
    Obes Res 13:1891-7. 2005
    ..Candidate genes are discussed in relationship to lipid abundance, lipid proportion, and starvation resistance...
  22. ncbi request reprint Environment-dependent survival of Drosophila melanogaster: a quantitative genetic analysis
    Mei Hui Wang
    School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68588, USA
    Aging Cell 3:133-40. 2004
    ..One such linkage group on the second chromosome conferred starvation resistance and longevity, supporting the hypothesis of an association between starvation resistance and lifespan...
  23. pmc Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging
    Valentina A Shchedrina
    Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588, USA
    Mech Ageing Dev 130:429-43. 2009
    ..Thus, MsrA and MsrB, the two proteins with similar function in antioxidant protein repair, have different effects on aging in fruit flies...
  24. ncbi request reprint A quantitative trait locus analysis of natural genetic variation for Drosophila melanogaster oxidative stress survival
    Yue Wang
    Department of Statistics, University of Nebraska Lincoln, Lincoln, NE 68583 0963, USA
    J Hered 97:355-66. 2006
    ..We also determined early-age egg production and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production...
  25. pmc Bioassays of compounds with potential juvenoid activity on Drosophila melanogaster: juvenile hormone III, bisepoxide juvenile hormone III and methyl farnesoates
    Lawrence G Harshman
    School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68588, United States
    J Insect Physiol 56:1465-70. 2010
    ..One possible explanation for the results is that methyl farnesoate is active as a hormone in larval stages, but has little activity at the pupal stage where only juvenile hormone has a major effect...
  26. pmc Longevity-fertility trade-offs in the tephritid fruit fly, Anastrepha ludens, across dietary-restriction gradients
    James R Carey
    Department of Entomology, University of California, Davis, Davis, CA 95616, USA
    Aging Cell 7:470-7. 2008
    ....
  27. ncbi request reprint Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovary
    David S Richard
    Department of Biology, Susquehanna University, Selinsgrove, PA 17870, USA
    J Insect Physiol 51:455-64. 2005
    ..The ovary transplant experiments corroborate the endocrine results and demonstrate that insulin/insulin-like signaling (IIS) is necessary for vitellogenesis even when sufficient levels of JH, ecdysteroids or other factors are present...