Research Topics
| Lee H HarrisonSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Meningococcal group A, C, Y and W-135 conjugate vaccineLee H Harrison
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15101, USA
Nat Rev Drug Discov 9:429-30. 2010....
Emergence and disappearance of a virulent clone of Haemophilus influenzae biogroup aegyptius, cause of Brazilian purpuric feverLee H Harrison
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School ofMedicine, Pittsburgh, Pennsylvania 15261, USA
Clin Microbiol Rev 21:594-605. 2008..After a series of outbreaks and sporadic cases through 1993, no additional cases of BPF have been reported...- Population structure and capsular switching of invasive Neisseria meningitidis isolates in the pre-meningococcal conjugate vaccine era--United States, 2000-2005Lee H Harrison
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
J Infect Dis 201:1208-24. 2010..Neisseria meningitidis changes its capsular phenotype through capsular switching, which has implications for vaccines that do not protect against all serogroups... 
Antigenic shift and increased incidence of meningococcal diseaseLee H Harrison
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
J Infect Dis 193:1266-74. 2006..The cyclical nature of endemic meningococcal disease remains unexplained. The purpose of this study was to investigate the mechanisms associated with the increase in the incidence of meningococcal disease...- Prospects for vaccine prevention of meningococcal infectionLee H Harrison
Infectious Diseases Epidemiology Research Unit, 521 Parran Hall, 130 DeSoto St, University of Pittsburgh, Pittsburgh, PA 15261, USA
Clin Microbiol Rev 19:142-64. 2006..This review covers the changing epidemiology of meningococcal disease in the United States, issues related to vaccine prevention, and recommendations on the use of the new vaccine... - Epidemiological profile of meningococcal disease in the United StatesLee H Harrison
University of Pittsburgh Graduate School of Public Health and School of Medicine, Pennsylvania, USA
Clin Infect Dis 50:S37-44. 2010..Broadly protective vaccines for endemic serogroup B disease are also needed... - Global epidemiology of meningococcal diseaseLee H Harrison
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, 521 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, United States
Vaccine 27:B51-63. 2009.... - The Global Meningococcal Initiative: recommendations for reducing the global burden of meningococcal diseaseLee H Harrison
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, Pittsburgh, PA 15261, USA
Vaccine 29:3363-71. 2011..Innovative approaches are needed to introduce and sustain meningococcal vaccination programs in resource-poor settings with a high incidence of meningococcal disease... - Risk factors for meningococcal disease in students in grades 9-12Lee H Harrison
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Pediatr Infect Dis J 27:193-9. 2008..Universal immunization of adolescents with meningococcal conjugate vaccine was recently recommended. We studied risk factors for meningococcal disease in students in grades 9-12... - High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospitalScott R Curry
Department of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Clin Infect Dis 48:425-9. 2009..difficile-associated disease. Rifampin resistance in C. difficile strains has been reported to be uncommon... - Multilocus variable-number tandem-repeat analysis and multilocus sequence typing reveal genetic relationships among Clostridium difficile isolates genotyped by restriction endonuclease analysisJane W Marsh
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Clin Microbiol 48:412-8. 2010..difficile disease pathogenesis. This study demonstrates that a combination of MLST and MLVA may prove useful for the investigation and surveillance of emergent C. difficile clones of global public health concern... - Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approachCarlene A Muto
Division of Hospital Epidemiology and Infection Control, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Clin Infect Dis 45:1266-73. 2007..Forty-seven (51%) of 92 HA CD isolates in 2001 were identified as the "epidemic BI strain." A comprehensive CD infection control "bundle" was implemented to control the outbreak of CD infection... - tcdC genotypes associated with severe TcdC truncation in an epidemic clone and other strains of Clostridium difficileScott R Curry
Department of Medicine, University of Pittsburgh, School of Medicine, PA 15261, USA
J Clin Microbiol 45:215-21. 2007..Further investigations are required to determine the effect of this and other tcdC genotypes on toxin production and clinical disease... - Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in HospitalsJane W Marsh
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Medical Center, Division of Hospital Epidemiology and Infection Control, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
J Clin Microbiol 44:2558-66. 2006..Thus, MLVA is an objective, portable genotyping method that permits reliable detection of C. difficile outbreaks and can aid epidemiologic investigations of nosocomial transmission... - Discordant responses to potent antiretroviral treatment in previously naive HIV-1-infected adults initiating treatment in resource-constrained countries: the antiretroviral therapy in low-income countries (ART-LINC) collaborationSuely H Tuboi
Infectious Diseases Epidemiology Research Unit, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
J Acquir Immune Defic Syndr 45:52-9. 2007..To assess the frequency of and risk factors for discordant responses at 6 months on highly active antiretroviral therapy (HAART) in previously treatment-naive HIV patients from resource-limited countries... - Perirectal swab surveillance for Clostridium difficile by use of selective broth preamplification and real-time PCR detection of tcdBScott R Curry
Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Clin Microbiol 49:3788-93. 2011..6%), and 422/422 (100.0%), respectively. These data demonstrate that selective broth preamplification and real-time PCR of perirectal swab specimens constitute a practical approach to the detection of asymptomatic C. difficile carriage... - Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in PennsylvaniaJennifer M Adams-Haduch
Division of Infectious Diseases, University of Pittsburgh Medical Center, S829 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261
Antimicrob Agents Chemother 52:3837-43. 2008..Fifty-nine percent of the MDR isolates belonged to a single clonal group over the course of the study period, as demonstrated by pulsed-field gel electrophoresis... - Whole genome sequencing to investigate the emergence of clonal complex 23 Neisseria meningitidis serogroup Y disease in the United StatesMary G Krauland
Infectious Diseases Epidemiology Research Unit, School of Medicine and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvanian, United States of America
PLoS ONE 7:e35699. 2012..These findings may predict which antigenic factors are important in the cyclic epidemiology of meningococcal disease... - Universal methicillin-resistant Staphylococcus aureus (MRSA) surveillance for adults at hospital admission: an economic model and analysisBruce Y Lee
Section of Decision Sciences and Clinical Systems Modeling, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania, USA
Infect Control Hosp Epidemiol 31:598-606. 2010..Although some have recommended universal surveillance for MRSA at hospital admission to identify and to isolate MRSA-colonized patients, there is a need for formal economic studies to determine the cost-effectiveness of such a strategy... - Diversity of factor H-binding protein in Neisseria meningitidis carriage isolatesJane W Marsh
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, PA, United States
Vaccine 29:6049-58. 2011..The FHbp genetic repertoire observed in carriage isolate populations will be useful in understanding the potential impact of FHbp-containing vaccines on meningococcal carriage... - Multi-locus variable number tandem repeat analysis for investigation of the genetic association of Clostridium difficile isolates from food, food animals and humansJane W Marsh
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine, Graduate School of Public Health, PA, USA
Anaerobe 17:156-60. 2011..Rigorous epidemiologic and laboratory investigations that employ highly discriminatory genotyping methods are necessary to compare C. difficile isolates from food and food animals to those from humans... - The economic effect of screening orthopedic surgery patients preoperatively for methicillin-resistant Staphylococcus aureusBruce Y Lee
Public Health Computational and Operations Research PHICOR Group, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Infect Control Hosp Epidemiol 31:1130-8. 2010..We sought to estimate the economic value of routine preoperative MRSA screening and decolonization of orthopedic surgery patients... - Locus-specific mutational events in a multilocus variable-number tandem repeat analysis of Escherichia coli O157:H7Anna C Noller
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, 521 Parran Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
J Clin Microbiol 44:374-7. 2006..The remaining four loci had no slippage events detected. The mutation rates were locus specific and may impact the interpretation of MLVA data for epidemiologic investigations... - Correlating epidemiologic trends with the genotypes causing meningococcal disease, MarylandM Catherine McEllistrem
University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania, USA
Emerg Infect Dis 10:451-6. 2004..The nonepidemic age-specific increases in serogroup C meningococcal infection in Maryland were clonal in nature and the changes in serogroup Y incidence were associated with a shift in the genotypes of strains causing invasive disease... - Erythromycin-nonsusceptible Streptococcus pneumoniae in children, 1999-2001M Catherine McEllistrem
University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15213 2582, USA
Emerg Infect Dis 11:969-72. 2005..The decline in infection rates was likely due to the pneumococcal 7-valent conjugate vaccine... - Effect of pneumococcal conjugate vaccine on pneumococcal meningitisHeather E Hsu
University of Pittsburgh, Pittsburgh, PA 15261, USA
N Engl J Med 360:244-56. 2009..Invasive pneumococcal disease declined among children and adults after the introduction of the pediatric heptavalent pneumococcal conjugate vaccine (PCV7) in 2000, but its effect on pneumococcal meningitis is unclear... - Deletion of fetA gene sequences in serogroup B and C Neisseria meningitidis isolatesJane W Marsh
University of Pittsburgh School of Medicine, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
J Clin Microbiol 45:1333-5. 2007..In this report, we describe the characterization of three meningococcal isolates that have deleted fetA sequences through genetic recombination at repetitive elements... - Integron-mediated multidrug resistance in a global collection of nontyphoidal Salmonella enterica isolatesMary G Krauland
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
Emerg Infect Dis 15:388-96. 2009..This study demonstrates that clonal expansion and horizontal gene transfer contribute to the global dissemination of antimicrobial drug resistance in S. enterica... - Screening for Acinetobacter baumannii colonization by use of spongesYohei Doi
Division of Infectious Diseases, University of Pittsburgh Medical Center, Scaife Hall S829, 3550 Terrace Street, Pittsburgh, PA 15261, USA
J Clin Microbiol 49:154-8. 2011..003). The combined sensitivity for the upper arm and leg with a sponge was 89.1%. The novel screening method using sterile sponges was easy to perform and achieved excellent sensitivity for the detection of A. baumannii colonization... - Geographic, demographic, and seasonal differences in penicillin-resistant Streptococcus pneumoniae in BaltimoreBernadette A Albanese
Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
Clin Infect Dis 34:15-21. 2002..The incidence of PRSP is increasing in Baltimore, and the seasonality of PRSP suggests that recent antibiotic use, which is more common in winter months, may rapidly affect the prevalence of resistant pneumococcal infections... - Prevalence of Clostridium difficile in uncooked ground meat products from Pittsburgh, PennsylvaniaScott R Curry
Division of Infectious Diseases, University of Pittsburgh School of Medicine, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Appl Environ Microbiol 78:4183-6. 2012..The prevalence of C. difficile in retail meat may not be as high as previously reported in North America. When contamination occurs, it may be related to events at processing facilities... - Patient-associated risk factors for acquisition of methicillin-resistant Staphylococcus aureus in a tertiary care hospitalJo anne M Salangsang
Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Infect Control Hosp Epidemiol 31:1139-47. 2010..Determining risk factors for acquisition of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals is important for defining infection-control measures that may lead to fewer hospital-acquired infections... - Association of relapse of Clostridium difficile disease with BI/NAP1/027Jane W Marsh
Infectious Diseases Epidemiology Research Unit, Division of Infectious Diseases, University of Pittsburgh School of Medicine and Department of Epidemiology, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
J Clin Microbiol 50:4078-82. 2012..Classification of recurrent CDI episodes by MLVA can be utilized to make informed patient care decisions and to accurately define new CDI cases for infection control and reimbursement purposes... - Predictors of virologic failure in HIV-1-infected patients starting highly active antiretroviral therapy in Porto Alegre, BrazilSuely H Tuboi
Infectious Diseases Epidemiology Research Unit, Graduate School of Public Health and School of Medicine, University of Pittsburgh, PA, USA
J Acquir Immune Defic Syndr 40:324-8. 2005..With currently available therapies, compliance and education were shown to be predictors of virologic response, particularly in more immunocompromised patients... - Serotype 14 variants of the France 9V(-3) clone from Baltimore, Maryland, can be differentiated by the cpsB geneM Catherine McEllistrem
Infectious Diseases Epidemiology Research Unit, Division of Infectious Diseases, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15229, USA
J Clin Microbiol 42:250-6. 2004..Although the correlation between serotype and the cpsB sequence was high, the overall diversity of the cpsB gene within a serotype likely will limit the role of this gene in a sequence-based serotyping method... - A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone useCarlene A Muto
Division of Hospital Epidemiology and Infection Control, University of Pittsburgh Medical Center, Presbyterian Campus, Pittsburgh, Pennsylvania 15213, USA
Infect Control Hosp Epidemiol 26:273-80. 2005..difficile infections; of these, 26 resulted in colectomy and 18 resulted in death. We conducted an investigation of a large C. difficile outbreak in our hospital to identify risk factors and characterize the outbreak... - Recurrent invasive pneumococcal disease in individuals with human immunodeficiency virus infectionM Catherine McEllistrem
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15213 2582, USA
J Infect Dis 185:1364-8. 2002..Although a substantial proportion of recurrent pneumococcal infections was potentially preventable by vaccine, creating an effective vaccine may be challenging for this population... - Distribution of penicillin-nonsusceptible pneumococcal clones in the Baltimore metropolitan area and variables associated with drug resistanceM Catherine McEllistrem
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, 15213, USA
Clin Infect Dis 34:704-7. 2002.... - Internet death notices as a novel source of mortality surveillance dataMarshall B Boak
University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 21666, USA
Am J Epidemiol 167:532-9. 2008..The Pittsburgh Post-Gazette Internet death notices provided accurate, timely mortality data for nearly three fourths of all Allegheny County deaths... - High prevalence of sexually transmitted diseases in young women seeking HIV testing in Rio de Janeiro, BrazilRobert L Cook
Division of General Internal Medicine, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15213, USA
Sex Transm Dis 31:67-72. 2004..Few data are available on the prevalence of and risk factors for sexually transmitted diseases (STDs) other than HIV in Brazil... - Should vascular surgery patients be screened preoperatively for methicillin-resistant Staphylococcus aureus?Bruce Y Lee
Section of Decision Sciences and Clinical Systems Modeling, Department of Biomedical Informatics, School of Medicine, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Infect Control Hosp Epidemiol 30:1158-65. 2009..Testing all vascular surgery patients preoperatively for MRSA and attempting to decolonize those who have positive results may be a strategy to prevent MRSA infection. The economic value of such a strategy has not yet been determined... - Multilocus variable-number tandem repeat analysis distinguishes outbreak and sporadic Escherichia coli O157:H7 isolatesAnna C Noller
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Clin Microbiol 41:5389-97. 2003..In addition to being a simple and validated method for E. coli O157:H7 outbreak detection, MLVA appears to have a sensitivity equal to that of PFGE and a specificity superior to that of PFGE... - High incidence and prevalence of HIV-1 infection in high risk population in Calcutta, IndiaPhalguni Gupta
Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Int J STD AIDS 14:463-8. 2003..Such a high annual seroincidence rate makes this population well suited for studies of HIV-1 prevention, including vaccine trials... - Creating a text classifier to detect radiology reports describing mediastinal findings associated with inhalational anthrax and other disordersWendy Webber Chapman
Center for Biomedical Informatics, University of Pittsburgh, Suite 8084 Forbes Tower, Pittsburgh, PA 15213, USA
J Am Med Inform Assoc 10:494-503. 2003..The aim of this study was to create a classifier for automatic detection of chest radiograph reports consistent with the mediastinal findings of inhalational anthrax... - Multilocus sequence typing reveals a lack of diversity among Escherichia coli O157:H7 isolates that are distinct by pulsed-field gel electrophoresisAnna C Noller
Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania, USA
J Clin Microbiol 41:675-9. 2003..E. coli O157:H7 has a striking lack of genetic diversity in the genes we explored, even among isolates that are clearly distinct by PFGE. Other approaches to identify improved molecular subtyping methods for E. coli 0157:H7 are needed... - Geographic diversity and temporal trends of antimicrobial resistance in Streptococcus pneumoniae in the United StatesAlthea W McCormick
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Nat Med 9:424-30. 2003.... - Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccineCynthia G Whitney
Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 348:1737-46. 2003..In early 2000, a protein-polysaccharide conjugate vaccine targeting seven pneumococcal serotypes was licensed in the United States for use in young children... - Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005Matthew R Moore
Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
J Infect Dis 197:1016-27. 2008..To understand this increase, we characterized serotype 19A isolates recovered during 2005... - Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005Christina R Phares
Epidemic Intelligence Service Program, Office of Workforce and Career Development, Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
JAMA 299:2056-65. 2008..Guidelines for prevention of perinatal disease through intrapartum chemoprophylaxis were revised in 2002. Candidate vaccines are under development... - A multivalent conjugate vaccine for prevention of meningococcal disease in infantsLee H Harrison
JAMA 299:217-9. 2008 - Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998-2004Lauri A Hicks
Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 196:1346-54. 2007..The benefits may be offset by increases in disease due to serotypes not included in the vaccine (hereafter, "nonvaccine serotypes"). We evaluated the effect of PCV7 on incidence of disease due to nonvaccine serotypes... - Association between antimicrobial resistance among pneumococcal isolates and burden of invasive pneumococcal disease in the communityJulia Y Morita
Division of Bacterial and Mycotic Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Clin Infect Dis 35:420-7. 2002..The proportion of multidrug-resistant pneumococcal isolates did not predict invasive cases among adults. The increasing prevalence of multidrug-resistant pneumococci among children may be leading to an increase in invasive disease... - College and university compliance with a required meningococcal vaccination lawAmanda D Castel
The Department of Epidemiology and Biostatistics, George Washington University s School of Public Health and Health Services, Washington, DC 20037, USA
J Am Coll Health 56:119-27. 2007..The authors sought to identify how Maryland colleges addressed the law and determine whether schools were in full compliance... - Clonal distribution of invasive pneumococcal isolates from children and selected adults in the United States prior to 7-valent conjugate vaccine introductionRobert E Gertz
Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Clin Microbiol 41:4194-216. 2003..In this work, we established the basic genetic structure within individual serotypes prior to PC7V use. The resultant database will be useful for detecting potential selective effects of this vaccine in postvaccine surveillance... - Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniaeMoe H Kyaw
Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA
N Engl J Med 354:1455-63. 2006..There was an increase in infections caused by serotypes not included in the vaccine... - Invasive pneumococcal disease among infants before and after introduction of pneumococcal conjugate vaccineKatherine A Poehling
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232 2504, USA
JAMA 295:1668-74. 2006..Streptococcus pneumoniae is a serious infection in young infants. A heptavalent pneumococcal conjugate vaccine (PCV7) was licensed in 2000 and recommended for all children aged 2 to 23 months... - Pre- and postvaccination clonal compositions of invasive pneumococcal serotypes for isolates collected in the United States in 1999, 2001, and 2002Bernard Beall
Repsiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mailstop C02, Atlanta, Georgia 30333, USA
J Clin Microbiol 44:999-1017. 2006..Continued genotypic surveillance is warranted, since certain clones not targeted by PCV7 are expanding, and their emergence as significant pathogens could occur with maintained vaccine pressure... - Changes in invasive Pneumococcal disease among HIV-infected adults living in the era of childhood pneumococcal immunizationBrendan Flannery
National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Ann Intern Med 144:1-9. 2006..Adults infected with HIV have high rates of invasive pneumococcal disease. Introduction of pneumococcal conjugate vaccine for children could affect disease among HIV-infected adults... - Changing epidemiology of invasive pneumococcal disease among older adults in the era of pediatric pneumococcal conjugate vaccineCatherine A Lexau
Minnesota Department of Health, Minneapolis 55155 2538, USA
JAMA 294:2043-51. 2005..Early after its introduction, incidence of invasive pneumococcal disease declined among older adults, a group at high risk for pneumococcal disease... - Excess mortality, hospital stay, and cost due to candidemia: a case-control study using data from population-based candidemia surveillanceJuliette Morgan
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Infect Control Hosp Epidemiol 26:540-7. 2005..Prior studies lack broad patient and hospital representation or cost-related information that accurately reflects current medical practices... - Effectiveness of antiretroviral therapy among patients who attend public HIV clinics in Rio de Janeiro, BrazilCristina B Hofer
Infectious Diseases Service, Hospital Universitario Clementino Fraga Filho, Department of Preventive Medicine, Universidade Federal do Rio de Janeiro, Brazil
J Acquir Immune Defic Syndr 36:967-71. 2004..Brazil provides antiretroviral therapy (ART) to HIV-infected persons free of charge. The objective of this study was to investigate factors associated with ART failure in patients receiving free ART in public clinics in Brazil... - Identification of a high-risk heterosexual cohort for HIV vaccine efficacy trials in Rio de Janeiro, Brazil, using a sensitive/less-sensitive assay: an updatePaulo Feijó Barroso
J Acquir Immune Defic Syndr 36:880-1. 2004 - Impact of childhood vaccination on racial disparities in invasive Streptococcus pneumoniae infectionsBrendan Flannery
Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 291:2197-203. 2004.... - Behavioral impact, acceptability, and HIV incidence among homosexual men with access to postexposure chemoprophylaxis for HIVMauro Schechter
Infectious Diseases Service, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
J Acquir Immune Defic Syndr 35:519-25. 2004..Little is known about the behavioral impact, acceptability, and incidence of HIV infection in persons with easy access to post-sexual exposure prophylaxis (PEP) to prevent HIV... - Emergence of a novel penicillin-nonsusceptible, invasive serotype 35B clone of Streptococcus pneumoniae within the United StatesBernard Beall
Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 186:118-22. 2002..The mosaic pbp2b and divergent ddl sequences were suggestive of interspecies recombination at the ddl-pbp2b chromosomal region... - Adherence to antiretroviral therapy and persistence of HIV RNA in semenPaulo F Barroso
Infectious Diseases Sevice, Department of Preventive Medicine, Hospital Universitario Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
J Acquir Immune Defic Syndr 32:435-40. 2003..Although antiretroviral therapy (ART) reduces HIV seminal shedding, little is known about the relationship between adherence to ART and HIV suppression in semen... - Invasive group A streptococcal infection in older adults in long-term care facilities and the community, United States, 1998-2003Michael C Thigpen
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Emerg Infect Dis 13:1852-9. 2007..95%, p<0.01). In multivariate logistic regression modeling, LTCF residence remained an independent predictor of death. Additional prevention strategies against GAS infection in this high-risk population are urgently needed... - Declining incidence of invasive Streptococcus pneumoniae infections among persons with AIDS in an era of highly active antiretroviral therapy, 1995-2000Richard T Heffernan
Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, Connecticut, USA
J Infect Dis 191:2038-45. 2005..Our goal was to describe trends in invasive pneumococcal disease incidence among persons with acquired immunodeficiency syndrome (AIDS) since the introduction of highly active antiretroviral therapy (HAART)... - Methicillin-resistant Staphylococcus aureus disease in three communitiesScott K Fridkin
Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 352:1436-44. 2005..Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. The national burden and clinical effect of this novel presentation of MRSA disease are unclear... - Genotyping primers for fully automated multilocus variable-number tandem repeat analysis of Escherichia coli O157:H7Anna C Noller
J Clin Microbiol 42:3908. 2004 - Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: A 60-year follow-up studyNaomi E Aronson
Department of Medicine, Infectious Disease Division, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
JAMA 291:2086-91. 2004..The duration of protection from tuberculosis of BCG vaccines is not known... - Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance programRana A Hajjeh
Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Clin Microbiol 42:1519-27. 2004..7% of isolates, and > or = 2 microg/ml for 0.4% of isolates. Our findings highlight changes in the epidemiology of Candida BSI in the 1990s and provide a basis upon which to conduct further studies of selected high-risk subpopulations... - Invasive group A streptococcal disease: risk factors for adultsStephanie H Factor
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Emerg Infect Dis 9:970-7. 2003..68, p=0.004), diabetes (RR=2.27, p=0.03), cardiac disease (RR=3.24, p=0.006), cancer (RR=3.54, p=0.006), and corticosteroid use (RR=5.18, p=0.03). Thus, host and environmental factors increased the risk for invasive GAS disease... - Comparison of visual and spectrophotometric methods of broth microdilution MIC end point determination and evaluation of a sterol quantitation method for in vitro susceptibility testing of fluconazole and itraconazole against trailing and nontrailing CandBeth A Arthington-Skaggs
Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Antimicrob Agents Chemother 46:2477-81. 2002..Our results indicate that MIC results determined by either of these end point rules may be more predictive of in vivo outcome for isolates that give unclear visual end points at 48 h due to trailing growth... - Risk factors for severe respiratory syncytial virus infection among Alaska native childrenLisa R Bulkow
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska 99508, USA
Pediatrics 109:210-6. 2002..CONCLUSIONS: In this region with extremely high risk of RSV hospitalization, several measures, such as encouraging breastfeeding and reducing household crowding, could reduce the risk of hospitalization attributable to RSV... - Determining risk factors for candidemia among newborn infants from population-based surveillance: Baltimore, Maryland, 1998-2000Sharmila S Shetty
Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 24:601-4. 2005..This study helps define a subgroup of preterm infants at high risk of developing bloodstream infections with Candida species... - Multistate surveillance for laboratory-confirmed, influenza-associated hospitalizations in children: 2003-2004Stephanie J Schrag
National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Pediatr Infect Dis J 25:395-400. 2006..We describe laboratory-confirmed, influenza-associated hospitalizations in a population representing almost 6% of children in the United States... - Increase in non-AIDS related conditions as causes of death among HIV-infected individuals in the HAART era in BrazilAntonio G Pacheco
Department of Epidemiology and Quantitative Methods in Health, National School of Public Health Scientific Computing Program, Oswaldo Cruz Foundation FIOCRUZ, Rio de Janeiro, Brazil
PLoS ONE 3:e1531. 2008.... - Invasive methicillin-resistant Staphylococcus aureus infections in the United StatesR Monina Klevens
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
JAMA 298:1763-71. 2007..As the epidemiology of infections with methicillin-resistant Staphylococcus aureus (MRSA) changes, accurate information on the scope and magnitude of MRSA infections in the US population is needed... - Risk factors for pediatric invasive group A streptococcal diseaseStephanie H Factor
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Emerg Infect Dis 11:1062-6. 2005..67, p=0.03) and household member(s) with runny nose (OR=0.09, p=0.002) were associated with decreased risk. Among children, household-level characteristics that influence exposure to GAS most affect development of invasive disease... - The epidemiology of invasive group A streptococcal infection and potential vaccine implications: United States, 2000-2004Rosalyn E O'Loughlin
Respiratory Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Infect Dis 45:853-62. 2007..We report the current epidemiologic characteristics of invasive GAS infections and estimate the potential impact of a multivalent GAS vaccine... - Prevalence of factor H-binding protein variants and NadA among meningococcal group B isolates from the United States: implications for the development of a multicomponent group B vaccinePeter T Beernink
Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
J Infect Dis 195:1472-9. 2007..Antibodies against fHBP are bactericidal against strains within a variant group. There are limited data on the prevalence of strains expressing different fHBP variants in the United States... - Community-associated methicillin-resistant Staphylococcus aureus and healthcare risk factorsR Monina Klevens
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 12:1991-3. 2006..Of patients with HRFs, 18%-28% had a "community-associated" strain, primarily USA300; of patients without HRFs, 26% had a "healthcare-associated" strain, typically USA100... - Vaccine prevention of meningococcal disease: making slow progressLee H Harrison
Clin Infect Dis 43:1395-7. 2006 - Epidemiology of community-onset candidemia in Connecticut and MarylandAndre N Sofair
Yale University School of Medicine, New Haven, Connecticut, USA
Clin Infect Dis 43:32-9. 2006..CONCLUSION: We report that community-onset candidemia is common and occurs in patients with extensive contact with the health care system. Disease caused by C. parapsilosis tends to involve unique strains... - Reduced risk of tuberculosis among Brazilian patients with advanced human immunodeficiency virus infection treated with highly active antiretroviral therapyGuilherme Santoro-Lopes
Infectious Diseases Clinic, Department of Preventive Medicine, , Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Clin Infect Dis 34:543-6. 2002..The use of highly active antiretroviral therapy in regions with a high prevalence of coinfection with HIV and Mycobacterium tuberculosis may contribute a lower incidence of tuberculosis...
Research Grants
- Shedding of HIV In Semen Despite Antiretroviral TherapyLee Harrison; Fiscal Year: 2006..abstract_text> ..
- Forensic Detection of Salmonella Resistance and SubtypeLee Harrison; Fiscal Year: 2005..enterica and 2) molecular methods for rapid outbreak detection among S. enterica serovars. ..