Lee H Harrison

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Risk factors for meningococcal disease in students in grades 9-12
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Pediatr Infect Dis J 27:193-9. 2008
  2. doi request reprint Meningococcal group A, C, Y and W-135 conjugate vaccine
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15101, USA
    Nat Rev Drug Discov 9:429-30. 2010
  3. pmc Emergence and disappearance of a virulent clone of Haemophilus influenzae biogroup aegyptius, cause of Brazilian purpuric fever
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School ofMedicine, Pittsburgh, Pennsylvania 15261, USA
    Clin Microbiol Rev 21:594-605. 2008
  4. pmc Population structure and capsular switching of invasive Neisseria meningitidis isolates in the pre-meningococcal conjugate vaccine era--United States, 2000-2005
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Infect Dis 201:1208-24. 2010
  5. pmc Prospects for vaccine prevention of meningococcal infection
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, 521 Parran Hall, 130 DeSoto St, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Microbiol Rev 19:142-64. 2006
  6. pmc Epidemiological profile of meningococcal disease in the United States
    Lee H Harrison
    University of Pittsburgh Graduate School of Public Health and School of Medicine, Pennsylvania, USA
    Clin Infect Dis 50:S37-44. 2010
  7. doi request reprint Global epidemiology of meningococcal disease
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, 521 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, United States
    Vaccine 27:B51-63. 2009
  8. ncbi request reprint Antigenic shift and increased incidence of meningococcal disease
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Infect Dis 193:1266-74. 2006
  9. doi request reprint The Global Meningococcal Initiative: recommendations for reducing the global burden of meningococcal disease
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Vaccine 29:3363-71. 2011
  10. pmc High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital
    Scott R Curry
    Department of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 48:425-9. 2009

Research Grants

Detail Information

Publications86

  1. doi request reprint Risk factors for meningococcal disease in students in grades 9-12
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Pediatr Infect Dis J 27:193-9. 2008
    ..Universal immunization of adolescents with meningococcal conjugate vaccine was recently recommended. We studied risk factors for meningococcal disease in students in grades 9-12...
  2. doi request reprint Meningococcal group A, C, Y and W-135 conjugate vaccine
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15101, USA
    Nat Rev Drug Discov 9:429-30. 2010
    ....
  3. pmc Emergence and disappearance of a virulent clone of Haemophilus influenzae biogroup aegyptius, cause of Brazilian purpuric fever
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School ofMedicine, Pittsburgh, Pennsylvania 15261, USA
    Clin Microbiol Rev 21:594-605. 2008
    ..After a series of outbreaks and sporadic cases through 1993, no additional cases of BPF have been reported...
  4. pmc Population structure and capsular switching of invasive Neisseria meningitidis isolates in the pre-meningococcal conjugate vaccine era--United States, 2000-2005
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Infect Dis 201:1208-24. 2010
    ..Neisseria meningitidis changes its capsular phenotype through capsular switching, which has implications for vaccines that do not protect against all serogroups...
  5. pmc Prospects for vaccine prevention of meningococcal infection
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, 521 Parran Hall, 130 DeSoto St, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Microbiol Rev 19:142-64. 2006
    ..This review covers the changing epidemiology of meningococcal disease in the United States, issues related to vaccine prevention, and recommendations on the use of the new vaccine...
  6. pmc Epidemiological profile of meningococcal disease in the United States
    Lee H Harrison
    University of Pittsburgh Graduate School of Public Health and School of Medicine, Pennsylvania, USA
    Clin Infect Dis 50:S37-44. 2010
    ..Broadly protective vaccines for endemic serogroup B disease are also needed...
  7. doi request reprint Global epidemiology of meningococcal disease
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, 521 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, United States
    Vaccine 27:B51-63. 2009
    ....
  8. ncbi request reprint Antigenic shift and increased incidence of meningococcal disease
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Infect Dis 193:1266-74. 2006
    ..The cyclical nature of endemic meningococcal disease remains unexplained. The purpose of this study was to investigate the mechanisms associated with the increase in the incidence of meningococcal disease...
  9. doi request reprint The Global Meningococcal Initiative: recommendations for reducing the global burden of meningococcal disease
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Vaccine 29:3363-71. 2011
    ..Innovative approaches are needed to introduce and sustain meningococcal vaccination programs in resource-poor settings with a high incidence of meningococcal disease...
  10. pmc High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital
    Scott R Curry
    Department of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 48:425-9. 2009
    ..difficile-associated disease. Rifampin resistance in C. difficile strains has been reported to be uncommon...
  11. pmc Multilocus variable-number tandem-repeat analysis and multilocus sequence typing reveal genetic relationships among Clostridium difficile isolates genotyped by restriction endonuclease analysis
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Clin Microbiol 48:412-8. 2010
    ..difficile disease pathogenesis. This study demonstrates that a combination of MLST and MLVA may prove useful for the investigation and surveillance of emergent C. difficile clones of global public health concern...
  12. ncbi request reprint Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approach
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 45:1266-73. 2007
    ..Forty-seven (51%) of 92 HA CD isolates in 2001 were identified as the "epidemic BI strain." A comprehensive CD infection control "bundle" was implemented to control the outbreak of CD infection...
  13. pmc tcdC genotypes associated with severe TcdC truncation in an epidemic clone and other strains of Clostridium difficile
    Scott R Curry
    Department of Medicine, University of Pittsburgh, School of Medicine, PA 15261, USA
    J Clin Microbiol 45:215-21. 2007
    ..Further investigations are required to determine the effect of this and other tcdC genotypes on toxin production and clinical disease...
  14. pmc Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Medical Center, Division of Hospital Epidemiology and Infection Control, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 44:2558-66. 2006
    ..Thus, MLVA is an objective, portable genotyping method that permits reliable detection of C. difficile outbreaks and can aid epidemiologic investigations of nosocomial transmission...
  15. ncbi request reprint Discordant responses to potent antiretroviral treatment in previously naive HIV-1-infected adults initiating treatment in resource-constrained countries: the antiretroviral therapy in low-income countries (ART-LINC) collaboration
    Suely H Tuboi
    Infectious Diseases Epidemiology Research Unit, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Acquir Immune Defic Syndr 45:52-9. 2007
    ..To assess the frequency of and risk factors for discordant responses at 6 months on highly active antiretroviral therapy (HAART) in previously treatment-naive HIV patients from resource-limited countries...
  16. pmc Perirectal swab surveillance for Clostridium difficile by use of selective broth preamplification and real-time PCR detection of tcdB
    Scott R Curry
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Clin Microbiol 49:3788-93. 2011
    ..6%), and 422/422 (100.0%), respectively. These data demonstrate that selective broth preamplification and real-time PCR of perirectal swab specimens constitute a practical approach to the detection of asymptomatic C. difficile carriage...
  17. pmc Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania
    Jennifer M Adams-Haduch
    Division of Infectious Diseases, University of Pittsburgh Medical Center, S829 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261
    Antimicrob Agents Chemother 52:3837-43. 2008
    ..Fifty-nine percent of the MDR isolates belonged to a single clonal group over the course of the study period, as demonstrated by pulsed-field gel electrophoresis...
  18. pmc Association of relapse of Clostridium difficile disease with BI/NAP1/027
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, Division of Infectious Diseases, University of Pittsburgh School of Medicine and Department of Epidemiology, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
    J Clin Microbiol 50:4078-82. 2012
    ..Classification of recurrent CDI episodes by MLVA can be utilized to make informed patient care decisions and to accurately define new CDI cases for infection control and reimbursement purposes...
  19. pmc Whole genome sequencing to investigate the emergence of clonal complex 23 Neisseria meningitidis serogroup Y disease in the United States
    Mary G Krauland
    Infectious Diseases Epidemiology Research Unit, School of Medicine and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvanian, United States of America
    PLoS ONE 7:e35699. 2012
    ..These findings may predict which antigenic factors are important in the cyclic epidemiology of meningococcal disease...
  20. pmc Universal methicillin-resistant Staphylococcus aureus (MRSA) surveillance for adults at hospital admission: an economic model and analysis
    Bruce Y Lee
    Section of Decision Sciences and Clinical Systems Modeling, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania, USA
    Infect Control Hosp Epidemiol 31:598-606. 2010
    ..Although some have recommended universal surveillance for MRSA at hospital admission to identify and to isolate MRSA-colonized patients, there is a need for formal economic studies to determine the cost-effectiveness of such a strategy...
  21. doi request reprint Diversity of factor H-binding protein in Neisseria meningitidis carriage isolates
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, PA, United States
    Vaccine 29:6049-58. 2011
    ..The FHbp genetic repertoire observed in carriage isolate populations will be useful in understanding the potential impact of FHbp-containing vaccines on meningococcal carriage...
  22. doi request reprint Multi-locus variable number tandem repeat analysis for investigation of the genetic association of Clostridium difficile isolates from food, food animals and humans
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine, Graduate School of Public Health, PA, USA
    Anaerobe 17:156-60. 2011
    ..Rigorous epidemiologic and laboratory investigations that employ highly discriminatory genotyping methods are necessary to compare C. difficile isolates from food and food animals to those from humans...
  23. pmc Locus-specific mutational events in a multilocus variable-number tandem repeat analysis of Escherichia coli O157:H7
    Anna C Noller
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, 521 Parran Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
    J Clin Microbiol 44:374-7. 2006
    ..The remaining four loci had no slippage events detected. The mutation rates were locus specific and may impact the interpretation of MLVA data for epidemiologic investigations...
  24. pmc The economic effect of screening orthopedic surgery patients preoperatively for methicillin-resistant Staphylococcus aureus
    Bruce Y Lee
    Public Health Computational and Operations Research PHICOR Group, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 31:1130-8. 2010
    ..We sought to estimate the economic value of routine preoperative MRSA screening and decolonization of orthopedic surgery patients...
  25. pmc Correlating epidemiologic trends with the genotypes causing meningococcal disease, Maryland
    M Catherine McEllistrem
    University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania, USA
    Emerg Infect Dis 10:451-6. 2004
    ..The nonepidemic age-specific increases in serogroup C meningococcal infection in Maryland were clonal in nature and the changes in serogroup Y incidence were associated with a shift in the genotypes of strains causing invasive disease...
  26. pmc Erythromycin-nonsusceptible Streptococcus pneumoniae in children, 1999-2001
    M Catherine McEllistrem
    University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15213 2582, USA
    Emerg Infect Dis 11:969-72. 2005
    ..The decline in infection rates was likely due to the pneumococcal 7-valent conjugate vaccine...
  27. doi request reprint Effect of pneumococcal conjugate vaccine on pneumococcal meningitis
    Heather E Hsu
    University of Pittsburgh, Pittsburgh, PA 15261, USA
    N Engl J Med 360:244-56. 2009
    ..Invasive pneumococcal disease declined among children and adults after the introduction of the pediatric heptavalent pneumococcal conjugate vaccine (PCV7) in 2000, but its effect on pneumococcal meningitis is unclear...
  28. pmc Integron-mediated multidrug resistance in a global collection of nontyphoidal Salmonella enterica isolates
    Mary G Krauland
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Emerg Infect Dis 15:388-96. 2009
    ..This study demonstrates that clonal expansion and horizontal gene transfer contribute to the global dissemination of antimicrobial drug resistance in S. enterica...
  29. pmc Deletion of fetA gene sequences in serogroup B and C Neisseria meningitidis isolates
    Jane W Marsh
    University of Pittsburgh School of Medicine, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 45:1333-5. 2007
    ..In this report, we describe the characterization of three meningococcal isolates that have deleted fetA sequences through genetic recombination at repetitive elements...
  30. pmc Screening for Acinetobacter baumannii colonization by use of sponges
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Scaife Hall S829, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 49:154-8. 2011
    ..003). The combined sensitivity for the upper arm and leg with a sponge was 89.1%. The novel screening method using sterile sponges was easy to perform and achieved excellent sensitivity for the detection of A. baumannii colonization...
  31. ncbi request reprint Geographic, demographic, and seasonal differences in penicillin-resistant Streptococcus pneumoniae in Baltimore
    Bernadette A Albanese
    Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
    Clin Infect Dis 34:15-21. 2002
    ..The incidence of PRSP is increasing in Baltimore, and the seasonality of PRSP suggests that recent antibiotic use, which is more common in winter months, may rapidly affect the prevalence of resistant pneumococcal infections...
  32. pmc Prevalence of Clostridium difficile in uncooked ground meat products from Pittsburgh, Pennsylvania
    Scott R Curry
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Appl Environ Microbiol 78:4183-6. 2012
    ..The prevalence of C. difficile in retail meat may not be as high as previously reported in North America. When contamination occurs, it may be related to events at processing facilities...
  33. doi request reprint Patient-associated risk factors for acquisition of methicillin-resistant Staphylococcus aureus in a tertiary care hospital
    Jo anne M Salangsang
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Infect Control Hosp Epidemiol 31:1139-47. 2010
    ..Determining risk factors for acquisition of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals is important for defining infection-control measures that may lead to fewer hospital-acquired infections...
  34. pmc Serotype 14 variants of the France 9V(-3) clone from Baltimore, Maryland, can be differentiated by the cpsB gene
    M Catherine McEllistrem
    Infectious Diseases Epidemiology Research Unit, Division of Infectious Diseases, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15229, USA
    J Clin Microbiol 42:250-6. 2004
    ..Although the correlation between serotype and the cpsB sequence was high, the overall diversity of the cpsB gene within a serotype likely will limit the role of this gene in a sequence-based serotyping method...
  35. ncbi request reprint A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, University of Pittsburgh Medical Center, Presbyterian Campus, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 26:273-80. 2005
    ..difficile infections; of these, 26 resulted in colectomy and 18 resulted in death. We conducted an investigation of a large C. difficile outbreak in our hospital to identify risk factors and characterize the outbreak...
  36. ncbi request reprint Predictors of virologic failure in HIV-1-infected patients starting highly active antiretroviral therapy in Porto Alegre, Brazil
    Suely H Tuboi
    Infectious Diseases Epidemiology Research Unit, Graduate School of Public Health and School of Medicine, University of Pittsburgh, PA, USA
    J Acquir Immune Defic Syndr 40:324-8. 2005
    ..To assess predictors of virologic response 6 months after initiation of highly active antiretroviral therapy (HAART) in a cohort of HIV-infected patients in Brazil...
  37. ncbi request reprint Recurrent invasive pneumococcal disease in individuals with human immunodeficiency virus infection
    M Catherine McEllistrem
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15213 2582, USA
    J Infect Dis 185:1364-8. 2002
    ..Although a substantial proportion of recurrent pneumococcal infections was potentially preventable by vaccine, creating an effective vaccine may be challenging for this population...
  38. ncbi request reprint Distribution of penicillin-nonsusceptible pneumococcal clones in the Baltimore metropolitan area and variables associated with drug resistance
    M Catherine McEllistrem
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, 15213, USA
    Clin Infect Dis 34:704-7. 2002
    ....
  39. ncbi request reprint Internet death notices as a novel source of mortality surveillance data
    Marshall B Boak
    University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 21666, USA
    Am J Epidemiol 167:532-9. 2008
    ..The Pittsburgh Post-Gazette Internet death notices provided accurate, timely mortality data for nearly three fourths of all Allegheny County deaths...
  40. ncbi request reprint High prevalence of sexually transmitted diseases in young women seeking HIV testing in Rio de Janeiro, Brazil
    Robert L Cook
    Division of General Internal Medicine, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15213, USA
    Sex Transm Dis 31:67-72. 2004
    ..Few data are available on the prevalence of and risk factors for sexually transmitted diseases (STDs) other than HIV in Brazil...
  41. pmc Should vascular surgery patients be screened preoperatively for methicillin-resistant Staphylococcus aureus?
    Bruce Y Lee
    Section of Decision Sciences and Clinical Systems Modeling, Department of Biomedical Informatics, School of Medicine, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 30:1158-65. 2009
    ..Testing all vascular surgery patients preoperatively for MRSA and attempting to decolonize those who have positive results may be a strategy to prevent MRSA infection. The economic value of such a strategy has not yet been determined...
  42. pmc Multilocus variable-number tandem repeat analysis distinguishes outbreak and sporadic Escherichia coli O157:H7 isolates
    Anna C Noller
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Clin Microbiol 41:5389-97. 2003
    ..In addition to being a simple and validated method for E. coli O157:H7 outbreak detection, MLVA appears to have a sensitivity equal to that of PFGE and a specificity superior to that of PFGE...
  43. ncbi request reprint High incidence and prevalence of HIV-1 infection in high risk population in Calcutta, India
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J STD AIDS 14:463-8. 2003
    ..Such a high annual seroincidence rate makes this population well suited for studies of HIV-1 prevention, including vaccine trials...
  44. pmc Creating a text classifier to detect radiology reports describing mediastinal findings associated with inhalational anthrax and other disorders
    Wendy Webber Chapman
    Center for Biomedical Informatics, University of Pittsburgh, Suite 8084 Forbes Tower, Pittsburgh, PA 15213, USA
    J Am Med Inform Assoc 10:494-503. 2003
    ..The aim of this study was to create a classifier for automatic detection of chest radiograph reports consistent with the mediastinal findings of inhalational anthrax...
  45. pmc Multilocus sequence typing reveals a lack of diversity among Escherichia coli O157:H7 isolates that are distinct by pulsed-field gel electrophoresis
    Anna C Noller
    Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania, USA
    J Clin Microbiol 41:675-9. 2003
    ..E. coli O157:H7 has a striking lack of genetic diversity in the genes we explored, even among isolates that are clearly distinct by PFGE. Other approaches to identify improved molecular subtyping methods for E. coli 0157:H7 are needed...
  46. ncbi request reprint Geographic diversity and temporal trends of antimicrobial resistance in Streptococcus pneumoniae in the United States
    Althea W McCormick
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 9:424-30. 2003
    ....
  47. ncbi request reprint Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine
    Cynthia G Whitney
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 348:1737-46. 2003
    ..In early 2000, a protein-polysaccharide conjugate vaccine targeting seven pneumococcal serotypes was licensed in the United States for use in young children...
  48. doi request reprint Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005
    Matthew R Moore
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Infect Dis 197:1016-27. 2008
    ..To understand this increase, we characterized serotype 19A isolates recovered during 2005...
  49. doi request reprint Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005
    Christina R Phares
    Epidemic Intelligence Service Program, Office of Workforce and Career Development, Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    JAMA 299:2056-65. 2008
    ..Guidelines for prevention of perinatal disease through intrapartum chemoprophylaxis were revised in 2002. Candidate vaccines are under development...
  50. doi request reprint A multivalent conjugate vaccine for prevention of meningococcal disease in infants
    Lee H Harrison
    JAMA 299:217-9. 2008
  51. ncbi request reprint Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998-2004
    Lauri A Hicks
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:1346-54. 2007
    ..The benefits may be offset by increases in disease due to serotypes not included in the vaccine (hereafter, "nonvaccine serotypes"). We evaluated the effect of PCV7 on incidence of disease due to nonvaccine serotypes...
  52. ncbi request reprint Association between antimicrobial resistance among pneumococcal isolates and burden of invasive pneumococcal disease in the community
    Julia Y Morita
    Division of Bacterial and Mycotic Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Clin Infect Dis 35:420-7. 2002
    ..The proportion of multidrug-resistant pneumococcal isolates did not predict invasive cases among adults. The increasing prevalence of multidrug-resistant pneumococci among children may be leading to an increase in invasive disease...
  53. ncbi request reprint College and university compliance with a required meningococcal vaccination law
    Amanda D Castel
    The Department of Epidemiology and Biostatistics, George Washington University s School of Public Health and Health Services, Washington, DC 20037, USA
    J Am Coll Health 56:119-27. 2007
    ..The authors sought to identify how Maryland colleges addressed the law and determine whether schools were in full compliance...
  54. pmc Clonal distribution of invasive pneumococcal isolates from children and selected adults in the United States prior to 7-valent conjugate vaccine introduction
    Robert E Gertz
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:4194-216. 2003
    ..In this work, we established the basic genetic structure within individual serotypes prior to PC7V use. The resultant database will be useful for detecting potential selective effects of this vaccine in postvaccine surveillance...
  55. ncbi request reprint Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae
    Moe H Kyaw
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 354:1455-63. 2006
    ..We examined the effect of this vaccine on invasive disease caused by resistant strains...
  56. ncbi request reprint Invasive pneumococcal disease among infants before and after introduction of pneumococcal conjugate vaccine
    Katherine A Poehling
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232 2504, USA
    JAMA 295:1668-74. 2006
    ..Streptococcus pneumoniae is a serious infection in young infants. A heptavalent pneumococcal conjugate vaccine (PCV7) was licensed in 2000 and recommended for all children aged 2 to 23 months...
  57. pmc Pre- and postvaccination clonal compositions of invasive pneumococcal serotypes for isolates collected in the United States in 1999, 2001, and 2002
    Bernard Beall
    Repsiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mailstop C02, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:999-1017. 2006
    ..Continued genotypic surveillance is warranted, since certain clones not targeted by PCV7 are expanding, and their emergence as significant pathogens could occur with maintained vaccine pressure...
  58. ncbi request reprint Changes in invasive Pneumococcal disease among HIV-infected adults living in the era of childhood pneumococcal immunization
    Brendan Flannery
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann Intern Med 144:1-9. 2006
    ..Adults infected with HIV have high rates of invasive pneumococcal disease. Introduction of pneumococcal conjugate vaccine for children could affect disease among HIV-infected adults...
  59. ncbi request reprint Changing epidemiology of invasive pneumococcal disease among older adults in the era of pediatric pneumococcal conjugate vaccine
    Catherine A Lexau
    Minnesota Department of Health, Minneapolis 55155 2538, USA
    JAMA 294:2043-51. 2005
    ..Early after its introduction, incidence of invasive pneumococcal disease declined among older adults, a group at high risk for pneumococcal disease...
  60. ncbi request reprint Excess mortality, hospital stay, and cost due to candidemia: a case-control study using data from population-based candidemia surveillance
    Juliette Morgan
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Infect Control Hosp Epidemiol 26:540-7. 2005
    ..Prior studies lack broad patient and hospital representation or cost-related information that accurately reflects current medical practices...
  61. ncbi request reprint Effectiveness of antiretroviral therapy among patients who attend public HIV clinics in Rio de Janeiro, Brazil
    Cristina B Hofer
    Infectious Diseases Service, Hospital Universitario Clementino Fraga Filho, Department of Preventive Medicine, Universidade Federal do Rio de Janeiro, Brazil
    J Acquir Immune Defic Syndr 36:967-71. 2004
    ..Brazil provides antiretroviral therapy (ART) to HIV-infected persons free of charge. The objective of this study was to investigate factors associated with ART failure in patients receiving free ART in public clinics in Brazil...
  62. ncbi request reprint Identification of a high-risk heterosexual cohort for HIV vaccine efficacy trials in Rio de Janeiro, Brazil, using a sensitive/less-sensitive assay: an update
    Paulo Feijó Barroso
    J Acquir Immune Defic Syndr 36:880-1. 2004
  63. ncbi request reprint Impact of childhood vaccination on racial disparities in invasive Streptococcus pneumoniae infections
    Brendan Flannery
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 291:2197-203. 2004
    ....
  64. ncbi request reprint Behavioral impact, acceptability, and HIV incidence among homosexual men with access to postexposure chemoprophylaxis for HIV
    Mauro Schechter
    Infectious Diseases Service, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Acquir Immune Defic Syndr 35:519-25. 2004
    ..Little is known about the behavioral impact, acceptability, and incidence of HIV infection in persons with easy access to post-sexual exposure prophylaxis (PEP) to prevent HIV...
  65. ncbi request reprint Emergence of a novel penicillin-nonsusceptible, invasive serotype 35B clone of Streptococcus pneumoniae within the United States
    Bernard Beall
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 186:118-22. 2002
    ..The mosaic pbp2b and divergent ddl sequences were suggestive of interspecies recombination at the ddl-pbp2b chromosomal region...
  66. ncbi request reprint Adherence to antiretroviral therapy and persistence of HIV RNA in semen
    Paulo F Barroso
    Infectious Diseases Sevice, Department of Preventive Medicine, Hospital Universitario Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Acquir Immune Defic Syndr 32:435-40. 2003
    ..Although antiretroviral therapy (ART) reduces HIV seminal shedding, little is known about the relationship between adherence to ART and HIV suppression in semen...
  67. pmc Invasive group A streptococcal infection in older adults in long-term care facilities and the community, United States, 1998-2003
    Michael C Thigpen
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 13:1852-9. 2007
    ..95%, p<0.01). In multivariate logistic regression modeling, LTCF residence remained an independent predictor of death. Additional prevention strategies against GAS infection in this high-risk population are urgently needed...
  68. ncbi request reprint Declining incidence of invasive Streptococcus pneumoniae infections among persons with AIDS in an era of highly active antiretroviral therapy, 1995-2000
    Richard T Heffernan
    Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, Connecticut, USA
    J Infect Dis 191:2038-45. 2005
    ..Our goal was to describe trends in invasive pneumococcal disease incidence among persons with acquired immunodeficiency syndrome (AIDS) since the introduction of highly active antiretroviral therapy (HAART)...
  69. ncbi request reprint Methicillin-resistant Staphylococcus aureus disease in three communities
    Scott K Fridkin
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 352:1436-44. 2005
    ..Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. The national burden and clinical effect of this novel presentation of MRSA disease are unclear...
  70. pmc Genotyping primers for fully automated multilocus variable-number tandem repeat analysis of Escherichia coli O157:H7
    Anna C Noller
    J Clin Microbiol 42:3908. 2004
  71. ncbi request reprint Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: A 60-year follow-up study
    Naomi E Aronson
    Department of Medicine, Infectious Disease Division, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    JAMA 291:2086-91. 2004
    ..The duration of protection from tuberculosis of BCG vaccines is not known...
  72. pmc Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program
    Rana A Hajjeh
    Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 42:1519-27. 2004
    ..7% of isolates, and > or = 2 microg/ml for 0.4% of isolates. Our findings highlight changes in the epidemiology of Candida BSI in the 1990s and provide a basis upon which to conduct further studies of selected high-risk subpopulations...
  73. pmc Invasive group A streptococcal disease: risk factors for adults
    Stephanie H Factor
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 9:970-7. 2003
    ..68, p=0.004), diabetes (RR=2.27, p=0.03), cardiac disease (RR=3.24, p=0.006), cancer (RR=3.54, p=0.006), and corticosteroid use (RR=5.18, p=0.03). Thus, host and environmental factors increased the risk for invasive GAS disease...
  74. pmc Comparison of visual and spectrophotometric methods of broth microdilution MIC end point determination and evaluation of a sterol quantitation method for in vitro susceptibility testing of fluconazole and itraconazole against trailing and nontrailing Cand
    Beth A Arthington-Skaggs
    Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 46:2477-81. 2002
    ..Our results indicate that MIC results determined by either of these end point rules may be more predictive of in vivo outcome for isolates that give unclear visual end points at 48 h due to trailing growth...
  75. ncbi request reprint Risk factors for severe respiratory syncytial virus infection among Alaska native children
    Lisa R Bulkow
    Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska 99508, USA
    Pediatrics 109:210-6. 2002
    ..We conducted this study to better understand factors associated with hospitalization attributable to RSV infection in this high-risk population...
  76. ncbi request reprint Determining risk factors for candidemia among newborn infants from population-based surveillance: Baltimore, Maryland, 1998-2000
    Sharmila S Shetty
    Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Pediatr Infect Dis J 24:601-4. 2005
    ..Our objective was to determine risks factors for late onset candidemia, independent of birth weight, in newborn infants...
  77. ncbi request reprint Multistate surveillance for laboratory-confirmed, influenza-associated hospitalizations in children: 2003-2004
    Stephanie J Schrag
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 25:395-400. 2006
    ..We describe laboratory-confirmed, influenza-associated hospitalizations in a population representing almost 6% of children in the United States...
  78. pmc Increase in non-AIDS related conditions as causes of death among HIV-infected individuals in the HAART era in Brazil
    Antonio G Pacheco
    Department of Epidemiology and Quantitative Methods in Health, National School of Public Health Scientific Computing Program, Oswaldo Cruz Foundation FIOCRUZ, Rio de Janeiro, Brazil
    PLoS ONE 3:e1531. 2008
    ....
  79. ncbi request reprint Invasive methicillin-resistant Staphylococcus aureus infections in the United States
    R Monina Klevens
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    JAMA 298:1763-71. 2007
    ..As the epidemiology of infections with methicillin-resistant Staphylococcus aureus (MRSA) changes, accurate information on the scope and magnitude of MRSA infections in the US population is needed...
  80. pmc Risk factors for pediatric invasive group A streptococcal disease
    Stephanie H Factor
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 11:1062-6. 2005
    ..67, p=0.03) and household member(s) with runny nose (OR=0.09, p=0.002) were associated with decreased risk. Among children, household-level characteristics that influence exposure to GAS most affect development of invasive disease...
  81. ncbi request reprint The epidemiology of invasive group A streptococcal infection and potential vaccine implications: United States, 2000-2004
    Rosalyn E O'Loughlin
    Respiratory Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 45:853-62. 2007
    ..We report the current epidemiologic characteristics of invasive GAS infections and estimate the potential impact of a multivalent GAS vaccine...
  82. pmc Prevalence of factor H-binding protein variants and NadA among meningococcal group B isolates from the United States: implications for the development of a multicomponent group B vaccine
    Peter T Beernink
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Infect Dis 195:1472-9. 2007
    ..Antibodies against fHBP are bactericidal against strains within a variant group. There are limited data on the prevalence of strains expressing different fHBP variants in the United States...
  83. pmc Community-associated methicillin-resistant Staphylococcus aureus and healthcare risk factors
    R Monina Klevens
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 12:1991-3. 2006
    ..Of patients with HRFs, 18%-28% had a "community-associated" strain, primarily USA300; of patients without HRFs, 26% had a "healthcare-associated" strain, typically USA100...
  84. ncbi request reprint Vaccine prevention of meningococcal disease: making slow progress
    Lee H Harrison
    Clin Infect Dis 43:1395-7. 2006
  85. ncbi request reprint Epidemiology of community-onset candidemia in Connecticut and Maryland
    Andre N Sofair
    Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Infect Dis 43:32-9. 2006
    ..e., community-onset candidemia). We compared the characteristics of patients who developed candidemia by the timing of onset of infection...
  86. ncbi request reprint Reduced risk of tuberculosis among Brazilian patients with advanced human immunodeficiency virus infection treated with highly active antiretroviral therapy
    Guilherme Santoro-Lopes
    Infectious Diseases Clinic, Department of Preventive Medicine, Hospital Universitario Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Clin Infect Dis 34:543-6. 2002
    ..The use of highly active antiretroviral therapy in regions with a high prevalence of coinfection with HIV and Mycobacterium tuberculosis may contribute a lower incidence of tuberculosis...

Research Grants3

  1. Shedding of HIV In Semen Despite Antiretroviral Therapy
    Lee Harrison; Fiscal Year: 2006
    ..abstract_text> ..
  2. Forensic Detection of Salmonella Resistance and Subtype
    Lee Harrison; Fiscal Year: 2005
    ..enterica and 2) molecular methods for rapid outbreak detection among S. enterica serovars. ..