Duygu Dee Harrison-Findik

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol
    Duygu Dee Harrison-Findik
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Houston, TX, USA
    Hepatology 46:1979-85. 2007
  2. ncbi Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
    Duygu Dee Harrison-Findik
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5820, USA
    J Biol Chem 281:22974-82. 2006
  3. ncbi Role of alcohol in the regulation of iron metabolism
    Duygu Dee Harrison-Findik
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    World J Gastroenterol 13:4925-30. 2007
  4. ncbi Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling
    Duygu Dee Harrison-Findik
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, 95820 UNMC, Omaha, NE 68198 5820, USA
    Am J Physiol Gastrointest Liver Physiol 296:G112-8. 2009
  5. ncbi Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease?
    Duygu Dee Harrison-Findik
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198 5820, United States
    World J Gastroenterol 15:1186-93. 2009

Research Grants

  1. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    DUYGU DEE DEE HARRISON FINDIK; Fiscal Year: 2010

Collaborators

Detail Information

Publications5

  1. ncbi Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol
    Duygu Dee Harrison-Findik
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Houston, TX, USA
    Hepatology 46:1979-85. 2007
    ..Our findings therefore suggest that alcohol negates the protective effect of hepcidin, which may have implications for the liver injury observed in alcoholic liver disease and genetic hemochromatosis in combination with alcohol...
  2. ncbi Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
    Duygu Dee Harrison-Findik
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5820, USA
    J Biol Chem 281:22974-82. 2006
    ..Collectively, these findings indicate that alcohol metabolism-mediated oxidative stress regulates hepcidin transcription via C/EBPalpha, which in turn leads to increased duodenal iron transport...
  3. ncbi Role of alcohol in the regulation of iron metabolism
    Duygu Dee Harrison-Findik
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    World J Gastroenterol 13:4925-30. 2007
    ....
  4. ncbi Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling
    Duygu Dee Harrison-Findik
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, 95820 UNMC, Omaha, NE 68198 5820, USA
    Am J Physiol Gastrointest Liver Physiol 296:G112-8. 2009
    ..Therefore, these findings suggest that alcohol acts within hepatocytes to suppress hepcidin expression and thereby influences iron homeostasis...
  5. ncbi Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease?
    Duygu Dee Harrison-Findik
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198 5820, United States
    World J Gastroenterol 15:1186-93. 2009
    ..The clarification of the mechanisms by which alcohol disrupts iron homeostasis will allow for further understanding of the pathogenesis of alcoholic liver disease...

Research Grants3

  1. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    DUYGU DEE DEE HARRISON FINDIK; Fiscal Year: 2010
    ..The knowledge obtained from these studies, characterizing the pivotal role of mitochondria, will enable us to determine the mechanisms of liver injury caused by iron and alcohol in patients with ALD. ..