Duygu Dee Harrison-Findik

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol
    Duygu Dee Harrison-Findik
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Houston, TX, USA
    Hepatology 46:1979-85. 2007
  2. pmc Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver
    Lisa Nicole Gerjevic
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, 95820 UNMC, Omaha, NE 68198 5820, USA
    Int J Hepatol 2012:459278. 2012
  3. ncbi Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
    Duygu Dee Harrison-Findik
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5820, USA
    J Biol Chem 281:22974-82. 2006
  4. ncbi Role of alcohol in the regulation of iron metabolism
    Duygu Dee Harrison-Findik
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    World J Gastroenterol 13:4925-30. 2007
  5. pmc Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling
    Duygu Dee Harrison-Findik
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, 95820 UNMC, Omaha, NE 68198 5820, USA
    Am J Physiol Gastrointest Liver Physiol 296:G112-8. 2009
  6. pmc Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease?
    Duygu Dee Harrison-Findik
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198 5820, United States
    World J Gastroenterol 15:1186-93. 2009
  7. pmc Regulation of heme oxygenase expression by alcohol, hypoxia and oxidative stress
    Lisa Nicole Gerjevic
    Lisa Nicole Gerjevic, Sizhao Lu, Jonathan Pascal Chaky, Duygu Dee Harrison Findik, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5820, United States
    World J Biol Chem 2:252-60. 2011

Research Grants

  1. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    Duygu Dee Harrison Findik; Fiscal Year: 2009
  2. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    DUYGU DEE DEE HARRISON FINDIK; Fiscal Year: 2010

Collaborators

Detail Information

Publications7

  1. ncbi Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol
    Duygu Dee Harrison-Findik
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Houston, TX, USA
    Hepatology 46:1979-85. 2007
    ..The iron-induced increase in DNA-binding activity of the transcription factor CCAAT/enhancer binding protein alpha (C/EBP alpha) was also suppressed by alcohol...
  2. pmc Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver
    Lisa Nicole Gerjevic
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, 95820 UNMC, Omaha, NE 68198 5820, USA
    Int J Hepatol 2012:459278. 2012
    ..These findings may help to further understand the mechanisms of alcohol and iron-induced liver injury...
  3. ncbi Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
    Duygu Dee Harrison-Findik
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5820, USA
    J Biol Chem 281:22974-82. 2006
    ..Collectively, these findings indicate that alcohol metabolism-mediated oxidative stress regulates hepcidin transcription via C/EBPalpha, which in turn leads to increased duodenal iron transport...
  4. ncbi Role of alcohol in the regulation of iron metabolism
    Duygu Dee Harrison-Findik
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    World J Gastroenterol 13:4925-30. 2007
    ....
  5. pmc Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling
    Duygu Dee Harrison-Findik
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, 95820 UNMC, Omaha, NE 68198 5820, USA
    Am J Physiol Gastrointest Liver Physiol 296:G112-8. 2009
    ..Therefore, these findings suggest that alcohol acts within hepatocytes to suppress hepcidin expression and thereby influences iron homeostasis...
  6. pmc Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease?
    Duygu Dee Harrison-Findik
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198 5820, United States
    World J Gastroenterol 15:1186-93. 2009
    ..The clarification of the mechanisms by which alcohol disrupts iron homeostasis will allow for further understanding of the pathogenesis of alcoholic liver disease...
  7. pmc Regulation of heme oxygenase expression by alcohol, hypoxia and oxidative stress
    Lisa Nicole Gerjevic
    Lisa Nicole Gerjevic, Sizhao Lu, Jonathan Pascal Chaky, Duygu Dee Harrison Findik, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5820, United States
    World J Biol Chem 2:252-60. 2011
    ..To study the effect of both acute and chronic alcohol exposure on heme oxygenases (HOs) in the brain, liver and duodenum...

Research Grants3

  1. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    Duygu Dee Harrison Findik; Fiscal Year: 2009
    ..The knowledge obtained from these studies, characterizing the pivotal role of mitochondria, will enable us to determine the mechanisms of liver injury caused by iron and alcohol in patients with ALD. ..
  2. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    DUYGU DEE DEE HARRISON FINDIK; Fiscal Year: 2010
    ..The knowledge obtained from these studies, characterizing the pivotal role of mitochondria, will enable us to determine the mechanisms of liver injury caused by iron and alcohol in patients with ALD. ..