William S Harris

Summary

Affiliation: University of South Dakota
Country: USA

Publications

  1. ncbi request reprint International recommendations for consumption of long-chain omega-3 fatty acids
    William S Harris
    Sanford Research USD, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota 57105, USA
    J Cardiovasc Med (Hagerstown) 8:S50-2. 2007
  2. ncbi request reprint The omega-6/omega-3 ratio and cardiovascular disease risk: uses and abuses
    William S Harris
    University of South Dakota, Nutrition and Metabolic Diseases Research Institute, South Dakota Health Research Foundation, 1400 West 22nd Street, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 8:453-9. 2006
  3. ncbi request reprint Why do omega-3 fatty acids lower serum triglycerides?
    William S Harris
    Mid America Heart Institute, Saint Luke s Health System, USA
    Curr Opin Lipidol 17:387-93. 2006
  4. pmc Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor
    William S Harris
    Nutrition and Metabolic Disease Research Institute, Sanford Research USD, Sanford School of Medicine of the University of South Dakota, 1400 West 22nd Street, Sioux Falls, SD 57105, USA
    Pharmacol Res 55:217-23. 2007
  5. ncbi request reprint n-3 Fatty acid fortification: opportunities and obstacles
    William S Harris
    Sanford Research USD, Nutrition and Metabolic Disease Research Institute, Internal Medicine Department, Sanford School of Medicine of The University of South Dakota and Sioux Valley Hospitals and Health Systems, Sioux Falls, USA
    Br J Nutr 97:593-5. 2007
  6. ncbi request reprint Expert opinion: omega-3 fatty acids and bleeding-cause for concern?
    William S Harris
    Sanford School of Medicine of University of South Dakota, Sioux Falls, South Dakota 57105, USA
    Am J Cardiol 99:44C-46C. 2007
  7. ncbi request reprint Tissue n-3 and n-6 fatty acids and risk for coronary heart disease events
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States
    Atherosclerosis 193:1-10. 2007
  8. ncbi request reprint Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids
    William S Harris
    Lipid and Diabetes Research Center, Saint Luke s Mid America Heart Institute, Kansas City, MO, USA
    Am J Clin Nutr 86:1621-5. 2007
  9. ncbi request reprint Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives
    William S Harris
    Nutrition and Metabolic Disease Research, Sanford Research USD, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA
    Atherosclerosis 197:12-24. 2008
  10. ncbi request reprint Tissue omega-6/omega-3 fatty acid ratio and risk for coronary artery disease
    William S Harris
    Department of Medicine, Mid America Heart Institute of Saint Luke s Health System, Kansas City, Missouri, USA
    Am J Cardiol 98:19i-26i. 2006

Research Grants

  1. Niacin, n-3 fatty acids and insulin resistance
    William Harris; Fiscal Year: 2006

Detail Information

Publications88

  1. ncbi request reprint International recommendations for consumption of long-chain omega-3 fatty acids
    William S Harris
    Sanford Research USD, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota 57105, USA
    J Cardiovasc Med (Hagerstown) 8:S50-2. 2007
    ..Fortification is perhaps the best long-term solution to the chronically-low intake of omega-3 fatty acids that plagues western cultures...
  2. ncbi request reprint The omega-6/omega-3 ratio and cardiovascular disease risk: uses and abuses
    William S Harris
    University of South Dakota, Nutrition and Metabolic Diseases Research Institute, South Dakota Health Research Foundation, 1400 West 22nd Street, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 8:453-9. 2006
    ..Metrics that include the n-3 FAs alone, especially eicosapentaenoic and docosahexaenoic acids, appear to hold the greatest promise...
  3. ncbi request reprint Why do omega-3 fatty acids lower serum triglycerides?
    William S Harris
    Mid America Heart Institute, Saint Luke s Health System, USA
    Curr Opin Lipidol 17:387-93. 2006
    ....
  4. pmc Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor
    William S Harris
    Nutrition and Metabolic Disease Research Institute, Sanford Research USD, Sanford School of Medicine of the University of South Dakota, 1400 West 22nd Street, Sioux Falls, SD 57105, USA
    Pharmacol Res 55:217-23. 2007
    ..For these and a number of other reasons, the omega-3 index compares very favourably with other risk factors for sudden cardiac death...
  5. ncbi request reprint n-3 Fatty acid fortification: opportunities and obstacles
    William S Harris
    Sanford Research USD, Nutrition and Metabolic Disease Research Institute, Internal Medicine Department, Sanford School of Medicine of The University of South Dakota and Sioux Valley Hospitals and Health Systems, Sioux Falls, USA
    Br J Nutr 97:593-5. 2007
  6. ncbi request reprint Expert opinion: omega-3 fatty acids and bleeding-cause for concern?
    William S Harris
    Sanford School of Medicine of University of South Dakota, Sioux Falls, South Dakota 57105, USA
    Am J Cardiol 99:44C-46C. 2007
    ..As such, the benefits of triglyceride lowering with omega-3 fatty acids more than outweigh any theoretical risks for increased bleeding...
  7. ncbi request reprint Tissue n-3 and n-6 fatty acids and risk for coronary heart disease events
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States
    Atherosclerosis 193:1-10. 2007
    ..The purpose of this paper is to evaluate the published associations between risk for CHD events and tissue n-3 and n-6 FA composition...
  8. ncbi request reprint Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids
    William S Harris
    Lipid and Diabetes Research Center, Saint Luke s Mid America Heart Institute, Kansas City, MO, USA
    Am J Clin Nutr 86:1621-5. 2007
    ..n-3 Fatty acids (FAs) have been shown to be beneficial for cardiovascular health. Whether n-3 FAs from oily fish consumed weekly or from fish-oil capsules taken daily are equally bioavailable is not clear...
  9. ncbi request reprint Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives
    William S Harris
    Nutrition and Metabolic Disease Research, Sanford Research USD, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA
    Atherosclerosis 197:12-24. 2008
    ..Our focus is to review the potential mechanisms by which these fatty acids reduce cardiovascular disease risk...
  10. ncbi request reprint Tissue omega-6/omega-3 fatty acid ratio and risk for coronary artery disease
    William S Harris
    Department of Medicine, Mid America Heart Institute of Saint Luke s Health System, Kansas City, Missouri, USA
    Am J Cardiol 98:19i-26i. 2006
    ..Tissue EPA + DHA appears to be the best fatty acid metric for evaluating for CAD risk...
  11. ncbi request reprint The omega-3 index as a risk factor for coronary heart disease
    William S Harris
    Metabolism and Nutrition Research Center, Sanford Research USD, Sanford School of Medicine of the University of South Dakota, Sioux Falls, SD, USA
    Am J Clin Nutr 87:1997S-2002S. 2008
    ..Before assessment of n-3 FA biostatus can be used in routine clinical evaluation of patients, standardized laboratory methods and quality control materials must become available...
  12. ncbi request reprint Stearidonic acid increases the red blood cell and heart eicosapentaenoic acid content in dogs
    William S Harris
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, MO, USA
    Lipids 42:325-33. 2007
    ..Compared to dietary EPA, SDA was 20-23% as efficient in raising tissue EPA levels. In conclusion, SDA supplementation increased the EPA content of RBC and heart and may have utility as a plant-based source of omega-3 FA...
  13. ncbi request reprint Blood omega-3 and trans fatty acids in middle-aged acute coronary syndrome patients
    William S Harris
    Sanford Research and School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA
    Am J Cardiol 99:154-8. 2007
    ..In conclusion, low blood EPA + DHA content is an independent predictor of increased risk for ACS, but higher blood trans FA content is not. Blood EPA + DHA may serve as a new, modifiable risk factor for ACS...
  14. ncbi request reprint Triacylglycerol-rich lipoprotein margination: a potential surrogate for whole-body lipoprotein lipase activity and effects of eicosapentaenoic and docosahexaenoic acids
    Yongsoon Park
    Lipid and Diabetes Research Center, Saint Luke s Hospital, and The University of Missouri Kansas City School of Medicine, 64111, USA
    Am J Clin Nutr 80:45-50. 2004
    ..Margination occurs when blood borne particles attach to the vessel wall. Triacylglycerol-rich lipoprotein (TRL) particles marginate when they bind to endothelial lipoprotein lipase (LpL)...
  15. pmc Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study
    William S Harris
    Sanford Research USD, 2301 E 60th St N, Sioux Falls, SD 57104, USA
    Atherosclerosis 225:425-31. 2012
    ..The objectives of this study were to define the relations between the omega-3 index and clinical factors and to determine the heritability of the omega-3 index...
  16. pmc Changes in erythrocyte membrane trans and marine fatty acids between 1999 and 2006 in older Americans
    William S Harris
    Sanford Research, University of South Dakota, Sioux Falls, SD, USA
    J Nutr 142:1297-303. 2012
    ..7 y, the proportion of trans fatty acids in RBC decreased. Those of EPA+DHA increased in people taking fish oil supplements. These changes could potentially translate into a lower risk for cardiovascular disease...
  17. pmc Relation between red blood cell omega-3 fatty acid index and bleeding during acute myocardial infarction
    Adam C Salisbury
    Saint Luke s Mid America Heart and Vascular Institute, Kansas City, Missouri, USA
    Am J Cardiol 109:13-8. 2012
    ....
  18. ncbi request reprint Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation
    William S Harris
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, MO, USA
    Circulation 110:1645-9. 2004
    ..The extent of incorporation has not been determined in humans...
  19. pmc Acute coronary syndrome patients with depression have low blood cell membrane omega-3 fatty acid levels
    Alpesh A Amin
    Department of Cardiology, Mid America Heart Institute, Saint Luke Hospital, Kansas City, Missouri, USA
    Psychosom Med 70:856-62. 2008
    ..Reduced levels of blood cell membrane omega-3 (n-3) fatty acids (FAs), an emerging risk factor for both CV disease and depression, may help to explain the link between depression and adverse CV outcomes...
  20. pmc Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: The Heart and Soul Study
    Ramin Farzaneh-Far
    Department of Medicine, University of California San Francisco, 94143 0124, United States
    Atherosclerosis 205:538-43. 2009
    ..We sought to investigate the relationship between n-3 fatty acid levels in erythrocyte membranes and markers of systemic inflammation in 992 individuals with stable coronary artery disease...
  21. doi request reprint Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study
    James V Pottala
    From the Department of Internal Medicine J V P, W S H, Sanford School of Medicine, University of South Dakota, Sioux Falls Health Diagnostic Laboratory Inc J V P, W S H, Richmond, VA Department of Psychiatry K Y, University of California Medical Center, San Francisco Departments of Epidemiology and Internal Medicine J R, R W, University of Iowa College of Public Health, Iowa City Department of Biostatistical Services M A E, Wake Forest School of Medicine, Winston Salem, NC and OmegaQuant Analytics W S H, Sioux Falls, SD
    Neurology 82:435-42. 2014
    ..To test whether red blood cell (RBC) levels of marine omega-3 fatty acids measured in the Women's Health Initiative Memory Study were related to MRI brain volumes measured 8 years later...
  22. pmc Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome: a randomized controlled trial
    Gregory C Shearer
    Sanford Research USD, University of South Dakota, Sioux Falls, SD, USA
    J Lipid Res 53:2429-35. 2012
    ..ERN and P-OM3 alone improved characteristics of metabolic syndrome; however, whereas subjects on combination therapy did not have improved vascular stiffness, TG and HDL levels improved as did certain lipoprotein subfractions...
  23. pmc Membrane level of omega-3 docosahexaenoic acid is associated with severity of obstructive sleep apnea
    James B Ladesich
    University of Missouri Kansas City School of Medicine, Kansas City, MO, USA
    J Clin Sleep Med 7:391-6. 2011
    ..A link between low DHA status and less mature sleep patterns was observed in newborns...
  24. pmc Red blood cell fatty acid patterns and acute coronary syndrome
    Gregory C Shearer
    Sanford Research USD, Cardiovascular Health Research Center, Sioux Falls, SD, USA
    PLoS ONE 4:e5444. 2009
    ....
  25. ncbi request reprint New evidence for the cardiovascular benefits of long chain omega-3 fatty acids
    Susan N Hansen
    Nutrition and Metabolic Disease Research Institute, Sanford Research University of South Dakota, 1400 West 22nd Street, L 07, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 9:434-40. 2007
    ..Finally, a supplementation study in cardiac surgery patients has demonstrated both the time course and extent of incorporation of LC n-3 FAs into the human heart...
  26. ncbi request reprint Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects
    Mark K Larson
    Sanford Research USD, 1100 E 21st Street, Sioux Falls, SD 57105, USA
    Thromb Haemost 100:634-41. 2008
    ..Since previous studies have not reported a clinically significant risk for bleeding in subjects on combined therapy, P-OM3 may safely enhance the anti-platelet effect of aspirin...
  27. pmc Predictors of omega-3 index in patients with acute myocardial infarction
    Adam C Salisbury
    Department of Cardiovascular Diseases, Saint Luke s Mid America Heart and Vascular Institute, Kansas City, MO 64111, USA
    Mayo Clin Proc 86:626-32. 2011
    ....
  28. doi request reprint Omega-3 fatty acids and cardiovascular disease: new developments and applications
    William S Harris
    Professor of Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD President, OmegaQuant Analytics, LLC, Sioux Falls, SD Senior Research Scientist, Health Diagnostic Laboratory, Inc, Richmond, VA
    Postgrad Med 125:100-13. 2013
    ..Given the favorable risk-to-benefit ratio for these essentially nutritional agents, use is expected to continue to expand. ..
  29. ncbi request reprint Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions
    James H O'Keefe
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, Missouri, USA
    Am J Cardiol 97:1127-30. 2006
    ..These changes are consistent with an increase in vagal activity and may in part explain the observed decrease in risk for sudden cardiac death seen with omega-3 fatty acid supplementation...
  30. doi request reprint Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker
    William S Harris
    Sanford Research USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Lipids 43:805-11. 2008
    ..Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs...
  31. doi request reprint Relation of whole blood n-3 fatty acid levels to exercise parameters in patients with stable coronary artery disease (from the heart and soul study)
    Brian Moyers
    Department of Medicine, University of California, San Francisco, California, USA
    Am J Cardiol 107:1149-54. 2011
    ..These findings support the hypothesis that n-3 fatty acids may increase vagal tone and physical conditioning...
  32. pmc Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: the Heart and Soul study
    James V Pottala
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, Sioux Falls, SD 57105, USA
    Circ Cardiovasc Qual Outcomes 3:406-12. 2010
    ..The purpose of this study was to determine the extent to which baseline blood n-3 FA levels are associated with reduced risk for all-cause mortality in patients with stable coronary heart disease...
  33. ncbi request reprint The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes
    Scott A Sands
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, Missouri 64111, USA
    Lipids 40:343-7. 2005
    ..Given the importance of n-3 FA in influencing risk for death from CHD, further studies are warranted to delineate the nondietary factors that influence RBC EPA + DHA content...
  34. ncbi request reprint Effects of omega-3 fatty acids on heart rate in cardiac transplant recipients
    William S Harris
    University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA
    Am J Cardiol 98:1393-5. 2006
    ..These findings suggest that n-3 FAs may modify electrophysiologic properties of the myocardium itself...
  35. doi request reprint ω-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA
    Eric M Ammann
    From the Department of Epidemiology E M A, R W, R M C, J G R, College of Public Health, and Departments of Internal Medicine R W, J G R and Neurology N L D, College of Medicine, University of Iowa, Iowa City OmegaQuant Analytics J V P, W S H, Sioux Falls Department of Medicine W S H, Sanford School of Medicine, University of South Dakota, Vermillion and Department of Biostatistical Sciences M A E, Wake Forest School of Medicine, Winston Salem, NC
    Neurology 81:1484-91. 2013
    ..To test the hypothesis that higher levels of red blood cell (RBC) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have a protective association with domain-specific cognitive function in women aged 65 years and older...
  36. pmc Fish oil -- how does it reduce plasma triglycerides?
    Gregory C Shearer
    Cardiovascular Health Research Center, Sanford Research USD, SD, USA
    Biochim Biophys Acta 1821:843-51. 2012
    ..This article is part of a Special Issue entitled Triglyceride Metabolism and Disease...
  37. pmc Myocardial infarction does not affect fatty-acid profiles in rats
    Gregory C Shearer
    Cardiovascular Health Research Center, Sanford Research USD, 1100 E 21st St, Sioux Falls, SD 57105, USA
    Prostaglandins Leukot Essent Fatty Acids 81:411-6. 2009
    ..This finding suggests that differences between cases and controls have prognostic implications...
  38. ncbi request reprint Atorvastatin reduces remnant lipoproteins and small, dense low-density lipoproteins regardless of the baseline lipid pattern
    James H O'Keefe
    Mid America Heart Institute, St Luke s Hospital, 4401 Wornall Road, Suite 2000, Kansas City, MO 64111
    Prev Cardiol 7:154-60. 2004
    ..Increased attention should be paid to absolute concentrations of LDL subfraction cholesterol, which may be a more sensitive indicator of coronary heart disease risk than total LDL or an LDL pattern...
  39. doi request reprint The omega-3 index: clinical utility for therapeutic intervention
    William S Harris
    Cardiovascular Health Research Center Sanford Research USD, 2301 East 60th Street North, Sioux Falls, SD 57104 0589, USA
    Curr Cardiol Rep 12:503-8. 2010
    ..Using the Omega-3 Index in the design of clinical studies might allow for a more efficient use of research resources...
  40. doi request reprint Stearidonic acid as a 'pro-eicosapentaenoic acid'
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA
    Curr Opin Lipidol 23:30-4. 2012
    ..Ocean-based supplies are limited, and so land-based sources are being sought. Stearidonic acid-fortified soybean oil may help to meet this demand...
  41. doi request reprint Stearidonic acid-enhanced soybean oil: a plant-based source of (n-3) fatty acids for foods
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA
    J Nutr 142:600S-604S. 2012
    ..Thus, the consumption of foods containing SDA-enhanced soybean oil may be both a practical and sustainable approach to enriching tissues with beneficial (n-3) fatty acids...
  42. ncbi request reprint Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
    Yongsoon Park
    Department of Medicine, University of Missouri, Kansas City, MO 64108, USA
    J Lipid Res 44:455-63. 2003
    ..The results suggest that omega-3 FA supplementation accelerates chylomicron TG clearance by increasing LPL activity, and that EPA and DHA are equally effective...
  43. ncbi request reprint The Omega-3 Index: a new risk factor for death from coronary heart disease?
    William S Harris
    Lipid and Diabetes Research Center, Mid America Heart Institute of Saint Luke s Hospital, University of Missouri KC School of Medicine, Kansas City, MO 64111, USA
    Prev Med 39:212-20. 2004
    ..Red blood cell (RBC) fatty acid (FA) composition reflects long-term intake of EPA + DHA. We propose that the RBC EPA + DHA (hereafter called the Omega-3 Index) be considered a new risk factor for death from CHD...
  44. pmc Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction
    Monika K Duda
    Division of Cardiology, Department of Medicine, University of Maryland Baltimore, 20 Penn Street, HSF2, Room S022, Baltimore, MD 21201, USA
    Cardiovasc Res 81:319-27. 2009
    ....
  45. ncbi request reprint Intakes of long-chain omega-3 fatty acid associated with reduced risk for death from coronary heart disease in healthy adults
    William S Harris
    Metabolism and Nutrition Research Center, Sanford Research University of South Dakota, 1100 E 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 10:503-9. 2008
    ..We conclude, therefore, that an intake of 400 to 500 mg/d of EPA + DHA is achievable by diet alone and would be expected to significantly reduce risk for death from CHD in healthy adults...
  46. doi request reprint Biological variability of blood omega-3 biomarkers
    William S Harris
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, Sioux Falls, SD 57105, USA
    Clin Biochem 43:338-40. 2010
    ..We conducted a pilot study to estimate the biological variability and effects of a prior meal on the omega-3 fatty acid (FA) content of 3 blood FA pools...
  47. pmc Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase G signaling in cardiac fibroblasts
    Jinghai Chen
    Cardiovascular Health Research Center, Sanford Research USD, Sioux Falls, SD 57104, USA
    Circulation 123:584-93. 2011
    ..The present study assessed the effects of ω-3 polyunsaturated fatty acids on cardiac fibrosis...
  48. ncbi request reprint Fish oil supplementation: evidence for health benefits
    William S Harris
    Lipid and Diabetes Research Center, Mid America Heart Institute of Saint Luke s Hospital, Kansas City, MO, USA
    Cleve Clin J Med 71:208-10, 212, 215-8 passim. 2004
    ..This article answers a series of questions that health care professionals often ask regarding fish oil, such as what are proper dosages, and are there risks of ingesting pollutants by eating more fish or using supplements?..
  49. doi request reprint Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids
    William S Harris
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine at University of South Dakota, Sioux Falls, SD 57105, USA
    J Nutr 139:804S-19S. 2009
    ....
  50. doi request reprint Are n-3 fatty acids still cardioprotective?
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA
    Curr Opin Clin Nutr Metab Care 16:141-9. 2013
    ..Several recent randomized trials and subsequent meta-analyses have questioned the value of n-3 fatty acid supplementation in cardiovascular disease risk reduction...
  51. doi request reprint Correcting the effects of -20 °C storage and aliquot size on erythrocyte fatty acid content in the Women's Health Initiative
    James V Pottala
    OmegaQuant LLC, Sioux Falls, SD, USA
    Lipids 47:835-46. 2012
    ..The FA compositions of the degraded RBC samples from WHIMS were rehabilitated by application of regression calibration equations and multiple imputations, and these imputed datasets should be used in all future WHIMS studies...
  52. ncbi request reprint Are omega-3 fatty acids the most important nutritional modulators of coronary heart disease risk?
    William S Harris
    St Luke s Mid America Heart Institute and Department of Medicine, University of Missouri Kansas City School of Medicine, 4320 Wornall Road, Suite 128, Kansas City, MO 64111, USA
    Curr Atheroscler Rep 6:447-52. 2004
    ..The strength of the n-3 story has now led to a proposal that blood levels of EPA plus DHA be considered a new, modifiable, and clinically relevant risk factor for death from CHD...
  53. ncbi request reprint Extending the cardiovascular benefits of omega-3 Fatty acids
    William S Harris
    Lipid and Diabetes Research Center, Mid America Heart Institute, Saint Luke s Health System, Kansas City, MO 64111, USA
    Curr Atheroscler Rep 7:375-80. 2005
    ..If intakes of the latter are adequate (perhaps over 250 mg/d), then there appears to be little need to consume more ALA or less LA...
  54. ncbi request reprint The omega-3 index: from biomarker to risk marker to risk factor
    William S Harris
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, University of South Dakota, Suite 700, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 11:411-7. 2009
    ..The omega-3 index appears to fulfill many of the requirements for a risk marker and, more importantly, for a risk factor...
  55. doi request reprint Omega-3 fatty acids for cardioprotection
    John H Lee
    Mid America Heart Institute and University of Missouri Kansas City, 4330 Wornall Road, Kansas City, MO 64111, USA
    Mayo Clin Proc 83:324-32. 2008
    ..Blood DHA and EPA levels could one day be used to identify patients with deficient levels and to individualize therapeutic recommendations...
  56. pmc Red blood cell fatty acid levels improve GRACE score prediction of 2-yr mortality in patients with myocardial infarction
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States
    Int J Cardiol 168:53-9. 2013
    ....
  57. pmc Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters
    Gregory C Shearer
    Cardiovascular Health Research Center, Sanford Research USD, Sioux Falls, SD, USA
    J Lipid Res 51:2074-81. 2010
    ..The extent to which the beneficial cardiovascular effects of n-3 FAs are mediated by increased n-3 and/or reduced n-6 oxylipin levels remains to be explored...
  58. doi request reprint Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility
    William S Harris
    Health Diagnostic Laboratory, Inc, 737 N 5th Street, Suite 103, Richmond, VA 23219, USA OmegaQuant Analytics, LLC, Sioux Falls, SD, USA Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA Electronic address
    J Clin Lipidol 7:433-40. 2013
    ..The matrix that exhibits the lower within-person variability and is less affected by an acute dose of n-3 FA is preferred in clinical practice...
  59. ncbi request reprint Metabolic syndrome-mediated inflammation following elective percutaneous coronary intervention
    Steven P Marso
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, Missouri 64111, USA
    Diab Vasc Dis Res 2:31-6. 2005
    ..In this patient population, the metabolic syndrome correlates with a heightened inflammatory response following elective PCI...
  60. doi request reprint Linoleic acid and coronary heart disease
    William S Harris
    Sanford Research USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Prostaglandins Leukot Essent Fatty Acids 79:169-71. 2008
    ..Thus, current recommendations to consume 5-10% of energy from LA are evidence-based, and should not be reduced...
  61. ncbi request reprint Cardiovascular disease and long-chain omega-3 fatty acids
    William S Harris
    Lipid and Diabetes Research Center, Saint Luke s Hospital, University of Missouri Kansas City School of Medicine, 64111, USA
    Curr Opin Lipidol 14:9-14. 2003
    ..Of all known dietary factors, long-chain omega-3 fatty acids may be the most protective against death from coronary heart disease. New evidence has confirmed and refined the cardioprotective role of these fatty acids...
  62. ncbi request reprint Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy
    John M Miles
    Mid America Heart Institute of Saint Luke s Hospital, University of Missouri Kansas City, Kansas City, MO, USA
    Diabetes 52:675-81. 2003
    ..In summary, nocturnal and postprandial FFA R(a) is increased in type 2 diabetes. Postprandial lipolysis appears to be preferentially improved by thiazolidinediones compared with nocturnal lipolysis...
  63. ncbi request reprint Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 106:2747-57. 2002
  64. ncbi request reprint n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits
    Sarah K Gebauer
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Am J Clin Nutr 83:1526S-1535S. 2006
    ..Foods enriched with EPA and DHA or fish oil supplements are a suitable alternate to achieve recommended intakes and may be necessary to achieve intakes of 1 g/d...
  65. ncbi request reprint Hypertriglyceridemia: management of atherogenic dyslipidemia
    Thomas Bersot
    Gladstone Institute of Cardiovascular Disease, School of Medicine, University of California San Francisco, San Francisco, CA, USA
    J Fam Pract 55:S1-8. 2006
    ..Fibrates, niacin, and omega-3 acid ethyl esters are highly effective at reducing triglycerides, while statins are considered moderately efficacious (SOR: A)...
  66. ncbi request reprint n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
    Chenchen Wang
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA, USA
    Am J Clin Nutr 84:5-17. 2006
    ..The evidence for the benefits of fish oil is stronger in secondary- than in primary-prevention settings. Adverse effects appear to be minor...
  67. ncbi request reprint Cardiovascular benefits of omega-3 fatty acids
    Clemens von Schacky
    Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Ziemssenstrasse 1, D 80336 Munich, Germany
    Cardiovasc Res 73:310-5. 2007
    ..As is the case now for LDL, in the future, the cardiac societies might very well recommend treatment with EPA and DHA to become goal oriented (e.g. an omega-3 index>8%)...
  68. ncbi request reprint Risks and benefits of fish intake
    Michel Lucas
    JAMA 297:585; author reply 586. 2007
  69. ncbi request reprint EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls
    Robert C Block
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, Box 644, 601 Elmwood Avenue, NY 14642, United States robert
    Atherosclerosis 197:821-8. 2008
    ....
  70. ncbi request reprint n-3 Fatty acids and cardiovascular disease
    Dennis W T Nilsen
    Am J Clin Nutr 79:166. 2004
  71. pmc UK Food Standards Agency Workshop Report: the effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health
    John C Stanley
    Trinity College and St Hugh s College, Oxford, UK
    Br J Nutr 98:1305-10. 2007
    ..Other markers of fatty acid intake, that more closely relate to physiological function, may be more useful...
  72. pmc Red blood cell docosahexaenoic acid and eicosapentaenoic acid concentrations are positively associated with socioeconomic status in patients with established coronary artery disease: data from the Heart and Soul Study
    Beth E Cohen
    Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Nutr 138:1135-40. 2008
    ..Our results raise the possibility that (n-3) fatty acids may be an important mediating factor in the association between low SES and CVD...
  73. ncbi request reprint Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Arterioscler Thromb Vasc Biol 23:e20-30. 2003
  74. doi request reprint You are what you eat applies to fish, too
    William S Harris
    J Am Diet Assoc 108:1131-3. 2008
  75. ncbi request reprint Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association
    Penny M Kris-Etherton
    Arterioscler Thromb Vasc Biol 23:151-2. 2003
  76. ncbi request reprint Preventive use of N-3 fatty acids
    William S Harris
    Circulation 108:e139; author reply e139. 2003
  77. ncbi request reprint Systemic and forearm triglyceride metabolism: fate of lipoprotein lipase-generated glycerol and free fatty acids
    John M Miles
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 53:521-7. 2004
    ..They further suggest that LPL-mediated fatty acid uptake is an inefficient process, but may be more efficient in muscle than in adipose tissue...
  78. ncbi request reprint Alpha-linolenic acid: a gift from the land?
    William S Harris
    Circulation 111:2872-4. 2005
  79. ncbi request reprint The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitus
    William L Isley
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Lipid Res 47:193-200. 2006
    ..The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitus...
  80. ncbi request reprint The effect of high-dose simvastatin on free fatty acid metabolism in patients with type 2 diabetes mellitus
    William L Isley
    Endocrine Research Unit, Division of Endocrinology, Nutrition, and Metabolism, Mayo Clinic, Rochester, MN 55905, USA
    Metabolism 55:758-62. 2006
    ..These results suggest that the triglyceride-lowering effect of statins is not mediated through an effect on FFA metabolism...
  81. ncbi request reprint Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee
    Alice H Lichtenstein
    Circulation 114:82-96. 2006
    ..By adhering to these diet and lifestyle recommendations, Americans can substantially reduce their risk of developing cardiovascular disease, which remains the leading cause of morbidity and mortality in the United States...
  82. ncbi request reprint n-3 Fatty acids and health: DaVinci's code
    William S Harris
    Am J Clin Nutr 88:595-6. 2008
  83. ncbi request reprint The effect of high dose simvastatin on, platelet size in patients with, type 2 diabetes mellitus
    William L Isley
    Division of Endocrinology, Nutrition, and Metabolism, Mayo Clinic, Endocrine Research Unit, Rochester, MN 55905, USA
    Platelets 17:292-5. 2006
    ..6 and 1.7%, respectively (P < 0.05), during simvastatin treatment as opposed to the placebo period. We conclude that some of the effects of high dose simvastatin therapy on platelets may not necessarily be anti-atherogenic...
  84. ncbi request reprint Cardiovascular risk and the omega-3 index
    Clemens von Schacky
    Preventive Cardiology, Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Cardiovasc Med (Hagerstown) 8:S46-9. 2007
    ..Cardiac societies recommend EPA + DHA for prevention of SCD. The omega-3 index can assess risk for SCD and monitor therapy with EPA + DHA. Moreover, it compares very favourably with other risk factors for SCD...
  85. ncbi request reprint Effects of moderate variations in the macronutrient content of the diet on cardiovascular disease risk factors in obese patients with the metabolic syndrome
    Fulvio Muzio
    Clinical Nutrition Unit, G Salvini Hospital, Garbagnate Milanese, Milan, Italy
    Am J Clin Nutr 86:946-51. 2007
    ..Even if there is full agreement that lifestyle changes to induce weight loss are the first-line approach, the ideal diet for the treatment of the metabolic syndrome remains uncertain...
  86. ncbi request reprint Conclusions and recommendations from the symposium, Beyond Cholesterol: Prevention and Treatment of Coronary Heart Disease with n-3 Fatty Acids
    Richard J Deckelbaum
    Institute of Human Nutrition, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA
    Am J Clin Nutr 87:2010S-2S. 2008
    ..Additional references for these conclusions can be found in the articles included in the supplement...
  87. ncbi request reprint Cardiovascular risk and alpha-linolenic acid: can Costa Rica clarify?
    William S Harris
    Circulation 118:323-4. 2008
  88. ncbi request reprint n-3 Long-chain polyunsaturated fatty acids reduce risk of coronary heart disease death: extending the evidence to the elderly
    William S Harris
    Am J Clin Nutr 77:279-80. 2003

Research Grants1

  1. Niacin, n-3 fatty acids and insulin resistance
    William Harris; Fiscal Year: 2006
    ..This should lead to more effective therapy for the dyslipidemia of insulin resistance and ultimately to reduced risk for CHD in this burgeoning patient population. ..