Thurl E Harris

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 282:20036-44. 2007
  2. pmc Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity
    Anil Kumar
    Department of Pharmacology, University of Virginia Health System, P O Box 800735, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA
    Mol Cell Biol 28:61-70. 2008
  3. pmc Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 284:14693-7. 2009
  4. pmc Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism
    Anil Kumar
    Department of Pharmacology, University of Virginia Health System, Charlottesville, Virginia, USA
    Diabetes 59:1397-406. 2010
  5. pmc Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors
    Hyun Bae Kim
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Cell Biol 30:3126-39. 2010

Collaborators

Detail Information

Publications5

  1. ncbi request reprint PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 282:20036-44. 2007
    ..We, therefore, propose that PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding...
  2. pmc Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity
    Anil Kumar
    Department of Pharmacology, University of Virginia Health System, P O Box 800735, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA
    Mol Cell Biol 28:61-70. 2008
    ..Thus, rictor in muscle tissue contributes to glucose homeostasis by positively regulating insulin-stimulated glucose uptake and negatively regulating basal glycogen synthase activity...
  3. pmc Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 284:14693-7. 2009
    ..Therefore, our findings indicate that mTOR-mediated raptor phosphorylation plays an important role on activation of mTORC1...
  4. pmc Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism
    Anil Kumar
    Department of Pharmacology, University of Virginia Health System, Charlottesville, Virginia, USA
    Diabetes 59:1397-406. 2010
    ..To determine the physiological role of rictor/mTORC2 in insulin signaling and action in fat cells, we developed fat cell-specific rictor knockout (FRic(-/-)) mice...
  5. pmc Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors
    Hyun Bae Kim
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Cell Biol 30:3126-39. 2010
    ..These observations place lipin 1 as a potentially important link between triacylglycerol synthesis and adipose tissue inflammation...