Samantha Harris

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament
    Samantha P Harris
    Department of Neurobiology, Physiology, and Behavior College of Biological Sciences, University of California, One Shields Ave, Davis, CA 95616, USA
    Circ Res 108:751-64. 2011
  2. pmc Functional differences between the N-terminal domains of mouse and human myosin binding protein-C
    Justin F Shaffer
    Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, CA 95616 8519, USA
    J Biomed Biotechnol 2010:789798. 2010
  3. pmc Contribution of the myosin binding protein C motif to functional effects in permeabilized rat trabeculae
    Maria V Razumova
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    J Gen Physiol 132:575-85. 2008
  4. pmc Species-specific differences in the Pro-Ala rich region of cardiac myosin binding protein-C
    Justin F Shaffer
    Department of Bioengineering, University of Washington, Seattle, WA, USA
    J Muscle Res Cell Motil 30:303-6. 2009
  5. pmc The myosin-binding protein C motif binds to F-actin in a phosphorylation-sensitive manner
    Justin F Shaffer
    Department of Neurobiology, Physiology, and Behavior, University of California, Davis, California 95616, USA
    J Biol Chem 284:12318-27. 2009
  6. pmc Identification of novel protein kinase A phosphorylation sites in the M-domain of human and murine cardiac myosin binding protein-C using mass spectrometry analysis
    Weitao Jia
    Department of Molecular and Cellular Biology, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    J Proteome Res 9:1843-53. 2010

Research Grants

  1. cMyBPC and Regulation of Myocardial Contraction
    Samantha Harris; Fiscal Year: 2009
  2. cMyBPC and Regulation of Myocardial Contraction
    Samantha Harris; Fiscal Year: 2005
  3. cMyBPC and Regulation of Myocardial Contraction
    Samantha Harris; Fiscal Year: 2006
  4. cMyBPC and Regulation of Myocardial Contraction
    Samantha Harris; Fiscal Year: 2007
  5. cMyBPC and Regulation of Myocardial Contraction
    Samantha Harris; Fiscal Year: 2007
  6. cMyBPC and Regulation of Myocardial Contraction
    Samantha Harris; Fiscal Year: 2009

Collaborators

Detail Information

Publications6

  1. pmc In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament
    Samantha P Harris
    Department of Neurobiology, Physiology, and Behavior College of Biological Sciences, University of California, One Shields Ave, Davis, CA 95616, USA
    Circ Res 108:751-64. 2011
    ..Additional work is still needed to determine the mechanisms by which individual mutations induce hypertrophic phenotypes...
  2. pmc Functional differences between the N-terminal domains of mouse and human myosin binding protein-C
    Justin F Shaffer
    Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, CA 95616 8519, USA
    J Biomed Biotechnol 2010:789798. 2010
    ..These results suggest that species-specific differences between homologous cMyBP-C isoforms confer differential effects that could fine-tune cMyBP-C function in hearts of different species...
  3. pmc Contribution of the myosin binding protein C motif to functional effects in permeabilized rat trabeculae
    Maria V Razumova
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    J Gen Physiol 132:575-85. 2008
    ..These results suggest that the C1 domain plus the motif constitute a functional unit of MyBP-C that can activate the thin filament...
  4. pmc Species-specific differences in the Pro-Ala rich region of cardiac myosin binding protein-C
    Justin F Shaffer
    Department of Bioengineering, University of Washington, Seattle, WA, USA
    J Muscle Res Cell Motil 30:303-6. 2009
    ....
  5. pmc The myosin-binding protein C motif binds to F-actin in a phosphorylation-sensitive manner
    Justin F Shaffer
    Department of Neurobiology, Physiology, and Behavior, University of California, Davis, California 95616, USA
    J Biol Chem 284:12318-27. 2009
    ..Reversible interactions with actin could contribute to effects of cMyBP-C to increase cross-bridge cycling...
  6. pmc Identification of novel protein kinase A phosphorylation sites in the M-domain of human and murine cardiac myosin binding protein-C using mass spectrometry analysis
    Weitao Jia
    Department of Molecular and Cellular Biology, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    J Proteome Res 9:1843-53. 2010
    ..Future studies are needed to investigate the phosphorylation state of murine and human cMyBP-C in vivo...

Research Grants7

  1. cMyBPC and Regulation of Myocardial Contraction
    Samantha Harris; Fiscal Year: 2009
    ..Results from the proposed experiments will provide new and relevant information regarding the function of MyBP-C, mechanisms of myosin regulation, and mechanisms by which mutations in the cMyBP-C cause human disease. ..
  2. cMyBPC and Regulation of Myocardial Contraction
    Samantha Harris; Fiscal Year: 2005
    ..Results from the proposed experiments will provide new and relevant information regarding the function of MyBP-C, mechanisms of myosin regulation, and mechanisms by which mutations in the cMyBP-C cause human disease. ..
  3. cMyBPC and Regulation of Myocardial Contraction
    Samantha Harris; Fiscal Year: 2006
    ..Results from the proposed experiments will provide new and relevant information regarding the function of MyBP-C, mechanisms of myosin regulation, and mechanisms by which mutations in the cMyBP-C cause human disease. ..
  4. cMyBPC and Regulation of Myocardial Contraction
    Samantha Harris; Fiscal Year: 2007
    ..Results from the proposed experiments will provide new and relevant information regarding the function of MyBP-C, mechanisms of myosin regulation, and mechanisms by which mutations in the cMyBP-C cause human disease. ..
  5. cMyBPC and Regulation of Myocardial Contraction
    Samantha Harris; Fiscal Year: 2007
    ..Results from the proposed experiments will provide new and relevant information regarding the function of MyBP-C, mechanisms of myosin regulation, and mechanisms by which mutations in the cMyBP-C cause human disease. ..
  6. cMyBPC and Regulation of Myocardial Contraction
    Samantha Harris; Fiscal Year: 2009
    ..Results from the proposed experiments will provide new and relevant information regarding the function of MyBP-C, mechanisms of myosin regulation, and mechanisms by which mutations in the cMyBP-C cause human disease. ..