Research Topics
Species | S D HarrisSummaryAffiliation: University of Nebraska Country: USA Publications
| Collaborators
|
Detail Information
Publications
Septum formation in Aspergillus nidulansS D Harris
Plant Science Initiative, N234 Beadle Center, University of Nebraska, Lincoln, NE 68588 0660, USA
Curr Opin Microbiol 4:736-9. 2001..Hyphal differentiation may reflect the regulation of this cascade by cyclin-dependent kinase activity. In this review, the dynamics and regulation underlying the assembly of the septal band are discussed...
Polarisome meets spitzenkörper: microscopy, genetics, and genomics convergeSteven D Harris
Plant Science Initiative, Department of Plant Pathology, University of Nebraska, Lincoln, NE 68588-0660, USA
Eukaryot Cell 4:225-9. 2005- Morphogenesis in germinating Fusarium graminearum macroconidiaSteven D Harris
Plant Science Initiative and Department of Plant Pathology, University of Nebraska, Lincoln, Nebraska 68588 0660, USA
Mycologia 97:880-7. 2005..These observations suggest that F. graminearum possesses a regulatory system that marks germ tube emergence sites. Perturbation of this system may represent an effective approach for inhibiting colonization of host plant surfaces... - Polarity in filamentous fungi: moving beyond the yeast paradigmSteven D Harris
Plant Science Initiative and Department of Plant Pathology, University of Nebraska, Lincoln, NE, USA
Fungal Genet Biol 41:391-400. 2004.... - Morphology and development in Aspergillus nidulans: a complex puzzleSteven D Harris
Department of Plant Pathology and Center for Plant Science Innovation, University of Nebraska, E126 Beadle Center, Lincoln, NE 68588 0660, USA
Fungal Genet Biol 46:S82-S92. 2009..nidulans genes encode proteins that may participate at some level in morphogenesis during vegetative growth and development... 
The Spitzenkörper: a signalling hub for the control of fungal development?Steven D Harris
Department of Plant Pathology, University of Nebraska, Lincoln, NE 68688 0660, USA
Mol Microbiol 73:733-6. 2009..Notably, these studies suggest that the Spitzenkörper (i.e. apical body), which is known to regulate hyphal morphogenesis, might also serve as a signalling hub that co-ordinates development transitions...- Cdc42/Rho GTPases in fungi: variations on a common themeSteven D Harris
Department of Plant Pathology and Center for Plant Science Innovation, University of Nebraska, Lincoln, NE 68688 0660, USA
Mol Microbiol 79:1123-7. 2011..Surprisingly, the partitioning of these roles between Cdc42 and Rac1 seems to vary even among related fungi. These observations highlight the variable use of a common signalling module in filamentous fungi... - Hyphal morphogenesis: an evolutionary perspectiveSteven D Harris
Center for Plant Science Innovation and Department of Plant Pathology, University of Nebraska, E126 Beadle Center, Lincoln, NE 68506, USA
Fungal Biol 115:475-84. 2011..e., yeast vs. hyphae) using an essentially identical inventory of gene products are also considered. Finally, processes implicated in the regulation of hyphal tip complexes are addressed from an evolutionary perspective... - Regulation of hyphal morphogenesis by cdc42 and rac1 homologues in Aspergillus nidulansAleksandra Virag
Plant Science Initiative and Department of Plant Pathology, University of Nebraska, Lincoln, NE 68588 0660, USA
Mol Microbiol 66:1579-96. 2007..Our results are consistent with the action of parallel Cdc42 and microtubule-based pathways in regulating the formation of a stable axis of hyphal polarity in A. nidulans... - Cell polarity in filamentous fungi: shaping the moldSteven D Harris
Plant Science Initiative and Department of Plant Pathology, University of Nebraska, Lincoln, NE 68588, USA
Int Rev Cytol 251:41-77. 2006..Moreover, the stabilization of nascent polarity axes may be the critical step that permits the emergence of a new hypha... - Characterization of Fusarium graminearum Mes1 reveals roles in cell-surface organization and virulenceWilliam R Rittenour
Department of Plant Pathology and Plant Science Initiative, University of Nebraska Lincoln, N234 Beadle Center, Lincoln, NE 68588 0660, USA
Fungal Genet Biol 45:933-46. 2008..Our results provide a basis for identifying determinants of fungal virulence that may localize to specialized domains at the cell surface... - In vitro induction of infection-related hyphal structures in plant pathogenic fungiW R Rittenour
Department of Plant Pathology and Center for Plant Science Innovation, University of Nebraska, Lincoln, NE, USA
Methods Mol Biol 835:377-83. 2012..This method could be adapted for different necrotrophic or hemi-biotrophic pathogens, on their host tissue types, in order to characterize their hyphal differentiation in vitro... - Molecular evolution of urea amidolyase and urea carboxylase in fungiPooja K Strope
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
BMC Evol Biol 11:80. 2011..In order to elucidate the evolutionary origin of urea amidolyase and urea carboxylase, we studied the distribution of urea amidolyase, urea carboxylase, as well as other proteins including urease, across kingdoms... - Branching of fungal hyphae: regulation, mechanisms and comparison with other branching systemsSteven D Harris
Department of Plant Pathology and Center for Plant Science Innovation, University of Nebraska, Lincoln, Nebraska 68588, USA
Mycologia 100:823-32. 2008..e., the Spitzenkorper, septins) are discussed. Finally, other forms of branching in the plant and animal kingdoms are briefly summarized and compared to hyphal branching... - Regulation of septum formation by the Bud3-Rho4 GTPase module in Aspergillus nidulansHaoyu Si
Department of Plant Pathology and Center for Plant Science Innovation, University of Nebraska, Lincoln, NE 68588 0660, USA
Genetics 185:165-76. 2010..Our observations provide new insight into the signaling pathways that regulate septum formation in filamentous fungi... - The Spitzenkörper: a molecular perspectiveAleksandra Virag
Plant Science Initiative, University of Nebraska Lincoln, 1901 Vine Street, Lincoln, NE 68588 0660, USA
Mycol Res 110:4-13. 2006..Morphogenesis of such highly polarized cells is complex, and requires the coordinated action of multiple protein complexes. We discuss the relevance of these complexes for the structure and function of the Spitzenkörper... - Functional characterization of Aspergillus nidulans homologues of Saccharomyces cerevisiae Spa2 and Bud6Aleksandra Virag
Plant Science Initiative, and Department of Plant Pathology, University of Nebraska, Lincoln, NE 68588 0660, USA
Eukaryot Cell 5:881-95. 2006..We propose that the core function of the polarisome in polarized growth is maintained but with different contributions of polarisome components to the process... - SepBCTF4 is required for the formation of DNA-damage-induced UvsCRAD51 foci in Aspergillus nidulansScott E Gygax
Department of Microbiology, University of Connecticut Health Center, Farmington, 06030 3205, USA
Genetics 169:1391-402. 2005..We also provide evidence that implicates SepB in sister-chromatid cohesion, thereby suggesting that cohesion may play a role in regulating the localization and/or assembly of UvsC(RAD51) complexes... - Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpACamile P Semighini
Plant Science Initiative and Department of Plant Pathology, University of Nebraska, Lincoln 68588 0660, USA
Genetics 173:87-98. 2006..Collectively, our results provide a gateway for probing the diverse functions of PARP in a sophisticated microbial genetic system... - Distinct ceramide synthases regulate polarized growth in the filamentous fungus Aspergillus nidulansShaojie Li
Department of Plant Pathology, University of Nebraska, Lincoln, NE 68588-0660, USA
Mol Biol Cell 17:1218-27. 2006.... - An in vitro method for the analysis of infection-related morphogenesis in Fusarium graminearumWilliam R Rittenour
Department of Plant Pathology and Center for Plant Science Innovation, University of Nebraska, E126 Beadle Center, Lincoln, NE 68588 0660, USA
Mol Plant Pathol 11:361-9. 2010..This relatively simple assay will contribute to the tractability of the F. graminearum system and help to uncover molecular requirements for infection-related development... - Methods to detect apoptotic-like cell death in filamentous fungiCamile P Semighini
Department of Plant Pathology and Center for Plant Science Innovation, University of Nebraska, Lincoln, NE, USA
Methods Mol Biol 638:269-79. 2010..We also present approaches for monitoring nuclear condensation and production of ROS... - Regulation of apical dominance in Aspergillus nidulans hyphae by reactive oxygen speciesCamile P Semighini
Plant Science Initiative and Department of Plant Pathology, University of Nebraska, Lincoln, Nebraska 68588 0660, USA
Genetics 179:1919-32. 2008..Collectively, our results support a model whereby localized Nox activity generates a pool of ROS that defines a dominant polarity axis at hyphal tips... - An antibiotic complex from Lysobacter enzymogenes strain C3: antimicrobial activity and role in plant disease controlS Li
Department of Plant Pathology, University of Nebraska, Lincoln 68583, USA
Phytopathology 98:695-701. 2008..Thus, HSAF appears to be a mechanism for biological control by strain C3 against some, but not all, plant pathogenic fungi... - Inhibition of Fusarium graminearum growth and development by farnesolCamile P Semighini
Plant Science Initiative and Department of Plant Pathology, University of Nebraska Lincoln, Lincoln, NE 68588, USA
FEMS Microbiol Lett 279:259-64. 2008..Given the economic importance of F. graminearum as a pathogen of small grains, this study proposes that farnesol may have potential value as an antifungal compound... - Farnesol-induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungiCamile P Semighini
Plant Science Initiative, University of Nebraska Lincoln, Lincoln, NE, USA
Mol Microbiol 59:753-64. 2006..albicans. Taken together, our data suggest that farnesol, in addition to its quorum-sensing function that regulates morphogenesis, is also employed by C. albicans to reduce competition from other microbes... - Structure and biosynthesis of heat-stable antifungal factor (HSAF), a broad-spectrum antimycotic with a novel mode of actionFengan Yu
Department of Chemistry, University of Nebraska Lincoln, 729 Hamilton Hall, Lincoln, NE 68588 0304, USA
Antimicrob Agents Chemother 51:64-72. 2007..The elucidation of the chemical structure of HSAF and the identification of the genetic locus for its biosynthesis establish the foundation for future exploitation of this group of compounds as new fungicides or antifungal drugs... - Evolutionary aspects of urea utilization by fungiDhammika H M L P Navarathna
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588 0666, USA
FEMS Yeast Res 10:209-13. 2010..Also, the absence of MccA in the hemiascomycetes coincides with and may explain their production of fusel alcohols... - Functional characterization and localization of the Aspergillus nidulans formin SEPAKathryn E Sharpless
Department of Microbiology, University of Connecticut Health Center, Farmington, Connecticut 06030 3205, USA
Mol Biol Cell 13:469-79. 2002..We propose that specific morphological cues activate common molecular pathways to direct SEPA localization to the appropriate morphogenetic site... - Characterization of the Aspergillus nidulans 14-3-3 homologue, ArtAPeter R Kraus
Department of Microbiology, University of Connecticut Health Center, Farmington 06030 3205, USA
FEMS Microbiol Lett 210:61-6. 2002..However, instead of blocking septation, over-expression of artA causes a severe delay in the polarization of conidiospores. This observation suggests that these proteins play an important role in hyphal morphogenesis... - Identification of a topoisomerase I mutant, scsA1, as an extragenic suppressor of a mutation in scaA(NBS1), the apparent homolog of human nibrin in Aspergillus nidulansMarcia R Z Kress Fagundes
, , , Brazil
Genetics 164:935-45. 2003..The scsA(TOP1) and the scaA(NBS1) gene products could functionally interact in pathways that either monitor or repair DNA double-strand breaks... - Regulation of hyphal morphogenesis and the DNA damage response by the Aspergillus nidulans ATM homolog AtmAIran Malavazi
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
Genetics 173:99-109. 2006..Our results suggest that AtmA regulates the function and/or localization of landmark proteins required for the formation of a polarity axis. We propose that a similar function may contribute to the establishment of neuronal polarity... - MesA, a novel fungal protein required for the stabilization of polarity axes in Aspergillus nidulansClaire L Pearson
Department of Microbiology, University of Connecticut Health Center, Farmington, Connecticut 06030-3205, USA
Mol Biol Cell 15:3658-72. 2004..We also provide evidence that MesA may regulate the formation or distribution of sterol-rich membrane domains. Our results suggest that these domains may be part of novel mechanism that directs SepA to hyphal tips... - Transcriptome analysis of Aspergillus nidulans exposed to camptothecin-induced DNA damageIran Malavazi
, , , , CEP 14040-903, , , Brazil
Eukaryot Cell 5:1688-704. 2006..Our results provide the first insight into the overall complexity of the response to DNA damage in filamentous fungi and suggest that multiple pathways may act in parallel to mediate DNA repair... - Aspergillus nidulans uvsBATR and scaANBS1 genes show genetic interactions during recovery from replication stress and DNA damageMarcia Regina von Zeska Kress Fagundes
, , , , CEP 14040-903, , , Brazil
Eukaryot Cell 4:1239-52. 2005..Our results highlight the extensive genetic interactions between UvsB and the Mre11 complex that are required for S-phase progression and recovery from DNA damage... - Functional characterization of the Aspergillus fumigatus calcineurinMárcia Eliana da Silva Ferreira
Faculdade de Ciências Farmacêuticas de Ribeirão, Universidade de Sao Paulo, Brazil
Fungal Genet Biol 44:219-30. 2007..These results suggest that calcineurin is involved in the regulation of the PHO pathway in A. fumigatus. Our work on calcineurin opens new venues for the research on sensing and nutrient acquisition in A. fumigatus... - The DNA damage response in filamentous fungiGustavo H Goldman
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
Fungal Genet Biol 35:183-95. 2002..Further characterization of this response will likely yield general insights that are applicable to animals and plants. Moreover, it may also become evident that the DNA damage response can be manipulated to control fungal growth...