R Adron Harris
Affiliation: University of Texas
Robinson G, Most D, Ferguson L, Mayfield J, Harris R, Blednov Y. Neuroimmune pathways in alcohol consumption: evidence from behavioral and genetic studies in rodents and humans. Int Rev Neurobiol. 2014;118:13-39 pubmed publisher
..Ultimately, the use of multiple datasets combined with behavioral validation will be needed to link specific neuroimmune pathways to addiction vulnerability. ..
Most D, Ferguson L, Harris R. Molecular basis of alcoholism. Handb Clin Neurol. 2014;125:89-111 pubmed publisher
..This chapter will describe the molecular adaptations caused by alcohol use and dependence, and will outline key neurochemical participants in alcoholism at the molecular level, which are also potential targets for therapy. ..
Blednov Y, Benavidez J, Black M, Leiter C, Osterndorff Kahanek E, Harris R. Glycine receptors containing Î±2 or Î±3 subunits regulate specific ethanol-mediated behaviors. J Pharmacol Exp Ther. 2015;353:181-91 pubmed publisher
..We provide evidence that GlyRÎ±2 and Î±3 subunits may regulate ethanol consumption and the aversive response to ethanol. ..
Blednov Y, Benavidez J, Black M, Mayfield J, Harris R. Role of interleukin-1 receptor signaling in the behavioral effects of ethanol and benzodiazepines. Neuropharmacology. 2015;95:309-20 pubmed publisher
Farris S, Pietrzykowski A, Miles M, O Brien M, Sanna P, Zakhari S, et al
. Applying the new genomics to alcohol dependence. Alcohol. 2015;49:825-36 pubmed publisher
..The combined use of diverse data types demonstrates how unique approaches and applications can help categorize genetic complexities into relevant biological networks using a systems-level model of disease. ..
Mayfield J, Arends M, Harris R, Blednov Y. Genes and Alcohol Consumption: Studies with Mutant Mice. Int Rev Neurobiol. 2016;126:293-355 pubmed publisher
..Overall, the effects of genetic manipulations on alcohol drinking often depend on the sex of the mice, alcohol concentration and time of access, genetic background, as well as the drinking test. ..
Harris R, Bajo M, Bell R, Blednov Y, Varodayan F, Truitt J, et al
. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. J Neurosci. 2017;37:1139-1155 pubmed publisher
..Current research efforts are directed at determining which neuroimmune pathways mediate excessive alcohol drinking and these findings will help to prioritize relevant pathways and potential therapeutic targets. ..
Blednov Y, Borghese C, Ruiz C, Cullins M, Da Costa A, Osterndorff Kahanek E, et al
. Mutation of the inhibitory ethanol site in GABAA Ï1 receptors promotes tolerance to ethanol-induced motor incoordination. Neuropharmacology. 2017;123:201-209 pubmed publisher
..We note that low sensitivity to alcohol intoxication has been linked to risk for development of alcohol dependence in humans. ..