Craig Harris

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Animal models in epigenetic research: institutional animal care and use committee considerations across the lifespan
    Craig Harris
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109 2029, USA
    ILAR J 53:370-6. 2012
  2. pmc Inhibition of glutathione biosynthesis alters compartmental redox status and the thiol proteome in organogenesis-stage rat conceptuses
    Craig Harris
    Developmental Toxicology Laboratory, Department of Environmental Health Sciences, 1420 Washington Heights, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Free Radic Biol Med 63:325-37. 2013
  3. doi request reprint Oxidative stress, thiols, and redox profiles
    Craig Harris
    Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA
    Methods Mol Biol 889:325-46. 2012
  4. doi request reprint Rodent whole embryo culture
    Craig Harris
    Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA
    Methods Mol Biol 889:215-37. 2012
  5. doi request reprint Developmental toxicology: methods and protocols. Volume overview: introduction
    Craig Harris
    Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA
    Methods Mol Biol 889:1-5. 2012
  6. doi request reprint Overview of in vitro models in developmental toxicology
    Craig Harris
    Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA
    Methods Mol Biol 889:105-13. 2012
  7. ncbi request reprint Glutathione depletion modulates methanol, formaldehyde and formate toxicity in cultured rat conceptuses
    C Harris
    Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Cell Biol Toxicol 20:133-45. 2004
  8. ncbi request reprint Methanol metabolism and embryotoxicity in rat and mouse conceptuses: comparisons of alcohol dehydrogenase (ADH1), formaldehyde dehydrogenase (ADH3), and catalase
    Craig Harris
    Toxicology Program, Department of Environmental Health Sciences, School of Public Health, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109 2029, USA
    Reprod Toxicol 17:349-57. 2003
  9. ncbi request reprint Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cells
    Rita Loch Caruso
    Toxicology Program, Department of Environmental Health, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109 2029, USA
    Toxicol Sci 86:417-26. 2005
  10. ncbi request reprint Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide
    Jason M Hansen
    Toxicology Program, Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    Dev Dyn 225:186-94. 2002

Research Grants

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Animal models in epigenetic research: institutional animal care and use committee considerations across the lifespan
    Craig Harris
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109 2029, USA
    ILAR J 53:370-6. 2012
    ....
  2. pmc Inhibition of glutathione biosynthesis alters compartmental redox status and the thiol proteome in organogenesis-stage rat conceptuses
    Craig Harris
    Developmental Toxicology Laboratory, Department of Environmental Health Sciences, 1420 Washington Heights, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Free Radic Biol Med 63:325-37. 2013
    ....
  3. doi request reprint Oxidative stress, thiols, and redox profiles
    Craig Harris
    Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA
    Methods Mol Biol 889:325-46. 2012
    ..Methods are presented for a determination of ROS production, soluble thiol oxidation, redox potential, and a proteomic approach to evaluate the thiol oxidation state of specific proteins...
  4. doi request reprint Rodent whole embryo culture
    Craig Harris
    Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA
    Methods Mol Biol 889:215-37. 2012
    ..Culture conditions and mechanical apparatus can be modified to suit a large number of different experimental approaches and paradigms...
  5. doi request reprint Developmental toxicology: methods and protocols. Volume overview: introduction
    Craig Harris
    Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA
    Methods Mol Biol 889:1-5. 2012
    ..New methods created and adapted for studies in developmental toxicology have taken on greater importance as gestational lesions can now be shown to have developmental and health consequences across the entire lifespan...
  6. doi request reprint Overview of in vitro models in developmental toxicology
    Craig Harris
    Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA
    Methods Mol Biol 889:105-13. 2012
    ..Different experimental approaches are used for the various stages of development and cover the spectrum from preimplantation, periimplantation, and on to postimplantation periods of development...
  7. ncbi request reprint Glutathione depletion modulates methanol, formaldehyde and formate toxicity in cultured rat conceptuses
    C Harris
    Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Cell Biol Toxicol 20:133-45. 2004
    ..HCOONa was selectively embryolethal and did not produce dysmorphogenesis. CH2O toxicity is potentiated by GSH depletion, indicating that GSH may be more directly involved in its detoxication in the embryo...
  8. ncbi request reprint Methanol metabolism and embryotoxicity in rat and mouse conceptuses: comparisons of alcohol dehydrogenase (ADH1), formaldehyde dehydrogenase (ADH3), and catalase
    Craig Harris
    Toxicology Program, Department of Environmental Health Sciences, School of Public Health, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109 2029, USA
    Reprod Toxicol 17:349-57. 2003
    ..These results show a more slowly maturing capacity of the mouse embryo to remove HCHO, which provides a rationale for increased sensitivity of this species to CH(3)OH-induced embryotoxicity and teratogenicity...
  9. ncbi request reprint Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cells
    Rita Loch Caruso
    Toxicology Program, Department of Environmental Health, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109 2029, USA
    Toxicol Sci 86:417-26. 2005
    ....
  10. ncbi request reprint Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide
    Jason M Hansen
    Toxicology Program, Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    Dev Dyn 225:186-94. 2002
    ..These findings show that NF-kappaB binding is diminished due to selective thalidomide-induced redox changes in the rabbit, resulting in the significant attenuation of expression of genes necessary for limb outgrowth...
  11. ncbi request reprint Thalidomide modulates nuclear redox status and preferentially depletes glutathione in rabbit limb versus rat limb
    Jason M Hansen
    University of Michigan, Department of Environmental Health Sciences Toxicology Program, Ann Arbor, Michigan, USA
    J Pharmacol Exp Ther 300:768-76. 2002
    ..Redox shifts in the nucleus may result in the misregulation of transcription factor/DNA interactions and cause defective growth and development...
  12. ncbi request reprint Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions
    Rita Loch-Caruso
    Toxicology Program, Department of Environmental Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Toxicol Sci 85:694-702. 2005
    ..These results suggest that GSH is required in the acute phase but protects against the secondary phase of lindane-induced inhibition of myometrial gap junctions...
  13. doi request reprint Inhibition of proteolysis in histiotrophic nutrition pathways alters DNA methylation and one-carbon metabolism in the organogenesis-stage rat conceptus
    Karilyn E Sant
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Nutr Biochem 24:1479-87. 2013
    ..Because epigenetic reprogramming is crucial for normal differentiation and growth, these findings suggest a possible mechanism through which nutrients and environmental factors may alter early developmental regulation. ..
  14. pmc Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro
    Lauren M Tetz
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Toxicol Appl Pharmacol 268:47-54. 2013
    ..The findings from the current study warrant future mechanistic studies of oxidative stress, apoptosis, and prostaglandins as molecular mediators of DEHP/MEHP-associated adverse pregnancy outcomes...
  15. doi request reprint Nrf2-mediated resistance to oxidant-induced redox disruption in embryos
    Craig Harris
    Developmental Toxicology Laboratory, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA
    Birth Defects Res B Dev Reprod Toxicol 95:213-8. 2012
    ..These data show that Nrf2 activation may serve as a means to protect the embryo from chemically induced oxidative stress through the preservation of intracellular redox states during development, allowing normal morphogenesis to ensue...
  16. ncbi request reprint Altered differentiation in rat and rabbit limb bud micromass cultures by glutathione modulating agents
    J M Hansen
    Toxicology Program, Department of Environmental and Industrial Health, University of Michigan, Ann Arbor, MI, USA
    Free Radic Biol Med 31:1582-92. 2001
    ..These results show species differences in GSH depletion in rat vs. rabbit limb bud cells and implicate GSH and cysteine in affecting pathways involved in chondrocyte differentiation...
  17. ncbi request reprint Differential antioxidant enzyme activities and glutathione content between rat and rabbit conceptuses
    J M Hansen
    Department of Environmental Health Sciences, Toxicology Program, University of Michigan, Ann Arbor, MI, USA
    Free Radic Biol Med 30:1078-88. 2001
    ..These may contribute to a more complete rationale for choosing a species for study and provide a better correlation with human developmental toxicants...
  18. ncbi request reprint Spatial glutathione and cysteine distribution and chemical modulation in the early organogenesis-stage rat conceptus in utero
    M J Beck
    Toxicology Program, Department of Environmental Health Sciences, The University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Toxicol Sci 62:92-102. 2001
    ..The mobilization of cysteine following chemical insult may influence the ability of conceptal cells to maintain normal GSH status due to reduced availability of cysteine for de novo GSH synthesis...
  19. ncbi request reprint Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: a potential role of the visceral yolk sac in embryotoxicity
    Jason M Hansen
    Department of Biochemistry, School of Medicine, Emory University, Atlanta, Georgia, USA
    Birth Defects Res A Clin Mol Teratol 73:72-82. 2005
    ..Methanol (CH3OH) is believed to be teratogenic based on rodent studies. The mouse is more sensitive than the rat, but mechanisms of toxicity and identification of teratogenic metabolites are uncertain...
  20. ncbi request reprint A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway
    Jason M Hansen
    Antioxid Redox Signal 6:1-14. 2004
    ..We hypothesize that species-selective alterations in redox microenvironment caused by free radical production from thalidomide results in attenuation of the NF-kappaB-mediated gene expression that is responsible for limb outgrowth...
  21. pmc A reducing redox environment promotes C2C12 myogenesis: implications for regeneration in aged muscle
    Jason M Hansen
    Department of Anesthesiology, School of Medicine, Emory University, 1462 Clifton Road NE, Suite 420, Atlanta, GA 30322, USA
    Cell Biol Int 31:546-53. 2007
    ..Thus, oxidative intracellular environments impair myoblast differentiation, while reducing environments favor myogenesis...
  22. ncbi request reprint Spatial activities and induction of glutamate-cysteine ligase (GCL) in the postimplantation rat embryo and visceral yolk sac
    Jason M Hansen
    Department of Biochemistry, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 81:371-8. 2004
    ..Following treatments, a marked increase was induced in embryonic GCL(C) content with both DEM (85%) and diamide (19%), but in the VYS, only DEM caused an increase in GCL(C) protein (38%)...
  23. ncbi request reprint Role of glutathione redox dysfunction in diabetic wounds
    Bradley P Mudge
    Section of Plastic Surgery, University of Michigan Medical Center, Michigan 48109 0340, USA
    Wound Repair Regen 10:52-8. 2002
    ..7%) than in the nondiabetic mouse (9.9%) (p=0.05). These data suggest that cellular redox dysfunction and lower glutathione levels are present in diabetic foot ulcers and diabetic mouse wounds...

Research Grants1