Marni E Harris-White

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition
    M E Harris-White
    University of California, Los Angeles, Department of Medicine, and the Veterans Administration Greater Los Angeles Healthcare System, Sepulveda 91343, USA
    Curr Drug Targets CNS Neurol Disord 4:469-80. 2005
  2. pmc Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease
    S Prasad Gabbita
    P2D Bioscience, Cincinnati, OH 45242, USA
    J Neuroinflammation 9:99. 2012
  3. ncbi request reprint Role of LRP in TGFbeta2-mediated neuronal uptake of Abeta and effects on memory
    Marni E Harris-White
    Department of Medicine, University of California, Los Angeles, California 91343, USA
    J Neurosci Res 77:217-28. 2004
  4. pmc Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models
    Qiu Lan Ma
    Department of Medicine, University of California, Los Angeles, California, USA
    J Neurochem 103:1594-607. 2007
  5. ncbi request reprint Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease
    Lixia Zhao
    Greater Los Angeles Veterans Affairs Healthcare System, Sepulveda, California 91343, USA
    Nat Neurosci 9:234-42. 2006
  6. pmc TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity
    Pirooz Eslami
    Department of Medicine, University of California, Los Angeles, CA, USA
    Brain Res 1241:176-87. 2008
  7. ncbi request reprint Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro
    Qiu Lan Ma
    Department of Medicine, University of California, Los Angeles, California 91343, USA
    J Neurosci Res 83:374-84. 2006
  8. ncbi request reprint Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions
    Greg M Cole
    Greater Los Angeles Veterans Affairs Healthcare System, Geriatric Research, Education and Clinical Center, Sepulveda, CA 91343, USA
    Neurobiol Aging 26:133-6. 2005
  9. pmc beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits
    Tarja Malm
    A I Virtanen Institute and Department of Chemistry, University of Kuopio, Kuopio, Finland
    Proc Natl Acad Sci U S A 103:8852-7. 2006

Research Grants

  1. Carrier Mediated Uptake of ABeta In Vivo & In Vitro
    MARNI HARRIS WHITE; Fiscal Year: 2007

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition
    M E Harris-White
    University of California, Los Angeles, Department of Medicine, and the Veterans Administration Greater Los Angeles Healthcare System, Sepulveda 91343, USA
    Curr Drug Targets CNS Neurol Disord 4:469-80. 2005
    ..The evidence supports a complex and significant role of LRP in cognition and AD...
  2. pmc Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease
    S Prasad Gabbita
    P2D Bioscience, Cincinnati, OH 45242, USA
    J Neuroinflammation 9:99. 2012
    ..Current Alzheimer's disease interventions are symptomatic treatments with limited efficacy that do not address etiology. Thus, a critical need exists for novel treatments directed towards modifying the pathophysiology and progression...
  3. ncbi request reprint Role of LRP in TGFbeta2-mediated neuronal uptake of Abeta and effects on memory
    Marni E Harris-White
    Department of Medicine, University of California, Los Angeles, California 91343, USA
    J Neurosci Res 77:217-28. 2004
    ..Using both in vitro and in vivo methods, we identify LRP as playing a role in TGFbeta2-mediated Abeta uptake, neurodegeneration, and spatial memory impairment...
  4. pmc Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models
    Qiu Lan Ma
    Department of Medicine, University of California, Los Angeles, California, USA
    J Neurochem 103:1594-607. 2007
    ..These effects were reversed by anti-oligomer. Our data strongly support the existence of an APPsw transgene-dependent and Abeta oligomer-mediated defect in regulation of ERK activation...
  5. ncbi request reprint Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease
    Lixia Zhao
    Greater Los Angeles Veterans Affairs Healthcare System, Sepulveda, California 91343, USA
    Nat Neurosci 9:234-42. 2006
    ....
  6. pmc TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity
    Pirooz Eslami
    Department of Medicine, University of California, Los Angeles, CA, USA
    Brain Res 1241:176-87. 2008
    ..Our data support a key role for low-density lipoprotein receptor-related protein/transforming growth factor beta receptor V in mediating transforming growth factor beta2 enhancement of amyloid beta peptide uptake and neurotoxicity...
  7. ncbi request reprint Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro
    Qiu Lan Ma
    Department of Medicine, University of California, Los Angeles, California 91343, USA
    J Neurosci Res 83:374-84. 2006
    ..These data suggest that antibodies that are highly specific for toxic oligomer subspecies may reduce toxicity via reduction of GSK-3beta, which could be an important strategy for Alzheimer's disease (AD) therapeutics...
  8. ncbi request reprint Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions
    Greg M Cole
    Greater Los Angeles Veterans Affairs Healthcare System, Geriatric Research, Education and Clinical Center, Sepulveda, CA 91343, USA
    Neurobiol Aging 26:133-6. 2005
    ..Both DHA and curcumin have favorable safety profiles, epidemiology and efficacy, and may exert general anti-aging benefits (anti-cancer and cardioprotective.)...
  9. pmc beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits
    Tarja Malm
    A I Virtanen Institute and Department of Chemistry, University of Kuopio, Kuopio, Finland
    Proc Natl Acad Sci U S A 103:8852-7. 2006
    ....

Research Grants5

  1. Carrier Mediated Uptake of ABeta In Vivo & In Vitro
    MARNI HARRIS WHITE; Fiscal Year: 2007
    ..Understanding this mechanism may help to resolve the paradox that "Abeta plaque deposition is not sufficient to cause Alzheimer's" and could lead to new and better targets of intervention in Alzheimer's disease. ..