J M Harper

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistant
    Maggie Vergara
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 0940, USA
    J Gerontol A Biol Sci Med Sci 59:1244-50. 2004
  2. pmc Fibroblasts from long-lived bird species are resistant to multiple forms of stress
    James M Harper
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Exp Biol 214:1902-10. 2011
  3. ncbi request reprint Effect of capture and season on fecal glucocorticoid levels in deer mice (Peromyscus maniculatus) and red-backed voles (Clethrionomys gapperi)
    J M Harper
    Department of Biological Sciences, University of Idaho, Moscow, Idaho 83844, USA
    Gen Comp Endocrinol 123:337-44. 2001
  4. pmc Macrophage migration inhibitory factor-knockout mice are long lived and respond to caloric restriction
    James M Harper
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, Michigan, USA
    FASEB J 24:2436-42. 2010
  5. pmc Wild-derived mouse stocks: an underappreciated tool for aging research
    James M Harper
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA
    Age (Dordr) 30:135-45. 2008
  6. pmc Stress resistance and aging: influence of genes and nutrition
    James M Harper
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, MI, United States
    Mech Ageing Dev 127:687-94. 2006
  7. pmc Hyperglycemia, impaired glucose tolerance and elevated glycated hemoglobin levels in a long-lived mouse stock
    James M Harper
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 0940, USA
    Exp Gerontol 40:303-14. 2005
  8. pmc Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice
    James M Harper
    University of Michigan, 190 Zina Pitcher Pl, Room 3005, BSRB Box 2200, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 61:1019-29. 2006
  9. ncbi request reprint Hormone levels and cataract scores as sex-specific, mid-life predictors of longevity in genetically heterogeneous mice
    James M Harper
    Department of Pathology, School of Medicine, University of Michigan, Ann Arbor, MI, USA
    Mech Ageing Dev 124:801-10. 2003
  10. ncbi request reprint Body weight, hormones and T cell subsets as predictors of life span in genetically heterogeneous mice
    James M Harper
    Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Mech Ageing Dev 125:381-90. 2004

Collaborators

Detail Information

Publications24

  1. pmc Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistant
    Maggie Vergara
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 0940, USA
    J Gerontol A Biol Sci Med Sci 59:1244-50. 2004
    ....
  2. pmc Fibroblasts from long-lived bird species are resistant to multiple forms of stress
    James M Harper
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Exp Biol 214:1902-10. 2011
    ....
  3. ncbi request reprint Effect of capture and season on fecal glucocorticoid levels in deer mice (Peromyscus maniculatus) and red-backed voles (Clethrionomys gapperi)
    J M Harper
    Department of Biological Sciences, University of Idaho, Moscow, Idaho 83844, USA
    Gen Comp Endocrinol 123:337-44. 2001
    ..In addition, a clear temporal pattern in the secretion of fecal GCs was observed between mid June and early November in both species...
  4. pmc Macrophage migration inhibitory factor-knockout mice are long lived and respond to caloric restriction
    James M Harper
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, Michigan, USA
    FASEB J 24:2436-42. 2010
    ..Overall, these data refute the suggestion that MIF is required for the CR effect on life span, but raise the possibility that MIF may limit life span in normal mice...
  5. pmc Wild-derived mouse stocks: an underappreciated tool for aging research
    James M Harper
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA
    Age (Dordr) 30:135-45. 2008
    ....
  6. pmc Stress resistance and aging: influence of genes and nutrition
    James M Harper
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, MI, United States
    Mech Ageing Dev 127:687-94. 2006
    ..These data thus suggest that while resistance to stress is a common characteristic of experimental life span extension in mice, the cell types showing resistance may differ among the various models of delayed or decelerated aging...
  7. pmc Hyperglycemia, impaired glucose tolerance and elevated glycated hemoglobin levels in a long-lived mouse stock
    James M Harper
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 0940, USA
    Exp Gerontol 40:303-14. 2005
    ..Taken together, these findings suggest that neither a reduction of blood glucose levels nor an increase in glucose tolerance is necessary for life span extension in mice...
  8. pmc Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice
    James M Harper
    University of Michigan, 190 Zina Pitcher Pl, Room 3005, BSRB Box 2200, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 61:1019-29. 2006
    ..Overall, these finding suggest that wild-derived mice harbor alleles that increase longevity, perhaps through effects on growth, maturation, and early-life hormone levels...
  9. ncbi request reprint Hormone levels and cataract scores as sex-specific, mid-life predictors of longevity in genetically heterogeneous mice
    James M Harper
    Department of Pathology, School of Medicine, University of Michigan, Ann Arbor, MI, USA
    Mech Ageing Dev 124:801-10. 2003
    ..Additional work is needed to evaluate the role of these hormones as potential modulators of the aging process, and to resolve the conflicting data obtained for cataract severity as a predictor of life span...
  10. ncbi request reprint Body weight, hormones and T cell subsets as predictors of life span in genetically heterogeneous mice
    James M Harper
    Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Mech Ageing Dev 125:381-90. 2004
    ....
  11. pmc Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone
    James M Harper
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI, USA
    Aging Cell 6:1-13. 2007
    ....
  12. pmc Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age
    Liou Sun
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 64:711-22. 2009
    ..These results introduce new protocols that can increase maximal life span and suggest that the spectrum of metabolic changes induced by low-calorie and low-methionine diets may differ in instructive ways...
  13. ncbi request reprint Fecal glucocorticoids: a noninvasive method of measuring adrenal activity in wild and captive rodents
    J M Harper
    Department of Biological Sciences, University of Idaho, Moscow, Idaho 83844, USA
    Physiol Biochem Zool 73:12-22. 2000
    ..Therefore, given a judicious trapping and trap-monitoring protocol, this assay has considerable utility for measuring the stress levels at which animals actually exist in the field...
  14. pmc Three-locus and four-locus QTL interactions influence mouse insulin-like growth factor-I
    Philip Hanlon
    Department of Mathematics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA
    Physiol Genomics 26:46-54. 2006
    ..The analysis method can detect multilocus interactions in a genome scan experiment and may provide new ways to explore the genetic architecture of complex physiological phenotypes...
  15. ncbi request reprint Quantitative trait loci for insulin-like growth factor I, leptin, thyroxine, and corticosterone in genetically heterogeneous mice
    James M Harper
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, USA
    Physiol Genomics 15:44-51. 2003
    ..These results show that the genetic controls over late-life hormone levels are complex and dependent on effects of genes that act both early and late in the life course...
  16. ncbi request reprint Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
    Richard A Miller
    Department of Pathology, Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, MI 48109 0940, USA
    Aging Cell 4:119-25. 2005
    ..Studies of the cellular and molecular biology of methionine-deprived mice may, in parallel to studies of calorie-restricted mice, provide insights into the way in which nutritional factors modulate longevity and late-life illnesses...
  17. ncbi request reprint Longer life spans and delayed maturation in wild-derived mice
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Exp Biol Med (Maywood) 227:500-8. 2002
    ..Genes present in the Id and Ma stocks may be valuable tools for the analysis of the physiology and biochemistry of aging in mice...
  18. pmc How long will my mouse live? Machine learning approaches for prediction of mouse life span
    William R Swindell
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 63:895-906. 2008
    ..Future work in this direction can provide tools for aging research and will shed light on associations between phenotypic traits and longevity...
  19. ncbi request reprint Big mice die young: early life body weight predicts longevity in genetically heterogeneous mice
    Richard A Miller
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Aging Cell 1:22-9. 2002
    ..The evidence that weight in 2-month-old mice is a significant predictor of life span suggests that at least some of the lethal diseases of old age can be timed by factors that influence growth rate in juvenile rodents...
  20. pmc Does caloric restriction extend life in wild mice?
    James M Harper
    Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA
    Aging Cell 5:441-9. 2006
    ....
  21. ncbi request reprint T cells in aging mice: genetic, developmental, and biochemical analyses
    Richard A Miller
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, 48109, USA
    Immunol Rev 205:94-103. 2005
    ....
  22. ncbi request reprint Fecal corticosteroids in agouti and non-agouti deer mice (Peromyscus maniculatus)
    V Hayssen
    Department of Biological Sciences, Smith College, Northampton, MA 01063, USA
    Comp Biochem Physiol A Mol Integr Physiol 132:439-46. 2002
    ..Thus, agouti and non-agouti deer mice differ in their hormonal reaction to stress. This is the first demonstration of corticosteroid differences associated with the agouti locus...
  23. ncbi request reprint CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis
    Erin E McCandless
    Division of Infectious Diseases, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 177:8053-64. 2006
    ....
  24. pmc Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    Mech Ageing Dev 127:653-7. 2006
    ..It is suggested that peroxidation-resistant membranes may be an important component of extended longevity...