Research Topics
Genomes and GenesSpecies | A R HaririSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Functional neuroimaging of genetic variation in serotonergic neurotransmissionA R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
Genes Brain Behav 2:341-9. 2003....
Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain functionAhmad R Hariri
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 66:9-16. 2009..Fatty acid amide hydrolase (FAAH) is a key enzyme in regulating endocannabinoid (eCB) signaling. A common single nucleotide polymorphism (C385A) in the human FAAH gene has been associated with increased risk for addiction and obesity...- Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activityAhmad R Hariri
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 26:13213-7. 2006..They also highlight a specific neurocognitive mechanism that may contribute to increased risk for addiction... - Genetics of emotional regulation: the role of the serotonin transporter in neural functionAhmad R Hariri
Department of Psychiatry and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Trends Cogn Sci 10:182-91. 2006..The study of the 5-HTT provides a new foundation for understanding the neurobiological and genetic basis of emotional regulation and affective illness... - Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivityE E Forbes
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Mol Psychiatry 14:60-70. 2009..They further suggest that altered VS reactivity may represent a key neurobiological pathway through which these polymorphisms contribute to variability in behavioral impulsivity and related risk for substance use disorders... - Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmissionH P Jedema
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15261, USA
Mol Psychiatry 15:512-22, 446. 2010..Moreover, these data highlight the vast potential of NHP models in advancing our understanding of human genetic variation affecting behavior and neuropsychiatric disease liability... - Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personalityJ W Buckholtz
Neuroimaging Core Facility, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1365, USA
Mol Psychiatry 13:313-24. 2008.... - Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulationEmily M Drabant
Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
Arch Gen Psychiatry 63:1396-406. 2006.... 
Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depressionL Pezawas
Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Mol Psychiatry 13:709-16. 2008....- A susceptibility gene for affective disorders and the response of the human amygdalaAhmad R Hariri
Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
Arch Gen Psychiatry 62:146-52. 2005.... - Salivary testosterone and a trinucleotide (CAG) length polymorphism in the androgen receptor gene predict amygdala reactivity in menStephen B Manuck
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, United States
Psychoneuroendocrinology 35:94-104. 2010.... - Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic riskRoberta Rasetti
Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
Am J Psychiatry 166:216-25. 2009..The purpose of the present study was to examine amygdala response to threatening faces among healthy siblings of schizophrenia patients in whom a subtler heritable deficit might be observed... - A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivityS M Brown
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Mol Psychiatry 10:884-8, 805. 2005..Here, we provide the first in vivo evidence that a relatively frequent regulatory variant (G(-844)T) of hTPH2 biases the reactivity of the amygdala, a neural structure critical in the generation and regulation of emotional behaviors... - Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depressionJack R Cornelius
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
Addict Behav 35:644-6. 2010..70, df = 5, p < 0.05, two-tailed). These findings are consistent with the reports by Phan et al. (2008) and Hariri et al. (2009) suggesting that cannabinoids have an inhibitory effect on threat-related amygdala reactivity... - Neural basis of individual differences in impulsivity: contributions of corticolimbic circuits for behavioral arousal and controlSarah M Brown
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Emotion 6:239-45. 2006..Together, these findings suggest that dispositional impulsivity is influenced by the functional interplay of corticolimbic behavioral arousal and control circuits... - Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adultsSarah M Conklin
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15260, United States
Neurosci Lett 421:209-12. 2007..Here, we test whether omega-3 fatty acid intake in humans varies with individual differences in gray matter volume, an in vivo, systems-level index of neuronal integrity... - Abnormalities in neural processing of emotional stimuli in Williams syndrome vary according to social vs. non-social contentKaren E Munoz
Section on Integrative Neuroimaging, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
Neuroimage 50:340-6. 2010..These data provide further evidence of disruption in amygdala-prefrontal circuitry in individuals with WS... - Altered striatal activation predicting real-world positive affect in adolescent major depressive disorderErika E Forbes
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Loeffler 319, Pittsburgh, PA 15213, USA
Am J Psychiatry 166:64-73. 2009..The authors tested differences in reward-related brain function in healthy and depressed adolescents, and the authors examined direct links between reward-related brain function and positive mood that occurred in real-world contexts... - Individual differences in stressor-evoked blood pressure reactivity vary with activation, volume, and functional connectivity of the amygdalaPeter J Gianaros
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 28:990-9. 2008.... - Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdalaPeter J Gianaros
Department of Psychiatry and Psychology, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 65:943-50. 2009.... - Potential neural embedding of parental social standingPeter J Gianaros
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Soc Cogn Affect Neurosci 3:91-6. 2008..Thus, these findings may provide insight into the neurodevelopmental pathways impacting socioeconomic disparities in health... - Perigenual anterior cingulate morphology covaries with perceived social standingPeter J Gianaros
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Soc Cogn Affect Neurosci 2:161-73. 2007..The pACC may represent a neuroanatomical substrate by which perceived social standing relates to mental and physical health... - Dopamine modulates the response of the human amygdala: a study in Parkinson's diseaseAlessandro Tessitore
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1384, USA
J Neurosci 22:9099-103. 2002..Furthermore, consistent with findings in experimental animal paradigms, our results provide in vivo evidence of the role of dopamine in modulating the response of the amygdala to sensory information in human subjects... - The amygdala response to emotional stimuli: a comparison of faces and scenesAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Neuroimage 17:317-23. 2002..These results suggest that the human amygdala shows a stronger response to affective facial expressions than to scenes, a bias that should be considered in the design of experimental paradigms interested in probing amygdala function... - Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performanceAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
J Neurosci 23:6690-4. 2003..These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans... - Neocortical modulation of the amygdala response to fearful stimuliAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 53:494-501. 2003.... - Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processingAhmad R Hariri
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213-2593, USA
Biol Psychiatry 59:888-97. 2006.... - Functional changes in the activity of brain regions underlying emotion processing in the elderlyAlessandro Tessitore
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Room 3C108, Bethesda, MD 20892-1384, USA
Psychiatry Res 139:9-18. 2005.... - Neural correlates of genetically abnormal social cognition in Williams syndromeAndreas Meyer-Lindenberg
Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Nat Neurosci 8:991-3. 2005..Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior... - Facial expressions of emotion reveal neuroendocrine and cardiovascular stress responsesJennifer S Lerner
Department of Social and Decision Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Biol Psychiatry 61:253-60. 2007..Specifically, it hypothesized contrasting patterns for indignation (comprised of anger and disgust) versus fear. Moreover, it hypothesized that facial expressions of these emotions would signal corresponding biological stress responses... - Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivityP M Fisher
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Nat Neurosci 9:1362-3. 2006..Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity... - Dextroamphetamine modulates the response of the human amygdalaAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Neuropsychopharmacology 27:1036-40. 2002..Our results provide the first evidence of a specific neural substrate for the anxiogenic effects of amphetamine and are consistent with animal models of dopaminergic activation of the amygdala... - Acute 5-HT reuptake blockade potentiates human amygdala reactivityKristin L Bigos
Department of Pharmaceutical Sciences, University of Pittsburgh, PA, USA
Neuropsychopharmacology 33:3221-5. 2008.... - Genetic variation in human NPY expression affects stress response and emotionZhifeng Zhou
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Nature 452:997-1001. 2008..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases... - Serotonin transporter genetic variation and the response of the human amygdalaAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Science 297:400-3. 2002.... - Facial expressions of emotion reveal neuroendocrine and cardiovascular stress responsesJennifer S Lerner
Department of Social and Decision Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 58:743-50. 2005..The present study hypothesized a new conception that disaggregates stress into emotion-specific, contrasting patterns of biological response... - Medial prefrontal cortex 5-HT(2A) density is correlated with amygdala reactivity, response habituation, and functional couplingPatrick M Fisher
Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
Cereb Cortex 19:2499-507. 2009..Collectively, our results indicate that mPFC 5-HT(2A) is strongly associated with threat-related amygdala reactivity as well as its temporal habituation and functional coupling with prefrontal regulatory regions... - Neuroimaging studies of serotonin gene polymorphisms: exploring the interplay of genes, brain, and behaviorSarah M Brown
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Room E-729, Pittsburgh, PA 15213-2593, USA
Cogn Affect Behav Neurosci 6:44-52. 2006.... - Neurophysiological correlates of age-related changes in human motor functionV S Mattay
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1379, USA
Neurology 58:630-5. 2002..There are well-defined and characteristic age-related deficits in motor abilities that may reflect structural and chemical changes in the aging brain... - Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophreniaMichael F Egan
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:12604-9. 2004..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia... - 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depressionLukas Pezawas
Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
Nat Neurosci 8:828-34. 2005.... - Neurophysiological correlates of age-related changes in working memory capacityVenkata S Mattay
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Neurosci Lett 392:32-7. 2006..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs... - Neuroimaging and human geneticsGeorg Winterer
Genes, Cognition and Psychosis Program, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
Int Rev Neurobiol 67:325-83. 2005 - Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamineVenkata S Mattay
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4S-235, Bethesda, MD 20982-1379, USA
Proc Natl Acad Sci U S A 100:6186-91. 2003..Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine... - Interleukin-6 covaries inversely with hippocampal grey matter volume in middle-aged adultsAnna L Marsland
Behavioral Immunology Laboratory, University of Pittsburgh, PA 15260, USA
Biol Psychiatry 64:484-90. 2008..In the current study, we extend this work to test whether systemic inflammation is associated with reduced grey matter volume of the hippocampus... - Neuroimaging: technologies at the interface of genes, brain, and behaviorKristin L Bigos
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15213, USA
Neuroimaging Clin N Am 17:459-67, viii. 2007.... - Neural correlates of facial affect processing in children and adolescents with autism spectrum disorderA Ting Wang
Department of Psychology, UCLA, Los Angeles, CA, USA
J Am Acad Child Adolesc Psychiatry 43:481-90. 2004..High-functioning individuals with ASD may be relatively unimpaired in the cognitive assessment of basic emotions, yet still show differences in the automatic processing of facial expressions... - Neural bases of different cognitive strategies for facial affect processing in schizophreniaEric Fakra
CIC UPCET, Hopital de la Timone, UMR CNRS 6193 INCM, Marseille, France
Schizophr Res 100:191-205. 2008..To examine the neural basis and dynamics of facial affect processing in schizophrenic patients as compared to healthy controls... - SerotoninAhmad R Hariri
Am J Psychiatry 163:12. 2006 - Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysisMarcus R Munafo
Department of Experimental Psychology, University of Bristol, United Kingdom
Biol Psychiatry 63:852-7. 2008..We evaluated the magnitude of the reported associations between amygdala activation and the serotonin transporter gene linked polymorphic region (5-HTTLPR) and the likely effect size of this relationship... - Temporal stability of individual differences in amygdala reactivityStephen B Manuck
Am J Psychiatry 164:1613-4. 2007 - Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activationAndreas Heinz
Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Germany
Biol Psychiatry 61:1011-4. 2007..However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers... - Human choline transporter gene variation is associated with corticolimbic reactivity and autonomic-cholinergic functionSerina A Neumann
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Avenue, Norfolk, VA 23501
Biol Psychiatry 60:1155-62. 2006..Here, functional magnetic resonance imaging (fMRI) was used to examine the relation between a single nucleotide polymorphism (SNP) in CHT1 on regional brain reactivity relevant to autonomic (cholinergic) function... - Developmental imaging genetics: challenges and promises for translational researchEssi Viding
University College London
Dev Psychopathol 18:877-92. 2006..We attempt to set out guidelines and provide exemplars that may help in designing fruitful translational research applications that incorporate a developmental imaging genetics strategy... - Imaging genomicsAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Br Med Bull 65:259-70. 2003....
Research Grants
- Development of Amygdala-Prefrontal InteractionsAhmad Hariri; Fiscal Year: 2007..abstract_text> ..