Affiliation: University of California
Bosch J, Sumabat T, Hariharan I. Persistence of RNAi-Mediated Knockdown in Drosophila Complicates Mosaic Analysis Yet Enables Highly Sensitive Lineage Tracing. Genetics. 2016;203:109-18 pubmed publisher
..Using i-TRACE, we demonstrate transient infidelities in the expression of some cell-identity markers near compartment boundaries in the wing imaginal disc. ..
Hariharan I. How growth abnormalities delay "puberty" in Drosophila. Sci Signal. 2012;5:pe27 pubmed publisher
..Similar mechanisms might operate in disease states in humans where alterations in growth or tissue inflammation can delay puberty. ..
Bosch J, Sumabat T, Hafezi Y, Pellock B, Gandhi K, Hariharan I. The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling. elife. 2014;3:e03383 pubmed publisher
..Fbxl7 can also regulate the trafficking of proteins between the apical membrane and intracellular vesicles. Thus Fbxl7 functions in a subset of pathways downstream of Ft and links Ft to D localization. ..
Bosch J, Tran N, Hariharan I. CoinFLP: a system for efficient mosaic screening and for visualizing clonal boundaries in Drosophila. Development. 2015;142:597-606 pubmed publisher
..By combining CoinFLP-LexGAD/Gal4 with the split-GFP system GRASP, boundaries between genetically distinct cell populations can be visualized at high resolution. ..
Hariharan I. Organ Size Control: Lessons from Drosophila. Dev Cell. 2015;34:255-65 pubmed publisher
..Mechanical forces also appear to have an important role along with the Hippo pathway, which may integrate multiple types of inputs to regulate the extent of growth. ..
Hariharan I. Size regulation blossoms in Kobe. Development. 2016;143:2691-5 pubmed publisher
..On display was the power of using diverse approaches ranging from the study of organoids to whole organisms. ..
Hariharan I, Serras F. Imaginal disc regeneration takes flight. Curr Opin Cell Biol. 2017;48:10-16 pubmed publisher
Sumabat T, Hariharan I. Ras Brakes for Hippo. Dev Cell. 2017;42:561-562 pubmed publisher
..In this issue of Developmental Cell, Pascual and colleagues (2017) investigate the dire consequences of simultaneous deregulation of both the Ras and Hippo pathways. ..