Research Topics
| Joshua HareSummaryAffiliation: University of Miami Country: USA Publications
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Publications
Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trialJoshua M Hare
Interdisciplinary Stem Cell Institute, and Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
JAMA 308:2369-79. 2012..Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic cardiomyopathy (ICM). Both autologous and allogeneic MSC therapies are possible; however, their safety and efficacy have not been compared...
Cardiac regeneration and stem cell therapyJoshua M Hare
Cardiovascular Division, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
Curr Opin Organ Transplant 13:536-42. 2008..Significant recent developments have occurred in the field of cardiac regeneration and stem-cell therapy. Understanding the new technological advances in cell therapy will ultimate allow us to achieve a goal of cell-based cardiac repair...
Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac diseaseAdam R Williams
Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Circ Res 109:923-40. 2011..This article reviews the current understanding of MSC biology, mechanism of action in cardiac repair, translational findings, and early clinical trial data of MSC therapy for cardiac disease...- Advances in cell-based therapy for structural heart diseaseRamesh Mazhari
Department of Medicine, Division of Cardiology and Interdisciplinary Stem Cell Institute, Leonard M Miller School of Medicine, Miami, FL 33136, USA
Prog Cardiovasc Dis 49:387-95. 2007..Indeed these cells may be harnessed as a therapeutic agent or may represent the target of regenerative therapeutic strategies... - Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF studyJoshua M Hare
The University of Miami Miller School of Medicine, Miami, Florida v, USA
J Am Coll Cardiol 51:2301-9. 2008.... - A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarctionJoshua M Hare
Department of Medicine, Cardiovascular Division and the Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
J Am Coll Cardiol 54:2277-86. 2009..Our aim was to investigate the safety and efficacy of intravenous allogeneic human mesenchymal stem cells (hMSCs) in patients with myocardial infarction (MI)... - Safety of serial MRI in patients with implantable cardioverter defibrillatorsM Juhani Junttila
Division of Cardiology, Miller School of Medicine, University of Miami, Florida, USA
Heart 97:1852-6. 2011..To address this issue, the safety of serial cardiac MR scans was evaluated in patients with implantable cardioverter defibrillators (ICDs)... - [Stem cell therapy for myocardial regeneration: mechanisms and current clinical applications]Marco Centola
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
G Ital Cardiol (Rome) 9:234-50. 2008.... - Cardiac cell-based therapy: cell types and mechanisms of actionsGeraldo A Ramos
The Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Cell Transplant 16:951-61. 2007..Together the new insights obtained from studies of cell-based cardiac therapy have ushered in new biological paradigms and enormous potential for novel therapeutic strategies for cardiac disease... - Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiationKonstantinos E Hatzistergos
University of Miami Miller School of Medicine, Interdisciplinary Stem Cell Institute, Miami, FL 33136, USA
Circ Res 107:913-22. 2010..Bone marrow-derived mesenchymal stem cells (MSCs) have the capacity for cardiac repair that appears to exceed their capacity for differentiation into cardiac myocytes... - Mesenchymal stem cells: future source for reparative medicineRinky Bhatia
Department of Medicine, Division of Cardiology and Institute for Cell Engineering (ICE, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Congest Heart Fail 11:87-91; quiz 92-3. 2005.... - Multimodality noninvasive imaging demonstrates in vivo cardiac regeneration after mesenchymal stem cell therapyLuciano C Amado
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Am Coll Cardiol 48:2116-24. 2006.... - Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathyKhalid M Minhas
Cardiology Division, Department of Medicine, Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21212, USA
Circ Res 98:271-9. 2006.... - Cardiovascular genetic medicine: genomic assessment of prognosis and diagnosis in patients with cardiomyopathy and heart failureBettina Heidecker
Cardiology, Miller School of Medicine, University of Miami, PO Box 019132 C 205, Miami, FL 33101, USA
J Cardiovasc Transl Res 1:225-31. 2008..In this paper, we review the basic principles of gene expression and molecular signature analysis in the context of potential clinical applications of transcriptomics... - Mesenchymal stem cell labeling and in vitro MR characterization at 1.5 T of new SPIO contrast agent: Molday ION Rhodamine-B™Benjamin Addicott
Diabetes Research Institute, University of Miami School of Medicine, FL 33101, USA
Contrast Media Mol Imaging 6:7-18. 2011..Properties evaluated in this study will be used as a reference for tracking labeled MSC for in vivo studies... - Inflammation, stem cells and atherosclerosis geneticsPascal J Goldschmidt-Clermont
University of Miami Leonard M Miller School of Medicine, Department of Medicine, Rosenstiel Medical Science Building, 1600 NW 10th Avenue, Miami, FL 33136, USA
Curr Opin Mol Ther 12:712-23. 2010..Most of the genes identified by using non-biased genomic techniques are associated with inflammation, immune response and stem cells. This review focuses on new genetic data in the field of atherosclerosis and arterial homeostasis... - Is stem cell therapy ready for patients? Stem Cell Therapy for Cardiac Repair. Ready for the Next Step Andrew J Boyle
Department of Medicine, Division of Cardiology, Institute for Cell Engineering, and Specialized Center for Cell Based Therapy, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circulation 114:339-52. 2006 - Emerging role for bone marrow derived mesenchymal stem cells in myocardial regenerative therapyJeffrey M Zimmet
Department of Medicine, Cardiology Division and Institute for Cell Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
Basic Res Cardiol 100:471-81. 2005..Here we review the characterization of MSCs, animal and human trials studying MSCs in cardiomyogenesis and vasculogenesis in postinfarct myocardium, routes of delivery, and potential mechanisms of stem cell repair... - Early improvement in cardiac tissue perfusion due to mesenchymal stem cellsKarl H Schuleri
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Physiol Heart Circ Physiol 294:H2002-11. 2008..Cardiac MRI-based measures of blood flow may be a useful tool to predict a successful myocardial regenerative process after MSC treatment... - Stem-cell therapy for renal diseasesDaniel J Mollura
Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21205, USA
Am J Kidney Dis 42:891-905. 2003..This field offers great promise, and there are significant opportunities for future investigation in clinical, biological, and ethical aspects of stem-cell therapy for kidney diseases... - Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacityHenry C Quevedo
Interdisciplinary Stem Cell Institute and Department of Medicine, Cardiovascular Division, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Proc Natl Acad Sci U S A 106:14022-7. 2009..MSCs are an adult stem cell with the capacity for cardiomyogenesis and vasculogenesis which contribute, at least in part, to their ability to repair chronically scarred myocardium... - Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarctionLuciano C Amado
Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 102:11474-9. 2005.... - Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heartWalter F Saavedra
Department of Medicine, Cardiology Division and Institute of Molecular Cardiobiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Circ Res 90:297-304. 2002..These data show that both NOS and XO signaling systems participate in the regulation of myocardial mechanical efficiency and that upregulation of XO relative to NOS contributes to mechanoenergetic uncoupling in heart failure... - Aging impairs the beneficial effect of granulocyte colony-stimulating factor and stem cell factor on post-myocardial infarction remodelingStephanie Lehrke
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Circ Res 99:553-60. 2006.... - Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathyKarl H Schuleri
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Eur Heart J 30:2722-32. 2009..Here we tested the hypothesis that autologous MSCs can be safely injected into a chronic myocardial infarct scar, reduce its size, and improve ventricular function... - Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarctionRosemeire M Kanashiro-Takeuchi
Division of Cardiology, Department of Medicine, Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Proc Natl Acad Sci U S A 107:2604-9. 2010..The phenotypic profile of the response to a potent GHRH agonist has therapeutic implications... - Mesenchymal stem cell therapy for cardiac repairAndrew J Boyle
Cardiology Division, Department of Medicine, University of California, San Francisco, CA, USA
Methods Mol Biol 660:65-84. 2010..This review discusses the mechanism of action of MSC therapy and summarizes the current literature in the field... - Gene expression analysis of ischemic and nonischemic cardiomyopathy: shared and distinct genes in the development of heart failureMichelle M Kittleson
Division of Cardiology, Department of Medicine, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
Physiol Genomics 21:299-307. 2005.... - Noninvasive diagnosis of biopsy-proven cardiac amyloidosisJoseph E Rahman
Division of Cardiology, Department of Medicine, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224-2780, USA
J Am Coll Cardiol 43:410-5. 2004..CONCLUSIONS: In patients with suspected cardiac amyloidosis, a combination of noninvasive parameters-namely, a low voltage and increased intraventricular septal thickness-is a useful diagnostic tool... - Xanthine oxidase inhibition ameliorates cardiovascular dysfunction in dogs with pacing-induced heart failureLuciano C Amado
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Mol Cell Cardiol 39:531-6. 2005..These results demonstrate a unique and potent hemodynamic profile of XOI, thereby providing further rationale for developing XOIs as a novel HF therapy... - The benefit of upgrading chronically right ventricle-paced heart failure patients to resynchronization therapy demonstrated by strain rate imagingZayd A Eldadah
Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Heart Rhythm 3:435-42. 2006..RV pacing induces conduction delay (CD), mechanical dyssynchrony, and increased morbidity in patients with HF. CRT improves HF symptoms and survival, but sparse data exist on its direct effect on chronically RV-paced HF patients... - Uric acid as a predictor of all-cause mortality in heart failure: a meta-analysisLeonardo Tamariz
Division of General Internal Medicine, Department of Medicine, Miller School of Medicine, University of Miami, FL 33136, USA
Congest Heart Fail 17:25-30. 2011..There was a linear association (P<.01) between SUA and mortality after 7 mg/dL. Uric acid is an important prognostic marker for all-cause mortality in HF. SUA levels >7 mg/dL are associated with higher all-cause mortality... - S-Nitrosylation of cardiac ion channelsDaniel R Gonzalez
Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
J Cardiovasc Pharmacol 54:188-95. 2009..S-Nitrosylation signaling is disrupted in pathological states in which the redox state of the cell is dysregulated, including ischemia, heart failure, and atrial fibrillation... - Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in miceLili A Barouch
Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, 600 North Wolfe St, Baltimore, MD 21287, USA
Circulation 108:754-9. 2003..Because leptin has cardiovascular bioactivity, we hypothesized that disruption of leptin signaling mediates the development of obesity-associated LVH... - The change in B-type natriuretic peptide levels over time predicts significant rejection in cardiac transplant recipientsMichelle M Kittleson
Department of Medicine, Division of Cardiology, University of California at Los Angeles, Los Angeles, California, USA
J Heart Lung Transplant 28:704-9. 2009.... - Inhibition of the SDF-1/CXCR4 axis attenuates neonatal hypoxia-induced pulmonary hypertensionKaren C Young
Department of Pediatrics Division of Neonatology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Circ Res 104:1293-301. 2009..These data offer novel insights into the role of the SDF-1/CXCR4 axis in the pathogenesis of neonatal hypoxia-induced cardiopulmonary remodeling and have important therapeutic implications... - Identification of a gene expression profile that differentiates between ischemic and nonischemic cardiomyopathyMichelle M Kittleson
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circulation 110:3444-51. 2004..This strongly supports ongoing efforts to incorporate expression profiling-based biomarkers in determining prognosis and response to therapy in heart failure... - Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and nitroso-redox imbalance in ob/ob miceRoberto M Saraiva
Cardiology Division, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Nitric Oxide 16:331-8. 2007..These data offer novel insights into potential mechanisms of myocardial dysfunction in obesity... - Role of xanthine oxidoreductase in cardiac nitroso-redox imbalanceKonstantinos Tziomalos
Interdisciplinary Stem Cell Institute and Division of Cardiology, Leonard M Miller School of Medicine, University of Miami, Miami, FL, USA
Front Biosci 14:237-62. 2009..A growing understanding of XOR and its role in nitroso-redox imbalance has great potential to lead to improved pathophysiologic insights and possibly therapeutic advances... - Elevated uric acid levels predict allograft vasculopathy in cardiac transplant recipientsMichelle M Kittleson
Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Heart Lung Transplant 26:498-503. 2007..We hypothesized that hyperuricemia is associated with CAV in cardiac transplant recipients... - Nitric oxide and cardiobiology-methods for intact hearts and isolated myocytesJoshua M Hare
Division of Cardiology and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, USA
Methods Enzymol 441:369-92. 2008..In summary, this chapter reviews the biochemical methods that assess the impact of nitroso/redox signaling in the cardiovascular system... - Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scarAlbert C Lardo
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Circulation 113:394-404. 2006.... - Cardiac nitric oxide synthase-1 localization within the cardiomyocyte is accompanied by the adaptor protein, CAPONFarideh Beigi
Division of Cardiology and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, USA
Nitric Oxide 21:226-33. 2009..Together these findings support the hypothesis that NOS1 redistribution in injured myocardium requires the formation of a complex with the PDZ adaptor protein CAPON... - A positive endomyocardial biopsy result for sarcoid is associated with poor prognosis in patients with initially unexplained cardiomyopathyHossein Ardehali
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Am Heart J 150:459-63. 2005..In patients with cardiomyopathy, the diagnosis of sarcoidosis has important treatment implications. We studied the prognostic implications of a cardiac biopsy diagnosis of sarcoidosis in patients with unexplained cardiomyopathy... - Role of nitric oxide in the pathophysiology of heart failureHunter C Champion
Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Heart Fail Rev 8:35-46. 2003..We discuss the notion of spatial compartmentalization of NO signaling within the myocyte in an effort to reconcile many controversies about derangements in the influences of NO in the heart and vasculature... - Transcriptomic biomarkers for the accurate diagnosis of myocarditisBettina Heidecker
Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Bldg, Room 824, PO Box 016960 R 125, Miami, FL 33101, USA
Circulation 123:1174-84. 2011..We hypothesized that the transcriptome obtained from an endomyocardial biopsy would yield clinically relevant and accurate molecular signatures... - Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodelingAdam R Williams
Interdisciplinary Stem Cell Institute, Department of Medicine, University of Miami Miller School of Medicine, 1501 NW 10th Ave, Miami, FL 33136, USA
Circ Res 108:792-6. 2011..Transcatheter, intramyocardial injections of bone marrow-derived cell therapy produces reverse remodeling in large animal models of ischemic cardiomyopathy... - Noninvasive differentiation of pulmonary arterial and venous hypertension using conventional and Doppler tissue imaging echocardiographyHoward J Willens
Department of Medicine, Division of Cardiology, University of Miami Miller School of Medicine, Miami, Florida, USA
J Am Soc Echocardiogr 21:715-9. 2008..Optimal cutoff for diagnosing PVH was 9.2 for E/E' (sensitivity 95%, specificity 96%) and 1.7 for E/A (sensitivity 75%, specificity 91%). PAH and PVH may be differentiated by readily obtainable conventional and tissue Doppler parameters... - Sex-specific impact of aldosterone receptor antagonism on ventricular remodeling and gene expression after myocardial infarctionRosemeire M Kanashiro-Takeuchi
University of Miami, Miller School of Medicine, Miami, Florida, USA
Clin Transl Sci 2:134-42. 2009..The use of transcriptomic signatures to detect greater benefit of eplerenone in females has potential implications for personalized medicine... - Pulmonary hypertension and risk of death in cardiomyopathy: patients with myocarditis are at higher riskThomas P Cappola
Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Circulation 105:1663-8. 2002..These findings suggest that secondary pulmonary hypertension may have different biological features in myocarditis and that patients with pulmonary hypertension and myocarditis should be targeted for aggressive medical therapy... - Transcriptomic biomarkers for individual risk assessment in new-onset heart failureBettina Heidecker
Miller School of Medicine, University of Miami Division of Cardiology, CRB, 1120 NW 14th St, Suite 1124, Miami, FL 33136, USA
Circulation 118:238-46. 2008..We hypothesized that a transcriptomic signature, generated from a single endomyocardial biopsy, could serve as a novel prognostic biomarker in HF... - Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthasesShakil A Khan
Department of Medicine, The Johns Hopkins Medical Institution, Baltimore, MD, USA
Circ Res 92:1322-9. 2003.... - Biomarkers of oxidative stress in heart failureBarry H Trachtenberg
University of Miami, Miami, FL 33136, USA
Heart Fail Clin 5:561-77. 2009..However, the clinical utility is limited by less than optimal standardization techniques and the lack of sufficient large-sized, multimarker prospective trials... - Cardiovascular repair and regeneration 2008: the fourth International Conference on Cell Therapy for Cardiovascular Disease (IC3D)Warren Sherman
Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA
EuroIntervention 4:47-9. 2008..While the role of cell-therapy in clinical practice is yet to be established, signals from existing data indicate that engagement of the interventional cardiology community in this field should be expanded... - The adult Göttingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapiesKarl H Schuleri
Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA
Comp Med 58:568-79. 2008..New heart failure therapies and devices can be tested preclinically in this adult animal model of chronic heart failure... - Characterization of peri-infarct zone heterogeneity by contrast-enhanced multidetector computed tomography: a comparison with magnetic resonance imagingKarl H Schuleri
Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Am Coll Cardiol 53:1699-707. 2009..This study examined whether multidetector computed tomography (MDCT) improves the ability to define peri-infarct zone (PIZ) heterogeneity relative to magnetic resonance imaging (MRI)... - Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failureDaniel R Gonzalez
Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
J Biol Chem 285:28938-45. 2010..The reversal of this phenotype by inhibition of xanthine oxidase has important pathophysiologic and therapeutic implications... - Endomyocardial biopsy plays a role in diagnosing patients with unexplained cardiomyopathyHossein Ardehali
Division of Cardiology, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA
Am Heart J 147:919-23. 2004..This study was undertaken to evaluate the utility of EMBx in confirming or excluding a clinically suspected diagnosis... - NO/redox disequilibrium in the failing heart and cardiovascular systemJoshua M Hare
Johns Hopkins University School of Medicine, Department of Medicine, Cardiology Division, Baltimore, Maryland 21205, USA
J Clin Invest 115:509-17. 2005.... - Permanent pacing is a risk factor for the development of heart failureRonald S Freudenberger
Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Am J Cardiol 95:671-4. 2005.... - Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesityLili A Barouch
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circ Res 98:119-24. 2006..These data offer novel insights into potential mechanisms of myocardial dysfunction and early mortality in obesity... - The use of transcriptomic biomarkers for personalized medicineBettina Heidecker
Divison of Cardiology, Miller School of Medicine, University of Miami, Clinical Research Building, 1120 NW 14th Street, Suite 1112, Miami, FL 33136, USA
Heart Fail Rev 12:1-11. 2007..Here we discuss possible pitfalls of transcriptomic analysis, review current developments in the cardiovascular area and address the use of transcriptomics for clinical applications... - Nitric oxide signaling in the cardiovascular system: implications for heart failureRoberto M Saraiva
Cardiology Division, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Curr Opin Cardiol 21:221-8. 2006.... - Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytesDaniel R Gonzalez
Department of Medicine, Cardiovascular Division, and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, 1120 Northwest 14th Street, Suite 1124, Miami, FL 33136, USA
Proc Natl Acad Sci U S A 104:20612-7. 2007..NOS1 dysregulation may be a proximate cause of key phenotypes associated with heart disease... - Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: role of nitroso-redox equilibriumRoberto M Saraiva
Cardiology Division, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Circulation 112:3415-22. 2005..Counter to this idea, we tested the hypothesis that NOS1 has a protective effect after MI... - Molecular signature analysis: using the myocardial transcriptome as a biomarker in cardiovascular diseaseMichelle M Kittleson
Department of Medicine, Cardiology Division, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Trends Cardiovasc Med 15:130-8. 2005.... - Chronic allopurinol administration ameliorates maladaptive alterations in Ca2+ cycling proteins and beta-adrenergic hyporesponsiveness in heart failureAnastasios P Saliaris
Johns Hopkins Medical Institutions, Broadway Research Bldg, Baltimore MD 21205, USA
Am J Physiol Heart Circ Physiol 292:H1328-35. 2007.... - In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarctionDara L Kraitchman
Johns Hopkins University, School of Medicine, Department of Radiology, 601 N Caroline St, Suite 4231, Baltimore, MD 21287 0845, USA
Circulation 107:2290-3. 2003..We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model... - Xanthine oxidase inhibitors: an emerging class of drugs for heart failureMichelle M Kittleson
Eur Heart J 26:1458-60. 2005 - Mechanisms of action of mesenchymal stem cells in cardiac repair: potential influences on the cardiac stem cell nicheRamesh Mazhari
Johns Hopkins Hospital, MD, USA
Nat Clin Pract Cardiovasc Med 4:S21-6. 2007..Effective cell therapy could lead to restoration of these niches through multifaceted cell-cell interactions... - Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimensRachel Ruckdeschel Smith
Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
Circulation 115:896-908. 2007..Ex vivo expansion of resident cardiac stem cells, followed by delivery to the heart, may favor regeneration and functional improvement... - Rationale, design and organisation of an efficacy and safety study of oxypurinol added to standard therapy in patients with NYHA class III - IV congestive heart failureRonald S Freudenberger
Univerfsity of Medicine and Dentistry of New Jersey, USA
Expert Opin Investig Drugs 13:1509-16. 2004..The efficacy end point for OPT-CHF is a composite that incorporates measures of patient outcome and well-being... - Cardiac Stem Cell Therapy. Need for Optimization of Efficacy and Safety MonitoringPeter Oettgen
Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
Circulation 114:353-8. 2006 - Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanismJochen Steppan
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 103:4759-64. 2006..These findings have implications for therapy in pathophysiologic states such as aging and heart failure in which myocardial NO signaling is disrupted... - L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trialSteven P Schulman
Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, USA
JAMA 295:58-64. 2006..The amino acid L-arginine is a substrate for nitric oxide synthase and is increasingly used as a health supplement. Prior studies suggest that L-arginine has the potential to reduce vascular stiffness... - Exhaled nitric oxide: a marker of pulmonary hemodynamics in heart failureJoshua M Hare
Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Am Coll Cardiol 40:1114-9. 2002..We sought to test the hypothesis that patients with decompensated heart failure (HF) lose a compensatory process whereby nitric oxide (NO) maintains pulmonary vascular tone... - Knockdown of arginase I restores NO signaling in the vasculature of old ratsAnthony R White
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Hypertension 47:245-51. 2006..AS oligonucleotides may, therefore, represent a novel therapeutic strategy against age-related vascular endothelial dysfunction... - Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoformsLili A Barouch
Department of Medicine Cardiology Division, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Nature 416:337-9. 2002..Thus, NOS1 and NOS3 mediate independent, and in some cases opposite, effects on cardiac structure and function... - A long and bumpy roadReza Ardehali
Department of Internal Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
Am J Med 119:923-6. 2006 - Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesityShubha V Y Raju
Division of Cardiology and Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 103:4222-7. 2006.... - Cell therapy for myocardial infarction: Special deliveryAlan W Heldman
J Mol Cell Cardiol 44:473-6. 2008 - Spatial confinement of isoforms of cardiac nitric-oxide synthase: unravelling the complexities of nitric oxide's cardiobiologyJoshua M Hare
Cardiology Division and Institute for Cellular Engineering, Johns Hopkins University Medical Institutions, Baltimore, MD 21287, USA
Lancet 363:1338-9. 2004 - L-arginine ameliorates the abnormal sympathetic response of the dysfunctional human coronary microvasculatureJoel Gellman
Department of Internal Medicine, Division of Cardiology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Angiology 55:1-8. 2004..L-arginine warrants further investigation as a therapy for coronary artery disease... - Increased levels of uric acid predict haemodynamic compromise in patients with heart failure independently of B-type natriuretic peptide levelsMichelle M Kittleson
Heart 93:365-7. 2007 - Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implicationsCristine E Berry
The Johns Hopkins Hospital School of Medicine, Cardiology Division, 600 N Wolfe Street, Carnegie 568, Baltimore, MD 21287, USA
J Physiol 555:589-606. 2004..Here we review XOR gene structure and regulation, protein structure, enzymology, tissue distribution and pathophysiological role in cardiovascular disease with an emphasis on heart failure... - Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vesselsDan E Berkowitz
Johns Hopkins U Sch Med, Baltimore, MD
Circulation 108:2000-6. 2003..Arginase upregulation contributes to endothelial dysfunction of aging and may therefore be a therapeutic target... - Characterization of uptake of the new PET imaging compound 18F-fluorobenzyl triphenyl phosphonium in dog myocardiumIgal Madar
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Nucl Med 47:1359-66. 2006..Here, we characterize the 18F-FBnTP uptake and retention kinetics, in vitro and in vivo, as well as the myocardial and whole-body biodistribution in healthy dogs, using PET... - Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction couplingShakil A Khan
Departments of Medicine Cardiology Division and Anesthesia and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 101:15944-8. 2004.... - Nitric oxide and excitation-contraction couplingJoshua M Hare
The Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, Johns Hopkins Medical Institutions, 600 N Wolfe Street, Carnegie 568, Baltimore, MD 21287 6568, USA
J Mol Cell Cardiol 35:719-29. 2003..There is accumulating evidence that NO participates in all aspects of EC coupling, including receptor signal transduction, L-type Ca(2+)-channel activity, SR calcium release through the RYR, and mitochondrial respiration... - Is skeletal myoblast transplantation proarrhythmic? The jury is still outM Roselle Abraham
Heart Rhythm 3:462-3. 2006 - Uric acid predicts clinical outcomes in heart failure: insights regarding the role of xanthine oxidase and uric acid in disease pathophysiologyJoshua M Hare
Circulation 107:1951-3. 2003
Research Grants
- Cellular Cardiomyoplasty for Chronic Heart FailureJoshua Hare; Fiscal Year: 2007....
- OXIDATIVE STRESS IN HEART FAILURE: MECHANISMSJoshua Hare; Fiscal Year: 2007..Finally, the present studies in 3 highly relevant animal models will provide mechanistic insights complementary to those expected from ongoing clinical trials designed to test the utility of XO inhibitors in human HF therapy. ..
- Nitroso/redox balance in myocardial infarctionJoshua M Hare; Fiscal Year: 2010..Our findings will have implications for developing new therapeutic strategies for myocardial infarction and other related common diseases. ..
- Aging impairs stem-cell mediated myocardial repairJoshua Hare; Fiscal Year: 2007..Taken together, our studies will help guide the development of age-specific treatment strategies employing cellular cardiomyoplasty. ..
- OXIDATIVE STRESS IN HEART FAILURE: MECHANISMSJoshua Hare; Fiscal Year: 2003..The results of these studies will clarify pathophysiologic consequences of oxidant stress in heart failure and may have therapeutic implications for humans. ..
- Mesenchymal Stem Cells and Ventricular RemodelingJoshua Hare; Fiscal Year: 2004..Furthermore, these noninvasive techniques will be immediately transferable to human clinical trials. ..
- Cellular Cardiomyoplasty for Chronic Heart FailureJoshua M Hare; Fiscal Year: 2010....