Joshua Hare

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial
    Joshua M Hare
    Interdisciplinary Stem Cell Institute, and Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    JAMA 308:2369-79. 2012
  2. pmc Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling
    Adam R Williams
    Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    J Am Heart Assoc 2:e000140. 2013
  3. pmc Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction
    Adam R Williams
    Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Circulation 127:213-23. 2013
  4. ncbi request reprint Advances in cell-based therapy for structural heart disease
    Ramesh Mazhari
    Department of Medicine, Division of Cardiology and Interdisciplinary Stem Cell Institute, Leonard M Miller School of Medicine, Miami, FL 33136, USA
    Prog Cardiovasc Dis 49:387-95. 2007
  5. ncbi request reprint Cardiac regeneration and stem cell therapy
    Joshua M Hare
    Cardiovascular Division, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Curr Opin Organ Transplant 13:536-42. 2008
  6. pmc A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction
    Joshua M Hare
    Department of Medicine, Cardiovascular Division and the Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Am Coll Cardiol 54:2277-86. 2009
  7. doi request reprint Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study
    Joshua M Hare
    The University of Miami Miller School of Medicine, Miami, Florida v, USA
    J Am Coll Cardiol 51:2301-9. 2008
  8. pmc Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease
    Adam R Williams
    Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Circ Res 109:923-40. 2011
  9. doi request reprint Safety of serial MRI in patients with implantable cardioverter defibrillators
    M Juhani Junttila
    Division of Cardiology, Miller School of Medicine, University of Miami, Florida, USA
    Heart 97:1852-6. 2011
  10. ncbi request reprint [Stem cell therapy for myocardial regeneration: mechanisms and current clinical applications]
    Marco Centola
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    G Ital Cardiol (Rome) 9:234-50. 2008

Research Grants

Detail Information

Publications94

  1. ncbi request reprint Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial
    Joshua M Hare
    Interdisciplinary Stem Cell Institute, and Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    JAMA 308:2369-79. 2012
    ..Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic cardiomyopathy (ICM). Both autologous and allogeneic MSC therapies are possible; however, their safety and efficacy have not been compared...
  2. pmc Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling
    Adam R Williams
    Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    J Am Heart Assoc 2:e000140. 2013
    ..Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular remodeling by producing durable and progressive scar size reduction in ischemic cardiomyopathy...
  3. pmc Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction
    Adam R Williams
    Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Circulation 127:213-23. 2013
    ....
  4. ncbi request reprint Advances in cell-based therapy for structural heart disease
    Ramesh Mazhari
    Department of Medicine, Division of Cardiology and Interdisciplinary Stem Cell Institute, Leonard M Miller School of Medicine, Miami, FL 33136, USA
    Prog Cardiovasc Dis 49:387-95. 2007
    ..Indeed these cells may be harnessed as a therapeutic agent or may represent the target of regenerative therapeutic strategies...
  5. ncbi request reprint Cardiac regeneration and stem cell therapy
    Joshua M Hare
    Cardiovascular Division, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Curr Opin Organ Transplant 13:536-42. 2008
    ..Significant recent developments have occurred in the field of cardiac regeneration and stem-cell therapy. Understanding the new technological advances in cell therapy will ultimate allow us to achieve a goal of cell-based cardiac repair...
  6. pmc A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction
    Joshua M Hare
    Department of Medicine, Cardiovascular Division and the Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Am Coll Cardiol 54:2277-86. 2009
    ..Our aim was to investigate the safety and efficacy of intravenous allogeneic human mesenchymal stem cells (hMSCs) in patients with myocardial infarction (MI)...
  7. doi request reprint Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study
    Joshua M Hare
    The University of Miami Miller School of Medicine, Miami, Florida v, USA
    J Am Coll Cardiol 51:2301-9. 2008
    ....
  8. pmc Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease
    Adam R Williams
    Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Circ Res 109:923-40. 2011
    ..This article reviews the current understanding of MSC biology, mechanism of action in cardiac repair, translational findings, and early clinical trial data of MSC therapy for cardiac disease...
  9. doi request reprint Safety of serial MRI in patients with implantable cardioverter defibrillators
    M Juhani Junttila
    Division of Cardiology, Miller School of Medicine, University of Miami, Florida, USA
    Heart 97:1852-6. 2011
    ..To address this issue, the safety of serial cardiac MR scans was evaluated in patients with implantable cardioverter defibrillators (ICDs)...
  10. ncbi request reprint [Stem cell therapy for myocardial regeneration: mechanisms and current clinical applications]
    Marco Centola
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    G Ital Cardiol (Rome) 9:234-50. 2008
    ....
  11. ncbi request reprint Cardiac cell-based therapy: cell types and mechanisms of actions
    Geraldo A Ramos
    The Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Cell Transplant 16:951-61. 2007
    ..Together the new insights obtained from studies of cell-based cardiac therapy have ushered in new biological paradigms and enormous potential for novel therapeutic strategies for cardiac disease...
  12. pmc Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation
    Konstantinos E Hatzistergos
    University of Miami Miller School of Medicine, Interdisciplinary Stem Cell Institute, Miami, FL 33136, USA
    Circ Res 107:913-22. 2010
    ..Bone marrow-derived mesenchymal stem cells (MSCs) have the capacity for cardiac repair that appears to exceed their capacity for differentiation into cardiac myocytes...
  13. ncbi request reprint Mesenchymal stem cells: future source for reparative medicine
    Rinky Bhatia
    Department of Medicine, Division of Cardiology and Institute for Cell Engineering ICE, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Congest Heart Fail 11:87-91; quiz 92-3. 2005
    ....
  14. ncbi request reprint Multimodality noninvasive imaging demonstrates in vivo cardiac regeneration after mesenchymal stem cell therapy
    Luciano C Amado
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Coll Cardiol 48:2116-24. 2006
    ..The purpose of this study was to test the hypothesis, with noninvasive multimodality imaging, that allogeneic mesenchymal stem cells (MSCs) produce and/or stimulate active cardiac regeneration in vivo after myocardial infarction (MI)...
  15. doi request reprint Cardiovascular genetic medicine: genomic assessment of prognosis and diagnosis in patients with cardiomyopathy and heart failure
    Bettina Heidecker
    Cardiology, Miller School of Medicine, University of Miami, PO Box 019132 C 205, Miami, FL 33101, USA
    J Cardiovasc Transl Res 1:225-31. 2008
    ..In this paper, we review the basic principles of gene expression and molecular signature analysis in the context of potential clinical applications of transcriptomics...
  16. ncbi request reprint Inflammation, stem cells and atherosclerosis genetics
    Pascal J Goldschmidt-Clermont
    University of Miami Leonard M Miller School of Medicine, Department of Medicine, Rosenstiel Medical Science Building, 1600 NW 10th Avenue, Miami, FL 33136, USA
    Curr Opin Mol Ther 12:712-23. 2010
    ..Most of the genes identified by using non-biased genomic techniques are associated with inflammation, immune response and stem cells. This review focuses on new genetic data in the field of atherosclerosis and arterial homeostasis...
  17. ncbi request reprint Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy
    Khalid M Minhas
    Cardiology Division, Department of Medicine, Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21212, USA
    Circ Res 98:271-9. 2006
    ....
  18. doi request reprint Mesenchymal stem cell labeling and in vitro MR characterization at 1.5 T of new SPIO contrast agent: Molday ION Rhodamine-B™
    Benjamin Addicott
    Diabetes Research Institute, University of Miami School of Medicine, FL 33101, USA
    Contrast Media Mol Imaging 6:7-18. 2011
    ..Properties evaluated in this study will be used as a reference for tracking labeled MSC for in vivo studies...
  19. ncbi request reprint Is stem cell therapy ready for patients? Stem Cell Therapy for Cardiac Repair. Ready for the Next Step
    Andrew J Boyle
    Department of Medicine, Division of Cardiology, Institute for Cell Engineering, and Specialized Center for Cell Based Therapy, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 114:339-52. 2006
  20. pmc Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction
    Luciano C Amado
    Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:11474-9. 2005
    ....
  21. ncbi request reprint Stem-cell therapy for renal diseases
    Daniel J Mollura
    Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21205, USA
    Am J Kidney Dis 42:891-905. 2003
    ..This field offers great promise, and there are significant opportunities for future investigation in clinical, biological, and ethical aspects of stem-cell therapy for kidney diseases...
  22. pmc Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity
    Henry C Quevedo
    Interdisciplinary Stem Cell Institute and Department of Medicine, Cardiovascular Division, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 106:14022-7. 2009
    ..MSCs are an adult stem cell with the capacity for cardiomyogenesis and vasculogenesis which contribute, at least in part, to their ability to repair chronically scarred myocardium...
  23. doi request reprint Early improvement in cardiac tissue perfusion due to mesenchymal stem cells
    Karl H Schuleri
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Physiol Heart Circ Physiol 294:H2002-11. 2008
    ..Cardiac MRI-based measures of blood flow may be a useful tool to predict a successful myocardial regenerative process after MSC treatment...
  24. ncbi request reprint Emerging role for bone marrow derived mesenchymal stem cells in myocardial regenerative therapy
    Jeffrey M Zimmet
    Department of Medicine, Cardiology Division and Institute for Cell Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Basic Res Cardiol 100:471-81. 2005
    ..Here we review the characterization of MSCs, animal and human trials studying MSCs in cardiomyogenesis and vasculogenesis in postinfarct myocardium, routes of delivery, and potential mechanisms of stem cell repair...
  25. ncbi request reprint Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart
    Walter F Saavedra
    Department of Medicine, Cardiology Division and Institute of Molecular Cardiobiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circ Res 90:297-304. 2002
    ..These data show that both NOS and XO signaling systems participate in the regulation of myocardial mechanical efficiency and that upregulation of XO relative to NOS contributes to mechanoenergetic uncoupling in heart failure...
  26. ncbi request reprint Aging impairs the beneficial effect of granulocyte colony-stimulating factor and stem cell factor on post-myocardial infarction remodeling
    Stephanie Lehrke
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 99:553-60. 2006
    ....
  27. pmc Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction
    Rosemeire M Kanashiro-Takeuchi
    Division of Cardiology, Department of Medicine, Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 107:2604-9. 2010
    ..The phenotypic profile of the response to a potent GHRH agonist has therapeutic implications...
  28. doi request reprint Mesenchymal stem cell therapy for cardiac repair
    Andrew J Boyle
    Cardiology Division, Department of Medicine, University of California, San Francisco, CA, USA
    Methods Mol Biol 660:65-84. 2010
    ..This review discusses the mechanism of action of MSC therapy and summarizes the current literature in the field...
  29. pmc Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy
    Karl H Schuleri
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Eur Heart J 30:2722-32. 2009
    ..Here we tested the hypothesis that autologous MSCs can be safely injected into a chronic myocardial infarct scar, reduce its size, and improve ventricular function...
  30. ncbi request reprint Xanthine oxidase inhibition ameliorates cardiovascular dysfunction in dogs with pacing-induced heart failure
    Luciano C Amado
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Mol Cell Cardiol 39:531-6. 2005
    ..These results demonstrate a unique and potent hemodynamic profile of XOI, thereby providing further rationale for developing XOIs as a novel HF therapy...
  31. ncbi request reprint Noninvasive diagnosis of biopsy-proven cardiac amyloidosis
    Joseph E Rahman
    Division of Cardiology, Department of Medicine, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224 2780, USA
    J Am Coll Cardiol 43:410-5. 2004
    ..This study analyzed the utility of electrocardiographic (ECG) and echocardiographic findings in the diagnosis of amyloidosis proven by endomyocardial biopsy...
  32. ncbi request reprint Gene expression analysis of ischemic and nonischemic cardiomyopathy: shared and distinct genes in the development of heart failure
    Michelle M Kittleson
    Division of Cardiology, Department of Medicine, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Physiol Genomics 21:299-307. 2005
    ....
  33. ncbi request reprint The benefit of upgrading chronically right ventricle-paced heart failure patients to resynchronization therapy demonstrated by strain rate imaging
    Zayd A Eldadah
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Heart Rhythm 3:435-42. 2006
    ..RV pacing induces conduction delay (CD), mechanical dyssynchrony, and increased morbidity in patients with HF. CRT improves HF symptoms and survival, but sparse data exist on its direct effect on chronically RV-paced HF patients...
  34. doi request reprint Uric acid as a predictor of all-cause mortality in heart failure: a meta-analysis
    Leonardo Tamariz
    Division of General Internal Medicine, Department of Medicine, Miller School of Medicine, University of Miami, FL 33136, USA
    Congest Heart Fail 17:25-30. 2011
    ..There was a linear association (P<.01) between SUA and mortality after 7 mg/dL. Uric acid is an important prognostic marker for all-cause mortality in HF. SUA levels >7 mg/dL are associated with higher all-cause mortality...
  35. pmc Inhibition of the SDF-1/CXCR4 axis attenuates neonatal hypoxia-induced pulmonary hypertension
    Karen C Young
    Department of Pediatrics Division of Neonatology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circ Res 104:1293-301. 2009
    ..These data offer novel insights into the role of the SDF-1/CXCR4 axis in the pathogenesis of neonatal hypoxia-induced cardiopulmonary remodeling and have important therapeutic implications...
  36. ncbi request reprint Elevated uric acid levels predict allograft vasculopathy in cardiac transplant recipients
    Michelle M Kittleson
    Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Heart Lung Transplant 26:498-503. 2007
    ..We hypothesized that hyperuricemia is associated with CAV in cardiac transplant recipients...
  37. doi request reprint The change in B-type natriuretic peptide levels over time predicts significant rejection in cardiac transplant recipients
    Michelle M Kittleson
    Department of Medicine, Division of Cardiology, University of California at Los Angeles, Los Angeles, California, USA
    J Heart Lung Transplant 28:704-9. 2009
    ....
  38. pmc S-Nitrosylation of cardiac ion channels
    Daniel R Gonzalez
    Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Cardiovasc Pharmacol 54:188-95. 2009
    ..S-Nitrosylation signaling is disrupted in pathological states in which the redox state of the cell is dysregulated, including ischemia, heart failure, and atrial fibrillation...
  39. pmc Cardiac nitric oxide synthase-1 localization within the cardiomyocyte is accompanied by the adaptor protein, CAPON
    Farideh Beigi
    Division of Cardiology and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, USA
    Nitric Oxide 21:226-33. 2009
    ..Together these findings support the hypothesis that NOS1 redistribution in injured myocardium requires the formation of a complex with the PDZ adaptor protein CAPON...
  40. ncbi request reprint Role of xanthine oxidoreductase in cardiac nitroso-redox imbalance
    Konstantinos Tziomalos
    Interdisciplinary Stem Cell Institute and Division of Cardiology, Leonard M Miller School of Medicine, University of Miami, Miami, FL, USA
    Front Biosci (Landmark Ed) 14:237-62. 2009
    ..A growing understanding of XOR and its role in nitroso-redox imbalance has great potential to lead to improved pathophysiologic insights and possibly therapeutic advances...
  41. ncbi request reprint Identification of a gene expression profile that differentiates between ischemic and nonischemic cardiomyopathy
    Michelle M Kittleson
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 110:3444-51. 2004
    ..We hypothesized that gene expression differentiates ischemic and nonischemic cardiomyopathy, demonstrating that gene expression profiling by clinical parameters is feasible in cardiology...
  42. pmc Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and nitroso-redox imbalance in ob/ob mice
    Roberto M Saraiva
    Cardiology Division, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Nitric Oxide 16:331-8. 2007
    ..These data offer novel insights into potential mechanisms of myocardial dysfunction in obesity...
  43. pmc Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar
    Albert C Lardo
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circulation 113:394-404. 2006
    ....
  44. ncbi request reprint A positive endomyocardial biopsy result for sarcoid is associated with poor prognosis in patients with initially unexplained cardiomyopathy
    Hossein Ardehali
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Am Heart J 150:459-63. 2005
    ..In patients with cardiomyopathy, the diagnosis of sarcoidosis has important treatment implications. We studied the prognostic implications of a cardiac biopsy diagnosis of sarcoidosis in patients with unexplained cardiomyopathy...
  45. ncbi request reprint Role of nitric oxide in the pathophysiology of heart failure
    Hunter C Champion
    Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Heart Fail Rev 8:35-46. 2003
    ..We discuss the notion of spatial compartmentalization of NO signaling within the myocyte in an effort to reconcile many controversies about derangements in the influences of NO in the heart and vasculature...
  46. doi request reprint Nitric oxide and cardiobiology-methods for intact hearts and isolated myocytes
    Joshua M Hare
    Division of Cardiology and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, USA
    Methods Enzymol 441:369-92. 2008
    ..In summary, this chapter reviews the biochemical methods that assess the impact of nitroso/redox signaling in the cardiovascular system...
  47. ncbi request reprint Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice
    Lili A Barouch
    Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, 600 North Wolfe St, Baltimore, MD 21287, USA
    Circulation 108:754-9. 2003
    ..Because leptin has cardiovascular bioactivity, we hypothesized that disruption of leptin signaling mediates the development of obesity-associated LVH...
  48. pmc Transcriptomic biomarkers for the accurate diagnosis of myocarditis
    Bettina Heidecker
    Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Biomedical Research Bldg, Room 824, PO Box 016960 R 125, Miami, FL 33101, USA
    Circulation 123:1174-84. 2011
    ..We hypothesized that the transcriptome obtained from an endomyocardial biopsy would yield clinically relevant and accurate molecular signatures...
  49. pmc Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling
    Adam R Williams
    Interdisciplinary Stem Cell Institute, Department of Medicine, University of Miami Miller School of Medicine, 1501 NW 10th Ave, Miami, FL 33136, USA
    Circ Res 108:792-6. 2011
    ..Transcatheter, intramyocardial injections of bone marrow-derived cell therapy produces reverse remodeling in large animal models of ischemic cardiomyopathy...
  50. pmc Transcriptomic biomarkers for individual risk assessment in new-onset heart failure
    Bettina Heidecker
    Miller School of Medicine, University of Miami Division of Cardiology, CRB, 1120 NW 14th St, Suite 1124, Miami, FL 33136, USA
    Circulation 118:238-46. 2008
    ..We hypothesized that a transcriptomic signature, generated from a single endomyocardial biopsy, could serve as a novel prognostic biomarker in HF...
  51. ncbi request reprint Cardiovascular repair and regeneration 2008: the fourth International Conference on Cell Therapy for Cardiovascular Disease (IC3D)
    Warren Sherman
    Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA
    EuroIntervention 4:47-9. 2008
    ..While the role of cell-therapy in clinical practice is yet to be established, signals from existing data indicate that engagement of the interventional cardiology community in this field should be expanded...
  52. ncbi request reprint Pulmonary hypertension and risk of death in cardiomyopathy: patients with myocarditis are at higher risk
    Thomas P Cappola
    Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 105:1663-8. 2002
    ....
  53. pmc Characterization of peri-infarct zone heterogeneity by contrast-enhanced multidetector computed tomography: a comparison with magnetic resonance imaging
    Karl H Schuleri
    Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Coll Cardiol 53:1699-707. 2009
    ..This study examined whether multidetector computed tomography (MDCT) improves the ability to define peri-infarct zone (PIZ) heterogeneity relative to magnetic resonance imaging (MRI)...
  54. pmc The adult Göttingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies
    Karl H Schuleri
    Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA
    Comp Med 58:568-79. 2008
    ..New heart failure therapies and devices can be tested preclinically in this adult animal model of chronic heart failure...
  55. pmc Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failure
    Daniel R Gonzalez
    Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Biol Chem 285:28938-45. 2010
    ..The reversal of this phenotype by inhibition of xanthine oxidase has important pathophysiologic and therapeutic implications...
  56. pmc NO/redox disequilibrium in the failing heart and cardiovascular system
    Joshua M Hare
    Johns Hopkins University School of Medicine, Department of Medicine, Cardiology Division, Baltimore, Maryland 21205, USA
    J Clin Invest 115:509-17. 2005
    ....
  57. ncbi request reprint Endomyocardial biopsy plays a role in diagnosing patients with unexplained cardiomyopathy
    Hossein Ardehali
    Division of Cardiology, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA
    Am Heart J 147:919-23. 2004
    ..This study was undertaken to evaluate the utility of EMBx in confirming or excluding a clinically suspected diagnosis...
  58. doi request reprint Biomarkers of oxidative stress in heart failure
    Barry H Trachtenberg
    University of Miami, Miami, FL 33136, USA
    Heart Fail Clin 5:561-77. 2009
    ..However, the clinical utility is limited by less than optimal standardization techniques and the lack of sufficient large-sized, multimarker prospective trials...
  59. pmc Sex-specific impact of aldosterone receptor antagonism on ventricular remodeling and gene expression after myocardial infarction
    Rosemeire M Kanashiro-Takeuchi
    University of Miami, Miller School of Medicine, Miami, Florida, USA
    Clin Transl Sci 2:134-42. 2009
    ..The use of transcriptomic signatures to detect greater benefit of eplerenone in females has potential implications for personalized medicine...
  60. ncbi request reprint Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases
    Shakil A Khan
    Department of Medicine, The Johns Hopkins Medical Institution, Baltimore, MD, USA
    Circ Res 92:1322-9. 2003
    ....
  61. ncbi request reprint Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: role of nitroso-redox equilibrium
    Roberto M Saraiva
    Cardiology Division, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Circulation 112:3415-22. 2005
    ..Counter to this idea, we tested the hypothesis that NOS1 has a protective effect after MI...
  62. ncbi request reprint Nitric oxide signaling in the cardiovascular system: implications for heart failure
    Roberto M Saraiva
    Cardiology Division, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Curr Opin Cardiol 21:221-8. 2006
    ..Here, we discuss new concepts regarding NO signaling, its effector pathways, and interactions between NO and the redox milieu within a framework of cardiac physiology and pathophysiology...
  63. doi request reprint Noninvasive differentiation of pulmonary arterial and venous hypertension using conventional and Doppler tissue imaging echocardiography
    Howard J Willens
    Department of Medicine, Division of Cardiology, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Am Soc Echocardiogr 21:715-9. 2008
    ..Optimal cutoff for diagnosing PVH was 9.2 for E/E' (sensitivity 95%, specificity 96%) and 1.7 for E/A (sensitivity 75%, specificity 91%). PAH and PVH may be differentiated by readily obtainable conventional and tissue Doppler parameters...
  64. ncbi request reprint Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity
    Lili A Barouch
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 98:119-24. 2006
    ..These data offer novel insights into potential mechanisms of myocardial dysfunction and early mortality in obesity...
  65. ncbi request reprint Permanent pacing is a risk factor for the development of heart failure
    Ronald S Freudenberger
    Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Am J Cardiol 95:671-4. 2005
    ....
  66. ncbi request reprint Molecular signature analysis: using the myocardial transcriptome as a biomarker in cardiovascular disease
    Michelle M Kittleson
    Department of Medicine, Cardiology Division, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Trends Cardiovasc Med 15:130-8. 2005
    ....
  67. pmc Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes
    Daniel R Gonzalez
    Department of Medicine, Cardiovascular Division, and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, 1120 Northwest 14th Street, Suite 1124, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 104:20612-7. 2007
    ..NOS1 dysregulation may be a proximate cause of key phenotypes associated with heart disease...
  68. ncbi request reprint The use of transcriptomic biomarkers for personalized medicine
    Bettina Heidecker
    Divison of Cardiology, Miller School of Medicine, University of Miami, Clinical Research Building, 1120 NW 14th Street, Suite 1112, Miami, FL 33136, USA
    Heart Fail Rev 12:1-11. 2007
    ..Here we discuss possible pitfalls of transcriptomic analysis, review current developments in the cardiovascular area and address the use of transcriptomics for clinical applications...
  69. ncbi request reprint Chronic allopurinol administration ameliorates maladaptive alterations in Ca2+ cycling proteins and beta-adrenergic hyporesponsiveness in heart failure
    Anastasios P Saliaris
    Johns Hopkins Medical Institutions, Broadway Research Bldg, Baltimore MD 21205, USA
    Am J Physiol Heart Circ Physiol 292:H1328-35. 2007
    ....
  70. ncbi request reprint Xanthine oxidase inhibitors: an emerging class of drugs for heart failure
    Michelle M Kittleson
    Eur Heart J 26:1458-60. 2005
  71. ncbi request reprint Cardiac Stem Cell Therapy. Need for Optimization of Efficacy and Safety Monitoring
    Peter Oettgen
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Circulation 114:353-8. 2006
  72. ncbi request reprint In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction
    Dara L Kraitchman
    Johns Hopkins University, School of Medicine, Department of Radiology, 601 N Caroline St, Suite 4231, Baltimore, MD 21287 0845, USA
    Circulation 107:2290-3. 2003
    ..We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model...
  73. ncbi request reprint Mechanisms of action of mesenchymal stem cells in cardiac repair: potential influences on the cardiac stem cell niche
    Ramesh Mazhari
    Johns Hopkins Hospital, MD, USA
    Nat Clin Pract Cardiovasc Med 4:S21-6. 2007
    ..Effective cell therapy could lead to restoration of these niches through multifaceted cell-cell interactions...
  74. ncbi request reprint Rationale, design and organisation of an efficacy and safety study of oxypurinol added to standard therapy in patients with NYHA class III - IV congestive heart failure
    Ronald S Freudenberger
    Univerfsity of Medicine and Dentistry of New Jersey, USA
    Expert Opin Investig Drugs 13:1509-16. 2004
    ..The efficacy end point for OPT-CHF is a composite that incorporates measures of patient outcome and well-being...
  75. ncbi request reprint Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens
    Rachel Ruckdeschel Smith
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Circulation 115:896-908. 2007
    ..Ex vivo expansion of resident cardiac stem cells, followed by delivery to the heart, may favor regeneration and functional improvement...
  76. ncbi request reprint L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial
    Steven P Schulman
    Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, USA
    JAMA 295:58-64. 2006
    ..The amino acid L-arginine is a substrate for nitric oxide synthase and is increasingly used as a health supplement. Prior studies suggest that L-arginine has the potential to reduce vascular stiffness...
  77. ncbi request reprint Uric acid predicts clinical outcomes in heart failure: insights regarding the role of xanthine oxidase and uric acid in disease pathophysiology
    Joshua M Hare
    Circulation 107:1951-3. 2003
  78. ncbi request reprint Knockdown of arginase I restores NO signaling in the vasculature of old rats
    Anthony R White
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Hypertension 47:245-51. 2006
    ..AS oligonucleotides may, therefore, represent a novel therapeutic strategy against age-related vascular endothelial dysfunction...
  79. ncbi request reprint Is skeletal myoblast transplantation proarrhythmic? The jury is still out
    M Roselle Abraham
    Heart Rhythm 3:462-3. 2006
  80. ncbi request reprint Exhaled nitric oxide: a marker of pulmonary hemodynamics in heart failure
    Joshua M Hare
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Am Coll Cardiol 40:1114-9. 2002
    ..We sought to test the hypothesis that patients with decompensated heart failure (HF) lose a compensatory process whereby nitric oxide (NO) maintains pulmonary vascular tone...
  81. ncbi request reprint Nitric oxide and excitation-contraction coupling
    Joshua M Hare
    The Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, Johns Hopkins Medical Institutions, 600 N Wolfe Street, Carnegie 568, Baltimore, MD 21287 6568, USA
    J Mol Cell Cardiol 35:719-29. 2003
    ..There is accumulating evidence that NO participates in all aspects of EC coupling, including receptor signal transduction, L-type Ca(2+)-channel activity, SR calcium release through the RYR, and mitochondrial respiration...
  82. pmc Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity
    Shubha V Y Raju
    Division of Cardiology and Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:4222-7. 2006
    ....
  83. ncbi request reprint Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels
    Dan E Berkowitz
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 108:2000-6. 2003
    ..We tested the hypotheses that arginase reciprocally regulates NOS by modulating L-arginine bioavailability and that arginase is upregulated in aging vasculature, contributing to depressed endothelial function...
  84. pmc Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling
    Shakil A Khan
    Departments of Medicine Cardiology Division and Anesthesia and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 101:15944-8. 2004
    ....
  85. pmc Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism
    Jochen Steppan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 103:4759-64. 2006
    ..These findings have implications for therapy in pathophysiologic states such as aging and heart failure in which myocardial NO signaling is disrupted...
  86. pmc Cell therapy for myocardial infarction: Special delivery
    Alan W Heldman
    J Mol Cell Cardiol 44:473-6. 2008
  87. pmc Increased levels of uric acid predict haemodynamic compromise in patients with heart failure independently of B-type natriuretic peptide levels
    Michelle M Kittleson
    Heart 93:365-7. 2007
  88. ncbi request reprint Spatial confinement of isoforms of cardiac nitric-oxide synthase: unravelling the complexities of nitric oxide's cardiobiology
    Joshua M Hare
    Cardiology Division and Institute for Cellular Engineering, Johns Hopkins University Medical Institutions, Baltimore, MD 21287, USA
    Lancet 363:1338-9. 2004
  89. ncbi request reprint A long and bumpy road
    Reza Ardehali
    Department of Internal Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Med 119:923-6. 2006
  90. ncbi request reprint Characterization of uptake of the new PET imaging compound 18F-fluorobenzyl triphenyl phosphonium in dog myocardium
    Igal Madar
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 47:1359-66. 2006
    ..Here, we characterize the 18F-FBnTP uptake and retention kinetics, in vitro and in vivo, as well as the myocardial and whole-body biodistribution in healthy dogs, using PET...
  91. ncbi request reprint L-arginine ameliorates the abnormal sympathetic response of the dysfunctional human coronary microvasculature
    Joel Gellman
    Department of Internal Medicine, Division of Cardiology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Angiology 55:1-8. 2004
    ..L-arginine warrants further investigation as a therapy for coronary artery disease...
  92. pmc Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications
    Cristine E Berry
    The Johns Hopkins Hospital School of Medicine, Cardiology Division, 600 N Wolfe Street, Carnegie 568, Baltimore, MD 21287, USA
    J Physiol 555:589-606. 2004
    ..Here we review XOR gene structure and regulation, protein structure, enzymology, tissue distribution and pathophysiological role in cardiovascular disease with an emphasis on heart failure...
  93. ncbi request reprint Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms
    Lili A Barouch
    Department of Medicine Cardiology Division, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Nature 416:337-9. 2002
    ..Thus, NOS1 and NOS3 mediate independent, and in some cases opposite, effects on cardiac structure and function...

Research Grants21

  1. OXIDATIVE STRESS IN HEART FAILURE: MECHANISMS
    Joshua Hare; Fiscal Year: 2000
    ..The results of these studies will clarify pathophysiologic consequences of oxidant stress in heart failure and may have therapeutic implications for humans. ..
  2. OXIDATIVE STRESS IN HEART FAILURE: MECHANISMS
    Joshua Hare; Fiscal Year: 2002
    ..The results of these studies will clarify pathophysiologic consequences of oxidant stress in heart failure and may have therapeutic implications for humans. ..
  3. Cellular Cardiomyoplasty for Chronic Heart Failure
    Joshua Hare; Fiscal Year: 2007
    ....
  4. OXIDATIVE STRESS IN HEART FAILURE: MECHANISMS
    Joshua Hare; Fiscal Year: 2007
    ..Finally, the present studies in 3 highly relevant animal models will provide mechanistic insights complementary to those expected from ongoing clinical trials designed to test the utility of XO inhibitors in human HF therapy. ..
  5. Aging impairs stem-cell mediated myocardial repair
    Joshua Hare; Fiscal Year: 2006
    ..Taken together, our studies will help guide the development of age-specific treatment strategies employing cellular cardiomyoplasty. ..
  6. Nitroso/redox balance in myocardial infarction
    Joshua Hare; Fiscal Year: 2009
    ..Our findings will have implications for developing new therapeutic strategies for myocardial infarction and other related common diseases. ..
  7. Cellular Cardiomyoplasty for Chronic Heart Failure
    Joshua Hare; Fiscal Year: 2009
    ....
  8. Nitroso/redox balance in myocardial infarction
    Joshua M Hare; Fiscal Year: 2010
    ..Our findings will have implications for developing new therapeutic strategies for myocardial infarction and other related common diseases. ..
  9. Aging impairs stem-cell mediated myocardial repair
    Joshua Hare; Fiscal Year: 2007
    ..Taken together, our studies will help guide the development of age-specific treatment strategies employing cellular cardiomyoplasty. ..
  10. OXIDATIVE STRESS IN HEART FAILURE: MECHANISMS
    Joshua Hare; Fiscal Year: 2001
    ..The results of these studies will clarify pathophysiologic consequences of oxidant stress in heart failure and may have therapeutic implications for humans. ..
  11. OXIDATIVE STRESS IN HEART FAILURE: MECHANISMS
    Joshua Hare; Fiscal Year: 2002
    ..The results of these studies will clarify pathophysiologic consequences of oxidant stress in heart failure and may have therapeutic implications for humans. ..
  12. OXIDATIVE STRESS IN HEART FAILURE: MECHANISMS
    Joshua Hare; Fiscal Year: 2003
    ..The results of these studies will clarify pathophysiologic consequences of oxidant stress in heart failure and may have therapeutic implications for humans. ..
  13. Mesenchymal Stem Cells and Ventricular Remodeling
    Joshua Hare; Fiscal Year: 2004
    ..Furthermore, these noninvasive techniques will be immediately transferable to human clinical trials. ..
  14. OXIDATIVE STRESS IN HEART FAILURE: MECHANISMS
    Joshua Hare; Fiscal Year: 2005
    ..Finally, the present studies in 3 highly relevant animal models will provide mechanistic insights complementary to those expected from ongoing clinical trials designed to test the utility of XO inhibitors in human HF therapy. ..
  15. Aging impairs stem-cell mediated myocardial repair
    Joshua Hare; Fiscal Year: 2005
    ..Taken together, our studies will help guide the development of age-specific treatment strategies employing cellular cardiomyoplasty. ..
  16. Aging impairs stem-cell mediated myocardial repair
    Joshua Hare; Fiscal Year: 2006
    ..Taken together, our studies will help guide the development of age-specific treatment strategies employing cellular cardiomyoplasty. ..
  17. OXIDATIVE STRESS IN HEART FAILURE: MECHANISMS
    Joshua Hare; Fiscal Year: 2006
    ..Finally, the present studies in 3 highly relevant animal models will provide mechanistic insights complementary to those expected from ongoing clinical trials designed to test the utility of XO inhibitors in human HF therapy. ..
  18. Cellular Cardiomyoplasty for Chronic Heart Failure
    Joshua M Hare; Fiscal Year: 2010
    ....