D S Hardin

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint The metabolic effects of pregnancy in cystic fibrosis
    Dana S Hardin
    University of Texas Southwestern Medical Center, Dallas, Texas 75093 9063, USA
    Obstet Gynecol 106:367-75. 2005
  2. ncbi request reprint GH improves growth and clinical status in children with cystic fibrosis -- a review of published studies
    Dana S Hardin
    University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard G2 220, Dallas, TX 75390 9063, USA
    Eur J Endocrinol 151:S81-5. 2004
  3. ncbi request reprint Protease inhibitor therapy improves protein catabolism in prepubertal children with HIV infection
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Houston 77030, USA
    J Pediatr Endocrinol Metab 17:321-5. 2004
  4. ncbi request reprint Growth hormone decreases protein catabolism in children with cystic fibrosis
    D S Hardin
    University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 86:4424-8. 2001
  5. ncbi request reprint Mechanisms of insulin resistance in cystic fibrosis
    D S Hardin
    University of Texas Southwestern Medical School, Dallas 75390, USA
    Am J Physiol Endocrinol Metab 281:E1022-8. 2001
  6. ncbi request reprint Growth hormone improves bone mineral content in children with cystic fibrosis
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Houston, TX, USA
    J Pediatr Endocrinol Metab 18:589-95. 2005
  7. ncbi request reprint Growth hormone treatment in children with cystic fibrosis
    D S Hardin
    Southwestern Medical School, University of Texas, Dallas, USA
    Minerva Pediatr 54:365-71. 2002
  8. ncbi request reprint Growth problems and growth hormone treatment in children with cystic fibrosis
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Dallas 75390 9063, USA
    J Pediatr Endocrinol Metab 15:731-5. 2002
  9. ncbi request reprint Hepatic insulin resistance and defects in substrate utilization in cystic fibrosis
    D S Hardin
    Department of Pediatrics, University of Texas, Houston, USA
    Diabetes 48:1082-7. 1999
  10. ncbi request reprint Growth hormone improves weight velocity and height velocity in prepubertal children with cystic fibrosis
    D S Hardin
    University of Texas Health Science Center, Houston 77030, USA
    Horm Metab Res 30:636-41. 1998

Research Grants

Detail Information

Publications31

  1. ncbi request reprint The metabolic effects of pregnancy in cystic fibrosis
    Dana S Hardin
    University of Texas Southwestern Medical Center, Dallas, Texas 75093 9063, USA
    Obstet Gynecol 106:367-75. 2005
    ..Our purpose was to determine glucose tolerance in pregnant women with cystic fibrosis (CF) and to relate glucose tolerance to insulin sensitivity, hepatic glucose production, and protein turnover...
  2. ncbi request reprint GH improves growth and clinical status in children with cystic fibrosis -- a review of published studies
    Dana S Hardin
    University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard G2 220, Dallas, TX 75390 9063, USA
    Eur J Endocrinol 151:S81-5. 2004
    ..To date significant side effects, including glucose intolerance, have not been reported. Thus mounting evidence suggests that human recombinant GH provides safe and effective therapy in children with CF...
  3. ncbi request reprint Protease inhibitor therapy improves protein catabolism in prepubertal children with HIV infection
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Houston 77030, USA
    J Pediatr Endocrinol Metab 17:321-5. 2004
    ..One action of these drugs is that of lowering the viral burden, and several studies suggest that these drugs result in increased growth and weight velocity. Our second aim was to determine whether PI therapy improves protein catabolism...
  4. ncbi request reprint Growth hormone decreases protein catabolism in children with cystic fibrosis
    D S Hardin
    University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 86:4424-8. 2001
    ..The results of this study suggest that one reason GH improves body weight and lean tissue mass is due to improved whole body protein catabolism and improved efficiency of whole body protein kinetics...
  5. ncbi request reprint Mechanisms of insulin resistance in cystic fibrosis
    D S Hardin
    University of Texas Southwestern Medical School, Dallas 75390, USA
    Am J Physiol Endocrinol Metab 281:E1022-8. 2001
    ..We conclude that IGTCF patients have decreased peripheral insulin sensitivity. Mechanisms include elevation of TNF-alpha and impaired translocation of GLUT-4...
  6. ncbi request reprint Growth hormone improves bone mineral content in children with cystic fibrosis
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Houston, TX, USA
    J Pediatr Endocrinol Metab 18:589-95. 2005
    ..Our second aim was to evaluate the effect of one year of treatment with human recombinant growth hormone (GH) on total body BMC...
  7. ncbi request reprint Growth hormone treatment in children with cystic fibrosis
    D S Hardin
    Southwestern Medical School, University of Texas, Dallas, USA
    Minerva Pediatr 54:365-71. 2002
    ..The purpose of this article is to summarize studies evaluating GH use in children with CF...
  8. ncbi request reprint Growth problems and growth hormone treatment in children with cystic fibrosis
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Dallas 75390 9063, USA
    J Pediatr Endocrinol Metab 15:731-5. 2002
    ..A large multicenter trial is currently underway to assess the effect of long-term therapy with GH on the quality of life and pulmonary status...
  9. ncbi request reprint Hepatic insulin resistance and defects in substrate utilization in cystic fibrosis
    D S Hardin
    Department of Pediatrics, University of Texas, Houston, USA
    Diabetes 48:1082-7. 1999
    ..Furthermore, these results suggest that high hepatic glucose production and hepatic insulin resistance contribute to the high incidence of abnormal glucose tolerance in CF...
  10. ncbi request reprint Growth hormone improves weight velocity and height velocity in prepubertal children with cystic fibrosis
    D S Hardin
    University of Texas Health Science Center, Houston 77030, USA
    Horm Metab Res 30:636-41. 1998
    ..These results suggest that growth hormone used in prepubertal children with cystic fibrosis can improve height and weight and may improve lean body mass...
  11. pmc Normal bone mineral density in cystic fibrosis
    D S Hardin
    Department of Pediatrics, The Feigen Center, Suite 410, 6621 Fannin, Houston, TX 77030, USA
    Arch Dis Child 84:363-8. 2001
    ..Osteoporosis has been reported as a complication of cystic fibrosis (CF)...
  12. ncbi request reprint Z score prediction model for assessment of bone mineral content in pediatric diseases
    K J Ellis
    US Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    J Bone Miner Res 16:1658-64. 2001
    ..5. These preliminary findings indicate that the prediction model should prove useful in determining potential bone mineral deficits in individual pediatric patients...
  13. ncbi request reprint Ingested IFN-alpha preserves residual beta cell function in type 1 diabetes
    S A Brod
    Department of Neurology, University of Texas Health Science Center Houston, Houston, TX 77225, USA
    J Interferon Cytokine Res 21:1021-30. 2001
    ..Our results support the potential of ingested IFN-alpha to preserve residual beta cell function in recent onset type 1 diabetes mellitus and the testing of IFN-alpha in a placebo-controlled trial...
  14. ncbi request reprint Current prescribing practices and opinions about growth hormone therapy: results of a nationwide survey of paediatric endocrinologists
    Dana S Hardin
    Ohio State University, Columbus, OH 43205, USA
    Clin Endocrinol (Oxf) 66:85-94. 2007
    ..The purpose of this study was to summarize prevailing attitudes about GH diagnosis and treatment among paediatric endocrinologists...
  15. ncbi request reprint Twenty years of recombinant human growth hormone in children: relevance to pediatric care providers
    Dana S Hardin
    Ohio State University and Columbus Children s Hospital, Columbus, OH 43205, USA
    Clin Pediatr (Phila) 46:279-86. 2007
    ....
  16. ncbi request reprint Insulin resistance in Hispanic large-for-gestational-age neonates at birth
    Jennifer Shine Dyer
    Department of Pediatrics, Division of Endocrinology, The Ohio State University, 700 Children s Drive, W322, Columbus, Ohio 43205, USA
    J Clin Endocrinol Metab 92:3836-43. 2007
    ..Although Hispanic youth have been shown to have a high prevalence of metabolic syndrome, it is unknown whether metabolic abnormalities and a predisposition for glucose intolerance are present at birth...
  17. doi request reprint A review of the management of two common clinical problems found in patients with cystic fibrosis: cystic fibrosis-related diabetes and poor growth
    Dana S Hardin
    Division of Pediatric Endocrinology, Columbus Children s Hospital, Ohio State University, Columbus, Ohio, USA
    Horm Res 68:113-6. 2007
    ..Recombinant human growth hormone (rhGH) is being explored in this patient population; studies overall show improvements in height and weight, without development of glucose intolerance...
  18. doi request reprint Improvement in insulin sensitivity and dyslipidemia in protease inhibitor-treated adult male patients after switch to atazanavir/ritonavir
    Anthony J Busti
    Texas Tech University Health Sciences Center School of Pharmacy, Dallas, Texas, USA
    J Investig Med 56:539-44. 2008
    ..However, its effects on insulin sensitivity have not been elucidated. We conducted this study to test the hypothesis that ATV improves insulin resistance and dyslipidemia...
  19. doi request reprint Elevated gluconeogenesis and lack of suppression by insulin contribute to cystic fibrosis-related diabetes
    Dana S Hardin
    Nationwide Children s Hospital, The Ohio State University, Columbus, OH 43205 2696, USA
    J Investig Med 56:567-73. 2008
    ..Gluconeogenesis correlated with protein breakdown. These studies suggest that high HGP in CF is mostly from elevated rates of GNG and that resistance to insulin's suppression of GNG may contribute to abnormal glucose tolerance in CF...
  20. ncbi request reprint Growth hormone treatment improves growth and clinical status in prepubertal children with cystic fibrosis: results of a multicenter randomized controlled trial
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Texas 75390, USA
    J Clin Endocrinol Metab 91:4925-9. 2006
    ....
  21. ncbi request reprint Growth hormone normalizes pubertal onset in children with cystic fibrosis
    Mark Vanderwel
    University of Texas Southwestern Medical School, Division of Pediatric Endocrinology, Dallas, USA
    J Pediatr Endocrinol Metab 19:237-44. 2006
    ..Testicular size progression was not accelerated in pubertal boys treated with GH. CONCLUSION: GH treatment normalizes pubertal onset in prepubertal children with CF...
  22. ncbi request reprint Growth hormone in cystic fibrosis
    Dana S Hardin
    The Ohio State University, Nationwide Children s Hospital, Columbus, OH 43205, USA
    J Pediatr Endocrinol Metab 21:727-8. 2008
  23. ncbi request reprint Treatment of type 2 diabetes mellitus in children and adolescents
    Mohammad I Zuhri-Yafi
    Department of Pediatrics, The University of Texas Medical School Houston, 77030, USA
    J Pediatr Endocrinol Metab 15:541-6. 2002
    ..To study possible treatment modalities for type 2 diabetes mellitus (T2DM) in children and adolescents...
  24. ncbi request reprint Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry
    Shawn C Burgess
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Anal Biochem 318:321-4. 2003
  25. ncbi request reprint Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee
    Thomas A Wilson
    Division of Pediatric Endocrinology, State University of New York at Stony Brook, Stony Brook, NY 11794 8111, USA
    J Pediatr 143:415-21. 2003
  26. ncbi request reprint Growth hormone treatment enhances nutrition and growth in children with cystic fibrosis receiving enteral nutrition
    Dana S Hardin
    University of Texas Southwestern Medical School, Department of Pediatrics, Dallas 75390 9063, USA
    J Pediatr 146:324-8. 2005
    ..This study evaluates the hypothesis that adjunctive growth hormone (GH) therapy augments the growth response to nutritional supplementation...
  27. ncbi request reprint A retrospective study of growth hormone use in adolescents with cystic fibrosis
    Dana S Hardin
    Department of Pediatrics, University of Texas South western Medical School, Dallas, TX 75390 9063, USA
    Clin Endocrinol (Oxf) 62:560-6. 2005
    ..Studies of growth hormone (GH) effectiveness in prepubertal children with cystic fibrosis (CF) have been published previously. We present a retrospective study of GH treatment in adolescents with CF...
  28. ncbi request reprint Growth hormone improves protein catabolism and growth in prepubertal children with HIV infection
    Dana S Hardin
    University of Texas South western Medical School, Dallas, TX, USA
    Clin Endocrinol (Oxf) 63:259-62. 2005
    ..We undertook this study to test the hypothesis that human recombinant GH would improve linear height in HIV-infected children. Our second goal was to determine if GH could reverse protein catabolism in HIV-infected children...
  29. ncbi request reprint Guide to bone health and disease in cystic fibrosis
    Robert M Aris
    CB 7020, 4131 Bioinformatics, University of North Carolina, Chapel Hill, North Carolina 27599 7524, USA
    J Clin Endocrinol Metab 90:1888-96. 2005
    ..The goal of this conference was to develop practice guidelines for optimizing bone health in patients with CF...
  30. ncbi request reprint Statement 6: patients who are unresponsive to GH therapy should be given a trial of IGF-I
    Dana S Hardin
    Division of Endocrinology, Metabolism and Diabetes, Department of Pediatrics, Columbus Children s Hospital, Ohio State University, Columbus, Ohio, USA
    Pediatr Endocrinol Rev 5:857-60. 2008
  31. ncbi request reprint Screening for type 2 diabetes in children with acanthosis nigricans
    Dana S Hardin
    Ohio State University, Columbus Children s Hospital, 700 Children s Drive, 5th Floor, Columbus, OH 43205, USA
    Diabetes Educ 32:547-52. 2006
    ..However, this has led to a large referral of children to pediatric endocrinologists. Presented is a schema for primary care physicians and school nurses to use as a guideline for referral of children with acanthosis nigricans...

Research Grants2

  1. Increased Gluconeogenesis Is One Cause of CFRD
    DANA HARDIN; Fiscal Year: 2006
    ..It is therefore expected that these studies will provide new information regarding potential causes of CF related diabetes and protein catabolism. ..