D S Hardin

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi The metabolic effects of pregnancy in cystic fibrosis
    Dana S Hardin
    University of Texas Southwestern Medical Center, Dallas, Texas 75093 9063, USA
    Obstet Gynecol 106:367-75. 2005
  2. ncbi GH improves growth and clinical status in children with cystic fibrosis -- a review of published studies
    Dana S Hardin
    University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard G2 220, Dallas, TX 75390 9063, USA
    Eur J Endocrinol 151:S81-5. 2004
  3. ncbi Protease inhibitor therapy improves protein catabolism in prepubertal children with HIV infection
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Houston 77030, USA
    J Pediatr Endocrinol Metab 17:321-5. 2004
  4. ncbi Growth hormone decreases protein catabolism in children with cystic fibrosis
    D S Hardin
    University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 86:4424-8. 2001
  5. ncbi Mechanisms of insulin resistance in cystic fibrosis
    D S Hardin
    University of Texas Southwestern Medical School, Dallas 75390, USA
    Am J Physiol Endocrinol Metab 281:E1022-8. 2001
  6. ncbi Growth hormone improves bone mineral content in children with cystic fibrosis
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Houston, TX, USA
    J Pediatr Endocrinol Metab 18:589-95. 2005
  7. ncbi Growth hormone treatment in children with cystic fibrosis
    D S Hardin
    Southwestern Medical School, University of Texas, Dallas, USA
    Minerva Pediatr 54:365-71. 2002
  8. ncbi Growth problems and growth hormone treatment in children with cystic fibrosis
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Dallas 75390 9063, USA
    J Pediatr Endocrinol Metab 15:731-5. 2002
  9. ncbi Hepatic insulin resistance and defects in substrate utilization in cystic fibrosis
    D S Hardin
    Department of Pediatrics, University of Texas, Houston, USA
    Diabetes 48:1082-7. 1999
  10. ncbi Growth hormone improves weight velocity and height velocity in prepubertal children with cystic fibrosis
    D S Hardin
    University of Texas Health Science Center, Houston 77030, USA
    Horm Metab Res 30:636-41. 1998

Research Grants

  1. Increased Gluconeogenesis Is One Cause of CFRD
    DANA HARDIN; Fiscal Year: 2006

Detail Information

Publications31

  1. ncbi The metabolic effects of pregnancy in cystic fibrosis
    Dana S Hardin
    University of Texas Southwestern Medical Center, Dallas, Texas 75093 9063, USA
    Obstet Gynecol 106:367-75. 2005
    ..Our purpose was to determine glucose tolerance in pregnant women with cystic fibrosis (CF) and to relate glucose tolerance to insulin sensitivity, hepatic glucose production, and protein turnover...
  2. ncbi GH improves growth and clinical status in children with cystic fibrosis -- a review of published studies
    Dana S Hardin
    University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard G2 220, Dallas, TX 75390 9063, USA
    Eur J Endocrinol 151:S81-5. 2004
    ..To date significant side effects, including glucose intolerance, have not been reported. Thus mounting evidence suggests that human recombinant GH provides safe and effective therapy in children with CF...
  3. ncbi Protease inhibitor therapy improves protein catabolism in prepubertal children with HIV infection
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Houston 77030, USA
    J Pediatr Endocrinol Metab 17:321-5. 2004
    ..One action of these drugs is that of lowering the viral burden, and several studies suggest that these drugs result in increased growth and weight velocity. Our second aim was to determine whether PI therapy improves protein catabolism...
  4. ncbi Growth hormone decreases protein catabolism in children with cystic fibrosis
    D S Hardin
    University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 86:4424-8. 2001
    ..The results of this study suggest that one reason GH improves body weight and lean tissue mass is due to improved whole body protein catabolism and improved efficiency of whole body protein kinetics...
  5. ncbi Mechanisms of insulin resistance in cystic fibrosis
    D S Hardin
    University of Texas Southwestern Medical School, Dallas 75390, USA
    Am J Physiol Endocrinol Metab 281:E1022-8. 2001
    ..We conclude that IGTCF patients have decreased peripheral insulin sensitivity. Mechanisms include elevation of TNF-alpha and impaired translocation of GLUT-4...
  6. ncbi Growth hormone improves bone mineral content in children with cystic fibrosis
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Houston, TX, USA
    J Pediatr Endocrinol Metab 18:589-95. 2005
    ..Our second aim was to evaluate the effect of one year of treatment with human recombinant growth hormone (GH) on total body BMC...
  7. ncbi Growth hormone treatment in children with cystic fibrosis
    D S Hardin
    Southwestern Medical School, University of Texas, Dallas, USA
    Minerva Pediatr 54:365-71. 2002
    ..The purpose of this article is to summarize studies evaluating GH use in children with CF...
  8. ncbi Growth problems and growth hormone treatment in children with cystic fibrosis
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Dallas 75390 9063, USA
    J Pediatr Endocrinol Metab 15:731-5. 2002
    ..A large multicenter trial is currently underway to assess the effect of long-term therapy with GH on the quality of life and pulmonary status...
  9. ncbi Hepatic insulin resistance and defects in substrate utilization in cystic fibrosis
    D S Hardin
    Department of Pediatrics, University of Texas, Houston, USA
    Diabetes 48:1082-7. 1999
    ..Furthermore, these results suggest that high hepatic glucose production and hepatic insulin resistance contribute to the high incidence of abnormal glucose tolerance in CF...
  10. ncbi Growth hormone improves weight velocity and height velocity in prepubertal children with cystic fibrosis
    D S Hardin
    University of Texas Health Science Center, Houston 77030, USA
    Horm Metab Res 30:636-41. 1998
    ..These results suggest that growth hormone used in prepubertal children with cystic fibrosis can improve height and weight and may improve lean body mass...
  11. ncbi Normal bone mineral density in cystic fibrosis
    D S Hardin
    Department of Pediatrics, The Feigen Center, Suite 410, 6621 Fannin, Houston, TX 77030, USA
    Arch Dis Child 84:363-8. 2001
    ..Osteoporosis has been reported as a complication of cystic fibrosis (CF)...
  12. ncbi Z score prediction model for assessment of bone mineral content in pediatric diseases
    K J Ellis
    US Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    J Bone Miner Res 16:1658-64. 2001
    ..5. These preliminary findings indicate that the prediction model should prove useful in determining potential bone mineral deficits in individual pediatric patients...
  13. ncbi Ingested IFN-alpha preserves residual beta cell function in type 1 diabetes
    S A Brod
    Department of Neurology, University of Texas Health Science Center Houston, Houston, TX 77225, USA
    J Interferon Cytokine Res 21:1021-30. 2001
    ..Our results support the potential of ingested IFN-alpha to preserve residual beta cell function in recent onset type 1 diabetes mellitus and the testing of IFN-alpha in a placebo-controlled trial...
  14. ncbi Current prescribing practices and opinions about growth hormone therapy: results of a nationwide survey of paediatric endocrinologists
    Dana S Hardin
    Ohio State University, Columbus, OH 43205, USA
    Clin Endocrinol (Oxf) 66:85-94. 2007
    ..The purpose of this study was to summarize prevailing attitudes about GH diagnosis and treatment among paediatric endocrinologists...
  15. ncbi Twenty years of recombinant human growth hormone in children: relevance to pediatric care providers
    Dana S Hardin
    Ohio State University and Columbus Children s Hospital, Columbus, OH 43205, USA
    Clin Pediatr (Phila) 46:279-86. 2007
    ....
  16. ncbi Insulin resistance in Hispanic large-for-gestational-age neonates at birth
    Jennifer Shine Dyer
    Department of Pediatrics, Division of Endocrinology, The Ohio State University, 700 Children s Drive, W322, Columbus, Ohio 43205, USA
    J Clin Endocrinol Metab 92:3836-43. 2007
    ..Although Hispanic youth have been shown to have a high prevalence of metabolic syndrome, it is unknown whether metabolic abnormalities and a predisposition for glucose intolerance are present at birth...
  17. ncbi A review of the management of two common clinical problems found in patients with cystic fibrosis: cystic fibrosis-related diabetes and poor growth
    Dana S Hardin
    Division of Pediatric Endocrinology, Columbus Children s Hospital, Ohio State University, Columbus, Ohio, USA
    Horm Res 68:113-6. 2007
    ..CONCLUSIONS: rhGH may be a useful growth-promoting therapy in children with CF...
  18. ncbi Improvement in insulin sensitivity and dyslipidemia in protease inhibitor-treated adult male patients after switch to atazanavir/ritonavir
    Anthony J Busti
    Texas Tech University Health Sciences Center School of Pharmacy, Dallas, Texas, USA
    J Investig Med 56:539-44. 2008
    ..However, its effects on insulin sensitivity have not been elucidated. We conducted this study to test the hypothesis that ATV improves insulin resistance and dyslipidemia...
  19. ncbi Elevated gluconeogenesis and lack of suppression by insulin contribute to cystic fibrosis-related diabetes
    Dana S Hardin
    Nationwide Children s Hospital, The Ohio State University, Columbus, OH 43205 2696, USA
    J Investig Med 56:567-73. 2008
    ..Gluconeogenesis correlated with protein breakdown. These studies suggest that high HGP in CF is mostly from elevated rates of GNG and that resistance to insulin's suppression of GNG may contribute to abnormal glucose tolerance in CF...
  20. ncbi Growth hormone treatment improves growth and clinical status in prepubertal children with cystic fibrosis: results of a multicenter randomized controlled trial
    Dana S Hardin
    Department of Pediatrics, University of Texas Southwestern Medical School, Texas 75390, USA
    J Clin Endocrinol Metab 91:4925-9. 2006
    ....
  21. ncbi Growth hormone normalizes pubertal onset in children with cystic fibrosis
    Mark Vanderwel
    University of Texas Southwestern Medical School, Division of Pediatric Endocrinology, Dallas, USA
    J Pediatr Endocrinol Metab 19:237-44. 2006
    ..Testicular size progression was not accelerated in pubertal boys treated with GH. CONCLUSION: GH treatment normalizes pubertal onset in prepubertal children with CF...
  22. ncbi Growth hormone in cystic fibrosis
    Dana S Hardin
    The Ohio State University, Nationwide Children's Hospital, Columbus, OH 43205, USA
    J Pediatr Endocrinol Metab 21:727-8. 2008
  23. ncbi Treatment of type 2 diabetes mellitus in children and adolescents
    Mohammad I Zuhri-Yafi
    Department of Pediatrics, The University of Texas Medical School-Houston, 77030, USA
    J Pediatr Endocrinol Metab 15:541-6. 2002
    ..Lifetime management strategies for children with T2DM will probably be as complex as those for adults...
  24. ncbi Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry
    Shawn C Burgess
    The Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235-9085, USA
    Anal Biochem 318:321-4. 2003
  25. ncbi Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee
    Thomas A Wilson
    Division of Pediatric Endocrinology, State University of New York at Stony Brook, Stony Brook, NY 11794-8111, USA
    J Pediatr 143:415-21. 2003
  26. ncbi Growth hormone treatment enhances nutrition and growth in children with cystic fibrosis receiving enteral nutrition
    Dana S Hardin
    University of Texas-Southwestern Medical School, Department of Pediatrics, Dallas 75390-9063, USA
    J Pediatr 146:324-8. 2005
    ..Caloric intake was similar in both groups during both years. CONCLUSIONS: These results suggest that GH is a useful for enhancing growth in children with cystic fibrosis receiving enteral nutritional supplementation...
  27. ncbi A retrospective study of growth hormone use in adolescents with cystic fibrosis
    Dana S Hardin
    Department of Pediatrics, University of Texas South western Medical School, Dallas, TX 75390 9063, USA
    Clin Endocrinol (Oxf) 62:560-6. 2005
    ..Studies of growth hormone (GH) effectiveness in prepubertal children with cystic fibrosis (CF) have been published previously. We present a retrospective study of GH treatment in adolescents with CF...
  28. ncbi Growth hormone improves protein catabolism and growth in prepubertal children with HIV infection
    Dana S Hardin
    University of Texas South western Medical School, Dallas, TX, USA
    Clin Endocrinol (Oxf) 63:259-62. 2005
    ..We undertook this study to test the hypothesis that human recombinant GH would improve linear height in HIV-infected children. Our second goal was to determine if GH could reverse protein catabolism in HIV-infected children...
  29. ncbi Guide to bone health and disease in cystic fibrosis
    Robert M Aris
    CB 7020, 4131 Bioinformatics, University of North Carolina, Chapel Hill, North Carolina 27599 7524, USA
    J Clin Endocrinol Metab 90:1888-96. 2005
    ..The goal of this conference was to develop practice guidelines for optimizing bone health in patients with CF...
  30. ncbi Statement 6: patients who are unresponsive to GH therapy should be given a trial of IGF-I
    Dana S Hardin
    Division of Endocrinology, Metabolism and Diabetes, Department of Pediatrics, Columbus Children's Hospital, Ohio State University, Columbus, Ohio, USA
    Pediatr Endocrinol Rev 5:857-60. 2008
  31. ncbi Screening for type 2 diabetes in children with acanthosis nigricans
    Dana S Hardin
    Ohio State University, Columbus Children s Hospital, 700 Children s Drive, 5th Floor, Columbus, OH 43205, USA
    Diabetes Educ 32:547-52. 2006
    ..However, this has led to a large referral of children to pediatric endocrinologists. Presented is a schema for primary care physicians and school nurses to use as a guideline for referral of children with acanthosis nigricans...

Research Grants2

  1. Increased Gluconeogenesis Is One Cause of CFRD
    DANA HARDIN; Fiscal Year: 2006
    ..It is therefore expected that these studies will provide new information regarding potential causes of CF related diabetes and protein catabolism. ..