Research Topics
| A Y HardanSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Corpus callosum size in autismA Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
Neurology 55:1033-6. 2000..No differences were found in the other subregions. This observation is consistent with the frontal lobe dysfunction reported in autism...- Posterior fossa magnetic resonance imaging in autismA Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 40:666-72. 2001..To determine whether the sizes and volumes of the posterior fossa structures are abnormal in non-mentally retarded autistic adolescents and adults... - Brain volume in autismA Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
J Child Neurol 16:421-4. 2001..Additional longitudinal neuroimaging and, more importantly, neuropathologic studies are warranted to provide a better understanding of the complexities underlying increased brain size in autism... - A retrospective open trial of adjunctive donepezil in children and adolescents with autistic disorderAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Child Adolesc Psychopharmacol 12:237-41. 2002..Double-blind, placebo-controlled investigations are needed to provide further evidence of the potential benefits of donepezil to patients with autistic disorder... - Retrospective study of quetiapine in children and adolescents with pervasive developmental disordersAntonio Y Hardan
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh 15213, USA
J Autism Dev Disord 35:387-91. 2005..Quetiapine may be beneficial in children and adolescents with pervasive developmental disorders, however open-label and double-blind, placebo-controlled studies are warranted... - A retrospective assessment of topiramate in children and adolescents with pervasive developmental disordersAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Child Adolesc Psychopharmacol 14:426-32. 2004..Topiramate may be beneficial for treating secondary symptoms of PDD, and prospective openlabel studies and double-blind, placebo-controlled studies to assess its efficacy and safety are needed... - Abnormal brain size effect on the thalamus in autismAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychiatry Res 147:145-51. 2006.... - Increased frontal cortical folding in autism: a preliminary MRI studyAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychiatry Res 131:263-8. 2004..These preliminary findings suggest that the gyrification patterns in autism may be abnormal, which could be related to the various cortical anomalies observed in this disorder... - Brief report: abnormal association between the thalamus and brain size in Asperger's disorderAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Autism Dev Disord 38:390-4. 2008.... - Neuropsychiatric problems in tuberous sclerosis complexMiya R Asato
Laboratory of Neurocognitive Development, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Child Neurol 19:241-9. 2004..Treatment of neuropsychiatric symptoms, including autism-like features, attention deficits, and sleep disorders, is also discussed... - Anatomic evaluation of the orbitofrontal cortex in major depressive disorderAcioly L T Lacerda
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Biol Psychiatry 55:353-8. 2004..Future studies examining the relationship between specific symptomatic dimensions of MDD and OFC volumes could be especially informative... - Measurement of the orbitofrontal cortex: a validation study of a new methodAcioly L T Lacerda
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Neuroimage 19:665-73. 2003..996 and 0.998. This method appears to be a valid method for measuring the OFC with excellent reliability. This uncomplicated approach is easy to apply and has the potential to be a valuable alternative to the previously published methods... 
An MRI and proton spectroscopy study of the thalamus in children with autismAntonio Y Hardan
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
Psychiatry Res 163:97-105. 2008..Further investigations of this structure are warranted, since it plays an important role in information processing as part of the cortico-thalamo-cortical pathways...- Morphology of the orbitofrontal cortex in first-episode schizophrenia: relationship with negative symptomatologyAcioly L T Lacerda
Interdisciplinary Lab of Neuroimaging and Cognition LiNC, Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 31:510-6. 2007..Future follow-up studies examining high-risk individuals who subsequently develop schizophrenia at different stages of disease could be especially instructive... - Magnetic resonance imaging study of the orbitofrontal cortex in autismAntonio Y Hardan
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA
J Child Neurol 21:866-71. 2006..The present study suggests the absence of global volumetric abnormalities in the orbitofrontal cortex in autism and indicates that the functional disturbances in this structure might not be related to anatomic alterations... - Open-label, prospective trial of olanzapine in adolescents with subaverage intelligence and disruptive behavioral disordersBenjamin L Handen
University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic, Pittsburgh, PA 15203, USA
J Am Acad Child Adolesc Psychiatry 45:928-35. 2006..However, side effects, especially weight gain, are a significant issue. Future double-blind, placebo-controlled studies need to confirm these findings and assess long-term safety and outcome of olanzapine treatment... - Volumetric alterations of the orbitofrontal cortex in autismRagy R Girgis
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, NY, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:41-5. 2007..These findings support the role of OFC in autism and warrant further investigations of this structure using structural and functional methodologies... - An MRI study of increased cortical thickness in autismAntonio Y Hardan
Stanford University, Department of Psychiatry and Behavioral Sciences, 401 Quarry Rd, Stanford, CA 94305, USA
Am J Psychiatry 163:1290-2. 2006..The purpose of this study was to examine cortical thickness in autism in light of the postmortem evidence of cortical abnormalities of the disorder... - An MRI study of minor physical anomalies in autismAntonio Y Hardan
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Autism Dev Disord 36:607-11. 2006..Hypotelorism is a MPA that may be present in a subgroup of individuals with autism. Additional research is warranted using large sample sizes with a wide range of intellectual functioning... - Risperidone in first-episode psychosis: a longitudinal, exploratory voxel-based morphometric studyRagy R Girgis
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
Schizophr Res 82:89-94. 2006..No areas of change were found in controls. The results of this exploratory investigation support the possibility that risperidone has short-term effects on brain parenchyma in individuals with first-episode psychosis... - Retrospective assessment of atomoxetine in children and adolescents with pervasive developmental disordersRoger J Jou
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
J Child Adolesc Psychopharmacol 15:325-30. 2005..Atomoxetine may be beneficial for treating secondary symptoms of PDD, and prospective open-label or double-blind, placebo-controlled studies are needed to assess its efficacy and safety... - Reduced cortical folding in individuals at high risk for schizophrenia: a pilot studyRoger J Jou
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Schizophr Res 75:309-13. 2005..The left GI was lower in HR when compared to controls, but no difference in the right GI was observed. These results are consistent with studies of affected individuals, supporting genetic and neurodevelopmental models of schizophrenia... - The functional neuroanatomy of autismPaolo Brambilla
Biological Psychiatry Unit, IRCCS S Giovanni di Dio, Fatebenefratelli, Brescia, Italy
Funct Neurol 19:9-17. 2004..Such studies will be instrumental in furthering understanding of the pathophysiology of autism and in exploring the importance of dimensional measures of the broader phenotype currently defined as autism... - Motor performance and anatomic magnetic resonance imaging (MRI) of the basal ganglia in autismAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Child Neurol 18:317-24. 2003.... 
Guanfacine in children with autism and/or intellectual disabilitiesBenjamin L Handen
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Dev Behav Pediatr 29:303-8. 2008..In addition, evidence suggests that children with developmental disabilities experience higher rates of adverse events. Guanfacine, an alpha2-adrenergic receptor agonist, has shown some promise as an alternative to psychostimulants...