Brian G Harbrecht

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. doi request reprint Statewide experience with Clostridium difficile colitis in academic and non-academic medical centers
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, Kentucky, USA
    Surg Infect (Larchmt) 13:88-92. 2012
  2. ncbi request reprint Defining the contribution of renal dysfunction to outcome after traumatic injury
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    Am Surg 73:836-40. 2007
  3. ncbi request reprint Is splenectomy after trauma an endangered species?
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    Am Surg 74:410-2. 2008
  4. pmc Assessment of transcutaneous bilirubinometry in hospitalized adults
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    J Am Coll Surg 206:1129-36. 2008
  5. ncbi request reprint Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core-standard operating procedures for clinical care: VI. Blood glucose control in the critically ill trauma patient
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, Kentucky, USA
    J Trauma 63:703-8. 2007
  6. ncbi request reprint Decreasing regional neurosurgical workforce-a blueprint for disaster
    Brian G Harbrecht
    Department of Surgery, University of Louisville, 550 S Jackson Street, Louisville, KY 40292, USA
    J Trauma 68:1367-72; discussion 1372-4. 2010
  7. pmc Insulin inhibits hepatocyte iNOS expression induced by cytokines by an Akt-dependent mechanism
    Brian G Harbrecht
    Department of Surgery and Price Institute for Surgical Research, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Am J Physiol Gastrointest Liver Physiol 302:G116-22. 2012
  8. ncbi request reprint Improved outcomes with routine respiratory therapist evaluation of non-intensive-care-unit surgery patients
    Brian G Harbrecht
    Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Respir Care 54:861-7. 2009
  9. doi request reprint Acute appendicitis--not just for the young
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, KY, USA
    Am J Surg 202:286-90. 2011
  10. ncbi request reprint Angiography for blunt splenic trauma does not improve the success rate of nonoperative management
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    J Trauma 63:44-9. 2007

Detail Information

Publications73

  1. doi request reprint Statewide experience with Clostridium difficile colitis in academic and non-academic medical centers
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, Kentucky, USA
    Surg Infect (Larchmt) 13:88-92. 2012
    ..However, most information on C. difficile colitis is from large tertiary-care medical centers. Whether the community hospital experience is similar to that of large referral centers is unknown...
  2. ncbi request reprint Defining the contribution of renal dysfunction to outcome after traumatic injury
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    Am Surg 73:836-40. 2007
    ..0 mg/dL is associated with a significantly increased likelihood of death in injured patients and is a stronger predictor than other common indicators of renal impairment...
  3. ncbi request reprint Is splenectomy after trauma an endangered species?
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    Am Surg 74:410-2. 2008
    ..As laparoscopic techniques for elective splenectomy become more common, the changing indication for splenectomy has important ramifications for surgical education and training...
  4. pmc Assessment of transcutaneous bilirubinometry in hospitalized adults
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    J Am Coll Surg 206:1129-36. 2008
    ..We evaluated transcutaneous bilirubinometry (TcB) in adults at risk for or diagnosed with hepatic dysfunction to determine if this technology has clinical use in quantifying the presence and magnitude of hyperbilirubinemia...
  5. ncbi request reprint Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core-standard operating procedures for clinical care: VI. Blood glucose control in the critically ill trauma patient
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, Kentucky, USA
    J Trauma 63:703-8. 2007
  6. ncbi request reprint Decreasing regional neurosurgical workforce-a blueprint for disaster
    Brian G Harbrecht
    Department of Surgery, University of Louisville, 550 S Jackson Street, Louisville, KY 40292, USA
    J Trauma 68:1367-72; discussion 1372-4. 2010
    ..Although many institutions have been individually affected by shortages of NS providing care to injured patients, data on regional changes in NS availability and the effect on patient care are limited...
  7. pmc Insulin inhibits hepatocyte iNOS expression induced by cytokines by an Akt-dependent mechanism
    Brian G Harbrecht
    Department of Surgery and Price Institute for Surgical Research, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Am J Physiol Gastrointest Liver Physiol 302:G116-22. 2012
    ..Our data demonstrate that insulin inhibits cytokine-stimulated hepatocyte iNOS expression and does so through effects on Akt-mediated signaling...
  8. ncbi request reprint Improved outcomes with routine respiratory therapist evaluation of non-intensive-care-unit surgery patients
    Brian G Harbrecht
    Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Respir Care 54:861-7. 2009
    ..Respiratory therapist (RT) driven protocols decrease ventilator days and resource utilization in the intensive care unit (ICU). Protocols have been studied in non-ICU settings, but their effect on mortality has been incompletely studied...
  9. doi request reprint Acute appendicitis--not just for the young
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, KY, USA
    Am J Surg 202:286-90. 2011
    ..The authors evaluated a statewide experience to assess the effect of age on resource utilization and outcomes for this common disease...
  10. ncbi request reprint Angiography for blunt splenic trauma does not improve the success rate of nonoperative management
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    J Trauma 63:44-9. 2007
    ..Previous reports, however, have compared SAE with historical controls. We compared nonoperative success with SAE with a contemporaneous group treated nonoperatively without SAE...
  11. ncbi request reprint Management differences for pediatric solid organ injuries in a rural state
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, Kentucky, USA
    Am Surg 75:725-9. 2009
    ..In Kentucky, pediatric solid organ injuries are usually managed nonoperatively in both trauma and nontrauma centers, but trauma centers cared for fewer isolated solid organ injuries...
  12. ncbi request reprint Hypothermia in massive transfusion: have we been paying enough attention to it?
    Benjamin R Reynolds
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 73:486-91. 2012
    ..We sought to characterize the importance of temperature as a risk factor for poor outcome relative to the changes in MT resuscitation that have occurred...
  13. ncbi request reprint Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patients
    Michael A West
    Department of Surgery, University of California, San Francisco, San Francisco, California 94110, USA
    J Trauma 65:1511-9. 2008
    ..It should also be noted that not all patients with increased temperature/WBC have an infection. Discontinuation of antibiotics is appropriate if cultures and other diagnostic studies are negative...
  14. doi request reprint Male gender is associated with excessive IL-6 expression following severe injury
    Jason L Sperry
    Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma 64:572-8; discussion 578-9. 2008
    ....
  15. ncbi request reprint Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock
    Christian Hierholzer
    Department of Surgery, University of Pittsburgh Medical Center, F1264 200 Lothrop St, Pittsburgh, PA 15213, USA
    Am J Physiol Gastrointest Liver Physiol 286:G225-33. 2004
    ....
  16. doi request reprint Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjury
    Rebecca D Edmonds
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 70:292-8. 2011
    ..We sought to avoid the confounding effects attributable to obesity and determine the association of BMI and outcomes following injury in nonobese patients...
  17. doi request reprint Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome
    Gregory A Watson
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:221-7; discussion 228-30. 2009
    ..We hypothesized that plasma-rich transfusion components would be independently associated with a lower risk of mortality but result in a greater risk of morbid complications...
  18. pmc Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long way
    Matthew D Neal
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 72:892-8. 2012
    ..We hypothesized that an increased crystalloid:PRBC (C:PRBC) ratio would be associated with increased morbidity and poor outcome after MT...
  19. doi request reprint Inflammation and the host response to injury a large-scale collaborative project: patient-oriented research core standard operating procedure for clinical care X. Guidelines for venous thromboembolism prophylaxis in the trauma patient
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    J Trauma 65:944-50. 2008
  20. ncbi request reprint V. Guidelines for sedation and analgesia during mechanical ventilation general overview
    Michael B Shapiro
    Department of Surgery, Northwestern University, Chicago, Illinois, USA
    J Trauma 63:945-50. 2007
  21. ncbi request reprint Inflammation and the host response to injury, a large-scale collaborative project: Patient-oriented research core-standard operating procedures for clinical care. IV. Guidelines for transfusion in the trauma patient
    Michael A West
    Department of Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Trauma 61:436-9. 2006
  22. ncbi request reprint Failure of observation of blunt splenic injury in adults: variability in practice and adverse consequences
    Andrew B Peitzman
    Department of Surgery, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
    J Am Coll Surg 201:179-87. 2005
    ..The purpose of this multiinstitutional study by the Eastern Association for the Surgery of Trauma was to determine common variables in failure of nonoperative management of blunt splenic injury in adults...
  23. pmc Activation of a cyclic amp-guanine exchange factor in hepatocytes decreases nitric oxide synthase expression
    Baochun Zhang
    Department of Surgery and Price Institute of Surgical Research, University of Louisville, Louisville, KY, USA
    Shock 39:70-6. 2013
    ..We conclude that Epac regulates hepatocyte iNOS expression through an Akt- and JNK-mediated signaling mechanism...
  24. ncbi request reprint Prevention of bile peritonitis by laparoscopic evacuation and lavage after nonoperative treatment of liver injuries
    Glen A Franklin
    Department of Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    Am Surg 73:611-6; discussion 616-7. 2007
    ..Delayed laparoscopic evacuation of these collections prevents bile peritonitis and decreases inflammatory response and avoiding early operation, which has been implicated in increased death from hemorrhage...
  25. ncbi request reprint Inflammation and the Host Response to Injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care. III. Guidelines for shock resuscitation
    Frederick A Moore
    Department of Surgery, University of Texas at Houston, 77030, USA
    J Trauma 61:82-9. 2006
  26. ncbi request reprint Evaluation of a 15-year experience with splenic injuries in a state trauma system
    Brian G Harbrecht
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Surgery 141:229-38. 2007
    ..We hypothesized that outcomes for patients with splenic injuries have improved as the paradigm for splenic injury treatment has shifted...
  27. ncbi request reprint Nonoperative management of severe blunt splenic injury: are we getting better?
    Gregory A Watson
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 61:1113-8; discussion 1118-9. 2006
    ..The infrequency of these injuries has made evaluation of factors critical to their management difficult...
  28. ncbi request reprint Management of adult blunt splenic injuries: comparison between level I and level II trauma centers
    Brian G Harbrecht
    Department of Surgery, University of Pittsburgh Medical Center, F1264 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Am Coll Surg 198:232-9. 2004
    ..The factors important in determining outcome when managing adult blunt splenic injuries continue to be debated. Whether trauma center level designation (Level I versus Level II) affects patient management has not been evaluated...
  29. ncbi request reprint Interhospital transfer of blunt multiply injured patients to a level 1 trauma center does not adversely affect outcome
    Adrian T Billeter
    Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Am J Surg 207:459-66. 2014
    ..Stops at nontrauma centers for severely injured patients are thought to increase deaths and costs, potentially because of unnecessary imaging and indecisive/delayed care of traumatic brain injuries (TBIs)...
  30. ncbi request reprint Inflammation and the Host Response to Injury, a Large-Scale Collaborative Project: patient-oriented research core--standard operating procedures for clinical care. II. Guidelines for prevention, diagnosis and treatment of ventilator-associated pneumonia (
    Joseph P Minei
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9158, USA
    J Trauma 60:1106-13; discussion 1113. 2006
  31. ncbi request reprint Use of computed tomography findings and contrast extravasation in predicting the need for embolization with pelvic fractures
    Matthew C Bozeman
    Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Am Surg 78:825-30. 2012
    ..The presence of contrast extravasation is highly associated with the need for pelvic embolization in patients with pelvic fractures, but its absence does not exclude the need for pelvic angiography...
  32. ncbi request reprint Blunt liver injury in children and adults: is there really a difference?
    W Patrick Klapheke
    Department of Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    Am Surg 74:798-801. 2008
    ..A higher rate of liver-related mortality was seen in the PED population. Overall, PED patients seemed to sustain fewer liver related complications necessitating invasive procedures despite similar injury patterns...
  33. ncbi request reprint Hepatic dysfunction increases length of stay and risk of death after injury
    Brian G Harbrecht
    Department of Surgery, University of Pittsburgh, Pennsylvania, USA
    J Trauma 53:517-23. 2002
    ..The relative importance of dysfunction or failure of different organ systems to recovery from critical illness is unclear. The purpose of this study was to evaluate the contribution of hepatic dysfunction to outcome after injury...
  34. ncbi request reprint Glucagon regulates hepatic inducible nitric oxide synthesis in vivo
    Brian G Harbrecht
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Shock 22:157-62. 2004
    ..These data suggest that glucagon may participate in the in vivo regulation of hepatic iNOS expression after proinflammatory stimuli...
  35. ncbi request reprint JNK signaling involved in the effects of cyclic AMP on IL-1beta plus IFNgamma-induced inducible nitric oxide synthase expression in hepatocytes
    Baochun Zhang
    Department of Surgery, University of Pittsburgh Medical Center, 3459 Fifth Ave, NW607, MUH, Pittsburgh, PA 15213, USA
    Cell Signal 16:837-46. 2004
    ..We conclude that JNK signaling plays an important role in the inhibitory effects of cAMP on IL-1beta+IFNgamma-induced iNOS gene expression in cultured hepatocytes...
  36. pmc Early blood product and crystalloid volume resuscitation: risk association with multiple organ dysfunction after severe blunt traumatic injury
    Scott C Brakenridge
    Department of Surgery, Division of Burn Trauma Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9158, USA
    J Trauma 71:299-305. 2011
    ..We sought to further delineate the relevance of the major individual components of early volume resuscitation to onset of MOD after severe blunt traumatic injury...
  37. ncbi request reprint Is outcome after blunt splenic injury in adults better in high-volume trauma centers?
    Brian G Harbrecht
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am Surg 71:942-8; discussion 948-9. 2005
    ..These data suggest that ACS criteria for trauma centers level designation are not associated with differences in outcome in the treatment of adult blunt splenic injuries in this regional trauma system...
  38. ncbi request reprint Flail chest injury: are we making any progress?
    Robert M Cannon
    Department of Surgery, University of Louisville, Louisville, Kentucky, USA
    Am Surg 78:398-402. 2012
    ..0001) and intensive care unit length of stay (P < 0.0001). The mortality associated with flail chest has greatly improved; however, the rate of pneumonia remains high. Further efforts at pneumonia prevention are thus warranted...
  39. pmc Changes in massive transfusion over time: an early shift in the right direction?
    Benjamin C Kautza
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 72:106-11. 2012
    ..We sought to characterize changes in resuscitation which have occurred over time in a cohort severely injured patients requiring MT...
  40. pmc Direct peritoneal resuscitation accelerates primary abdominal wall closure after damage control surgery
    Jason W Smith
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    J Am Coll Surg 210:658-64, 664-7. 2010
    ....
  41. pmc Akt-mediated signaling is induced by cytokines and cyclic adenosine monophosphate and suppresses hepatocyte inducible nitric oxide synthase expression independent of MAPK P44/42
    Baochun Zhang
    University of Louisville, Department of Surgery, Louisville, KY 40292, USA
    Biochim Biophys Acta 1813:73-9. 2011
    ..These data demonstrate that dbcAMP regulates hepatocyte iNOS expression through an Akt-mediated signaling mechanism that is independent of MAPK P44/42...
  42. ncbi request reprint A brief episode of hypotension increases mortality in critically ill trauma patients
    Mazen S Zenati
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Trauma 53:232-6; discussion 236-7. 2002
    ..Hypotension is associated with increased mortality, however previous studies have failed to account for the depth and duration of hypotension. We evaluated the effect of the duration of hypotension on outcome in injured patients...
  43. ncbi request reprint Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patients
    Matthew J Sena
    Department of Surgery, University of California Davis Medical Center, Sacramento, CA, USA
    J Am Coll Surg 207:459-67. 2008
    ..The purpose of this study is to determine whether early administration of parenteral nutrition is associated with an increased risk for infection after severe injury...
  44. ncbi request reprint Increased interactive format for Morbidity & Mortality conference improves educational value and enhances confidence
    Jose M Prince
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Surg Educ 64:266-72. 2007
    ..We analyzed which features of M&M case reviews are associated with greater perceived educational value and enhanced confidence to deal with similar future clinical scenarios...
  45. pmc 17β-Estradiol attenuates cytokine-induced nitric oxide production in rat hepatocyte
    Ikenna C Nweze
    Department of Surgery and Price Institute of Surgical Research, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    J Trauma Acute Care Surg 73:408-12. 2012
    ..Estrogen improves organ function and outcome after shock and sepsis, but the mechanism is unknown. We hypothesized that 17β-estradiol would improve organ function by regulating the production of hepatocyte NO...
  46. ncbi request reprint Impact of hollow viscus injuries on outcome of abdominal gunshot wounds
    Brady T Harris
    Department of Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    Am Surg 75:378-84. 2009
    ..Primary repair of HVI is preferred although no survival disadvantage is seen in other forms of repair in marginally stable patients. Definitive repair at the initial operation decreases complications...
  47. pmc Cyclic AMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB translocation in hepatocytes by a PKA independent mechanism
    Guiying Hong
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Surg Res 159:565-71. 2010
    ..We demonstrated that cAMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB binding due to its blockade of the upstream signal(s) leading to IkappaB phosphorylation and degradation, and is mediated by PKA-independent signaling pathways...
  48. ncbi request reprint Early VATS for blunt chest trauma: a management technique underutilized by acute care surgeons
    Jason W Smith
    Department of Surgery, University of Louisville, Louisville, KY, USA
    J Trauma 71:102-5; discussion 105-7. 2011
    ..Our acute care surgeon (ACS) group aggressively treats complications of penetrating chest trauma with VATS, and our results suggested that the early use of VATS by ACS should be expanded...
  49. ncbi request reprint Inflammation and the Host Response to Injury, a large-scale collaborative project: Patient-Oriented Research Core--standard operating procedures for clinical care. I. Guidelines for mechanical ventilation of the trauma patient
    Avery B Nathens
    Department of Surgery, University of Washington, Seattle, Washington, USA
    J Trauma 59:764-9. 2005
  50. ncbi request reprint Optimization of donor management goals yields increased organ use
    Glen A Franklin
    Department of Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Am Surg 76:587-94. 2010
    ..Surprisingly, not all standard goals are necessary for optimal organ use. The most significant parameters were the low use of vasopressor agents and oxygenation. Donor management strategies should strive to optimize these goals...
  51. ncbi request reprint Cytochrome P-450 activity is differentially altered in severely injured patients
    Brian G Harbrecht
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 33:541-6. 2005
    ..To assess whether changes in cytochrome P-450 (CYP) activity of specific CYP enzymes occur in severely injured patients and to assess changes in CYP activity during recovery...
  52. ncbi request reprint Cytokines increase CRE binding but decrease CRE-mediated reporter activity in rat hepatocytes by increasing c-Jun
    Baochun Zhang
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 39:1343-52. 2004
    ....
  53. doi request reprint Traumatic injury may be a predisposing factor for cerebrovascular accident
    Jodi B Wojcik
    Trauma Institute, University of Louisville Hospital, Louisville, Kentucky 40202, USA
    J Trauma Nurs 20:139-43; quiz 144-5. 2013
    ..Several statistically significant differences between the groups were identified. On the basis of these results, trauma appears to be an independent, nonmodifiable risk factor for CVA. ..
  54. pmc Glucose control and its implications for the general surgeon
    Maya Leggett
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    Am Surg 75:1031-5. 2009
    ....
  55. ncbi request reprint Closed midshaft femur fractures: are they only for trauma centers?
    Nicholas Ryan
    Department of Surgery, Office of Medical Education, University of Louisville, Louisville, Kentucky, USA
    Am Surg 77:476-9. 2011
    ..9%, TCs vs NTCs, P = 0.62). Although differences in patient populations exist between TCs and NTCs, both TCs and NTCs manage substantial numbers of patients with closed, midshaft femur fractures with low mortality in this state database...
  56. ncbi request reprint Successful endovascular repair of a ruptured aortic pseudoaneurysm after swallowing sulfuric acid
    Vishal Bansal
    Department of Surgery, University Presbyterian Hospital, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 65:470-2. 2008
  57. doi request reprint Socioeconomic disparities in the operative management of peptic ulcer disease
    Jason W Smith
    Hiram C Polk Department of Surgery, University of Louisville School of Medicine, Louisville, KY Electronic address
    Surgery 154:672-8; discussion 678-9. 2013
    ..We hypothesized that differences in frequency of PUD operation may occur in hospitals that serve different patient populations. The purpose of this study was to evaluate our experience with PUD and compare it with national trends...
  58. ncbi request reprint Cyclic AMP regulate adenovirus mediated inducible nitric oxide synthase expression and CMV promoter activity in cultured hepatocytes
    Baochun Zhang
    Department of Surgery, University of Pittsburgh Medical Center, 3459 Fifth Avenue NW607, MUH, Pittsburgh, PA 15213, USA
    Nitric Oxide 8:262-5. 2003
    ..We concluded that dbcAMP can regulate adenovirus-mediated human iNOS expression in primary hepatocytes by the mechanisms regulating the CMV promoter used in the adenovirus vector...
  59. ncbi request reprint Therapeutic use of nitric oxide scavengers in shock and sepsis
    Brian G Harbrecht
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Curr Pharm Des 12:3543-9. 2006
    ..The relevant biology of NO in these disease states is presented and the therapeutic potential of NO scavengers in clinical care is explored...
  60. ncbi request reprint Interactions between fatty acids and arginine metabolism: implications for the design of immune-enhancing diets
    Vishal Bansal
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    JPEN J Parenter Enteral Nutr 29:S75-80. 2005
    ..This study examines whether omega-3 fatty acids alter the metabolic fate of arginine. Thus, we hypothesized there could be differential effects of varying prostaglandins on regulation of arginase...
  61. ncbi request reprint A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock
    Christian Hierholzer
    Department of Surgery, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Shock 17:98-103. 2002
    ..These data indicate that NOX prevents lung injury in this HS model, possibly through downmodulation of proinflammatory signaling and the shock-induced inflammatory response...
  62. doi request reprint The evolving management of venous bullet emboli: a case series and literature review
    Keith R Miller
    University of Louisville, Department of Surgery, Louisville, KY 40292, United States
    Injury 42:441-6. 2011
    ..Review of the literature focusing on the reported management of these injuries, comparison of techniques of management, as well as the evolving role of endovascular techniques in the management of bullet emboli is provided...
  63. doi request reprint Bcl-xL prevents staurosporine-induced hepatocyte apoptosis by restoring protein kinase B/mitogen-activated protein kinase activity and mitochondria integrity
    Yinna Wang
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Cell Physiol 215:676-83. 2008
    ..Our data suggest that Bcl-x(L) prevents staurosporine-induced hepatocyte apoptosis by modulating protein kinase B and p44/42 mitogen-activated protein kinase activity and disrupts mitochondria death signaling...
  64. pmc Carbohydrate provision in the era of tight glucose control
    Keith R Miller
    Department of Surgery, University of Louisville, Louisville, KY 40202, USA
    Curr Gastroenterol Rep 13:388-94. 2011
    ..Achieving realistic goals in both carbohydrate provision and glycemic control may improve patient outcome, and are not mutually exclusive practices...
  65. ncbi request reprint The modulation of hepatic injury and heat shock expression by inhibition of inducible nitric oxide synthase after hemorrhagic shock
    John M Menezes
    Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA
    Shock 17:13-8. 2002
    ..We conclude that excessive NO production from iNOS contributes to shock-induced hepatic injury. Our data suggest HSP expression may reflect the degree of ischemic injury after hemorrhage...
  66. pmc Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications
    Ramsey M Dallal
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Ann Surg 235:363-72. 2002
    ..To review the epidemiology and characteristics of patients who died or underwent colectomy secondary to fulminant Clostridium difficile colitis...
  67. ncbi request reprint Nonoperative management of blunt splenic trauma in the elderly: does age play a role?
    Kris Siriratsivawong
    Department of General Surgery, Naval Medical Center San Diego, San Diego, California 92134 5000, USA
    Am Surg 73:585-9; discussion 590. 2007
    ..Mortality was high regardless of management, and failure of NOM in older patients is associated with significantly longer hospital and ICU LOS...
  68. ncbi request reprint Control of glucose after injury
    Brian G Harbrecht
    Am Surg 74:199-200. 2008
  69. ncbi request reprint Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients
    Aman Russom
    Surgical Services and Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, Boston, MA, USA
    Clin Chem 54:891-900. 2008
    ..Here, we report the clinical validation of a novel microfluidic leukocyte nucleic acid isolation technique for gene expression analysis from critically ill, hospitalized patients that can be readily used on small volumes of blood...
  70. doi request reprint Early use of vasopressors after injury: caution before constriction
    Jason L Sperry
    Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 64:9-14. 2008
    ..We sought to characterize early vasopressor (EV) use and aggressive early crystalloid resuscitation (ECR) and their association with mortality in severely injured patients...
  71. ncbi request reprint Is anything new in adult blunt splenic trauma?
    Brian G Harbrecht
    UPMC Presbyterian Hospital, F1264 200 Lothrop St, Pittsburgh, PA 15213, USA
    Am J Surg 190:273-8. 2005
    ..Recent refinements in the management of adult blunt splenic injuries will be reviewed...
  72. pmc Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock
    Runkuan Yang
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, PA 15621, USA
    Mol Med 12:105-14. 2006
    ..These data support the notion that HMGB1 is a mediator of HS/R-induced gut barrier dysfunction and suggest that anti-HMGB1 antibodies warrant further evaluation as a therapeutic to ameliorate the morbidity of HS/R in trauma patients...
  73. ncbi request reprint The practice of venous thromboembolism prophylaxis in the major trauma patient
    Avery B Nathens
    Department of Surgery, Univeristy of Toronto, Canada
    J Trauma 62:557-62; discussion 562-3. 2007
    ..As the effect of delays in the initiation of prophylaxis on VTE rates is unknown, we set out to evaluate the relationship between late initiation of prophylaxis and VTE...

Research Grants8

  1. GLUCAGON AND HEPATIC GENE EXPRESSION IN SURGICAL SEPSIS
    Brian Harbrecht; Fiscal Year: 2001
    ..These insights will contribute to uncovering the basic cellular mechanisms involved in multiple organ dysfunction and may lead to potential therapeutic approaches. ..
  2. GLUCAGON AND HEPATIC GENE EXPRESSION IN SURGICAL SEPSIS
    Brian Harbrecht; Fiscal Year: 2002
    ..These insights will contribute to uncovering the basic cellular mechanisms involved in multiple organ dysfunction and may lead to potential therapeutic approaches. ..
  3. GLUCAGON AND HEPATIC GENE EXPRESSION IN SURGICAL SEPSIS
    Brian Harbrecht; Fiscal Year: 2003
    ..These insights will contribute to uncovering the basic cellular mechanisms involved in multiple organ dysfunction and may lead to potential therapeutic approaches. ..
  4. GLUCAGON AND HEPATIC GENE EXPRESSION IN SURGICAL SEPSIS
    Brian Harbrecht; Fiscal Year: 2004
    ..These insights will contribute to uncovering the basic cellular mechanisms involved in multiple organ dysfunction and may lead to potential therapeutic approaches. ..
  5. GLUCAGON AND HEPATIC GENE EXPRESSION IN SURGICAL SEPSIS
    Brian Harbrecht; Fiscal Year: 2005
    ..These insights will contribute to uncovering the basic cellular mechanisms involved in multiple organ dysfunction and may lead to potential therapeutic approaches. ..
  6. Hepatocyte Nitric Oxide Synthase Regulation by Glucagon and Insulin
    Brian Harbrecht; Fiscal Year: 2007
    ..By defining these mechanisms, we will provide a framework for understanding the basic cellular events in shock and sepsis, which may lead to novel cellular-based therapies for critically ill patients. ..
  7. Hepatocyte Nitric Oxide Synthase Regulation by Glucagon and Insulin
    Brian Harbrecht; Fiscal Year: 2009
    ..By defining these mechanisms, we will provide a framework for understanding the basic cellular events in shock and sepsis, which may lead to novel cellular-based therapies for critically ill patients. ..
  8. Hepatocyte Nitric Oxide Synthase Regulation by Glucagon and Insulin
    Brian G Harbrecht; Fiscal Year: 2010
    ..By defining these mechanisms, we will provide a framework for understanding the basic cellular events in shock and sepsis, which may lead to novel cellular-based therapies for critically ill patients. ..