Research Topics
Genomes and Genes | Brian G HarbrechtSummaryAffiliation: University of Louisville Country: USA Publications
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Publications
Statewide experience with Clostridium difficile colitis in academic and non-academic medical centersBrian G Harbrecht
Department of Surgery, University of Louisville, Louisville, Kentucky, USA
Surg Infect (Larchmt) 13:88-92. 2012..However, most information on C. difficile colitis is from large tertiary-care medical centers. Whether the community hospital experience is similar to that of large referral centers is unknown...
Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core-standard operating procedures for clinical care: VI. Blood glucose control in the critically ill trauma patientBrian G Harbrecht
Department of Surgery, University of Louisville, Louisville, Kentucky, USA
J Trauma 63:703-8. 2007
Assessment of transcutaneous bilirubinometry in hospitalized adultsBrian G Harbrecht
Department of Surgery, University of Louisville, Louisville, KY 40292, USA
J Am Coll Surg 206:1129-36. 2008..We evaluated transcutaneous bilirubinometry (TcB) in adults at risk for or diagnosed with hepatic dysfunction to determine if this technology has clinical use in quantifying the presence and magnitude of hyperbilirubinemia...- Defining the contribution of renal dysfunction to outcome after traumatic injuryBrian G Harbrecht
Department of Surgery, University of Louisville, Louisville, Kentucky 40292, USA
Am Surg 73:836-40. 2007..0 mg/dL is associated with a significantly increased likelihood of death in injured patients and is a stronger predictor than other common indicators of renal impairment... - Angiography for blunt splenic trauma does not improve the success rate of nonoperative managementBrian G Harbrecht
Department of Surgery, University of Louisville, Louisville, KY 40292, USA
J Trauma 63:44-9. 2007..Previous reports, however, have compared SAE with historical controls. We compared nonoperative success with SAE with a contemporaneous group treated nonoperatively without SAE... - Improved outcomes with routine respiratory therapist evaluation of non-intensive-care-unit surgery patientsBrian G Harbrecht
Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA
Respir Care 54:861-7. 2009..Respiratory therapist (RT) driven protocols decrease ventilator days and resource utilization in the intensive care unit (ICU). Protocols have been studied in non-ICU settings, but their effect on mortality has been incompletely studied... - Management differences for pediatric solid organ injuries in a rural stateBrian G Harbrecht
Department of Surgery, University of Louisville, Louisville, Kentucky, USA
Am Surg 75:725-9. 2009..In Kentucky, pediatric solid organ injuries are usually managed nonoperatively in both trauma and nontrauma centers, but trauma centers cared for fewer isolated solid organ injuries... - Decreasing regional neurosurgical workforce-a blueprint for disasterBrian G Harbrecht
Department of Surgery, University of Louisville, 550 S Jackson Street, Louisville, KY 40292, USA
J Trauma 68:1367-72; discussion 1372-4. 2010..Although many institutions have been individually affected by shortages of NS providing care to injured patients, data on regional changes in NS availability and the effect on patient care are limited... - Acute appendicitis--not just for the youngBrian G Harbrecht
Department of Surgery, University of Louisville, Louisville, KY, USA
Am J Surg 202:286-90. 2011..The authors evaluated a statewide experience to assess the effect of age on resource utilization and outcomes for this common disease... - Is splenectomy after trauma an endangered species?Brian G Harbrecht
Department of Surgery, University of Louisville, Louisville, Kentucky 40292, USA
Am Surg 74:410-2. 2008..As laparoscopic techniques for elective splenectomy become more common, the changing indication for splenectomy has important ramifications for surgical education and training... - Insulin inhibits hepatocyte iNOS expression induced by cytokines by an Akt-dependent mechanismBrian G Harbrecht
Department of Surgery and Price Institute for Surgical Research, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Am J Physiol Gastrointest Liver Physiol 302:G116-22. 2012..Our data demonstrate that insulin inhibits cytokine-stimulated hepatocyte iNOS expression and does so through effects on Akt-mediated signaling... - Hypothermia in massive transfusion: have we been paying enough attention to it?Benjamin R Reynolds
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma Acute Care Surg 73:486-91. 2012..We sought to characterize the importance of temperature as a risk factor for poor outcome relative to the changes in MT resuscitation that have occurred... - Male gender is associated with excessive IL-6 expression following severe injuryJason L Sperry
Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Trauma 64:572-8; discussion 578-9. 2008.... - Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patientsMichael A West
Department of Surgery, University of California, San Francisco, San Francisco, California 94110, USA
J Trauma 65:1511-9. 2008..It should also be noted that not all patients with increased temperature/WBC have an infection. Discontinuation of antibiotics is appropriate if cultures and other diagnostic studies are negative... - Induced nitric oxide promotes intestinal inflammation following hemorrhagic shockChristian Hierholzer
Department of Surgery, University of Pittsburgh Medical Center, F1264-200 Lothrop St, Pittsburgh, PA 15213, USA
Am J Physiol Gastrointest Liver Physiol 286:G225-33. 2004.... - Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjuryRebecca D Edmonds
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma 70:292-8. 2011..We sought to avoid the confounding effects attributable to obesity and determine the association of BMI and outcomes following injury in nonobese patients... - Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndromeGregory A Watson
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma 67:221-7; discussion 228-30. 2009..We hypothesized that plasma-rich transfusion components would be independently associated with a lower risk of mortality but result in a greater risk of morbid complications... - Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long wayMatthew D Neal
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma Acute Care Surg 72:892-8. 2012..We hypothesized that an increased crystalloid:PRBC (C:PRBC) ratio would be associated with increased morbidity and poor outcome after MT... - V. Guidelines for sedation and analgesia during mechanical ventilation general overviewMichael B Shapiro
Department of Surgery, Northwestern University, Chicago, Illinois, USA
J Trauma 63:945-50. 2007 - Inflammation and the host response to injury a large-scale collaborative project: patient-oriented research core standard operating procedure for clinical care X. Guidelines for venous thromboembolism prophylaxis in the trauma patientJoseph Cuschieri
Department of Surgery, University of Washington, Seattle, Washington, USA
J Trauma 65:944-50. 2008 - Failure of observation of blunt splenic injury in adults: variability in practice and adverse consequencesAndrew B Peitzman
Department of Surgery, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
J Am Coll Surg 201:179-87. 2005.... - Prevention of bile peritonitis by laparoscopic evacuation and lavage after nonoperative treatment of liver injuriesGlen A Franklin
Department of Surgery, University of Louisville, Louisville, Kentucky 40292, USA
Am Surg 73:611-6; discussion 616-7. 2007..Delayed laparoscopic evacuation of these collections prevents bile peritonitis and decreases inflammatory response and avoiding early operation, which has been implicated in increased death from hemorrhage... - Evaluation of a 15-year experience with splenic injuries in a state trauma systemBrian G Harbrecht
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Surgery 141:229-38. 2007..We hypothesized that outcomes for patients with splenic injuries have improved as the paradigm for splenic injury treatment has shifted... - Nonoperative management of severe blunt splenic injury: are we getting better?Gregory A Watson
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Trauma 61:1113-8; discussion 1118-9. 2006..The infrequency of these injuries has made evaluation of factors critical to their management difficult... - Inflammation and the host response to injury, a large-scale collaborative project: Patient-oriented research core-standard operating procedures for clinical care. IV. Guidelines for transfusion in the trauma patientMichael A West
Department of Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
J Trauma 61:436-9. 2006 - Inflammation and the Host Response to Injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care. III. Guidelines for shock resuscitationFrederick A Moore
Department of Surgery, University of Texas at Houston, 77030, USA
J Trauma 61:82-9. 2006 - Management of adult blunt splenic injuries: comparison between level I and level II trauma centersBrian G Harbrecht
Department of Surgery, University of Pittsburgh Medical Center, F1264-200 Lothrop Street, Pittsburgh, PA 15213, USA
J Am Coll Surg 198:232-9. 2004..Multicenter studies should account for this finding in design and implementation... - Inflammation and the Host Response to Injury, a Large-Scale Collaborative Project: patient-oriented research core--standard operating procedures for clinical care. II. Guidelines for prevention, diagnosis and treatment of ventilator-associated pneumonia (Joseph P Minei
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-9158, USA
J Trauma 60:1106-13; discussion 1113. 2006 - Use of computed tomography findings and contrast extravasation in predicting the need for embolization with pelvic fracturesMatthew C Bozeman
Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA
Am Surg 78:825-30. 2012..The presence of contrast extravasation is highly associated with the need for pelvic embolization in patients with pelvic fractures, but its absence does not exclude the need for pelvic angiography... - Blunt liver injury in children and adults: is there really a difference?W Patrick Klapheke
Department of Surgery, University of Louisville, Louisville, Kentucky 40292, USA
Am Surg 74:798-801. 2008..A higher rate of liver-related mortality was seen in the PED population. Overall, PED patients seemed to sustain fewer liver related complications necessitating invasive procedures despite similar injury patterns... - Hepatic dysfunction increases length of stay and risk of death after injuryBrian G Harbrecht
Department of Surgery, University of Pittsburgh, Pennsylvania, USA
J Trauma 53:517-23. 2002..The relative importance of dysfunction or failure of different organ systems to recovery from critical illness is unclear. The purpose of this study was to evaluate the contribution of hepatic dysfunction to outcome after injury... - Glucagon regulates hepatic inducible nitric oxide synthesis in vivoBrian G Harbrecht
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Shock 22:157-62. 2004..These data suggest that glucagon may participate in the in vivo regulation of hepatic iNOS expression after proinflammatory stimuli... - JNK signaling involved in the effects of cyclic AMP on IL-1beta plus IFNgamma-induced inducible nitric oxide synthase expression in hepatocytesBaochun Zhang
Department of Surgery, University of Pittsburgh Medical Center, 3459 Fifth Ave, NW607, MUH, Pittsburgh, PA 15213, USA
Cell Signal 16:837-46. 2004..We conclude that JNK signaling plays an important role in the inhibitory effects of cAMP on IL-1beta+IFNgamma-induced iNOS gene expression in cultured hepatocytes... - Early blood product and crystalloid volume resuscitation: risk association with multiple organ dysfunction after severe blunt traumatic injuryScott C Brakenridge
Department of Surgery, Division of Burn Trauma Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9158, USA
J Trauma 71:299-305. 2011..We sought to further delineate the relevance of the major individual components of early volume resuscitation to onset of MOD after severe blunt traumatic injury... - Is outcome after blunt splenic injury in adults better in high-volume trauma centers?Brian G Harbrecht
Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Am Surg 71:942-8; discussion 948-9. 2005..These data suggest that ACS criteria for trauma centers level designation are not associated with differences in outcome in the treatment of adult blunt splenic injuries in this regional trauma system... - Flail chest injury: are we making any progress?Robert M Cannon
Department of Surgery, University of Louisville, Louisville, Kentucky, USA
Am Surg 78:398-402. 2012..0001) and intensive care unit length of stay (P < 0.0001). The mortality associated with flail chest has greatly improved; however, the rate of pneumonia remains high. Further efforts at pneumonia prevention are thus warranted... - Changes in massive transfusion over time: an early shift in the right direction?Benjamin C Kautza
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma Acute Care Surg 72:106-11. 2012..We sought to characterize changes in resuscitation which have occurred over time in a cohort severely injured patients requiring MT... - Akt-mediated signaling is induced by cytokines and cyclic adenosine monophosphate and suppresses hepatocyte inducible nitric oxide synthase expression independent of MAPK P44/42Baochun Zhang
University of Louisville, Department of Surgery, Louisville, KY 40292, USA
Biochim Biophys Acta 1813:73-9. 2011..These data demonstrate that dbcAMP regulates hepatocyte iNOS expression through an Akt-mediated signaling mechanism that is independent of MAPK P44/42... - Direct peritoneal resuscitation accelerates primary abdominal wall closure after damage control surgeryJason W Smith
Department of Surgery, University of Louisville, Louisville, KY 40292, USA
J Am Coll Surg 210:658-64, 664-7. 2010.... - A brief episode of hypotension increases mortality in critically ill trauma patientsMazen S Zenati
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Trauma 53:232-6; discussion 236-7. 2002..0001). CONCLUSION: Brief episodes of hypotension are associated with an increased risk of death in patients requiring admission to the ICU after injury and a longer ICU recovery for those who survive... - Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patientsMatthew J Sena
Department of Surgery, University of California Davis Medical Center, Sacramento, CA, USA
J Am Coll Surg 207:459-67. 2008..The purpose of this study is to determine whether early administration of parenteral nutrition is associated with an increased risk for infection after severe injury... - Increased interactive format for Morbidity & Mortality conference improves educational value and enhances confidenceJose M Prince
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Surg Educ 64:266-72. 2007..We analyzed which features of M&M case reviews are associated with greater perceived educational value and enhanced confidence to deal with similar future clinical scenarios... - 17β-Estradiol attenuates cytokine-induced nitric oxide production in rat hepatocyteIkenna C Nweze
Department of Surgery and Price Institute of Surgical Research, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
J Trauma Acute Care Surg 73:408-12. 2012..Estrogen improves organ function and outcome after shock and sepsis, but the mechanism is unknown. We hypothesized that 17β-estradiol would improve organ function by regulating the production of hepatocyte NO... - Inflammation and the Host Response to Injury, a large-scale collaborative project: Patient-Oriented Research Core--standard operating procedures for clinical care. I. Guidelines for mechanical ventilation of the trauma patientAvery B Nathens
Department of Surgery, University of Washington, Seattle, Washington, USA
J Trauma 59:764-9. 2005 - Early VATS for blunt chest trauma: a management technique underutilized by acute care surgeonsJason W Smith
Department of Surgery, University of Louisville, Louisville, KY, USA
J Trauma 71:102-5; discussion 105-7. 2011..Our acute care surgeon (ACS) group aggressively treats complications of penetrating chest trauma with VATS, and our results suggested that the early use of VATS by ACS should be expanded... - Optimization of donor management goals yields increased organ useGlen A Franklin
Department of Surgery, University of Louisville, Louisville, Kentucky 40202, USA
Am Surg 76:587-94. 2010..Surprisingly, not all standard goals are necessary for optimal organ use. The most significant parameters were the low use of vasopressor agents and oxygenation. Donor management strategies should strive to optimize these goals... - Cyclic AMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB translocation in hepatocytes by a PKA independent mechanismGuiying Hong
Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
J Surg Res 159:565-71. 2010..We demonstrated that cAMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB binding due to its blockade of the upstream signal(s) leading to IkappaB phosphorylation and degradation, and is mediated by PKA-independent signaling pathways... - Impact of hollow viscus injuries on outcome of abdominal gunshot woundsBrady T Harris
Department of Surgery, University of Louisville, Louisville, Kentucky 40292, USA
Am Surg 75:378-84. 2009..Primary repair of HVI is preferred although no survival disadvantage is seen in other forms of repair in marginally stable patients. Definitive repair at the initial operation decreases complications... - Cytokines increase CRE binding but decrease CRE-mediated reporter activity in rat hepatocytes by increasing c-JunBaochun Zhang
Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
Hepatology 39:1343-52. 2004.... - Cytochrome P-450 activity is differentially altered in severely injured patientsBrian G Harbrecht
Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 33:541-6. 2005..The metabolic activity of selected CYP isoforms may have potential for evaluating acute hepatic dysfunction in critically ill trauma patients... - Glucose control and its implications for the general surgeonMaya Leggett
Department of Surgery, University of Louisville, Louisville, KY 40292, USA
Am Surg 75:1031-5. 2009.... - Successful endovascular repair of a ruptured aortic pseudoaneurysm after swallowing sulfuric acidVishal Bansal
Department of Surgery, University Presbyterian Hospital, Pittsburgh, Pennsylvania 15213, USA
J Trauma 65:470-2. 2008 - Closed midshaft femur fractures: are they only for trauma centers?Nicholas Ryan
Department of Surgery, Office of Medical Education, University of Louisville, Louisville, Kentucky, USA
Am Surg 77:476-9. 2011..9%, TCs vs NTCs, P = 0.62). Although differences in patient populations exist between TCs and NTCs, both TCs and NTCs manage substantial numbers of patients with closed, midshaft femur fractures with low mortality in this state database... - Activation of a cyclic amp-guanine exchange factor in hepatocytes decreases nitric oxide synthase expressionBaochun Zhang
Department of Surgery and Price Institute of Surgical Research, University of Louisville, Louisville, KY, USA
Shock 39:70-6. 2013..We conclude that Epac regulates hepatocyte iNOS expression through an Akt- and JNK-mediated signaling mechanism... - Cyclic AMP regulate adenovirus mediated inducible nitric oxide synthase expression and CMV promoter activity in cultured hepatocytesBaochun Zhang
Department of Surgery, University of Pittsburgh Medical Center, 3459 Fifth Avenue NW607, MUH, Pittsburgh, PA 15213, USA
Nitric Oxide 8:262-5. 2003..We concluded that dbcAMP can regulate adenovirus-mediated human iNOS expression in primary hepatocytes by the mechanisms regulating the CMV promoter used in the adenovirus vector... - A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shockChristian Hierholzer
Department of Surgery, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
Shock 17:98-103. 2002..These data indicate that NOX prevents lung injury in this HS model, possibly through downmodulation of proinflammatory signaling and the shock-induced inflammatory response... - Carbohydrate provision in the era of tight glucose controlKeith R Miller
Department of Surgery, University of Louisville, Louisville, KY 40202, USA
Curr Gastroenterol Rep 13:388-94. 2011..Achieving realistic goals in both carbohydrate provision and glycemic control may improve patient outcome, and are not mutually exclusive practices... - Interactions between fatty acids and arginine metabolism: implications for the design of immune-enhancing dietsVishal Bansal
Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
JPEN J Parenter Enteral Nutr 29:S75-80. 2005..By decreasing arginase I expression, prostaglandins from omega-3 fatty acids may increase available arginine. The specific combinations of dietary fatty acids and arginine should be considered when tailoring dietary regimens... - The evolving management of venous bullet emboli: a case series and literature reviewKeith R Miller
University of Louisville, Department of Surgery, Louisville, KY 40292, United States
Injury 42:441-6. 2011..Review of the literature focusing on the reported management of these injuries, comparison of techniques of management, as well as the evolving role of endovascular techniques in the management of bullet emboli is provided... - Therapeutic use of nitric oxide scavengers in shock and sepsisBrian G Harbrecht
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Curr Pharm Des 12:3543-9. 2006..The relevant biology of NO in these disease states is presented and the therapeutic potential of NO scavengers in clinical care is explored... - Bcl-xL prevents staurosporine-induced hepatocyte apoptosis by restoring protein kinase B/mitogen-activated protein kinase activity and mitochondria integrityYinna Wang
Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Cell Physiol 215:676-83. 2008..Our data suggest that Bcl-x(L) prevents staurosporine-induced hepatocyte apoptosis by modulating protein kinase B and p44/42 mitogen-activated protein kinase activity and disrupts mitochondria death signaling... - The modulation of hepatic injury and heat shock expression by inhibition of inducible nitric oxide synthase after hemorrhagic shockJohn M Menezes
Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA
Shock 17:13-8. 2002..We conclude that excessive NO production from iNOS contributes to shock-induced hepatic injury. Our data suggest HSP expression may reflect the degree of ischemic injury after hemorrhage... - Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complicationsRamsey M Dallal
Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Ann Surg 235:363-72. 2002..To review the epidemiology and characteristics of patients who died or underwent colectomy secondary to fulminant Clostridium difficile colitis... - Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patientsAman Russom
Surgical Services and Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, Boston, MA, USA
Clin Chem 54:891-900. 2008..Here, we report the clinical validation of a novel microfluidic leukocyte nucleic acid isolation technique for gene expression analysis from critically ill, hospitalized patients that can be readily used on small volumes of blood... - Control of glucose after injuryBrian G Harbrecht
Am Surg 74:199-200. 2008 - Nonoperative management of blunt splenic trauma in the elderly: does age play a role?Kris Siriratsivawong
Department of General Surgery, Naval Medical Center San Diego, San Diego, California 92134 5000, USA
Am Surg 73:585-9; discussion 590. 2007..Mortality was high regardless of management, and failure of NOM in older patients is associated with significantly longer hospital and ICU LOS... - Is anything new in adult blunt splenic trauma?Brian G Harbrecht
UPMC Presbyterian Hospital, F1264 200 Lothrop St, Pittsburgh, PA 15213, USA
Am J Surg 190:273-8. 2005..Recent refinements in the management of adult blunt splenic injuries will be reviewed... - Early use of vasopressors after injury: caution before constrictionJason L Sperry
Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Trauma 64:9-14. 2008..We sought to characterize early vasopressor (EV) use and aggressive early crystalloid resuscitation (ECR) and their association with mortality in severely injured patients... - The practice of venous thromboembolism prophylaxis in the major trauma patientAvery B Nathens
Department of Surgery, Univeristy of Toronto, Canada
J Trauma 62:557-62; discussion 562-3. 2007..As the effect of delays in the initiation of prophylaxis on VTE rates is unknown, we set out to evaluate the relationship between late initiation of prophylaxis and VTE... - Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shockRunkuan Yang
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, PA 15621, USA
Mol Med 12:105-14. 2006..These data support the notion that HMGB1 is a mediator of HS/R-induced gut barrier dysfunction and suggest that anti-HMGB1 antibodies warrant further evaluation as a therapeutic to ameliorate the morbidity of HS/R in trauma patients...
Research Grants
- GLUCAGON AND HEPATIC GENE EXPRESSION IN SURGICAL SEPSISBrian Harbrecht; Fiscal Year: 2005..These insights will contribute to uncovering the basic cellular mechanisms involved in multiple organ dysfunction and may lead to potential therapeutic approaches. ..
- Hepatocyte Nitric Oxide Synthase Regulation by Glucagon and InsulinBrian Harbrecht; Fiscal Year: 2007..By defining these mechanisms, we will provide a framework for understanding the basic cellular events in shock and sepsis, which may lead to novel cellular-based therapies for critically ill patients. ..
- Hepatocyte Nitric Oxide Synthase Regulation by Glucagon and InsulinBrian G Harbrecht; Fiscal Year: 2010..By defining these mechanisms, we will provide a framework for understanding the basic cellular events in shock and sepsis, which may lead to novel cellular-based therapies for critically ill patients. ..