J William Harbour

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc A molecular revolution in uveal melanoma: implications for patient care and targeted therapy
    J William Harbour
    Ocular Oncology Service, Bascom Palmer Eye Institute and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida Electronic address
    Ophthalmology 121:1281-8. 2014
  2. pmc BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma
    Katie A Matatall
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St, Louis, Missouri, USA
    BMC Cancer 13:371. 2013
  3. pmc Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Genet 45:133-5. 2013
  4. pmc Frequent mutation of BAP1 in metastasizing uveal melanomas
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 330:1410-3. 2010
  5. ncbi request reprint A metastasis modifier locus on human chromosome 8p in uveal melanoma identified by integrative genomic analysis
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Cancer Res 14:3737-45. 2008
  6. ncbi request reprint Loss of Id2 potentiates the tumorigenic effect of Rb inactivation in a mouse model of retinoblastoma
    Solange Landreville
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Eye Res 35:435-9. 2010
  7. pmc Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma
    Solange Landreville
    Departments of Ophthalmology and Visual Sciences, Otolaryngology, and Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Cancer Res 18:408-16. 2012
  8. ncbi request reprint Functional analysis of the p53 pathway in response to ionizing radiation in uveal melanoma
    Young Sun
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Invest Ophthalmol Vis Sci 46:1561-4. 2005
  9. ncbi request reprint Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma
    Lori A Worley
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
    Clin Cancer Res 13:1466-71. 2007
  10. ncbi request reprint Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase
    Jonathan H Lieman
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
    J Biol Chem 280:10484-90. 2005

Collaborators

Detail Information

Publications56

  1. pmc A molecular revolution in uveal melanoma: implications for patient care and targeted therapy
    J William Harbour
    Ocular Oncology Service, Bascom Palmer Eye Institute and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida Electronic address
    Ophthalmology 121:1281-8. 2014
    ..Taken together, these advances are transforming our understanding and management of uveal melanoma with the ultimate goal of improving patient outcomes. ..
  2. pmc BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma
    Katie A Matatall
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St, Louis, Missouri, USA
    BMC Cancer 13:371. 2013
    ..The aim of this study was to investigate the role of BAP1 in uveal melanoma progression...
  3. pmc Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Genet 45:133-5. 2013
    ..Thus, uveal melanoma is among a small group of cancers associated with SF3B1 mutations, and these mutations denote a distinct molecular subset of uveal melanomas...
  4. pmc Frequent mutation of BAP1 in metastasizing uveal melanomas
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 330:1410-3. 2010
    ..These findings implicate loss of BAP1 in uveal melanoma metastasis and suggest that the BAP1 pathway may be a valuable therapeutic target...
  5. ncbi request reprint A metastasis modifier locus on human chromosome 8p in uveal melanoma identified by integrative genomic analysis
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Cancer Res 14:3737-45. 2008
    ....
  6. ncbi request reprint Loss of Id2 potentiates the tumorigenic effect of Rb inactivation in a mouse model of retinoblastoma
    Solange Landreville
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Eye Res 35:435-9. 2010
    ..The role of Id2 has not yet been investigated in the prototype cancer Rb-defective cancer, retinoblastoma itself. This study investigated whether loss of Id2 modified the effects of Rb inactivation in a mouse model of retinoblastoma...
  7. pmc Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma
    Solange Landreville
    Departments of Ophthalmology and Visual Sciences, Otolaryngology, and Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Cancer Res 18:408-16. 2012
    ..The purpose of this study was to identify therapeutic agents that reverse the phenotypic effects of BAP1 loss in UM...
  8. ncbi request reprint Functional analysis of the p53 pathway in response to ionizing radiation in uveal melanoma
    Young Sun
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Invest Ophthalmol Vis Sci 46:1561-4. 2005
    ..The current study was conducted to analyze the functional integrity of the p53 pathway in primary uveal melanoma cells...
  9. ncbi request reprint Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma
    Lori A Worley
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
    Clin Cancer Res 13:1466-71. 2007
    ..To compare a gene expression-based classifier versus the standard genetic prognostic marker, monosomy 3, for predicting metastasis in uveal melanoma...
  10. ncbi request reprint Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase
    Jonathan H Lieman
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
    J Biol Chem 280:10484-90. 2005
    ..These findings reveal a new mechanistic link between Rb-E2F and the extrinsic (caspase 8-mediated) apoptotic pathway...
  11. doi request reprint Hepatic metastasis from uveal melanoma: angiographic pattern predictive of survival after hepatic arterial chemoembolization
    Pouya N Dayani
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 127:628-32. 2009
    ..To identify clinical features associated with survival after hepatic arterial chemoembolization (HACE) for uveal melanoma metastasis...
  12. pmc Oncogenic mutations in GNAQ occur early in uveal melanoma
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Invest Ophthalmol Vis Sci 49:5230-4. 2008
    ..An extensive search for such mutations was undertaken, focusing on the RAF/MEK/ERK pathway, which is often the target of initiating mutations in other types of cancer...
  13. ncbi request reprint Loss of heterozygosity of chromosome 3 detected with single nucleotide polymorphisms is superior to monosomy 3 for predicting metastasis in uveal melanoma
    Michael D Onken
    Department of Ophthalmology, Washington University, St Louis, Missouri, USA
    Clin Cancer Res 13:2923-7. 2007
    ..It is not known whether techniques that identify loss of heterozygosity for chromosome 3 predict metastasis more accurately than those that detect only numerical loss of chromosome 3 (monosomy 3)...
  14. doi request reprint Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling
    Lori A Worley
    Department of Ophthalmology and Visual Sciences and Siteman Comprehensive Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
    Melanoma Res 18:184-90. 2008
    ..miRNA expression may represent a highly accurate biomarker for metastatic risk in uveal melanoma. In addition, these results may provide new insights into the role of miRNAs in tumor progression and the metastatic phenotype...
  15. ncbi request reprint DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma
    Justis P Ehlers
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Cancer Res 11:3609-13. 2005
    ..In this profile, a cluster of genes at chromosome 8q was overexpressed in high-grade tumors, providing an opportunity to search for potential oncogenes in this region...
  16. pmc An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Diagn 12:461-8. 2010
    ..This prognostic assay provides an important addition to the armamentarium for managing patients with uveal melanoma, and it provides a proof of principle for the development of similar assays for other cancers...
  17. doi request reprint Prognostic biomarkers in uveal melanoma: evidence for a stem cell-like phenotype associated with metastasis
    Shu Hong Chang
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Melanoma Res 18:191-200. 2008
    ....
  18. pmc Association between gene expression profile, proliferation and metastasis in uveal melanoma
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Eye Res 35:857-63. 2010
    ..Towards such an explanation, this study was conducted to determine whether class 2 tumors have a higher proliferative rate than class 1 tumors...
  19. pmc Prognostic testing in uveal melanoma by transcriptomic profiling of fine needle biopsy specimens
    Michael D Onken
    Box 8096, 660 South Euclid Ave, St Louis, MO 63124, USA
    J Mol Diagn 8:567-73. 2006
    ..This method can be applied to specimens obtained from distant geographic locations and can stratify uveal melanoma patients based on metastatic risk...
  20. ncbi request reprint Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Res 64:7205-9. 2004
    ..These studies offer new insights into melanoma pathogenesis, and they provide a practical foundation for effective clinical predictive testing...
  21. doi request reprint Diagnostic testing and treatment choices in primary vitreoretinal lymphoma
    Rithwick Rajagopal
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Retina 31:435-40. 2011
    ..Primary vitreoretinal lymphoma is a rare intraocular malignancy often seen in the context of central nervous system lymphoma. This review updates the current approaches to the management of primary vitreoretinal lymphoma...
  22. ncbi request reprint Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 66:4602-9. 2006
    ..These findings reveal new roles for Id2 and E-cadherin in uveal melanoma progression, and they identify potential targets for therapeutic intervention...
  23. ncbi request reprint NBS1 expression as a prognostic marker in uveal melanoma
    Justis P Ehlers
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Clin Cancer Res 11:1849-53. 2005
    ..Here, we use microarray gene expression data to identify a new prognostic marker...
  24. ncbi request reprint Association between microarray gene expression signature and extravascular matrix patterns in primary uveal melanomas
    Michael D Onken
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 140:748-9. 2005
    ..To determine whether there is an association between gene expression profile and looping extravascular matrix patterns in primary uveal melanomas...
  25. ncbi request reprint Transducible peptide therapy for uveal melanoma and retinoblastoma
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Campus Box 8069, 660 S Euclid Ave, St Louis, MO 63110, USA
    Arch Ophthalmol 120:1341-6. 2002
    ..To determine whether transducible peptides that inhibit the oncoproteins HDM2 and Bcl-2 may selectively kill uveal melanoma and retinoblastoma cells...
  26. doi request reprint Molecular prognostic testing and individualized patient care in uveal melanoma
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 148:823-9.e1. 2009
    ..To critically assess the status of molecular prognostic testing and its use for individualized patient care in uveal melanoma...
  27. ncbi request reprint Recent developments in prognostic and predictive testing in uveal melanoma
    Matthew G Field
    Ocular Oncology Service, Bascom Palmer Eye Institute and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USA
    Curr Opin Ophthalmol 25:234-9. 2014
    ..To provide an update on the rapidly evolving methods for assessing prognosis and predicting response to targeted molecular therapy in uveal melanoma...
  28. pmc MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A
    Amy E Loercher
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 168:35-40. 2005
    ....
  29. doi request reprint Outcomes of iodine-125 plaque brachytherapy for uveal melanoma with intraoperative ultrasonography and supplemental transpupillary thermotherapy
    Shahed N Badiyan
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, St Louis, Missouri
    Int J Radiat Oncol Biol Phys 88:801-5. 2014
    ....
  30. ncbi request reprint Correlation study of benign cytomorphology and final clinical diagnosis
    Jing Zhai
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Acta Cytol 52:196-200. 2008
    ..To assess significance of cytologically benign vitreous samples and identify cellular patterns that may correspond to specific clinical entities...
  31. doi request reprint Id2 deficiency promotes metastasis in a mouse model of ocular cancer
    Olga A Agapova
    Department of Ophthalmology and Visual Sciences and Siteman Cancer Center, Washington University School of Medicine, Campus Box 8096, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Clin Exp Metastasis 27:91-6. 2010
    ..These findings provide new insights into the role of Id2 in metastasis...
  32. pmc Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma
    Michael D Onken
    Washington University and Siteman Cancer Center, St Louis, Missouri, USA
    Ophthalmology 119:1596-603. 2012
    ..This study evaluates the prognostic performance of a 15 gene expression profiling (GEP) assay that assigns primary posterior uveal melanomas to prognostic subgroups: class 1 (low metastatic risk) and class 2 (high metastatic risk)...
  33. ncbi request reprint Lipid exudation following plaque radiotherapy for posterior uveal melanoma
    Michael D Mills
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Ophthalmol 141:594-595. 2006
    ..To investigate factors associated with lipid exudation after plaque radiotherapy for uveal melanoma...
  34. pmc ABCB1 identifies a subpopulation of uveal melanoma cells with high metastatic propensity
    Solange Landreville
    Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA Département d Ophtalmologie, Universite Laval, Quebec, QC, Canada Department of Otolaryngology, Washington University School of Medicine, St Louis, MO, USA
    Pigment Cell Melanoma Res 24:430-7. 2011
    ..These findings suggest that some uveal melanoma cells have greater potential for metastasis than others and that a better understanding of such cells may be necessary for more successful therapies for metastatic melanoma...
  35. pmc Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration
    Abdoulaye Sene
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Cell Metab 17:549-61. 2013
    ..Monocytes from older humans with age-related macular degeneration showed similar changes. These findings provide an avenue for therapeutic modulation of macrophage function in common age-related diseases...
  36. doi request reprint The genetics of uveal melanoma: an emerging framework for targeted therapy
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Pigment Cell Melanoma Res 25:171-81. 2012
    ..These mutations appear to be key events that provide the potential for targeted therapy. This article will review the genetic findings in uveal melanoma over the past two decades and suggest important areas for future work...
  37. ncbi request reprint Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management
    Beverly E Faulkner-Jones
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Acta Cytol 49:297-308. 2005
    ..To assess the effectiveness of fine needle aspiration biopsy (FNAB), with and without immunohistochemistry (IHC), in the management of solid intraocular tumors...
  38. ncbi request reprint A prognostic test to predict the risk of metastasis in uveal melanoma based on a 15-gene expression profile
    J William Harbour
    Bascom Palmer Eye Institute, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA
    Methods Mol Biol 1102:427-40. 2014
    ..This is the only prognostic test in uveal melanoma ever to undergo such extensive validation, and it is currently being used in a commercial format under the trade name DecisionDx-UM in over 100 centers in the USA and Canada. ..
  39. ncbi request reprint Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb
    Duanduan Ma
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:19358-66. 2003
    ..As a survival strategy, some cancer cells may exploit this dual role of Rb by phosphorylating sites that regulate tumor suppression but avoiding phosphorylation of Ser567 and consequent apoptotic stimulus...
  40. ncbi request reprint Hepatic arterial chemoembolization for management of metastatic melanoma
    Karun V Sharma
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    AJR Am J Roentgenol 190:99-104. 2008
    ..However, the reports of outcomes are limited. We present our outcomes with hepatic arterial chemoembolization for metastasis of stage 4 melanoma...
  41. ncbi request reprint Status of the NF1 tumor suppressor locus in uveal melanoma
    William J Foster
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 121:1311-5. 2003
    ..A clinical association has been observed between uveal melanoma and neurofibromatosis type 1 (NF1). This study aims to determine whether the NF1 tumor suppressor gene is mutated in uveal melanoma...
  42. ncbi request reprint Transpupillary thermotherapy versus plaque radiotherapy for suspected choroidal melanomas
    J William Harbour
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Ophthalmology 110:2207-14; discussion 2215. 2003
    ..To examine the outcomes and complications of transpupillary thermotherapy for treatment of small choroidal melanomas...
  43. pmc Eye cancer: unique insights into oncogenesis: the Cogan Lecture
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Invest Ophthalmol Vis Sci 47:1736-45. 2006
  44. doi request reprint Tilting of radioactive plaques after initial accurate placement for treatment of uveal melanoma
    Arghavan Almony
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 126:65-70. 2008
    ..To evaluate plaque movement as a potential factor in local failure using intraoperative ultrasonography at plaque insertion and removal...
  45. ncbi request reprint Rate of resolution of exudative retinal detachment after plaque radiotherapy for uveal melanoma
    J William Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, PO Box 8069, 660 S Euclid Ave, St Louis, MO 63110, USA
    Arch Ophthalmol 120:1463-9. 2002
    ..To determine the clinical relevance of exudative retinal detachment (ERD) and the rate of ERD resolution after plaque radiotherapy of posterior uveal melanomas...
  46. ncbi request reprint Pars plana vitrectomy in eyes containing a treated posterior uveal melanoma
    William J Foster
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, and Barnes Retina Institute, St Louis, Missouri 63110, USA
    Am J Ophthalmol 136:471-6. 2003
    ..To determine the safety of pars plana vitrectomy in eyes containing a treated posterior uveal melanoma...
  47. ncbi request reprint Optical coherence tomography in the evaluation of retinal changes associated with suspicious choroidal melanocytic tumors
    Gabriella Espinoza
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences and Barnes Retina Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 137:90-5. 2004
    ..This study investigates optical coherence tomography (OCT) in evaluating SRF in suspicious choroidal melanocytic tumors...
  48. ncbi request reprint Molecular genetics of uveal melanoma
    Amy E Loercher
    Department of Ophthalmology and Visual Sciences, Washington University, School of Medicine, St Louis, MO 63110, USA
    Curr Eye Res 27:69-74. 2003
    ..Herein, we review the findings to date, discuss the insights they provide, and suggest future directions for molecular research in uveal melanoma...
  49. ncbi request reprint Photodynamic therapy for choroidal metastasis from carcinoid tumor
    J William Harbour
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 137:1143-5. 2004
    ..To determine the efficacy of photodynamic therapy for the treatment of a choroidal metastasis unresponsive to chemotherapy and radiation therapy...
  50. pmc Emerging insights into the molecular pathogenesis of uveal melanoma
    Solange Landreville
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Future Oncol 4:629-36. 2008
    ..Taken together, this pathogenetic scheme can be used to construct a molecularly based and prognostically relevant classification of uveal melanomas that can be used clinically for personalized patient management...
  51. ncbi request reprint Rb at the interface between cell cycle and apoptotic decisions
    Rachel B Delston
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Mol Med 6:713-8. 2006
    ..For many of these studies, we have chosen the melanocyte lineage as a model cell system because of the established role for Rb in melanocyte differentiation and survival, and the frequent deregulation of the Rb pathway in melanoma...
  52. doi request reprint Review of 676 second primary tumors in patients with retinoblastoma: association between age at onset and tumor type
    Kyung In Woo
    Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Arch Ophthalmol 128:865-70. 2010
    ..To obtain a more accurate understanding of second primary tumors (SPTs) by analyzing a large number of SPTs from the published literature...
  53. ncbi request reprint Cytologic diagnosis of intraocular lymphoma in vitreous aspirates
    Tunde Farkas
    Department of Pathology and Immunology, Washington University Medical Center, St Louis, Missouri 63110, USA
    Acta Cytol 48:487-91. 2004
    ..To evaluate the cytologic findings of vitreous fluids with atypical, suspicious for malignancy or malignant lymphoid cells to assess cytologic parameters that may help in reaching the diagnosis of intraoclular lymphoma...
  54. ncbi request reprint GNAQ/11 mutations in uveal melanoma: is YAP the key to targeted therapy?
    Matthew G Field
    Ocular Oncology Service, Bascom Palmer Eye Institute and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cancer Cell 25:714-5. 2014
    ..In this issue of Cancer Cell, Feng and colleagues and Yu and colleagues demonstrate that the oncogenic activity of mutant GNAQ/11 is mediated at least in part through YAP, potentially uncovering a new therapeutic strategy. ..
  55. ncbi request reprint Ocular melanoma: a review and the relationship to cutaneous melanoma
    Eva A Hurst
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Dermatol 139:1067-73. 2003
    ..We review the incidence and characteristics of OM, evaluate the existent data regarding its potential relationship to CM, and provide some guidance for the dermatologist regarding the evaluation and diagnosis of this ocular tumor...
  56. ncbi request reprint Altered expression of Rb and p53 in uveal melanomas following plaque radiotherapy
    Milam A Brantley
    Center for Ocular Oncology, Department of Ophthalmology and Visual Sciences and Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 133:242-8. 2002
    ..To examine the expression of proteins in the Rb and p53 tumor suppressor pathways in uveal melanomas following plaque radiotherapy...