Shuanglin Hao

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats
    Wenwen Zheng
    Department of Anesthesiology, University of Miami Miller School of Medicine, 1550 NW 10th Ave, Fox BLDG, Rm 304C, Miami, FL 33136, USA
    Mol Pain 10:49. 2014
  2. pmc Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats
    J Sun
    Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Gene Ther 19:101-8. 2012
  3. pmc The role of TNFα in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats
    Shuanglin Hao
    Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Neuropsychopharmacology 36:664-76. 2011
  4. pmc Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Michigan and Ann Arbor VA Healthcare System, Ann Arbor, MI, USA
    Behav Brain Res 197:84-9. 2009
  5. pmc Effects of transgene-mediated endomorphin-2 in inflammatory pain
    Shuanglin Hao
    Department of Neurology and VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Eur J Pain 13:380-6. 2009
  6. ncbi request reprint Mechanical allodynia induced by nucleoside reverse transcriptase inhibitor is suppressed by p55TNFSR mediated by herpes simplex virus vector through the SDF1α/CXCR4 system in rats
    Wan Huang
    From the Department of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida Department of Anesthesiology, State Key Laboratory of Oncology on Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan Hussman Institute of Human Genomics, University of Miami Miller School of Medicine and Veterans Affairs Medical Center, Miami, Florida
    Anesth Analg 118:671-80. 2014
  7. pmc Gene transfer of glutamic acid decarboxylase reduces neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Michigan Health System and Ann Arbor VA Healthcare System, Ann Arbor, MI 48109 0316, USA
    Ann Neurol 57:914-8. 2005
  8. pmc HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Michigan Health System, 1500 E, Medical Center Drive, Room 1914 TC, Ann Arbor, Michigan 48109 0316, USA
    Mol Pain 2:6. 2006
  9. pmc Glial TNFα in the spinal cord regulates neuropathic pain induced by HIV gp120 application in rats
    Wenwen Zheng
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Pain 7:40. 2011
  10. ncbi request reprint Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain
    Jun Liu
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Ther 10:57-66. 2004

Research Grants

Collaborators

Detail Information

Publications21

  1. pmc IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats
    Wenwen Zheng
    Department of Anesthesiology, University of Miami Miller School of Medicine, 1550 NW 10th Ave, Fox BLDG, Rm 304C, Miami, FL 33136, USA
    Mol Pain 10:49. 2014
    ..In this study, we investigated whether inhibition of proinflammatory factors reduces the HIV-associated neuropathic pain state...
  2. pmc Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats
    J Sun
    Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Gene Ther 19:101-8. 2012
    ..These results support the concept that proinflammatory cytokines may have an important role in the pathogenesis induced by morphine. This study provides a novel approach to treating morphine tolerance...
  3. pmc The role of TNFα in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats
    Shuanglin Hao
    Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Neuropsychopharmacology 36:664-76. 2011
    ..These results support the concept that proinflammatory cytokines expressed in astrocytes in the PAG may play an important role in the pathogenesis of morphine withdrawal response...
  4. pmc Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Michigan and Ann Arbor VA Healthcare System, Ann Arbor, MI, USA
    Behav Brain Res 197:84-9. 2009
    ..The global withdrawal score was also reduced significantly by vector-mediated overexpression of proenkephalin. These studies demonstrate a role for opioid peptide in the spinal cord in mediating some of the withdrawal response...
  5. pmc Effects of transgene-mediated endomorphin-2 in inflammatory pain
    Shuanglin Hao
    Department of Neurology and VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Eur J Pain 13:380-6. 2009
    ..These results suggest that transgene-mediated expression of endomorphin-2 in transduced DRG neurons in vivo acts both peripherally and centrally through mu opioid receptors to reduce pain perception...
  6. ncbi request reprint Mechanical allodynia induced by nucleoside reverse transcriptase inhibitor is suppressed by p55TNFSR mediated by herpes simplex virus vector through the SDF1α/CXCR4 system in rats
    Wan Huang
    From the Department of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida Department of Anesthesiology, State Key Laboratory of Oncology on Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan Hussman Institute of Human Genomics, University of Miami Miller School of Medicine and Veterans Affairs Medical Center, Miami, Florida
    Anesth Analg 118:671-80. 2014
    ..In this study, we investigated the role of these proinflammatory molecules in the dorsal root ganglion (DRG) and the spinal dorsal horn in NRTIs-mediated neuropathic pain state...
  7. pmc Gene transfer of glutamic acid decarboxylase reduces neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Michigan Health System and Ann Arbor VA Healthcare System, Ann Arbor, MI 48109 0316, USA
    Ann Neurol 57:914-8. 2005
    ..QHGAD67 inoculation also suppressed induction of c-Fos and phosphorylated extracellular signal-regulated kinase 1 and 2 in the spinal cord...
  8. pmc HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Michigan Health System, 1500 E, Medical Center Drive, Room 1914 TC, Ann Arbor, Michigan 48109 0316, USA
    Mol Pain 2:6. 2006
    ....
  9. pmc Glial TNFα in the spinal cord regulates neuropathic pain induced by HIV gp120 application in rats
    Wenwen Zheng
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Pain 7:40. 2011
    ..Glia activation in the spinal cord has become an attractive target for attenuating chronic pain. This study will investigate the role of spinal TNFα released from glia in HIV-related neuropathic pain...
  10. ncbi request reprint Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain
    Jun Liu
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Ther 10:57-66. 2004
    ..These results suggest that HSV-mediated gene transfer to DRG could be used to treat below-level central neuropathic pain after incomplete SCI...
  11. pmc TNFα is involved in neuropathic pain induced by nucleoside reverse transcriptase inhibitor in rats
    Xuexing Zheng
    Department of Anesthesiology, University of Miami Miller School of Medicine, Miami, FL 33136, United States
    Brain Behav Immun 25:1668-76. 2011
    ..Intrathecal administration of glial inhibitor or recombinant TNF soluble receptor, reversed mechanical allodynia induced by ddC. These results suggest that TNFα is involved in NRTI-induced neuropathic pain...
  12. pmc An emerging new paradigm in opioid withdrawal: a critical role for glia-neuron signaling in the periaqueductal gray
    Handong Ouyang
    Department of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    ScientificWorldJournal 2012:940613. 2012
    ..We summarize those neurochemical mechanisms associated with opioid withdrawal including the recently defined importance of TNFα release from activated glial cells that communicate with TNF receptors on PAG neurons...
  13. ncbi request reprint Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Pain 102:135-42. 2003
    ..The pharmacologic analysis demonstrates that transgene-mediated expression and local release of opioid peptides produce some effects that are distinct from peptide analogues delivered pharmacologically...
  14. ncbi request reprint HSV-mediated gene transfer of the glial cell-derived neurotrophic factor provides an antiallodynic effect on neuropathic pain
    Shuanglin Hao
    Department of Neurology, Pittsburgh, Pennsylvania 15213, USA
    Mol Ther 8:367-75. 2003
    ..Gene transfer to produce a trophic factor offers a novel approach to the treatment of neuropathic pain that may be appropriate for human therapy...
  15. pmc Viral vector-based gene transfer for treatment of chronic pain
    Shuanglin Hao
    University of Michigan Health System VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA
    Int Anesthesiol Clin 45:59-71. 2007
  16. ncbi request reprint Crosstalk between JNK and NF-κB in the KDO2-mediated production of TNFα in HAPI cells
    Xuexing Zheng
    Department of Anesthesiology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cell Mol Neurobiol 32:1375-83. 2012
    ..The current study may provide a new insight in the modulation of TNFα in the microglial cell line...
  17. ncbi request reprint Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation
    Jian Hu
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Eur J Neurosci 20:1705-12. 2004
    ..The formation of new projections by uninjured fibers into a functionally but not anatomically deafferented field in the adult may play a role in the development of chronic pain...
  18. pmc Applications of gene therapy to the treatment of chronic pain
    Marina Mata
    Department of Neurology, University of Michigan School of Medicine and VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Curr Gene Ther 8:42-8. 2008
    ....
  19. pmc Gene therapy directed at the neuroimmune component of chronic pain with particular attention to the role of TNF alpha
    Marina Mata
    Department of Neurology, University of Michigan, 1914 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0316, USA VA Ann Arbor Healthcare System, Ann Arbor, MI 48109 0316, USA
    Neurosci Lett 437:209-13. 2008
    ..The results of these experiments suggest a novel role for "reverse signaling" through the full-length membrane form of TNFalpha in spinal glia in the modulation of chronic pain...
  20. pmc Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy
    Munmun Chattopadhyay
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Mol Pain 8:17. 2012
    ....

Research Grants1

  1. HIV and NRTI's-induced painful pathogenic mechanisms and gene therapy
    Shuanglin Hao; Fiscal Year: 2010
    ..This study may help us understand the mechanism of pain better so that we can find a novel way to reduce pain. ..