Jinsong Hao

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Distribution of propranolol in periocular tissues: a comparison of topical and systemic administration
    Jinsong Hao
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Ocul Pharmacol Ther 27:453-9. 2011
  2. pmc Time-dependent electrical properties of human nail upon hydration in vivo
    Jinsong Hao
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 99:107-18. 2010
  3. pmc Characterization of human sclera barrier properties for transscleral delivery of bevacizumab and ranibizumab
    He Wen
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 102:892-903. 2013
  4. pmc Iontophoretic transport of charged macromolecules across human sclera
    Poonam Chopra
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 388:107-13. 2010
  5. pmc Influence of pH on transungual passive and iontophoretic transport
    Kelly A Smith
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Ave, 136 HPB, Cincinnati, Ohio 45267, USA
    J Pharm Sci 99:1955-67. 2010
  6. pmc Chemical method to enhance transungual transport and iontophoresis efficiency
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 357:61-9. 2008
  7. pmc Influence of drug lipophilicity on drug release from sclera after iontophoretic delivery of mixed micellar carrier system to human sclera
    Poonam Chopra
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 102:480-8. 2013
  8. pmc Effects of ionic strength on passive and iontophoretic transport of cationic permeant across human nail
    Kelly A Smith
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Pharm Res 26:1446-55. 2009
  9. pmc Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera
    Poonam Chopra
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    J Control Release 160:96-104. 2012
  10. pmc Iontophoretically enhanced ciclopirox delivery into and across human nail plate
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 98:3608-16. 2009

Collaborators

Detail Information

Publications18

  1. pmc Distribution of propranolol in periocular tissues: a comparison of topical and systemic administration
    Jinsong Hao
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Ocul Pharmacol Ther 27:453-9. 2011
    ..The objective of this study was to investigate the distribution of propranolol in periocular tissues and in plasma after topical application of propranolol as compared with intravenous and oral administration of propranolol...
  2. pmc Time-dependent electrical properties of human nail upon hydration in vivo
    Jinsong Hao
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 99:107-18. 2010
    ..The in vitro and in vivo correlation suggests that the in vitro nail plate can be a model in the research and development of transungual iontophoretic delivery...
  3. pmc Characterization of human sclera barrier properties for transscleral delivery of bevacizumab and ranibizumab
    He Wen
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 102:892-903. 2013
    ..Thus, the polysaccharides may not be good surrogate permeants to model transscleral transport of therapeutic proteins in transscleral delivery studies...
  4. pmc Iontophoretic transport of charged macromolecules across human sclera
    Poonam Chopra
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 388:107-13. 2010
    ..Both electroosmosis and electrophoresis affected iontophoretic fluxes of the macromolecules; the relative contributions of electroosmosis and electrophoresis were a function of molecular size and charge of the macromolecules...
  5. pmc Influence of pH on transungual passive and iontophoretic transport
    Kelly A Smith
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Ave, 136 HPB, Cincinnati, Ohio 45267, USA
    J Pharm Sci 99:1955-67. 2010
    ..Hydronium and hydroxide ion competition in iontophoretic transport was generally negligible at pH 3-11 was significant at the extreme pH conditions studied...
  6. pmc Chemical method to enhance transungual transport and iontophoresis efficiency
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 357:61-9. 2008
    ..The effect of TGA on the nail plates was irreversible. The present study shows the possibility of using a chemical enhancer to reduce transport hindrance in the nail plate and thus enhance passive and iontophoretic transungual transport...
  7. pmc Influence of drug lipophilicity on drug release from sclera after iontophoretic delivery of mixed micellar carrier system to human sclera
    Poonam Chopra
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 102:480-8. 2013
    ..These results suggest that the combination of transscleral iontophoresis and micellar carriers is more effective in sustaining transscleral delivery of the more lipophilic drugs studied in this investigation...
  8. pmc Effects of ionic strength on passive and iontophoretic transport of cationic permeant across human nail
    Kelly A Smith
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Pharm Res 26:1446-55. 2009
    ..The present study investigated the effects of ionic strength upon transungual passive and iontophoretic transport...
  9. pmc Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera
    Poonam Chopra
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    J Control Release 160:96-104. 2012
    ..These micellar carrier systems can be efficiently delivered into and across the sclera by iontophoresis for drug delivery...
  10. pmc Iontophoretically enhanced ciclopirox delivery into and across human nail plate
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 98:3608-16. 2009
    ..The results demonstrate that iontophoresis was able to deliver an effective amount of CIC into and across the nails, and this suggests the feasibility of a constant voltage battery-powered transungual iontophoretic device...
  11. pmc Evaluation of skin permeation of β-blockers for topical drug delivery
    Doungdaw Chantasart
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Avenue, 136 HPB, Cincinnati, Ohio 45267, USA
    Pharm Res 30:866-77. 2013
    ..To develop an effective topical skin delivery system for the β-blockers, the present study evaluated skin permeation of β-blockers propranolol, betaxolol, timolol, and atenolol...
  12. pmc Mechanistic study of electroosmotic transport across hydrated nail plates: effects of pH and ionic strength
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 97:5186-97. 2008
    ..Under the studied pH and ionic strength conditions, the effects of electroosmosis were small compared to the direct-field effects in transungual iontophoretic transport of small to moderate size permeants...
  13. pmc Gene delivery to cornea
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Brain Res Bull 81:256-61. 2010
    ..The combination of iontophoresis and electroporation was found to be effective in delivering siRNA but not plasmid DNA into the corneal epithelium. Nanocarriers such as polymeric micelles are promising methods of corneal gene delivery...
  14. pmc Effects of alternating current frequency and permeation enhancers upon human epidermal membrane
    Qingfang Xu
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA
    Int J Pharm 372:24-32. 2009
    ..The enhancers reversibly reduced the AC voltage required to sustain a constant state of pore induction in HEM during AC iontophoresis, consistent with the mechanism of lipid lamellae electroporation in the stratum corneum...
  15. pmc MRI study of subconjunctival and intravitreal injections
    S Kevin Li
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 101:2353-63. 2012
    ..MRI continues to provide insights into the transport barriers and clearance pathways of hydrophilic molecules in ocular delivery...
  16. pmc Influence of permeant lipophilicity on permeation across human sclera
    He Wen
    Division of Pharmaceutical Sciences James L Winkle College of Pharmacy, University of Cincinnati, 3225 Eden Avenue 136 HPB, Cincinnati, Ohio 45267, USA
    Pharm Res 27:2446-56. 2010
    ..The objectives of this study were to determine the effects of permeant lipophilicity on permeant uptake into and transport across human sclera for transscleral delivery...
  17. pmc Electrically assisted delivery of macromolecules into the corneal epithelium
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Ave, HPB 136, Cincinnati, OH 45267, USA
    Exp Eye Res 89:934-41. 2009
    ..These results illustrate the feasibility of electrically assisted delivery of macromolecules such as siRNA into the cornea...
  18. pmc Transungual iontophoretic transport of polar neutral and positively charged model permeants: effects of electrophoresis and electroosmosis
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 97:893-905. 2008
    ..The present results with hydrated nail plates are consistent with electrophoresis-dominant (the direct field effect) transungual iontophoretic transport of small ionic permeants with small contribution from electroosmosis...