R Scott Hansen

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Sequencing newly replicated DNA reveals widespread plasticity in human replication timing
    R Scott Hansen
    Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:139-44. 2010
  2. pmc The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
    R S Hansen
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:14412-7. 1999
  3. ncbi request reprint Escape from gene silencing in ICF syndrome: evidence for advanced replication time as a major determinant
    R S Hansen
    Department of Medicine, Box 357360, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 9:2575-87. 2000
  4. ncbi request reprint X inactivation-specific methylation of LINE-1 elements by DNMT3B: implications for the Lyon repeat hypothesis
    R Scott Hansen
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, 98195 7720, USA
    Hum Mol Genet 12:2559-67. 2003
  5. pmc Systematic localization of common disease-associated variation in regulatory DNA
    Matthew T Maurano
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Science 337:1190-5. 2012
  6. ncbi request reprint Hemimethylation and non-CpG methylation levels in a promoter region of human LINE-1 (L1) repeated elements
    Alice F Burden
    Department of Biology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:14413-9. 2005
  7. pmc An expansive human regulatory lexicon encoded in transcription factor footprints
    Shane Neph
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Nature 489:83-90. 2012
  8. pmc Abnormal X: autosome ratio, but normal X chromosome inactivation in human triploid cultures
    Stanley M Gartler
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    BMC Genet 7:41. 2006
  9. pmc Molecular barcodes detect redundancy and contamination in hairpin-bisulfite PCR
    Brooks E Miner
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    Nucleic Acids Res 32:e135. 2004
  10. pmc The accessible chromatin landscape of the human genome
    Robert E Thurman
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Nature 489:75-82. 2012

Collaborators

Detail Information

Publications17

  1. pmc Sequencing newly replicated DNA reveals widespread plasticity in human replication timing
    R Scott Hansen
    Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:139-44. 2010
    ..The data collectively provide a unique, genome-wide picture of the epigenetic compartmentalization of the human genome and suggest that cell-lineage specification involves extensive reprogramming of replication timing patterns...
  2. pmc The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
    R S Hansen
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:14412-7. 1999
    ..None of the mutations were found in over 200 normal chromosomes. We conclude that mutations in the DNMT3B are responsible for the ICF syndrome...
  3. ncbi request reprint Escape from gene silencing in ICF syndrome: evidence for advanced replication time as a major determinant
    R S Hansen
    Department of Medicine, Box 357360, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 9:2575-87. 2000
    ..The persistence of inactivation in these latter cases appears to depend critically on delayed replication of DNA because escape from silencing was only seen when replication was advanced to an active X-like pattern...
  4. ncbi request reprint X inactivation-specific methylation of LINE-1 elements by DNMT3B: implications for the Lyon repeat hypothesis
    R Scott Hansen
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, 98195 7720, USA
    Hum Mol Genet 12:2559-67. 2003
    ....
  5. pmc Systematic localization of common disease-associated variation in regulatory DNA
    Matthew T Maurano
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Science 337:1190-5. 2012
    ..Our results suggest pervasive involvement of regulatory DNA variation in common human disease and provide pathogenic insights into diverse disorders...
  6. ncbi request reprint Hemimethylation and non-CpG methylation levels in a promoter region of human LINE-1 (L1) repeated elements
    Alice F Burden
    Department of Biology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:14413-9. 2005
    ....
  7. pmc An expansive human regulatory lexicon encoded in transcription factor footprints
    Shane Neph
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Nature 489:83-90. 2012
    ....
  8. pmc Abnormal X: autosome ratio, but normal X chromosome inactivation in human triploid cultures
    Stanley M Gartler
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    BMC Genet 7:41. 2006
    ....
  9. pmc Molecular barcodes detect redundancy and contamination in hairpin-bisulfite PCR
    Brooks E Miner
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    Nucleic Acids Res 32:e135. 2004
    ..Useful applications will include analyses of limited template DNA for biomedical, ancient DNA and forensic purposes...
  10. pmc The accessible chromatin landscape of the human genome
    Robert E Thurman
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Nature 489:75-82. 2012
    ....
  11. pmc Normal histone modifications on the inactive X chromosome in ICF and Rett syndrome cells: implications for methyl-CpG binding proteins
    Stanley M Gartler
    Department of Medicine, University of Washington, Seattle, WA, USA
    BMC Biol 2:21. 2004
    ..In addition, we determined whether a specific methyl-CpG binding protein, MeCP2, is necessary for the inactive X histone modification pattern by studying Rett syndrome cells which are deficient in MeCP2 function...
  12. pmc Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules
    Charles D Laird
    Department of Biology, Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 101:204-9. 2004
    ..Hairpin-bisulfite PCR will be a powerful tool in studying other processes for which genetic or epigenetic information differs on the two complementary strands of DNA...
  13. ncbi request reprint Encoding PCR products with batch-stamps and barcodes
    Megan L McCloskey
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 0002, USA
    Biochem Genet 45:761-7. 2007
    ..We recommend that batch-stamps and barcodes be used when amplifying irreplaceable DNAs and cDNAs available for forensic, clinical, single cell, and ancient DNA analyses...
  14. pmc Dosage regulation of the active X chromosome in human triploid cells
    Xinxian Deng
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 5:e1000751. 2009
    ..Indeed, we found that there was a range of individual X-linked gene expression in relation to ploidy and that a small subset ( approximately 7%) of genes had expression levels apparently proportional to the number of autosomal sets...
  15. ncbi request reprint An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals
    Paula D Ladd
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 16:3174-87. 2007
    ..Moreover, it exhibits premutation-specific alternative splicing. Taken together, these observations suggest that in addition to FMR1, ASFMR1 may contribute to the variable phenotypes associated with the CGG repeat expansion...
  16. ncbi request reprint Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes
    Maria Rosaria Matarazzo
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Naples, Italy
    Hum Mol Genet 11:3191-8. 2002
    ....
  17. ncbi request reprint A new regulatory pathway for fragile X syndrome?
    R Scott Hansen
    Nat Med 8:1204-5. 2002