Marlan Hansen

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Constitutive neuregulin-1/ErbB signaling contributes to human vestibular schwannoma proliferation
    Marlan R Hansen
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, 52242, USA
    Glia 53:593-600. 2006
  2. ncbi request reprint Expression of neuregulin and activation of erbB receptors in vestibular schwannomas: possible autocrine loop stimulation
    Marlan R Hansen
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Otol Neurotol 25:155-9. 2004
  3. ncbi request reprint Surgical outcomes in patients with endolymphatic sac tumors
    Marlan R Hansen
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
    Laryngoscope 114:1470-4. 2004
  4. doi request reprint Effects of ErbB2 signaling on the response of vestibular schwannoma cells to gamma-irradiation
    Marlan R Hansen
    Department of Otolaryngology Head and Neck, University of Iowa, Iowa City, Iowa 52242, USA
    Laryngoscope 118:1023-30. 2008
  5. ncbi request reprint Overexpression of Bcl-2 or Bcl-xL prevents spiral ganglion neuron death and inhibits neurite growth
    Marlan R Hansen
    Department of Otolaryngology, Head, and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA
    Dev Neurobiol 67:316-25. 2007
  6. ncbi request reprint Zinc as a possible treatment for tinnitus
    Claudia Barros Coelho
    Department of Otolaryngology, Head and Neck Surgery, The University of Iowa, Iowa City, IA, USA
    Prog Brain Res 166:279-85. 2007
  7. doi request reprint Acute radiographic workup of blunt temporal bone trauma: maxillofacial versus temporal bone CT
    Ryan Dempewolf
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA
    Laryngoscope 119:442-8. 2009
  8. pmc Membrane depolarization inhibits spiral ganglion neurite growth via activation of multiple types of voltage sensitive calcium channels and calpain
    Pamela C Roehm
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
    Mol Cell Neurosci 37:376-87. 2008
  9. ncbi request reprint Optically guided stereotactic radiotherapy for facial nerve paralysis secondary to occult malignant neoplasms
    Min Yao
    Department of Radiation Oncology, The University of Iowa Health Care, Iowa City, Iowa 52242, USA
    Otolaryngol Head Neck Surg 135:657-9. 2006
  10. ncbi request reprint Diagnosis of ear pain
    John W Ely
    Department of Family Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am Fam Physician 77:621-8. 2008

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Constitutive neuregulin-1/ErbB signaling contributes to human vestibular schwannoma proliferation
    Marlan R Hansen
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, 52242, USA
    Glia 53:593-600. 2006
    ..Inhibition of constitutive NRG:ErbB signaling reduces VS cell proliferation in vitro and may have therapeutic potential for patients with VSs...
  2. ncbi request reprint Expression of neuregulin and activation of erbB receptors in vestibular schwannomas: possible autocrine loop stimulation
    Marlan R Hansen
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Otol Neurotol 25:155-9. 2004
    ..We sought to determine whether vestibular schwannomas are capable of producing and responding to the glial growth factor neuregulin...
  3. ncbi request reprint Surgical outcomes in patients with endolymphatic sac tumors
    Marlan R Hansen
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
    Laryngoscope 114:1470-4. 2004
    ..To determine the surgical outcomes in patients with endolymphatic sac tumors (ELSTs)...
  4. doi request reprint Effects of ErbB2 signaling on the response of vestibular schwannoma cells to gamma-irradiation
    Marlan R Hansen
    Department of Otolaryngology Head and Neck, University of Iowa, Iowa City, Iowa 52242, USA
    Laryngoscope 118:1023-30. 2008
    ..Development of alternative therapies that augment or replace microsurgery or IR would benefit patients not suitable for current therapies. This study explored the ability of ErbB2 inhibitors to modulate the effects of IR on VS cells...
  5. ncbi request reprint Overexpression of Bcl-2 or Bcl-xL prevents spiral ganglion neuron death and inhibits neurite growth
    Marlan R Hansen
    Department of Otolaryngology, Head, and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA
    Dev Neurobiol 67:316-25. 2007
    ....
  6. ncbi request reprint Zinc as a possible treatment for tinnitus
    Claudia Barros Coelho
    Department of Otolaryngology, Head and Neck Surgery, The University of Iowa, Iowa City, IA, USA
    Prog Brain Res 166:279-85. 2007
    ....
  7. doi request reprint Acute radiographic workup of blunt temporal bone trauma: maxillofacial versus temporal bone CT
    Ryan Dempewolf
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA
    Laryngoscope 119:442-8. 2009
    ..To evaluate the radiographic workup of blunt temporal bone trauma and determine the utility of maxillofacial computed tomography (CT) versus temporal bone CT in identifying carotid canal fractures...
  8. pmc Membrane depolarization inhibits spiral ganglion neurite growth via activation of multiple types of voltage sensitive calcium channels and calpain
    Pamela C Roehm
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
    Mol Cell Neurosci 37:376-87. 2008
    ....
  9. ncbi request reprint Optically guided stereotactic radiotherapy for facial nerve paralysis secondary to occult malignant neoplasms
    Min Yao
    Department of Radiation Oncology, The University of Iowa Health Care, Iowa City, Iowa 52242, USA
    Otolaryngol Head Neck Surg 135:657-9. 2006
  10. ncbi request reprint Diagnosis of ear pain
    John W Ely
    Department of Family Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am Fam Physician 77:621-8. 2008
    ....
  11. doi request reprint Middle ear cancer: a population-based study
    Richard K Gurgel
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, U S A
    Laryngoscope 119:1913-7. 2009
    ..The objective of this study was to utilize the Surveillance, Epidemiology, and End Results (SEER) database to determine the incidence, treatment, and survival of middle ear carcinoma...
  12. pmc Hybrid 10 clinical trial: preliminary results
    Bruce J Gantz
    Department of Otolaryngology Head and Neck Surgery, Iowa Cochlear Implant Clinical Research Center, University of Iowa, Iowa City, Iowa 52242 1078, USA
    Audiol Neurootol 14:32-8. 2009
    ..Duration of profound high-frequency hearing loss appears to be an important variable when determining selection criteria for the Hybrid implant...
  13. doi request reprint Neurolymphomatosis mimicking chemotherapy-induced ototoxicity
    Robert S Hong
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Otol Neurotol 30:566-9. 2009
    ..To present an unusual cause of bilateral sensorineural hearing loss mimicking chemotherapy-induced ototoxicity...
  14. ncbi request reprint Canal wall reconstruction tympanomastoidectomy with mastoid obliteration
    Bruce J Gantz
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, 52242, USA
    Laryngoscope 115:1734-40. 2005
    ..This study was designed to evaluate the authors' experience with canal wall reconstruction (CWR) tympanomastoidectomy with mastoid obliteration in the treatment of chronic otitis media with cholesteatoma...
  15. pmc Interaction of neurotrophin signaling with Bcl-2 localized to the mitochondria and endoplasmic reticulum on spiral ganglion neuron survival and neurite growth
    John P Renton
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, Iowa
    J Neurosci Res 88:2239-51. 2010
    ..Additionally, Bcl-2 targeted to the mitochondria results in SGN death in the presence of neurotrophins. (c) 2010 Wiley-Liss, Inc...
  16. doi request reprint Lipid raft localization of ErbB2 in vestibular schwannoma and schwann cells
    Kevin D Brown
    Department of Otolaryngology Head and Neck Surgery, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Otol Neurotol 29:79-85. 2008
    ..ErbB2 resides in lipid rafts (regions of receptor regulation) in vestibular schwannoma (VS) cells...
  17. ncbi request reprint p75NTR and sortilin increase after facial nerve injury
    Matthew J Provenzano
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, U S A
    Laryngoscope 118:87-93. 2008
    ..This study investigated the role of p75, sortilin, and proneurotrophins in SC survival after facial nerve (FN) axotomy...
  18. ncbi request reprint Disseminated histoplasmosis presenting as a unilateral cranial nerve VIII mass: a case report
    Richard K Gurgel
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Otol Neurotol 27:1014-6. 2006
    ..To report a unique presentation of disseminated histoplasmosis...
  19. ncbi request reprint Small acoustic neuromas: surgical outcomes versus observation or radiation
    Ted A Meyer
    Medical University of South Carolina, Department of Otolaryngology HNS, Charleston, SC, USA, and Royal Children s Hospital, Department of Otolaryngology, Melbourne, Australia
    Otol Neurotol 27:380-92. 2006
    ..Evaluate factors affecting outcomes of small acoustic neuroma (AN) removal via a middle cranial fossa (MCF) approach, and compare results to published data on observation and radiation therapy...
  20. pmc The ErbB inhibitors trastuzumab and erlotinib inhibit growth of vestibular schwannoma xenografts in nude mice: a preliminary study
    J Jason Clark
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242 1078, USA
    Otol Neurotol 29:846-53. 2008
    ..To analyze the ability of ErbB inhibitors to reduce the growth of vestibular schwannoma (VS) xenografts...
  21. ncbi request reprint Ca2+/calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neurons
    Marlan R Hansen
    Department of Biological Sciences, University of Iowa, Iowa City 52242 1324, USA
    J Neurosci Res 72:169-84. 2003
    ..Although both CaMKII and CaMKIV activities converge in promoting survival, their actions on axon growth are markedly different: Transfection of truncated CaMKII, but not of truncated CaMKIV, into SGNs prevents axon outgrowth...
  22. ncbi request reprint Cavernous hemangioma of the endolymphatic sac
    Eric P Wilkinson
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Otol Neurotol 27:1203-4. 2006
  23. ncbi request reprint Cerebral venous sinus thrombosis following jugular bulb decompression
    Vinay A Shah
    University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1091, USA
    Semin Ophthalmol 21:41-4. 2006
    ..To our knowledge this is the first reported case of venous thrombosis following jugular bulb surgery in the English language ophthalmologic literature...
  24. ncbi request reprint Strategies to preserve or regenerate spiral ganglion neurons
    Pamela C Roehm
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA
    Curr Opin Otolaryngol Head Neck Surg 13:294-300. 2005
    ..Replacement of these factors may help preserve or regenerate the auditory nerve in patients with extensive hair cell loss...
  25. pmc Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides
    Wei Ying Yue
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Neuro Oncol 13:961-73. 2011
    ..Taken together, these results indicate that persistent JNK activity enhances VS cell survival, at least in part, by suppressing accumulation of mitochondrial superoxides...
  26. ncbi request reprint Retrograde labeling of the rat facial nerve with carbocyanine dyes to enhance intraoperative identification
    Salim Dogru
    Dept of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
    Ann Otol Rhinol Laryngol 117:753-8. 2008
    ..Here we tested a method of labeling the facial nerve with fluorescent lipophilic dyes as a method of providing intraoperative visual confirmation of nerve fibers...
  27. ncbi request reprint The Coxsackievirus and Adenovirus Receptor: a new adhesion protein in cochlear development
    Katherine J D A Excoffon
    Department of Internal Medicine, Division of Pulmonary Medicine, University of Iowa, 440 EMRB, Iowa City, IA 52242, USA
    Hear Res 215:1-9. 2006
    ....

Research Grants4

  1. Regulation of auditory neuron neurite growth by activity
    Marlan Hansen; Fiscal Year: 2007
    The goal of this application is to develop Dr. Marlan Hansen into an independent physician/scientist. Drs. Steve Green and Jack Lilien will serve as mentors to guide his development. Drs...
  2. Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growth
    Marlan R Hansen; Fiscal Year: 2010
    ..These studies seek to identify the underlying cellular abnormalities that lead to tumor formation and to identify novel therapies that specifically limit schwannoma growth. ..