Research Topics
Species | Marlan HansenSummaryAffiliation: University of Iowa Country: USA Publications
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Publications
Constitutive neuregulin-1/ErbB signaling contributes to human vestibular schwannoma proliferationMarlan R Hansen
Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, 52242, USA
Glia 53:593-600. 2006..Inhibition of constitutive NRG:ErbB signaling reduces VS cell proliferation in vitro and may have therapeutic potential for patients with VSs...- Expression of neuregulin and activation of erbB receptors in vestibular schwannomas: possible autocrine loop stimulationMarlan R Hansen
Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Otol Neurotol 25:155-9. 2004..We sought to determine whether vestibular schwannomas are capable of producing and responding to the glial growth factor neuregulin... - Surgical outcomes in patients with endolymphatic sac tumorsMarlan R Hansen
Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
Laryngoscope 114:1470-4. 2004..To determine the surgical outcomes in patients with endolymphatic sac tumors (ELSTs)... 
Effects of ErbB2 signaling on the response of vestibular schwannoma cells to gamma-irradiationMarlan R Hansen
Department of Otolaryngology Head and Neck, University of Iowa, Iowa City, Iowa 52242, USA
Laryngoscope 118:1023-30. 2008..Development of alternative therapies that augment or replace microsurgery or IR would benefit patients not suitable for current therapies. This study explored the ability of ErbB2 inhibitors to modulate the effects of IR on VS cells...- Overexpression of Bcl-2 or Bcl-xL prevents spiral ganglion neuron death and inhibits neurite growthMarlan R Hansen
Department of Otolaryngology, Head, and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA
Dev Neurobiol 67:316-25. 2007.... - Zinc as a possible treatment for tinnitusClaudia Barros Coelho
Department of Otolaryngology, Head and Neck Surgery, The University of Iowa, Iowa City, IA, USA
Prog Brain Res 166:279-85. 2007.... - Acute radiographic workup of blunt temporal bone trauma: maxillofacial versus temporal bone CTRyan Dempewolf
Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA
Laryngoscope 119:442-8. 2009..To evaluate the radiographic workup of blunt temporal bone trauma and determine the utility of maxillofacial computed tomography (CT) versus temporal bone CT in identifying carotid canal fractures... 
Membrane depolarization inhibits spiral ganglion neurite growth via activation of multiple types of voltage sensitive calcium channels and calpainPamela C Roehm
Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
Mol Cell Neurosci 37:376-87. 2008....- Optically guided stereotactic radiotherapy for facial nerve paralysis secondary to occult malignant neoplasmsMin Yao
Department of Radiation Oncology, The University of Iowa Health Care, Iowa City, Iowa 52242, USA
Otolaryngol Head Neck Surg 135:657-9. 2006 - Diagnosis of ear painJohn W Ely
Department of Family Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Am Fam Physician 77:621-8. 2008.... - Middle ear cancer: a population-based studyRichard K Gurgel
Department of Otolaryngology Head and Neck Surgery, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, U S A
Laryngoscope 119:1913-7. 2009..The objective of this study was to utilize the Surveillance, Epidemiology, and End Results (SEER) database to determine the incidence, treatment, and survival of middle ear carcinoma... - Hybrid 10 clinical trial: preliminary resultsBruce J Gantz
Department of Otolaryngology Head and Neck Surgery, Iowa Cochlear Implant Clinical Research Center, University of Iowa, Iowa City, Iowa 52242 1078, USA
Audiol Neurootol 14:32-8. 2009..Duration of profound high-frequency hearing loss appears to be an important variable when determining selection criteria for the Hybrid implant... - Neurolymphomatosis mimicking chemotherapy-induced ototoxicityRobert S Hong
Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Otol Neurotol 30:566-9. 2009..To present an unusual cause of bilateral sensorineural hearing loss mimicking chemotherapy-induced ototoxicity... - Canal wall reconstruction tympanomastoidectomy with mastoid obliterationBruce J Gantz
Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, 52242, USA
Laryngoscope 115:1734-40. 2005..This study was designed to evaluate the authors' experience with canal wall reconstruction (CWR) tympanomastoidectomy with mastoid obliteration in the treatment of chronic otitis media with cholesteatoma... - Interaction of neurotrophin signaling with Bcl-2 localized to the mitochondria and endoplasmic reticulum on spiral ganglion neuron survival and neurite growthJohn P Renton
Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, Iowa
J Neurosci Res 88:2239-51. 2010..Additionally, Bcl-2 targeted to the mitochondria results in SGN death in the presence of neurotrophins. (c) 2010 Wiley-Liss, Inc... - Lipid raft localization of ErbB2 in vestibular schwannoma and schwann cellsKevin D Brown
Department of Otolaryngology Head and Neck Surgery, University of Iowa College of Medicine, Iowa City, Iowa, USA
Otol Neurotol 29:79-85. 2008..ErbB2 resides in lipid rafts (regions of receptor regulation) in vestibular schwannoma (VS) cells... - p75NTR and sortilin increase after facial nerve injuryMatthew J Provenzano
Department of Otolaryngology Head and Neck Surgery, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, U S A
Laryngoscope 118:87-93. 2008..This study investigated the role of p75, sortilin, and proneurotrophins in SC survival after facial nerve (FN) axotomy... - Disseminated histoplasmosis presenting as a unilateral cranial nerve VIII mass: a case reportRichard K Gurgel
Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Otol Neurotol 27:1014-6. 2006..CONCLUSION: Infectious processes, including disseminated histoplasmosis, should be considered in the differential of internal auditory canal masses, especially in the setting of rapid progression of symptoms... - Small acoustic neuromas: surgical outcomes versus observation or radiationTed A Meyer
Medical University of South Carolina, Department of Otolaryngology-HNS, Charleston, SC, USA, and Royal Children's Hospital, Department of Otolaryngology, Melbourne, Australia
Otol Neurotol 27:380-92. 2006..Radiation may prevent most tumors from growing, and more data are needed to determine long-term tumor control and hearing preservation rates... - The ErbB inhibitors trastuzumab and erlotinib inhibit growth of vestibular schwannoma xenografts in nude mice: a preliminary studyJ Jason Clark
Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242 1078, USA
Otol Neurotol 29:846-53. 2008..To analyze the ability of ErbB inhibitors to reduce the growth of vestibular schwannoma (VS) xenografts... - Ca2+/calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neuronsMarlan R Hansen
Department of Biological Sciences, University of Iowa, Iowa City 52242-1324, USA
J Neurosci Res 72:169-84. 2003..Although both CaMKII and CaMKIV activities converge in promoting survival, their actions on axon growth are markedly different: Transfection of truncated CaMKII, but not of truncated CaMKIV, into SGNs prevents axon outgrowth... - Cavernous hemangioma of the endolymphatic sacEric P Wilkinson
Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Otol Neurotol 27:1203-4. 2006 - Cerebral venous sinus thrombosis following jugular bulb decompressionVinay A Shah
University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242-1091, USA
Semin Ophthalmol 21:41-4. 2006..To our knowledge this is the first reported case of venous thrombosis following jugular bulb surgery in the English language ophthalmologic literature... - Strategies to preserve or regenerate spiral ganglion neuronsPamela C Roehm
Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA
Curr Opin Otolaryngol Head Neck Surg 13:294-300. 2005..While still preliminary, such strategies show promise for future clinical applications... - Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxidesWei Ying Yue
Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Neuro Oncol 13:961-73. 2011..Taken together, these results indicate that persistent JNK activity enhances VS cell survival, at least in part, by suppressing accumulation of mitochondrial superoxides... - Retrograde labeling of the rat facial nerve with carbocyanine dyes to enhance intraoperative identificationSalim Dogru
Dept of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
Ann Otol Rhinol Laryngol 117:753-8. 2008..Here we tested a method of labeling the facial nerve with fluorescent lipophilic dyes as a method of providing intraoperative visual confirmation of nerve fibers... - The Coxsackievirus and Adenovirus Receptor: a new adhesion protein in cochlear developmentKatherine J D A Excoffon
Department of Internal Medicine, Division of Pulmonary Medicine, University of Iowa, 440 EMRB, Iowa City, IA 52242, USA
Hear Res 215:1-9. 2006....
Research Grants
- Regulation of auditory neuron neurite growth by activityMarlan Hansen; Fiscal Year: 2007The goal of this application is to develop Dr. Marlan Hansen into an independent physician/scientist. Drs. Steve Green and Jack Lilien will serve as mentors to guide his development. Drs...
- Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growthMarlan R Hansen; Fiscal Year: 2010..These studies seek to identify the underlying cellular abnormalities that lead to tumor formation and to identify novel therapies that specifically limit schwannoma growth. ..