Research Topics
Species | L A HansenSummaryAffiliation: University of California Country: USA Publications
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Publications
Institution animal care and use committees need greater ethical diversityLawrence Arthur Hansen
Department of Neurosciences and Pathology, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093 0624, USA
J Med Ethics 39:188-90. 2013....
Use of live animals in the curricula of U.S. medical schools: survey results from 2001Lawrence A Hansen
Department of Neurosciences, University of California, San Diego, La Jolla 92093, USA
Acad Med 77:1147-9. 2002..The use of live animals in U.S. medical education declined progressively from 1985 to 1994. This study determined whether this trend continued into 2001...
Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementiaL A Hansen
Department of Pathology, University of California, San Diego, La Jolla 92093 0624, USA
J Neurol Neurosurg Psychiatry 64:653-6. 1998..The aim was to determine if dementia in Lewy body disease was associated with diminished concentrations of midfrontal cortex synaptophysin...- E4 allele dosage does not predict cholinergic activity or synapse loss in Alzheimer's diseaseJ Corey-Bloom
Department of Neurosciences, University of California, San Diego, La Jolla, USA
Neurology 54:403-6. 2000..To investigate the relationship between apolipoprotein E (APOE) genotype and both cholinergic dysfunction and synapse loss in AD... - Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of GuamE Masliah
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624, USA
Neuroreport 12:3901-3. 2001..This deficit was similar to that seen in Alzheimer's disease and less severe than Lewy body disease. Thus, cholinergic deficits in the neocortex might contribute to some of the cognitive alterations in PDC of Guam... - Altered expression of synaptic proteins occurs early during progression of Alzheimer's diseaseE Masliah
Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA
Neurology 56:127-9. 2001..Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD... - Position paper on diagnostic criteria for Alzheimer diseaseL A Hansen
Department of Neurosciences, University of California, San Diego, La Jolla 92093 0624, USA
Neurobiol Aging 18:S71-3. 1997..We endorse the semiquantitative neuritic-plaque based criteria from CERAD for routine diagnosis, and Braak staging with descriptive profiling of AD lesions in a research context... - Choline acetyltransferase activity and cognitive domain scores of Alzheimer's patientsB A Pappas
Alzheimer s Disease Research Center, University of California at San Diego, La Jolla, CA 92093 0948, USA
Neurobiol Aging 21:11-7. 2000..Hippocampal ChAT correlated significantly only with recent memory scores. These results are consistent with current animal research regarding the effect of selective cholinergic lesions on behavior... - Correlation of nicotinic receptor binding with clinical and neuropathological changes in Alzheimer's disease and dementia with Lewy bodiesM N Sabbagh
Department of Neurosciences, UCSD, La Jolla, CA, USA
J Neural Transm 108:1149-57. 2001..Loss of nAChR activity does not appear to be related to plaques or NFTs in AD or DLB... - In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distributionD Weisman
Department of Neurosciences, University of California, San Diego, CA, USA
Neurology 69:356-9. 2007..Clinical diagnosis of DLB, however, depended on the presence of low Alzheimer disease pathology (by Braak staging) rather than on Lewy body distribution... - Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodiesA R Merdes
Department of Neurosciences, University of California, San Diego 92161, USA
Neurology 60:1586-90. 2003..0039). CONCLUSIONS: The degree of concomitant AD tangle pathology has an important influence on the clinical characteristics and, therefore, the clinical diagnostic accuracy of DLB... - Disparate letter and semantic category fluency deficits in autopsy-confirmed frontotemporal dementia and Alzheimer's diseaseKatya Rascovsky
Department of Neurosciences, University of California, San Diego, CA, USA
Neuropsychology 21:20-30. 2007..These unique patterns of letter and semantic category fluency deficits may be indicative of differences in the relative contribution of frontal-lobe-mediated retrieval deficits and temporal-lobe-mediated semantic deficits in FTD and AD... - Relationship between severe amyloid angiopathy, apolipoprotein E genotype, and vascular lesions in Alzheimer's diseaseJ M Olichney
Alzheimer s Disease Research Center, University of California, San Diego, La Jolla, California 92093 0948, USA
Ann N Y Acad Sci 903:138-43. 2000..We discuss the implications of this finding as advancing a pathogenic role for severe CAA in producing many of the VLs commonly found in AD cases... - Distinct cognitive profiles and rates of decline on the Mattis Dementia Rating Scale in autopsy-confirmed frontotemporal dementia and Alzheimer's diseaseKatya Rascovsky
Memory and Aging Center, University of California, San Francisco, California, USA
J Int Neuropsychol Soc 14:373-83. 2008..8 points/year) on MDRS total and specific subscale scores. These results suggest that the MDRS may be a useful adjunct to other clinical measures for distinguishing FTD from AD and tracking the progression of the disorder... - Detection of borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric patientsJ C de La Torre
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
Virology 223:272-82. 1996..This is the first demonstration that BDV can infect human brain tissue, possibly contributing to the pathophysiology of specific human neuropsychiatric disorders... - Early and persistent alterations in prefrontal cortex MAO A and B in Alzheimer's diseaseB P Kennedy
Department of Medicine, University of California, San Diego Medical Center, San Diego, CA 92103, USA
J Neural Transm 110:789-801. 2003..We conclude that the changes in MAO A and B in the prefrontal cortex occur very early in Alzheimer's disease and remain relatively constant as the disease progresses... - Cognitive profiles differ in autopsy-confirmed frontotemporal dementia and ADK Rascovsky
Department of Neurosciences, University of California at San Diego, La Jolla 92093 0948, USA
Neurology 58:1801-8. 2002..Therefore, a retrospective examination of neuropsychological test performance in autopsy-confirmed patients is warranted... - Age at onset is associated with disease severity in Lewy body variant and Alzheimer's diseaseGilbert J Ho
Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093-0624, USA
Neuroreport 13:1825-8. 2002..Taken together, these results suggest that for both LBV and AD, earlier age at onset may predict a more aggressive disease course... - Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodiesJoanne M Hamilton
Department of Neurosciences, University of California, USA
Neuropsychology 22:729-37. 2008.... - Reduced hypocretin (orexin) levels in dementia with Lewy bodiesSTEPHANIE LESSIG
Departments of Neurosciences, University of California, San Diego, La Jolla, California, USA
Neuroreport 21:756-60. 2010..These results suggest the involvement of hypocretin in sleep disorders in dementia with Lewy bodies... - Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional roleGilbert J Ho
Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0624, USA
Neurobiol Aging 26:625-35. 2005..Taken together, these findings suggest that alterations in Fyn localization might be associated with neurofibrillary pathology and synapse loss in AD... - A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's diseaseJoanne M Hamilton
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0948, USA
J Int Neuropsychol Soc 10:689-97. 2004..These results indicate that while both DLB and AD patients exhibit significant memory impairment, the ability to consolidate information may be less severely impaired in DLB patients than in AD patients... - Primary anaplastic glio-neuronal tumor of the pineal gland: a new type of pineal neoplasm?Henry E Aryan
Division of Neurosurgery, University of California, San Diego, CA 92103 8893, USA
J Clin Neurosci 11:163-5. 2004..Most are solid, infiltrative lesions characterized by either germ cell, glial, or pineal parenchymal origin. To our knowledge, none have been described that contain an admixture of both anaplastic glial and neuronal elements... - Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's diseaseMark W Bondi
Psychology Service, Veterans Affairs San Diego Healthcare System and Department of Psychiatry, University of California 92161, USA
Neuropsychology 16:335-43. 2002..Results of clinicopathologic correlations in an autopsy-confirmed AD subgroup further suggest the invocation of a broad network of integrated cortical regions and executive and language processes underlying successful SCWT performance... - Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive functionB P Kennedy
Department of Medicine, University of California, San Diego Medical Center, San Diego, CA 92103 8341, USA
J Neural Transm 111:547-67. 2004..326), levels of synaptophysin (r=0.506), and negatively with tangles (r=-0.216 P=0.039). Elevated SAH in Alzheimer brain inhibits methyltransferases and is related to markers of disease progression and cognitive impairment... - Anosmia is very common in the Lewy body variant of Alzheimer's diseaseJ M Olichney
Alzheimer s Disease Research Center, University of California, San Diego, CA, USA
J Neurol Neurosurg Psychiatry 76:1342-7. 2005..Olfactory abnormalities are reported in Alzheimer's disease and Parkinson's disease. Anosmia appears to be common in dementia with Lewy bodies but not in pure Alzheimer's disease... - Diagnostic validity of the dementia questionnaire for Alzheimer diseaseR J Ellis
Department of Neurosciences, University of California, San Diego, La Jolla 92093 0948, USA
Arch Neurol 55:360-5. 1998..To determine the sensitivity and specificity of postmortem dementia diagnoses based on a retrospective informant interview by comparison with criterion standard neuropathological diagnoses and the results of previous clinical examinations... - Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's diseaseE Rockenstein
Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92093 0624, USA
Brain Res 914:48-56. 2001..This study suggests that a critical balance among products of the synuclein gene is important to maintain normal brain function and that alterations in this balance might be associated with neurodegenerative disorders... - Is DNA repair compromised in Alzheimer's disease?Vladislav Davydov
Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0624, USA
Neurobiol Aging 24:953-68. 2003..Immunohistochemical analysis suggested that DNA-PK protein levels reflected both number of neurons and regulation of cellular expression... - The shifting patterns of HIV encephalitis neuropathologyI P Everall
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0624, USA
Neurotox Res 8:51-61. 2005..More detailed characterization of these proposed variants of HIVE is important in order to better understand the pathogenesis of HIV-associated neurological damage and to design more effective treatments to protect the nervous system... - Abeta1-42 promotes cholinergic sprouting in patients with AD and Lewy body variant of ADE Masliah
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA emasliah ucsd edu
Neurology 61:206-11. 2003.... - Interactions between the amyloid precursor protein C-terminal domain and G proteins mediate calcium dysregulation and amyloid beta toxicity in Alzheimer's diseaseGideon M Shaked
Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0624, USA
FEBS J 276:2736-51. 2009..These results also suggest that specific antagonists of G-protein activity may have a therapeutic relevance in Alzheimer's disease... - The neuropathology of aging, mild cognitive impairment, and Alzheimer diseaseLawrence A Hansen
Arch Neurol 63:647-8. 2006 - What best differentiates Lewy body from Alzheimer's disease in early-stage dementia?Pietro Tiraboschi
Dipartimento di Scienze Neurologiche, Ospedale Niguarda Ca Granda, Milano, Italy
Brain 129:729-35. 2006..This suggests that clinical history plus a brief assessment of visuospatial function may be of the greatest value in correctly identifying DLB early during the course of disease...