L A Hansen

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The Nuremberg Code subverts human health and safety by requiring animal modeling
    Ray Greek
    Americans for Medical Advancement, 2251 Refugio Rd, Goleta, CA 93117, USA
    BMC Med Ethics 13:16. 2012
  2. pmc Institution animal care and use committees need greater ethical diversity
    Lawrence Arthur Hansen
    Department of Neurosciences and Pathology, University of California San Diego, La Jolla, CA 92093 0624, USA
    J Med Ethics 39:188-90. 2013
  3. ncbi request reprint Use of live animals in the curricula of U.S. medical schools: survey results from 2001
    Lawrence A Hansen
    Department of Neurosciences, University of California, San Diego, La Jolla 92093, USA
    Acad Med 77:1147-9. 2002
  4. pmc Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementia
    L A Hansen
    Department of Pathology, University of California, San Diego, La Jolla 92093 0624, USA
    J Neurol Neurosurg Psychiatry 64:653-6. 1998
  5. ncbi request reprint E4 allele dosage does not predict cholinergic activity or synapse loss in Alzheimer's disease
    J Corey-Bloom
    Department of Neurosciences, University of California, San Diego, La Jolla, USA
    Neurology 54:403-6. 2000
  6. ncbi request reprint Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of Guam
    E Masliah
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624, USA
    Neuroreport 12:3901-3. 2001
  7. ncbi request reprint Position paper on diagnostic criteria for Alzheimer disease
    L A Hansen
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0624, USA
    Neurobiol Aging 18:S71-3. 1997
  8. ncbi request reprint Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
    E Masliah
    Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Neurology 56:127-9. 2001
  9. ncbi request reprint Choline acetyltransferase activity and cognitive domain scores of Alzheimer's patients
    B A Pappas
    Alzheimer s Disease Research Center, University of California at San Diego, La Jolla, CA 92093 0948, USA
    Neurobiol Aging 21:11-7. 2000
  10. ncbi request reprint In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution
    D Weisman
    Department of Neurosciences, University of California, San Diego, CA, USA
    Neurology 69:356-9. 2007

Collaborators

Detail Information

Publications35

  1. pmc The Nuremberg Code subverts human health and safety by requiring animal modeling
    Ray Greek
    Americans for Medical Advancement, 2251 Refugio Rd, Goleta, CA 93117, USA
    BMC Med Ethics 13:16. 2012
    ..The requirement that animals be used in research and testing in order to protect humans was formalized in the Nuremberg Code and subsequent national and international laws, codes, and declarations...
  2. pmc Institution animal care and use committees need greater ethical diversity
    Lawrence Arthur Hansen
    Department of Neurosciences and Pathology, University of California San Diego, La Jolla, CA 92093 0624, USA
    J Med Ethics 39:188-90. 2013
    ....
  3. ncbi request reprint Use of live animals in the curricula of U.S. medical schools: survey results from 2001
    Lawrence A Hansen
    Department of Neurosciences, University of California, San Diego, La Jolla 92093, USA
    Acad Med 77:1147-9. 2002
    ..The use of live animals in U.S. medical education declined progressively from 1985 to 1994. This study determined whether this trend continued into 2001...
  4. pmc Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementia
    L A Hansen
    Department of Pathology, University of California, San Diego, La Jolla 92093 0624, USA
    J Neurol Neurosurg Psychiatry 64:653-6. 1998
    ..The aim was to determine if dementia in Lewy body disease was associated with diminished concentrations of midfrontal cortex synaptophysin...
  5. ncbi request reprint E4 allele dosage does not predict cholinergic activity or synapse loss in Alzheimer's disease
    J Corey-Bloom
    Department of Neurosciences, University of California, San Diego, La Jolla, USA
    Neurology 54:403-6. 2000
    ..To investigate the relationship between apolipoprotein E (APOE) genotype and both cholinergic dysfunction and synapse loss in AD...
  6. ncbi request reprint Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of Guam
    E Masliah
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624, USA
    Neuroreport 12:3901-3. 2001
    ..This deficit was similar to that seen in Alzheimer's disease and less severe than Lewy body disease. Thus, cholinergic deficits in the neocortex might contribute to some of the cognitive alterations in PDC of Guam...
  7. ncbi request reprint Position paper on diagnostic criteria for Alzheimer disease
    L A Hansen
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0624, USA
    Neurobiol Aging 18:S71-3. 1997
    ..We endorse the semiquantitative neuritic-plaque based criteria from CERAD for routine diagnosis, and Braak staging with descriptive profiling of AD lesions in a research context...
  8. ncbi request reprint Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
    E Masliah
    Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Neurology 56:127-9. 2001
    ..Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD...
  9. ncbi request reprint Choline acetyltransferase activity and cognitive domain scores of Alzheimer's patients
    B A Pappas
    Alzheimer s Disease Research Center, University of California at San Diego, La Jolla, CA 92093 0948, USA
    Neurobiol Aging 21:11-7. 2000
    ..Hippocampal ChAT correlated significantly only with recent memory scores. These results are consistent with current animal research regarding the effect of selective cholinergic lesions on behavior...
  10. ncbi request reprint In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution
    D Weisman
    Department of Neurosciences, University of California, San Diego, CA, USA
    Neurology 69:356-9. 2007
    ..Clinical diagnosis of DLB, however, depended on the presence of low Alzheimer disease pathology (by Braak staging) rather than on Lewy body distribution...
  11. ncbi request reprint Correlation of nicotinic receptor binding with clinical and neuropathological changes in Alzheimer's disease and dementia with Lewy bodies
    M N Sabbagh
    Department of Neurosciences, UCSD, La Jolla, CA, USA
    J Neural Transm 108:1149-57. 2001
    ..Loss of nAChR activity does not appear to be related to plaques or NFTs in AD or DLB...
  12. ncbi request reprint Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies
    A R Merdes
    Department of Neurosciences, University of California, San Diego 92161, USA
    Neurology 60:1586-90. 2003
    ..To determine whether AD neurofibrillary pathology influences clinical diagnostic accuracy in dementia with Lewy bodies (DLB)...
  13. ncbi request reprint Disparate letter and semantic category fluency deficits in autopsy-confirmed frontotemporal dementia and Alzheimer's disease
    Katya Rascovsky
    Department of Neurosciences, University of California, San Diego, CA, USA
    Neuropsychology 21:20-30. 2007
    ..These unique patterns of letter and semantic category fluency deficits may be indicative of differences in the relative contribution of frontal-lobe-mediated retrieval deficits and temporal-lobe-mediated semantic deficits in FTD and AD...
  14. ncbi request reprint Relationship between severe amyloid angiopathy, apolipoprotein E genotype, and vascular lesions in Alzheimer's disease
    J M Olichney
    Alzheimer s Disease Research Center, University of California, San Diego, La Jolla, California 92093 0948, USA
    Ann N Y Acad Sci 903:138-43. 2000
    ..We discuss the implications of this finding as advancing a pathogenic role for severe CAA in producing many of the VLs commonly found in AD cases...
  15. pmc Distinct cognitive profiles and rates of decline on the Mattis Dementia Rating Scale in autopsy-confirmed frontotemporal dementia and Alzheimer's disease
    Katya Rascovsky
    Memory and Aging Center, University of California, San Francisco, California, USA
    J Int Neuropsychol Soc 14:373-83. 2008
    ..8 points/year) on MDRS total and specific subscale scores. These results suggest that the MDRS may be a useful adjunct to other clinical measures for distinguishing FTD from AD and tracking the progression of the disorder...
  16. ncbi request reprint Detection of borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric patients
    J C de La Torre
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Virology 223:272-82. 1996
    ..This is the first demonstration that BDV can infect human brain tissue, possibly contributing to the pathophysiology of specific human neuropsychiatric disorders...
  17. ncbi request reprint Early and persistent alterations in prefrontal cortex MAO A and B in Alzheimer's disease
    B P Kennedy
    Department of Medicine, University of California, San Diego Medical Center, San Diego, CA 92103, USA
    J Neural Transm 110:789-801. 2003
    ..We conclude that the changes in MAO A and B in the prefrontal cortex occur very early in Alzheimer's disease and remain relatively constant as the disease progresses...
  18. ncbi request reprint Cognitive profiles differ in autopsy-confirmed frontotemporal dementia and AD
    K Rascovsky
    Department of Neurosciences, University of California at San Diego, La Jolla 92093 0948, USA
    Neurology 58:1801-8. 2002
    ..Therefore, a retrospective examination of neuropsychological test performance in autopsy-confirmed patients is warranted...
  19. ncbi request reprint Age at onset is associated with disease severity in Lewy body variant and Alzheimer's disease
    Gilbert J Ho
    Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Neuroreport 13:1825-8. 2002
    ..Taken together, these results suggest that for both LBV and AD, earlier age at onset may predict a more aggressive disease course...
  20. ncbi request reprint Primary anaplastic glio-neuronal tumor of the pineal gland: a new type of pineal neoplasm?
    Henry E Aryan
    Division of Neurosurgery, University of California, San Diego, CA 92103 8893, USA
    J Clin Neurosci 11:163-5. 2004
    ..Most are solid, infiltrative lesions characterized by either germ cell, glial, or pineal parenchymal origin. To our knowledge, none have been described that contain an admixture of both anaplastic glial and neuronal elements...
  21. ncbi request reprint Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease
    Mark W Bondi
    Psychology Service, Veterans Affairs San Diego Healthcare System and Department of Psychiatry, University of California 92161, USA
    Neuropsychology 16:335-43. 2002
    ..Results of clinicopathologic correlations in an autopsy-confirmed AD subgroup further suggest the invocation of a broad network of integrated cortical regions and executive and language processes underlying successful SCWT performance...
  22. ncbi request reprint A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease
    Joanne M Hamilton
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0948, USA
    J Int Neuropsychol Soc 10:689-97. 2004
    ..These results indicate that while both DLB and AD patients exhibit significant memory impairment, the ability to consolidate information may be less severely impaired in DLB patients than in AD patients...
  23. ncbi request reprint Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role
    Gilbert J Ho
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0624, USA
    Neurobiol Aging 26:625-35. 2005
    ..Taken together, these findings suggest that alterations in Fyn localization might be associated with neurofibrillary pathology and synapse loss in AD...
  24. pmc Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodies
    Joanne M Hamilton
    Department of Neurosciences, University of California, USA
    Neuropsychology 22:729-37. 2008
    ....
  25. pmc Reduced hypocretin (orexin) levels in dementia with Lewy bodies
    STEPHANIE LESSIG
    Departments of Neurosciences, University of California, San Diego, La Jolla, California, USA
    Neuroreport 21:756-60. 2010
    ..These results suggest the involvement of hypocretin in sleep disorders in dementia with Lewy bodies...
  26. pmc Anosmia is very common in the Lewy body variant of Alzheimer's disease
    J M Olichney
    Alzheimer s Disease Research Center, University of California, San Diego, CA, USA
    J Neurol Neurosurg Psychiatry 76:1342-7. 2005
    ..Olfactory abnormalities are reported in Alzheimer's disease and Parkinson's disease. Anosmia appears to be common in dementia with Lewy bodies but not in pure Alzheimer's disease...
  27. ncbi request reprint Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive function
    B P Kennedy
    Department of Medicine, University of California, San Diego Medical Center, San Diego, CA 92103 8341, USA
    J Neural Transm 111:547-67. 2004
    ..326), levels of synaptophysin (r=0.506), and negatively with tangles (r=-0.216 P=0.039). Elevated SAH in Alzheimer brain inhibits methyltransferases and is related to markers of disease progression and cognitive impairment...
  28. ncbi request reprint Diagnostic validity of the dementia questionnaire for Alzheimer disease
    R J Ellis
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0948, USA
    Arch Neurol 55:360-5. 1998
    ..To determine the sensitivity and specificity of postmortem dementia diagnoses based on a retrospective informant interview by comparison with criterion standard neuropathological diagnoses and the results of previous clinical examinations...
  29. ncbi request reprint Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease
    E Rockenstein
    Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92093 0624, USA
    Brain Res 914:48-56. 2001
    ..This study suggests that a critical balance among products of the synuclein gene is important to maintain normal brain function and that alterations in this balance might be associated with neurodegenerative disorders...
  30. ncbi request reprint Is DNA repair compromised in Alzheimer's disease?
    Vladislav Davydov
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0624, USA
    Neurobiol Aging 24:953-68. 2003
    ..Immunohistochemical analysis suggested that DNA-PK protein levels reflected both number of neurons and regulation of cellular expression...
  31. ncbi request reprint Abeta1-42 promotes cholinergic sprouting in patients with AD and Lewy body variant of AD
    E Masliah
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA emasliah ucsd edu
    Neurology 61:206-11. 2003
    ....
  32. ncbi request reprint The shifting patterns of HIV encephalitis neuropathology
    I P Everall
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Neurotox Res 8:51-61. 2005
    ..More detailed characterization of these proposed variants of HIVE is important in order to better understand the pathogenesis of HIV-associated neurological damage and to design more effective treatments to protect the nervous system...
  33. pmc Interactions between the amyloid precursor protein C-terminal domain and G proteins mediate calcium dysregulation and amyloid beta toxicity in Alzheimer's disease
    Gideon M Shaked
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0624, USA
    FEBS J 276:2736-51. 2009
    ..These results also suggest that specific antagonists of G-protein activity may have a therapeutic relevance in Alzheimer's disease...
  34. ncbi request reprint The neuropathology of aging, mild cognitive impairment, and Alzheimer disease
    Lawrence A Hansen
    Arch Neurol 63:647-8. 2006
  35. ncbi request reprint What best differentiates Lewy body from Alzheimer's disease in early-stage dementia?
    Pietro Tiraboschi
    Dipartimento di Scienze Neurologiche, Ospedale Niguarda Ca Granda, Milano, Italy
    Brain 129:729-35. 2006
    ..This suggests that clinical history plus a brief assessment of visuospatial function may be of the greatest value in correctly identifying DLB early during the course of disease...