Gary V D Hankins

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi request reprint Maternal mortality, near misses, and severe morbidity: lowering rates through designated levels of maternity care
    Gary D V Hankins
    Department of Obstetrics and Gynecology, University of Texas Medical Branch Galveston, Galveston, Texas 77555 0587, USA
    Obstet Gynecol 120:929-34. 2012
  2. pmc Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport
    Kunju Sathishkumar
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch Galveston, Texas, USA
    Reprod Biol Endocrinol 9:110. 2011
  3. ncbi request reprint Neonatal organ system injury in acute birth asphyxia sufficient to result in neonatal encephalopathy
    Gary D V Hankins
    Departments of Obstetrics and Gynecology, Galveston, Texas, USA
    Obstet Gynecol 99:688-91. 2002
  4. ncbi request reprint The role of stillbirth prevention and late preterm (near-term) births
    Gary D V Hankins
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX 77555 0587, USA
    Semin Perinatol 30:20-3. 2006
  5. ncbi request reprint Defining the pathogenesis and pathophysiology of neonatal encephalopathy and cerebral palsy
    Gary D V Hankins
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    Obstet Gynecol 102:628-36. 2003
  6. ncbi request reprint Obstetric litigation is asphyxiating our maternity services
    Gary D V Hankins
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Obstet Gynecol 107:1382-5. 2006
  7. ncbi request reprint The long journey: defining the true pathogenesis and pathophysiology of neonatal encephalopathy and cerebral palsy
    Gary D V Hankins
    University of Texas Medical Branch, 302 University Boulevard, Galveston, TX 77555, USA
    Obstet Gynecol Surv 58:435-7. 2003
  8. ncbi request reprint Factors influencing twins and zygosity
    Gary V D Hankins
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX, USA
    Paediatr Perinat Epidemiol 19:8-9. 2005
  9. doi request reprint A review of the 2008 NICHD Research Planning Workshop: recommendations for fetal heart rate terminology and interpretation
    Gary D V Hankins
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA
    Clin Obstet Gynecol 54:3-7. 2011
  10. ncbi request reprint Cesarean section on request at 39 weeks: impact on shoulder dystocia, fetal trauma, neonatal encephalopathy, and intrauterine fetal demise
    Gary D V Hankins
    The University of Texas Medical Branch, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Galveston, TX 77555 0587, USA
    Semin Perinatol 30:276-87. 2006

Research Grants

  1. Obstetric-Fetal Pharmacology Research Units Network
    Gary Hankins; Fiscal Year: 2007
  2. Bupropion for smoking cessation during pregnancy
    Tatiana Nanovskaya; Fiscal Year: 2010

Detail Information

Publications85

  1. ncbi request reprint Maternal mortality, near misses, and severe morbidity: lowering rates through designated levels of maternity care
    Gary D V Hankins
    Department of Obstetrics and Gynecology, University of Texas Medical Branch Galveston, Galveston, Texas 77555 0587, USA
    Obstet Gynecol 120:929-34. 2012
    ..In addition to accepting transfers, the central facility functioning at the highest level would also be responsible for education, evidence-based best practices, policy development, and quality review and improvement within the network...
  2. pmc Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport
    Kunju Sathishkumar
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch Galveston, Texas, USA
    Reprod Biol Endocrinol 9:110. 2011
    ..We examined whether maternal testosterone crosses the placenta to directly suppress fetal growth or if it modifies placental function to reduce the capacity for transport of nutrients to the fetus...
  3. ncbi request reprint Neonatal organ system injury in acute birth asphyxia sufficient to result in neonatal encephalopathy
    Gary D V Hankins
    Departments of Obstetrics and Gynecology, Galveston, Texas, USA
    Obstet Gynecol 99:688-91. 2002
    ..To identify the proportion of major organ system injury in cases of acute intrapartum asphyxia that result in neonatal encephalopathy...
  4. ncbi request reprint The role of stillbirth prevention and late preterm (near-term) births
    Gary D V Hankins
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX 77555 0587, USA
    Semin Perinatol 30:20-3. 2006
    ....
  5. ncbi request reprint Defining the pathogenesis and pathophysiology of neonatal encephalopathy and cerebral palsy
    Gary D V Hankins
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    Obstet Gynecol 102:628-36. 2003
    ..Other criteria that together suggest intrapartum timing are also discussed...
  6. ncbi request reprint Obstetric litigation is asphyxiating our maternity services
    Gary D V Hankins
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Obstet Gynecol 107:1382-5. 2006
    ..Potential solutions include an emphasis on evidence-based medicine, a qualification and review process for medical experts, and a more rational and fair health court system...
  7. ncbi request reprint The long journey: defining the true pathogenesis and pathophysiology of neonatal encephalopathy and cerebral palsy
    Gary D V Hankins
    University of Texas Medical Branch, 302 University Boulevard, Galveston, TX 77555, USA
    Obstet Gynecol Surv 58:435-7. 2003
  8. ncbi request reprint Factors influencing twins and zygosity
    Gary V D Hankins
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX, USA
    Paediatr Perinat Epidemiol 19:8-9. 2005
    ..In contrast, dizygotic twinning appears to be influenced by race, genetic factors, maternal age, fertility enhancing drugs, folic acid supplementation, and maternal nutritional status...
  9. doi request reprint A review of the 2008 NICHD Research Planning Workshop: recommendations for fetal heart rate terminology and interpretation
    Gary D V Hankins
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA
    Clin Obstet Gynecol 54:3-7. 2011
    ..This article summarizes the proposals and recommendations of the 2008 NICHD Research Planning Workshop...
  10. ncbi request reprint Cesarean section on request at 39 weeks: impact on shoulder dystocia, fetal trauma, neonatal encephalopathy, and intrauterine fetal demise
    Gary D V Hankins
    The University of Texas Medical Branch, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Galveston, TX 77555 0587, USA
    Semin Perinatol 30:276-87. 2006
    ....
  11. ncbi request reprint Neonatal encephalopathy and cerebral palsy: a knowledge survey of Fellows of The American College of Obstetricians and Gynecologists
    Gary D V Hankins
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    Obstet Gynecol 101:11-7. 2003
    ..To assess practicing obstetricians' knowledge of the etiology and pathophysiology of neonatal encephalopathy and its relationship to cerebral palsy...
  12. ncbi request reprint The effect of over-expression of sFlt-1 on blood pressure and the occurrence of other manifestations of preeclampsia in unrestrained conscious pregnant mice
    Fangxian Lu
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555 1062, USA
    Am J Obstet Gynecol 196:396.e1-7; discussion 396.e7. 2007
    ..Our objective was to determine the effect of the over-expression of sFlt-1 on blood pressure and the occurrence of other manifestations of preeclampsia in pregnant mice...
  13. pmc Effect of intrauterine fetal programming on response to postnatal shaker stress in endothelial nitric oxide knockout mouse model
    Maged M Costantine
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 201:301.e1-6. 2009
    ..To determine whether the intrauterine environment affects the postnatal vascular response to stress in a model of fetal programming induced by endothelial nitric oxide synthase deficiency...
  14. doi request reprint Effect of maternal body mass index on in vitro response to tocolytics in term myometrium
    Giuseppe Chiossi
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 203:261.e1-5. 2010
    ..We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics...
  15. doi request reprint Transfer of methadone across the dually perfused preterm human placental lobule
    Tatiana N Nanovskaya
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555 0587, USA
    Am J Obstet Gynecol 198:126.e1-4. 2008
    ..The objective of the study was to determine the effect of gestational age and P-glycoprotein expression on transplacental transfer of methadone...
  16. doi request reprint Individualized norms of optimal fetal growth: fetal growth potential
    Radek Bukowski
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Obstet Gynecol 111:1065-76. 2008
    ..To demonstrate that individualized optimal fetal growth norms, accounting for physiologic and pathologic determinants of fetal growth, better identify normal and abnormal outcomes of pregnancy than existing methods...
  17. pmc Fetal growth in early pregnancy and risk of delivering low birth weight infant: prospective cohort study
    Radek Bukowski
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    BMJ 334:836. 2007
    ..To determine if first trimester fetal growth is associated with birth weight, duration of pregnancy, and the risk of delivering a small for gestational age infant...
  18. ncbi request reprint The validity of cervical dilation as an indication of true labor between 32 and 36 weeks 6 days of gestation
    Sangeeta Jain
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Am J Obstet Gynecol 197:431.e1-3. 2007
    ..This diagnostic criterion has not been tested as most patients receive tocolytics. Our objective was to determine the time from admission to delivery in women with preterm contractions and advanced cervical dilation without tocolytics...
  19. ncbi request reprint Gender-specific effect of overexpression of sFlt-1 in pregnant mice on fetal programming of blood pressure in the offspring later in life
    Fangxian Lu
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, TX 77555 1062, USA
    Am J Obstet Gynecol 197:418.e1-5. 2007
    ..The purpose of this study was to determine whether fetal programming of adult blood pressure is altered in a previously characterized mouse model of preeclampsia that was induced by sFlt-1...
  20. ncbi request reprint Effect of a previous pregnancy on vascular function in endothelial nitric oxide synthase 3 knockout mice
    Labib M Ghulmiyyah
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555 0144, USA
    Am J Obstet Gynecol 197:279.e1-5. 2007
    ..Mice that lack endothelial nitric oxide synthase (NOS3) have abnormal in vitro vascular reactivity. Our objective was to assess the effect of a previous pregnancy on the abnormal vascular function of NOS3 knockout mice...
  21. pmc The effect of the postnatal environment on altered fetal programming of adult vascular function in mice that lack endothelial nitric oxide synthase
    Shannon M Clark
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, TX 77550, USA
    Am J Obstet Gynecol 196:354.e1-7. 2007
    ....
  22. ncbi request reprint Calcitonin gene-related peptide (CALCA) is a proangiogenic growth factor in the human placental development
    Yuan Lin Dong
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555 1062, USA
    Biol Reprod 76:892-9. 2007
    ....
  23. ncbi request reprint Human sexual size dimorphism in early pregnancy
    Radek Bukowski
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555 1062, USA
    Am J Epidemiol 165:1216-8. 2007
    ..009; spontaneous conception = 120 g, 95% CI: 107, 132, p < 0.00001). These data demonstrate that human fetuses exhibit sexual size dimorphism in the first trimester of pregnancy...
  24. pmc Transgenerational effect of fetal programming on vascular phenotype and reactivity in endothelial nitric oxide synthase knockout mouse model
    Maged M Costantine
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555 0144, USA
    Am J Obstet Gynecol 199:250.e1-7. 2008
    ..The objective of the study was to investigate the transgenerational effect of fetal vascular programming..
  25. pmc Role of transporter-mediated efflux in the placental biodisposition of bupropion and its metabolite, OH-bupropion
    Sarah J Hemauer
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0587, USA
    Biochem Pharmacol 80:1080-6. 2010
    ..In conclusion, our data indicate that human placenta actively regulates the disposition of bupropion (via metabolism, active transport), but not its major hepatic metabolite, OH-bupropion...
  26. doi request reprint Using pravastatin to improve the vascular reactivity in a mouse model of soluble fms-like tyrosine kinase-1-induced preeclampsia
    Maged M Costantine
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    Obstet Gynecol 116:114-20. 2010
    ..To estimate the effects of pravastatin on the altered vascular function in a mouse model of preeclampsia induced by overexpression of soluble fms-like tyrosine kinase-1 (sFlt-1)...
  27. doi request reprint Does sildenafil citrate affect myometrial contractile response to nifedipine in vitro?
    Giuseppe Chiossi
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 203:252.e1-5. 2010
    ..We sought to test the hypothesis that sildenafil citrate (SC) at low concentrations potentiates the tocolytic effects of nifedipine in vitro...
  28. doi request reprint von Willebrand disease and pregnancy: a practical approach for the diagnosis and treatment
    Luis D Pacheco
    Divisions of Maternal Fetal Medicine and Surgical Critical Care, Departments of Obstetrics and Gynecology and Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 203:194-200. 2010
    ..Delayed postpartum hemorrhage may occur, despite adequate prophylaxis. Frequent monitoring and continued prophylaxis and/or treatment are recommended for at least 2 weeks after delivery...
  29. doi request reprint Validation of the prediction model for success of vaginal birth after cesarean delivery
    Maged M Costantine
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Obstet Gynecol 114:1029-33. 2009
    ..To validate a previously developed vaginal birth after cesarean (VBAC) prediction model using a patient cohort different than that from which it was derived...
  30. doi request reprint Long-term maternal cardiovascular function in a mouse model of sFlt-1-induced preeclampsia
    Egle Bytautiene
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555 1062, USA
    Am J Physiol Heart Circ Physiol 298:H189-93. 2010
    ..Our findings favor the hypothesis that increased cardiovascular diseases in women with history of preeclampsia are likely the result of preexisting risk factors common to preeclampsia and cardiovascular diseases...
  31. pmc Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms
    Sarah J Hemauer
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555 0587, USA
    Biochem Pharmacol 79:921-5. 2010
    ....
  32. pmc Transplacental transfer and metabolism of bupropion
    Angela D Earhart
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    J Matern Fetal Neonatal Med 23:409-16. 2010
    ....
  33. pmc Opiates inhibit paclitaxel uptake by P-glycoprotein in preparations of human placental inside-out vesicles
    Sarah J Hemauer
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0587, USA
    Biochem Pharmacol 78:1272-8. 2009
    ....
  34. pmc Expression of adrenomedullin 2 (ADM2)/intermedin (IMD) in human placenta: role in trophoblast invasion and migration
    Madhu Chauhan
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA
    Biol Reprod 81:777-83. 2009
    ..2-fold compared with controls. Taken together, the findings from this study suggest that ADM2 may have a role in the physiology of human pregnancy via regulation of trophoblast invasion and migration...
  35. pmc Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study
    Radek Bukowski
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Med 6:e1000061. 2009
    ..Low plasma folate concentrations in pregnancy are associated with preterm birth. Here we show an association between preconceptional folate supplementation and the risk of spontaneous preterm birth...
  36. doi request reprint Acute antihypertensive therapy in pregnancy-induced hypertension: is nicardipine the answer?
    Rakesh B Vadhera
    Department of Anesthesiology, The University of Texas Medical Branch at Galveston, Texas 77555 0591, USA
    Am J Perinatol 26:495-9. 2009
    ....
  37. doi request reprint Antenatal antecedents and the impact of obstetric care in the etiology of cerebral palsy
    Shannon M Clark
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    Clin Obstet Gynecol 51:775-86. 2008
    ..The focus of this paper is to explore antenatal antecedents as etiologies of CP and the impact of obstetric care on the prevention of CP...
  38. ncbi request reprint Circulating calcitonin gene-related peptide and its placental origins in normotensive and preeclamptic pregnancies
    Yuan Lin Dong
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Room 11 138, Rt 1062, Galveston, TX 77555 1062, USA
    Am J Obstet Gynecol 195:1657-67. 2006
    ..The present study was designed to determine plasma calcitonin gene-related peptide concentration in both maternal and fetal circulations in normotensive and pre-eclamptic pregnancies and investigate whether placenta is 1 of its origins...
  39. ncbi request reprint A patient-centered health care delivery system by a university obstetrics and gynecology department
    Garland D Anderson
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA
    Obstet Gynecol 105:205-10. 2005
    ..Our experience has shown that patient-centered care can be a viable business strategy to maintain and expand patient volumes and will work even where there are serious geographic disadvantages...
  40. ncbi request reprint Burns in pregnancy
    Luis D Pacheco
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    Obstet Gynecol 106:1210-2. 2005
    ..Treatment of a major burn injury during pregnancy must incorporate modifications in management resulting from gestational physiologic changes...
  41. ncbi request reprint The use of a continuous infusion of epinephrine for anaphylactic shock during labor
    Alfredo F Gei
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 0587, USA
    Obstet Gynecol 102:1332-5. 2003
    ..This immunoglobulin E-mediated process is the result of the action of basophils and mast cell mediators, causing severe brochospasm, laringospasm, angioedema, urticaria, and cardiovascular collapse...
  42. ncbi request reprint Conference report: complex clinical, legal, and ethical issues of pregnant and postpartum women as subjects in clinical trials
    Linda A Goodrum
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0587, USA
    J Womens Health (Larchmt) 12:857-67. 2003
    ....
  43. ncbi request reprint Embolism during pregnancy: thrombus, air, and amniotic fluid
    Alfredo F Gei
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 0587, USA
    Anesthesiol Clin North America 21:165-82. 2003
    ..Several clinical characteristics will assist practitioners to distinguish among the different forms of embolism and to institute specific measures of treatment...
  44. ncbi request reprint Involvement of calcitonin gene-related peptide in control of human fetoplacental vascular tone
    Yuan Lin Dong
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 Univ Blvd, Medical Research Bldg, Rm 11 138, Galveston, TX 77555 1062, USA
    Am J Physiol Heart Circ Physiol 286:H230-9. 2004
    ..We propose that CGRP may play a role in the control of human fetoplacental vascular tone, and the vascular dilations in response to CGRP may involve activation of KATP channels, cAMP, and a nitric oxide pathway...
  45. pmc Labor-associated gene expression in the human uterine fundus, lower segment, and cervix
    Radek Bukowski
    Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA
    PLoS Med 3:e169. 2006
    ..We aimed to assess labor-associated gene expression profiles in these functionally distinct areas of the human uterus by using microarrays...
  46. ncbi request reprint Evidence for decreased calcitonin gene-related peptide (CGRP) receptors and compromised responsiveness to CGRP of fetoplacental vessels in preeclamptic pregnancies
    Yuan Lin Dong
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Medical Research Building, 11 138, Galveston, Texas 77555 1062, USA
    J Clin Endocrinol Metab 90:2336-43. 2005
    ..We concluded that CGRP may contribute to the low fetoplacental vascular resistance in normal pregnancies; however, CGRP-dependent vascular relaxation appears to be compromised in preeclamptic pregnancies...
  47. ncbi request reprint Management of uterine hyperstimulation with concomitant use of oxytocin and terbutaline
    Luis D Pacheco
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Am J Perinatol 23:377-80. 2006
    ..In the management of uterine hyperstimulation, subcutaneous terbutaline without discontinuation of oxytocin is more effective than the traditional approach of oxytocin discontinuation...
  48. ncbi request reprint Enhanced growth and improved vascular function in offspring from successive pregnancies in endothelial nitric oxide synthase knockout mice
    Monica Longo
    Department of Gynecology and Obstetrics, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1062, USA
    Am J Obstet Gynecol 191:1470-6. 2004
    ..Our objective was to evaluate the role of parity in the modulation of the fetal programming of growth and vascular responses in these transgenic mice...
  49. ncbi request reprint Pharmacokinetics and pharmacotherapy of thionamides in pregnancy
    Shannon M Clark
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Ther Drug Monit 28:477-83. 2006
    ..None of the above have been substantiated in more recent studies. The pharmacokinetics of the thionamides in the pregnant and nonpregnant states, as well as the pharmacotherapeutic recommendation for hyperthyroidism will be reviewed...
  50. ncbi request reprint Smallpox and pregnancy: from eradicated disease to bioterrorist threat
    Victor R Suarez
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston 77555 0587, USA
    Obstet Gynecol 100:87-93. 2002
    ..Under such emergency circumstances, pregnant women exposed to the variola virus should be vaccinated because of the lethality of the disease during pregnancy. Currently, there is a limited supply of vaccine available...
  51. ncbi request reprint Brachial plexus paresis associated with fetal neck compression from forceps
    Alfredo F Gei
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    Am J Perinatol 20:289-91. 2003
    ..The paresis resolved during the first day of life. Direct cervical compression of the fetal neck by forceps in procedures involving rotations of the presentation may result in brachial plexus injuries...
  52. pmc Maternal hypercholesterolemia leads to activation of endogenous cholesterol synthesis in the offspring
    Nima Goharkhay
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 199:273.e1-6. 2008
    ..The purpose of this study was to determine the effect of maternal hypercholesterolemia on hepatic cholesterol metabolism in the offspring in a mouse model...
  53. ncbi request reprint The 30-minute decision-to-incision interval for emergency cesarean delivery: fact or fiction?
    Fayez K Nasrallah
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    Am J Perinatol 21:63-8. 2004
    ..Maternal complications were higher in group I, but not statistically significant. Although it was achieved in most of the ECDs, the guideline of 30-minute D-I does not seem to improve neonatal nor worsen maternal outcomes...
  54. doi request reprint Effect of plasma proteins on buprenorphine transfer across dually perfused placental lobule
    Tatiana N Nanovskaya
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    J Matern Fetal Neonatal Med 22:646-53. 2009
    ..The aim of this investigation is to determine the effect of human serum albumin (HSA) and alpha-acid glycoprotein (AAG) on buprenorphine (BUP) transplacental transfer and distribution...
  55. ncbi request reprint High compared with standard gentamicin dosing for chorioamnionitis: a comparison of maternal and fetal serum drug levels
    Gregory J Locksmith
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Obstet Gynecol 105:473-9. 2005
    ..To compare umbilical cord and maternal serum peak gentamicin concentration, gentamicin elimination, and clinical outcomes between women who received once-daily compared with standard, thrice-daily dosing for clinical chorioamnionitis...
  56. doi request reprint Transplacental transfer and metabolism of 17-alpha-hydroxyprogesterone caproate
    Sarah J Hemauer
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 199:169.e1-5. 2008
    ..Determine transplacental transfer and metabolism of 17-alpha-hydroxyprogesterone caproate and its distribution between the tissue and the maternal and fetal circuits of the dually perfused placental lobule...
  57. pmc 17-alpha-hydroxyprogesterone caproate for the prevention of preterm birth in women with prior preterm birth and a short cervical length
    Vincenzo Berghella
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
    Am J Obstet Gynecol 202:351.e1-6. 2010
    ..We sought to evaluate 17-alpha-hydroxyprogesterone caproate (17P) for prevention of preterm birth (PTB) in women with prior spontaneous PTB (SPTB) and cervical length (CL) <25 mm...
  58. ncbi request reprint Characterization of a murine model of fetal programming of atherosclerosis
    Nima Goharkhay
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 197:416.e1-5. 2007
    ..The objective of the study was to investigate the effect of fetal programming on the development of atherosclerosis in the offspring in a mouse model...
  59. ncbi request reprint Documentation of amniotic fluid embolism via lung histopathology. Fact or fiction?
    Gary D V Hankins
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0587, USA
    J Reprod Med 47:1021-4. 2002
    ..To evaluate pulmonary histopathology for confirming amniotic fluid embolism...
  60. ncbi request reprint Expression of regulator of G protein signaling-2 in rat myometrium during pregnancy and parturition
    Victor R Suarez
    Division of Maternal Fetal Medicine, University of Texas Medical Branch, Galveston, USA
    Am J Obstet Gynecol 188:973-7. 2003
    ....
  61. doi request reprint The effect of prepregnancy obesity and sFlt-1-induced preeclampsia-like syndrome on fetal programming of adult vascular function in a mouse model
    Benjamin D Byers
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 200:432.e1-7. 2009
    ..The purpose of this study was to test the hypothesis that prepregnancy obesity and soluble fms-like tyrosine kinase-1 (sFlt-1)-induced preeclampsia lead to altered vascular function in the offspring later in life...
  62. doi request reprint Progesterone, but not 17-alpha-hydroxyprogesterone caproate, inhibits human myometrial contractions
    Nicole K Ruddock
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 199:391.e1-7. 2008
    ..The aim was to determine whether progesterone (P4) or 17-alpha-hydroxyprogesterone caproate (17P) directly inhibit human uterine contractility in vitro and thereby clarify their mechanisms of action...
  63. ncbi request reprint The effect of methadone and buprenorphine on human placental aromatase
    Olga L Zharikova
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, 77555, USA
    Biochem Pharmacol 71:1255-64. 2006
    ..Therefore, data reported here suggest that methadone, BUP, and their metabolites are inhibitors of androgen aromatization in the placental biosynthesis of estrogens...
  64. ncbi request reprint Impairment of fetal growth potential and neonatal encephalopathy
    Radek Bukowski
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, USA
    Am J Obstet Gynecol 188:1011-5. 2003
    ..This study was undertaken to determine the frequency of growth impairment in neonates with encephalopathy...
  65. pmc Bupropion metabolism by human placenta
    Xiaoming Wang
    Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, 77555 0587, USA
    Biochem Pharmacol 79:1684-90. 2010
    ..On the other hand, CYP2B6 was responsible for the formation of OH-bupropion. These data suggest that both placental microsomal carbonyl-reducing and oxidizing enzymes are involved in the metabolism of bupropion...
  66. ncbi request reprint Temporal and demographic trends in cerebral palsy--fact and fiction
    Steven L Clark
    University of Utah School of Medicine, LDS Hospital, Salt Lake City, USA
    Am J Obstet Gynecol 188:628-33. 2003
    ..Except in rare instances, cerebral palsy is a developmental event that is unpreventable given our current state of technology...
  67. ncbi request reprint The contribution of birth defects to preterm birth and low birth weight
    Siobhan M Dolan
    Albert Einstein College of Medicine Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Obstet Gynecol 110:318-24. 2007
    ..To assess the impact of birth defects on preterm birth and low birth weight...
  68. pmc Discussion required for correct interpretation
    Radek Bukowski
    PLoS Med 3:e369. 2006
  69. ncbi request reprint Neonatal encephalopathy and cerebral palsy revisited: the current state of knowledge and the impact of american college of obstetricians and gynecologists task force report
    Maria A Morgan
    American College of Obstetricians and Gynecologists, Washington, DC 20024, USA
    J Perinatol 25:519-25. 2005
    ..To re-assess obstetrician-gynecologists' knowledge of neonatal encephalopathy and cerebral palsy after publication of the ACOG/AAP Task Force report...
  70. ncbi request reprint The effect of low body mass index on the development of gestational hypertension and preeclampsia
    Victoria Belogolovkin
    Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Matern Fetal Neonatal Med 20:509-13. 2007
    ..To evaluate the relationship between low maternal body mass index (BMI) as calculated in the first trimester and the risk of preeclampsia and gestational hypertension...
  71. pmc A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy
    Dwight J Rouse
    University of Alabama at Birmingham, Birmingham, USA
    N Engl J Med 359:895-905. 2008
    ..Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy...
  72. ncbi request reprint Gender mix in twins and fetal growth, length of gestation and adult cancer risk
    Barbara Luke
    Department of Epidemiology and Public Health, University of Miami School of Medicine, Miami, FL, USA
    Paediatr Perinat Epidemiol 19:41-7. 2005
    ..In contrast, there is no evidence to suggest that there might be a similar feminising effect on males from unlike-gender pairs. This hormonal exposure in utero may influence adult body size and susceptability to breast cancer...
  73. ncbi request reprint The effect of in utero exposure to indomethacin on the need for surgical closure of a patent ductus arteriosus in the neonate
    Victor R Suarez
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 187:886-8. 2002
    ..Our purpose was to determine the effect of in utero exposure to indomethacin on the need for surgical closure of a patent ductus arteriosus (PDA)...
  74. ncbi request reprint Methadone metabolism by early gestational age placentas
    Todd Lewis Hieronymus
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA
    Am J Perinatol 23:287-94. 2006
    ..The variability in enzyme activity among individuals should be reflected by the concentration of methadone in the fetal circulation and might be one of the factors affecting the incidence and intensity of neonatal abstinence syndrome...
  75. ncbi request reprint Role of human placental efflux transporter P-glycoprotein in the transfer of buprenorphine, levo-alpha-acetylmethadol, and paclitaxel
    Ilona A Nekhayeva
    Department of Clinical Pharmacology, Belarussian State Medical University, Minsk, Republic of Belarus
    Am J Perinatol 23:423-30. 2006
    ..Therefore, it is reasonable to assume that the activity of P-gp could be one of the factors affecting the extent of fetal exposure to LAAM during pregnancy...
  76. ncbi request reprint Variation in the rates of operative delivery in the United States
    Steven L Clark
    Hospital Corporation of America, Division of Perinatal Safety, Nashville, TN, USA
    Am J Obstet Gynecol 196:526.e1-5. 2007
    ....
  77. ncbi request reprint Effect of human serum albumin on transplacental transfer of glyburide
    Tatiana N Nanovskaya
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0587, USA
    Biochem Pharmacol 72:632-9. 2006
    ..Data obtained indicates the dependence of glyburide transfer and its retention by the placental tissue on the concentration of HSA...
  78. ncbi request reprint The effect of opiates on the activity of human placental aromatase/CYP19
    Olga L Zharikova
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0587, USA
    Biochem Pharmacol 73:279-86. 2007
    ..It is unlikely that the acute administration of the opiates that inhibit estrogen formation would affect maternal and/or neonatal outcome. However, the effects of abusing any of them during the entire pregnancy are unclear at this time...
  79. ncbi request reprint The Hispanic paradox in twin pregnancies
    Barbara Luke
    University of Miami School of Nursing and Health Studies, Coral Gables, Florida, USA
    Twin Res Hum Genet 8:532-7. 2005
    ..7 g/week and by 4.5 g/week, respectively). These findings in twins reflect the racial and ethnic disparities previously shown in singletons, including the Hispanic paradox of longer gestations and higher rates of fetal growth...
  80. ncbi request reprint Defining the true pathogenesis and pathophysiology of neonatal encephalopathy and cerebral palsy
    Michael Speer
    J Perinatol 23:179-80. 2003
  81. ncbi request reprint Value of ultrasound in the early diagnosis of prerupture uterine horn pregnancy. A case report
    Cau Van Vo
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, USA
    J Reprod Med 48:471-3. 2003
    ..The poor outcome of rudimentary horn pregnancies is due to delayed diagnosis...
  82. pmc The effect of esterases on 17alpha-hydroxyprogesterone caproate
    Ru Yan
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 198:229.e1-5. 2008
    ..The aim of this investigation is to determine whether 17alpha-hydroxyprogesterone caproate is hydrolyzed, in vitro, to 17alpha-hydroxyprogesterone and caproate...
  83. doi request reprint The 2008 National Institute of Child Health and Human Development workshop report on electronic fetal monitoring: update on definitions, interpretation, and research guidelines
    George A Macones
    Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Obstet Gynecol 112:661-6. 2008
    ..A three-tier system for fetal heart rate tracing interpretation is also described. Lastly, prioritized topics for future research are provided...
  84. ncbi request reprint Bidirectional transfer of methadone across human placenta
    Ilona A Nekhayeva
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0587, USA
    Biochem Pharmacol 69:187-97. 2005
    ....
  85. ncbi request reprint N-demethylation of levo-alpha-acetylmethadol by human placental aromatase
    Sujal V Deshmukh
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0587, USA
    Biochem Pharmacol 67:885-92. 2004
    ..Taken together, the above data indicate that CYP 19/aromatase is the enzyme responsible for the N-demethylation of LAAM to norLAAM in term human placentas obtained from healthy pregnant women...

Research Grants4

  1. Obstetric-Fetal Pharmacology Research Units Network
    Gary Hankins; Fiscal Year: 2007
    ..The Division of Neonatology, the GCRC, and other departments at UTMB will provide support for this project. ..
  2. Bupropion for smoking cessation during pregnancy
    Tatiana Nanovskaya; Fiscal Year: 2010
    ..This research is necessary for the development of medications to treat pregnant smokers which will, in turn, improve infant health. ..