Andreas Handel

Summary

Affiliation: University of Georgia
Country: USA

Publications

  1. pmc A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence
    Andreas Handel
    Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia, United States of America
    PLoS Comput Biol 9:e1002989. 2013
  2. pmc A review of mathematical models of influenza A infections within a host or cell culture: lessons learned and challenges ahead
    Catherine A A Beauchemin
    Department of Physics, Ryerson University, Toronto, ON, M5B 2K3, Canada
    BMC Public Health 11:S7. 2011
  3. pmc Intervention strategies for an influenza pandemic taking into account secondary bacterial infections
    Andreas Handel
    Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30602, USA
    Epidemics 1:185-95. 2009
  4. pmc The impact of population size on the evolution of asexual microbes on smooth versus rugged fitness landscapes
    Andreas Handel
    Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30602, USA
    BMC Evol Biol 9:236. 2009
  5. doi request reprint Exploring the role of the immune response in preventing antibiotic resistance
    Andreas Handel
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    J Theor Biol 256:655-62. 2009
  6. pmc Towards a quantitative understanding of the within-host dynamics of influenza A infections
    Andreas Handel
    Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30602, USA
    J R Soc Interface 7:35-47. 2010
  7. pmc Sharing the burden: antigen transport and firebreaks in immune responses
    Andreas Handel
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    J R Soc Interface 6:447-54. 2009
  8. pmc Antiviral resistance and the control of pandemic influenza: the roles of stochasticity, evolution and model details
    Andreas Handel
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    J Theor Biol 256:117-25. 2009
  9. pmc Neuraminidase inhibitor resistance in influenza: assessing the danger of its generation and spread
    Andreas Handel
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Comput Biol 3:e240. 2007
  10. pmc A simple mathematical model helps to explain the immunodominance of CD8 T cells in influenza A virus infections
    Andreas Handel
    Emory University, Department of Biology, 1510 Clifton Road NE, Atlanta, GA 30322, USA
    J Virol 82:7768-72. 2008

Detail Information

Publications17

  1. pmc A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence
    Andreas Handel
    Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia, United States of America
    PLoS Comput Biol 9:e1002989. 2013
    ..For all other scenarios, influenza viruses with good environmental persistence at low temperatures seem to be favored...
  2. pmc A review of mathematical models of influenza A infections within a host or cell culture: lessons learned and challenges ahead
    Catherine A A Beauchemin
    Department of Physics, Ryerson University, Toronto, ON, M5B 2K3, Canada
    BMC Public Health 11:S7. 2011
    ..Finally, we explain the contributions of such modeling efforts to important public health issues, and suggest future modeling studies that can help to address additional questions relevant to public health...
  3. pmc Intervention strategies for an influenza pandemic taking into account secondary bacterial infections
    Andreas Handel
    Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30602, USA
    Epidemics 1:185-95. 2009
    ....
  4. pmc The impact of population size on the evolution of asexual microbes on smooth versus rugged fitness landscapes
    Andreas Handel
    Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30602, USA
    BMC Evol Biol 9:236. 2009
    ....
  5. doi request reprint Exploring the role of the immune response in preventing antibiotic resistance
    Andreas Handel
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    J Theor Biol 256:655-62. 2009
    ..We discuss the predictions and hypotheses derived from this study and how they can be tested experimentally...
  6. pmc Towards a quantitative understanding of the within-host dynamics of influenza A infections
    Andreas Handel
    Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30602, USA
    J R Soc Interface 7:35-47. 2010
    ..We also find that different model variants for both innate and adaptive responses fit the data well, indicating the need for additional data to allow further model discrimination...
  7. pmc Sharing the burden: antigen transport and firebreaks in immune responses
    Andreas Handel
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    J R Soc Interface 6:447-54. 2009
    ..Our study thus shows the potential benefits of GMAT and illustrates how spatial effects may be crucial for the quantitative understanding of infection dynamics and immune responses...
  8. pmc Antiviral resistance and the control of pandemic influenza: the roles of stochasticity, evolution and model details
    Andreas Handel
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    J Theor Biol 256:117-25. 2009
    ..If containment is not possible, mitigation works best at intermediate levels of antiviral control. Finally, we show that the results are not very sensitive to the way resistance generation is modeled...
  9. pmc Neuraminidase inhibitor resistance in influenza: assessing the danger of its generation and spread
    Andreas Handel
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Comput Biol 3:e240. 2007
    ..Better knowledge of the quantitative dynamics of the immune response during influenza infections will be crucial to further improve the results...
  10. pmc A simple mathematical model helps to explain the immunodominance of CD8 T cells in influenza A virus infections
    Andreas Handel
    Emory University, Department of Biology, 1510 Clifton Road NE, Atlanta, GA 30322, USA
    J Virol 82:7768-72. 2008
    ..This "numbers game" between antigen and CD8(+) T cells can reproduce the observed immunodominance of the NP336- and PA224-specific CD8(+) T cells, thereby explaining the reported experimental data...
  11. pmc What is the best control strategy for multiple infectious disease outbreaks?
    Andreas Handel
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Proc Biol Sci 274:833-7. 2007
    ..Here, we identify the best control strategy for such a situation. We further discuss ways in which such a strategy can be implemented to achieve additional public health objectives...
  12. pmc How to minimize the attack rate during multiple influenza outbreaks in a heterogeneous population
    Isaac Chun Hai Fung
    Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia, United States of America
    PLoS ONE 7:e36573. 2012
    ..Any control measures above that optimal level will lead to an outcome that may be as sub-optimal as that achieved by an intervention that is too weak. We studied this scenario in more detail...
  13. pmc How sticky should a virus be? The impact of virus binding and release on transmission fitness using influenza as an example
    Andreas Handel
    Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30602, USA
    J R Soc Interface 11:20131083. 2014
    ..Overall, our findings provide potentially useful conceptual insights for future vaccine and drug development and can be applied to other budding viruses beyond influenza. ..
  14. doi request reprint Molecular evolution and emergence of avian gammacoronaviruses
    Mark W Jackwood
    Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States
    Infect Genet Evol 12:1305-11. 2012
    ....
  15. pmc The role of compensatory mutations in the emergence of drug resistance
    Andreas Handel
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Comput Biol 2:e137. 2006
    ..We further show that resistance emergence depends on the level of drug use in a strongly nonlinear fashion. We also discuss what data need to be obtained to allow future quantitative predictions of resistance emergence...
  16. pmc Severe outcomes are associated with genogroup 2 genotype 4 norovirus outbreaks: a systematic literature review
    Rishi Desai
    Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 55:189-93. 2012
    ..This report reviews published NoV outbreak reports to quantify hospitalization and mortality rates and assess their relationship with outbreak setting, transmission route, and strain...
  17. ncbi request reprint Gap junction-mediated antigen transport in immune responses
    Andreas Handel
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Trends Immunol 28:463-6. 2007
    ..Here, we discuss this idea in more detail and suggest possible ways in which this mechanism might have both positive and negative impacts during an immune response...