Affiliation: University of Rochester
- CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivoJoerg Dietrich
Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Biol 5:22. 2006..The underlying cellular basis for these adverse effects is poorly understood...
- Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous systemRuolan Han
Department of Biomedical Genetics and University of Rochester Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, Elmwood Avenue, Rochester, NY 14642, USA
J Biol 7:12. 2008..Nor are there any animal models that could enable the study of this important problem...
- MEK1/2 inhibition suppresses tamoxifen toxicity on CNS glial progenitor cellsHsing Yu Chen
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642
J Neurosci 33:15069-74. 2013..Our results demonstrate unexpected cytotoxicity of this putatively benign antihormonal agent and offer a potential strategy for rescuing CNS cells from adverse effects of TMX. ..