Affiliation: University of Iowa
- The effect of the PKC inhibitor calphostin C and the PKC agonist phorbol 12-myristate 13-acetate on regulation of cytosolic Ca(2+) in mammalian skeletal muscle cellsRenzhi Han
Physiology, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
Toxicol Appl Pharmacol 212:247-55. 2006..These results indicate that PKC plays a role in modulation of SR function in skeletal muscle cells, and the PKC inhibitor CC may alter Ca(2+) handling via both PKC-dependent and PKC-independent pathways...
- Measurement of sub-membrane [Ca2+] in adult myofibers and cytosolic [Ca2+] in myotubes from normal and mdx mice using the Ca2+ indicator FFP-18Renzhi Han
School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
Cell Calcium 40:299-307. 2006..This study suggests that the sub-sarcolemmal Ca(2+) homeostasis is well maintained in isolated adult mdx myofibers and also further supports the hypothesis that cytosolic Ca(2+) handling is compromised in mdx myotubes...
- Effect of indomethacin on force responses and sarcoplasmic reticulum function in skinned skeletal muscle fibers and cytosolic [Ca2+] in myotubesRenzhi Han
School of Biomedical and Chemical Studies, The University of Western Australia, Crawley, Australia
Am J Physiol Cell Physiol 285:C881-90. 2003..These data suggest that intracellular PLA2 may be an important modulator of ECC in skeletal muscle...
- The effect of chelerythrine on depolarization-induced force responses in skinned fast skeletal muscle fibres of the ratRenzhi Han
School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Australia
Br J Pharmacol 138:417-26. 2003..Chelerythrine may be an important pharmacological probe for examining the mechanisms of contraction-induced muscle injury...
- Thapsigargin modulates osteoclastogenesis through the regulation of RANKL-induced signaling pathways and reactive oxygen species productionKirk H M Yip
Molecular Orthopaedic Laboratory, School of Surgery and Pathology, and Western Australian Institute for Medical Research, Nedlands, WA 6009, Australia
J Bone Miner Res 20:1462-71. 2005..In this study, we showed a biphasic effect of TG on osteoclast formation and apoptosis through the regulation of ROS production, caspase-3 activity, cytosolic Ca2+, and RANKL-induced activation of NF-kappaB and AP-1 activities...
- Fibrin sealant promotes migration and proliferation of human articular chondrocytes: possible involvement of thrombin and protease-activated receptorsYaowanuj Kirilak
School of Surgery and Pathology Orthopaedics, The University of Western Australia, Crawley WA 6009, Australia
Int J Mol Med 17:551-8. 2006..Together, these data demonstrate that FS supports both the migration and proliferation of human chondrocytes. We propose that these effects are mediated, at least in part, via thrombin-induced PAR-1 signalling in human chondrocytes...
- Dysferlin and muscle membrane repairRenzhi Han
Howard Hughes Medical Institute, Department of Molecular Physiology and Biophysics, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Curr Opin Cell Biol 19:409-16. 2007..Future research on dysferlin and its interacting partners will enhance the understanding of this important process and provide novel avenues to potential therapies...
- Evidence of reciprocal regulation between the high extracellular calcium and RANKL signal transduction pathways in RAW cell derived osteoclastsJiake Xu
Molecular Orthopaedic Laboratory, School of Surgery and Pathology, University of Western Australia, Nedlands WA, Australia
J Cell Physiol 202:554-62. 2005..Our data imply a cross talk mechanism of extracellular Ca2+ on osteoclast survival through the regulation of RANKL...
- Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injuryRenzhi Han
Howard Hughes Medical Institute, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
J Clin Invest 117:1805-13. 2007..Thus, our study establishes what we believe is a novel mechanism underlying the cardiomyopathy that results from a defective membrane repair in the absence of dysferlin...